ypt71 (SPAPB1A10.10c)


Gene Standard Nameypt71 Characterisation Statuspublished
Systematic IDSPAPB1A10.10c Feature Typeprotein coding
Synonyms Name Description
ProductGTPase Ypt71 Product Size208aa, 23.47 kDa
Genomic Location Chromosome I, 1881970-1880698 (1273nt); CDS:1881910-1880879 (1032nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005525GTP bindingIEAUniProtKB-KW:KW-0342GO_REF:0000037113
GO:0003924GTPase activityISOSGD:S000004460GO_REF:000002461
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006184GTP catabolic processISOSGD:S000004460GO_REF:000002448
GO:0006896Golgi to vacuole transportISOSGD:S000004460GO_REF:000002418
GO:0006897endocytosisISOSGD:S000004460GO_REF:000002465
GO:0006886intracellular protein transportICGO:0006897GO_REF:0000001330
GO:0061192negative regulation of vacuole fusion, non-autophagicIMPPMID:194539731
GO:0007264small GTPase mediated signal transductionIEAIPR001806GO_REF:000000262
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722316
GO:0005634nucleusIDAPMID:168233722740
GO:0005774vacuolar membraneIDAPMID:19453973108
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyypt71ΔNullPECO:0000005, PECO:0000137PMID:236978063760
Microscopyypt71ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000123large vacuoles during vegetative growthnot recorded (overexpression)PMID:1635744312
FYPO:0002177viable vegetative cell with normal cell morphology3086
penetrance FYPO_EXT:0000001Microscopyypt71ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
118819701881830
218814781881380
318813251880698

UTRs

Region Coordinates Reference
five_prime_UTR1881970..1881911PMID:21511999
three_prime_UTR1880878..1880698PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00071 Pfam IPR001806 Small GTPase superfamily 10 176 18
SM00175 SMART IPR003579 Small GTPase superfamily, Rab type 9 179 8
PS51419 Prosite Profiles 4 208 9
PTHR24073 HMMPANTHER 1 208 9
PTHR24073:SF57 HMMPANTHER 1 208 2
3.40.50.300 Gene3D IPR027417 P-loop containing nucleoside triphosphate hydrolase 4 184 279
SSF52540 SuperFamily IPR027417 P-loop containing nucleoside triphosphate hydrolase 5 185 294
PR00449 PRINTS IPR001806 Small GTPase superfamily 9 30 19
PR00449 PRINTS IPR001806 Small GTPase superfamily 50 72 19
PR00449 PRINTS IPR001806 Small GTPase superfamily 154 176 19
PR00449 PRINTS IPR001806 Small GTPase superfamily 32 48 19
PR00449 PRINTS IPR001806 Small GTPase superfamily 115 128 19
TIGR00231 tigrfam IPR005225 Small GTP-binding protein domain 10 172 35

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001222Rab subfamilyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001222

Protein Properties

Ave. residue weight 112.86 Da
Charge -2.50
Isoelectric point 5.33
Molecular weight 23.47 kDa
Number of residues 208
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
8075.49during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
32161during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
34422during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
30987during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
29551during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
32586during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
15190.98during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.81during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
1.4during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
rhb1Rheb GTPase Rhb1 Positive GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Positive GeneticPMID:22681890
SPAC1687.09ENTH/VHS domain protein (predicted) Negative GeneticPMID:22681890
rxt2histone deacetylase complex subunit Rxt2 Positive GeneticPMID:22681890
SPCPB16A4.02cconserved fungal protein Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPAPB1A10.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAPB1A10.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAPB1A10.10c BioGRID Interaction Datasets
Expression Viewer SPAPB1A10.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAPB1A10.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAPB1A10.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAPB1A10.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAPB1A10.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAPB1A10.10c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAPB1A10.10c Cell Cycle Data
GEO SPAPB1A10.10c GEO profiles
PInt SPAPB1A10.10c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2543411GTPase Ypt71
EntrezGene2543411GTPase Ypt71
UniProtKB/SwissProtQ9HDY0GTP-binding protein ypt71
ModBaseQ9HDY0Database of comparative protein structure models
STRINGQ9HDY0Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593524GTPase Ypt71
RefSeq mRNANM_001018958972h- GTPase Ypt71 (ypt71), mRNA
European Nucleotide ArchiveCAC21483ENA Protein Mapping
European Nucleotide ArchiveCAC21483.1ENA Protein Mapping
UniParcUPI000006C051UniProt Archive

Literature for ypt71

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014