mcl1 (SPAPB1E7.02c)

Gene Standard Namemcl1 Characterisation Statuspublished
Systematic IDSPAPB1E7.02c Feature Typeprotein coding
Synonymsslr3 Name Description
ProductDNA polymerase alpha accessory factor Mcl1 Product Size815aa, 90.99 kDa
Genomic Location Chromosome I, 3285778-3283004 (2775nt); CDS:3285745-3283195 (2551nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
protein binding848
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process

GO Slim Terms

DNA replication

GO Cellular Component
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viability depends on conditions

Population Phenotype

Term NameAlleleExpressionCount
decreased cell population growth during glucose limitationmcl1ΔNull8
decreased vegetative cell population growth400
expressivity FYPO_EXT:0000002mcl1-1 (ntG372A)Not specified
inviable vegetative cell populationmcl1+ (wild type)Knockdown1427
mcl1-1 (ntG372A)Not specified
sensitive to bortezomib256
expressivity FYPO_EXT:0000002mcl1ΔNull
sensitive to camptothecinmcl1ΔNull214
sensitive to clotrimazole105
expressivity FYPO_EXT:0000003mcl1ΔNull
sensitive to cobalt56
expressivity FYPO_EXT:0000001mcl1ΔNull
sensitive to DNA damage during mitotic S phasemcl1+ (wild type)Knockdown1
sensitive to doxorubicin91
expressivity FYPO_EXT:0000002mcl1ΔNull
sensitive to hydroxyureamcl1+ (wild type)Knockdown518
mcl1-1 (ntG372A)Not specified
sensitive to ionizing radiationmcl1-1 (ntG372A)Not specified58
sensitive to methyl methanesulfonatemcl1+ (wild type)Knockdown227
mcl1-1 (ntG372A)Not specified
sensitive to sodium butyrate93
expressivity FYPO_EXT:0000002mcl1ΔNull
sensitive to tacrolimus81
expressivity FYPO_EXT:0000001mcl1ΔNull
sensitive to terbinafine102
expressivity FYPO_EXT:0000003mcl1ΔNull
sensitive to thiabendazolemcl1+ (wild type)Knockdown185
mcl1-1 (ntG372A)Not specified
sensitive to trichostatin A42
expressivity FYPO_EXT:0000003mcl1ΔNull
sensitive to valproic acid155
expressivity FYPO_EXT:0000003mcl1ΔNull
viable vegetative cell populationmcl1ΔNull3781
not recorded (unrecorded)

Cell Phenotype

Term NameAlleleExpressionCount
abnormal ascospore wall biogenesismcl1ΔNull16
abnormal chromosome morphologymcl1-1 (ntG372A)Not specified18
abnormal microtubule cytoskeleton morphology during mitotic interphase186
penetrance FYPO_EXT:0000001mcl1ΔNull
abnormal mitotic cell cyclemcl1ΔNull794
abnormal mitotic cell cycle arrest with unreplicated DNAmcl1+ (wild type)Overexpression45
complete but unequal mitotic sister chromatid segregation21
penetrance FYPO_EXT:0000003mcl1-1 (ntG372A)Not specified
decreased mitotic centromeric sister chromatid cohesionmcl1-1 (ntG372A)Not specified4
decreased origin firing efficiencymcl1-1 (ntG372A)Not specified2
elongated telomeresmcl1-1 (ntG372A)Not specified160
elongated vegetative cell703
expressivity FYPO_EXT:0000002mcl1+ (wild type)Knockdown
expressivity FYPO_EXT:0000003mcl1+ (wild type)Knockdown
incomplete mitotic sister chromatid segregation, with chromatin bridge2
penetrance FYPO_EXT:0000003mcl1-1 (ntG372A)Not specified
increased duration of mitotic S phasemcl1-1 (ntG372A)Not specified13
increased minichromosome loss during vegetative growthmcl1-1 (ntG372A)Not specified41
inviable after spore germination, multiple cell divisions, unequal chromosome segregationmcl1ΔNull2
lagging mitotic chromosomes19
penetrance FYPO_EXT:0000003mcl1-1 (ntG372A)Not specified
mislocalized mitotic spindle1
penetrance FYPO_EXT:0000002mcl1-1 (ntG372A)Not specified
normal conjugation frequencymcl1ΔNull10
septation following abnormal chromosome segregation117
penetrance FYPO_EXT:0000003mcl1-1 (ntG372A)Not specified
septation following abnormal chromosome segregation, with binucleate cell formation10
penetrance FYPO_EXT:0000003mcl1-1 (ntG372A)Not specified
spores sensitive to acetonemcl1ΔNull3
viable branched, elongated vegetative cellmcl1ΔNull11
viable elongated vegetative cell231
penetrance FYPO_EXT:0000001mcl1ΔNull
penetrance FYPO_EXT:0000003, expressivity FYPO_EXT:0000001mcl1ΔNull
viable vegetative cell with abnormal cell shape472
penetrance FYPO_EXT:0000001mcl1ΔNull
Target Of
FYPO affected by mutation in cds1 replication checkpoint kinase Cds1 PMID:15643072
FYPO affected by mutation in hsk1 Dbf4(Dfp1)-dependent protein kinase Hsk1 PMID:15643072
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00400 Pfam IPR001680 WD40 repeat 229 258 104
PF00400 Pfam IPR001680 WD40 repeat 51 80 104
PF12341 Pfam IPR022100 Protein of unknown function DUF3639 518 544 1
SM00320 SMART IPR001680 WD40 repeat 44 81 112
SM00320 SMART IPR001680 WD40 repeat 126 165 112
SM00320 SMART IPR001680 WD40 repeat 217 258 112
SM00320 SMART IPR001680 WD40 repeat 3 41 112
SM00320 SMART IPR001680 WD40 repeat 84 123 112
SM00320 SMART IPR001680 WD40 repeat 175 214 112
PS50082 Prosite Profiles IPR001680 WD40 repeat 226 267 100
PS50294 Prosite Profiles IPR017986 WD40-repeat-containing domain 9 267 104
PTHR19932 HMMPANTHER 1 812 1 Gene3D IPR015943 WD40/YVTN repeat-like-containing domain 10 294 145
SSF50978 SuperFamily IPR017986 WD40-repeat-containing domain 10 294 135

