ypt71 (SPAPB1A10.10c)

Gene Standard Nameypt71 Characterisation Statuspublished
Systematic IDSPAPB1A10.10c Feature Typeprotein coding
Synonyms Name Description
ProductGTPase Ypt71 Product Size208aa, 23.47 kDa
Genomic Location Chromosome I, 1881970-1880698 (1273nt); CDS:1881910-1880879 (1032nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005525GTP bindingIEAUniProtKB-KW:KW-0342GO_REF:0000037113
GO:0003924GTPase activityISOSGD:S000004460GO_REF:000002461
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006896Golgi to vacuole transportISOSGD:S000004460GO_REF:000002418
GO:0006886intracellular protein transportICGO:0006897GO_REF:0000001338
GO:0061192negative regulation of vacuole fusion, non-autophagicIMPPMID:194539731
GO:0007264small GTPase mediated signal transductionIEAIPR001806GO_REF:0000002139
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005774vacuolar membraneIDAPMID:19453973108
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyypt71ΔNullPMID:204732893759
Microscopyypt71ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000123large vacuoles during vegetative growthMicroscopynot recorded (overexpression)PMID:1635744324
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyypt71ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00071 Pfam IPR001806 Small GTPase superfamily 10 176 18
SM00174 SMART IPR003578 Small GTPase superfamily, Rho type 11 179 19
SM00173 SMART IPR020849 Small GTPase superfamily, Ras type 5 179 19
SM00175 SMART IPR003579 Small GTPase superfamily, Rab type 9 179 22
SM00176 SMART IPR002041 Ran GTPase 14 206 13
PS51419 Prosite Profiles 4 208 9
PTHR24073 HMMPANTHER 2 208 9
PTHR24073:SF57 HMMPANTHER 2 208 2 Gene3D 4 184 288
SSF52540 SuperFamily IPR027417 P-loop containing nucleoside triphosphate hydrolase 5 185 294
PR00449 PRINTS IPR001806 Small GTPase superfamily 115 128 19
PR00449 PRINTS IPR001806 Small GTPase superfamily 9 30 19
PR00449 PRINTS IPR001806 Small GTPase superfamily 50 72 19
PR00449 PRINTS IPR001806 Small GTPase superfamily 32 48 19
PR00449 PRINTS IPR001806 Small GTPase superfamily 154 176 19
TIGR00231 tigrfam IPR005225 Small GTP-binding protein domain 10 172 35

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001222Rab subfamilyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001222

Protein Properties

Ave. residue weight 112.86 Da
Charge -2.50
Isoelectric point 5.33
Molecular weight 23.47 kDa
Number of residues 208
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
30987during GO:0000080PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
34422during GO:0000084PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
29551during GO:0000085PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
32586during GO:0000087PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
8075.49during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
32161during GO:0072690PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
15190.98during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.4during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.81during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Disease Association
neurological disorders PMID:2329357898
Charcot-Marie-Tooth disease PMID:232935789
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
rhb1Rheb GTPase Rhb1 Positive GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Positive GeneticPMID:22681890
SPAC1687.09ENTH/VHS domain protein (predicted) Negative GeneticPMID:22681890
rxt2histone deacetylase complex subunit Rxt2 Positive GeneticPMID:22681890
SPCPB16A4.02cconserved fungal protein Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPAPB1A10.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAPB1A10.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAPB1A10.10c BioGRID Interaction Datasets
Expression Viewer SPAPB1A10.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAPB1A10.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAPB1A10.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAPB1A10.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAPB1A10.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAPB1A10.10c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAPB1A10.10c Cell Cycle Data
GEO SPAPB1A10.10c GEO profiles
PInt SPAPB1A10.10c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAPB1A10.10c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAPB1A10.10c Fission yeast phenotypic data & analysis
UniProtKB/SwissProtQ9HDY0GTP-binding protein ypt71
ModBaseQ9HDY0Database of comparative protein structure models
STRINGQ9HDY0Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593524GTPase Ypt71
RefSeq mRNANM_001018958972h- GTPase Ypt71 (ypt71), mRNA
European Nucleotide ArchiveCAC21483.1ENA Protein Mapping
UniParcUPI000006C051UniProt Archive

Literature for ypt71

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014