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000190WD repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000190

Protein Properties

Ave. residue weight 111.64 Da
Charge -21.50
Isoelectric point 4.96
Molecular weight 90.99 kDa
Number of residues 815
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5376during GO:0000080PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
5075during GO:0000084PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
4606during GO:0000085PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
4646during GO:0000087PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
4733during GO:0072690PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
183.3during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.9during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
0.52during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in eukaryotes only2503

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
pol1DNA polymerase alpha catalytic subunit Reconstituted ComplexPMID:15643072
Affinity Capture-Western
pof3F-box protein Pof3 Two-hybridPMID:16997270
Affinity Capture-Western
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
pnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:18818364
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:22681890
pmc1mediator complex subunit Pmc1 Negative GeneticPMID:22681890
mph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
cdc24DNA replication protein Cdc24 Synthetic LethalityPMID:12455694
bdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC11C11.11cATP helicase Irc3 (predicted) Negative GeneticPMID:22681890
php5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
pcf2CAF assembly factor (CAF-1) complex subunit B, Pcf2 Negative GeneticPMID:22681890
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
SPAC732.02cfructose-2,6-bisphosphate 2-phosphatase activity (predicted) Negative GeneticPMID:22681890
rad9checkpoint clamp complex protein Rad9 Synthetic Growth DefectPMID:12455694
Negative GeneticPMID:18818364
pol1DNA polymerase alpha catalytic subunit Synthetic Growth DefectPMID:12455694
Synthetic LethalityPMID:15915339
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:22681890
SPCC70.03cproline dehydrogenase (predicted) Positive GeneticPMID:22681890
swd1Set1C complex subunit Swd1 Negative GeneticPMID:18818364
not3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rem1meiosis-specific cyclin Rem1 Negative GeneticPMID:22681890
ppk27serine/threonine protein kinase Ppk27 (predicted) Negative GeneticPMID:22681890
cdm1DNA polymerase delta subunit Cdm1 Negative GeneticPMID:22681890
SPAC821.05translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
arb1argonaute inhibitor protein 1 Negative GeneticPMID:22681890
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC839.03cneddylation protein Dcn1 (predicted) Negative GeneticPMID:22681890
rad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
SPBC1703.11optic atrophy 3 family protein Positive GeneticPMID:18818364
pmc3mediator complex subunit Pmc3/Med27 Positive GeneticPMID:18818364
swi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rik1silencing protein Rik1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rad1checkpoint clamp complex protein Rad1 Synthetic Growth DefectPMID:12455694
Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
far10SIP/FAR complex FHA domain subunit Far10/Csc1 Negative GeneticPMID:22681890
rad57RecA family ATPase Rad57/Rhp57 Negative GeneticPMID:18818364
SPBC29A10.16ccytochrome b5 (predicted) Negative GeneticPMID:22681890
rtn1reticulon-like protein Rtn1 Negative GeneticPMID:22681890
dnm1mitochindrial dynamin family GTPase Dnm1 Negative GeneticPMID:22681890
sap10splicing factor 3B Negative GeneticPMID:22681890
csk1cyclin-dependent kinase/ cyclin-dependent kinase activating kinase Csk1 Positive GeneticPMID:22681890
rad17RFC related checkpoint protein Rad17 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
swc5Swr1 complex subunit Swc5 Negative GeneticPMID:18818364
rqh1RecQ type DNA helicase Rqh1 Synthetic LethalityPMID:12455694
Synthetic LethalityPMID:15643072
swc2Swr1 complex complex subunit Swc2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPBC1778.03cNADH pyrophosphatase (predicted) Negative GeneticPMID:22681890
hhf2histone H4 h4.2 Negative GeneticPMID:22681890
sts5RNB-like protein Negative GeneticPMID:22681890
psl1cyclin pho85 family Psl1 (predicted) Negative GeneticPMID:22681890
hsk1Dbf4(Dfp1)-dependent protein kinase Hsk1 Synthetic LethalityPMID:12455694
Negative GeneticPMID:22681890
Synthetic LethalityPMID:15643072
hip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
spc34DASH complex subunit Spc34 Negative GeneticPMID:22681890
csn3COP9/signalosome complex subunit Csn3 (predicted) Negative GeneticPMID:22681890
hhf1histone H4 h4.1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
meu7alpha-amylase homolog Aah4 Positive GeneticPMID:22681890
bob1prefoldin subunit 5 (predicted) Positive GeneticPMID:22681890
bzz1diacylglycerol binding protein Bzz1 (predicted) Negative GeneticPMID:22681890
rrg9mitochondrial genome maintenance protein Rrg9 (predicted) Negative GeneticPMID:22681890
ssp2serine/threonine protein kinase Ssp2 Negative GeneticPMID:22681890
php3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
jmj1histone demethylase Jmj1 (predicted) Positive GeneticPMID:22681890
rad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:18818364
Synthetic LethalityPMID:15915339
pof3F-box protein Pof3 Synthetic LethalityPMID:16997270
Negative GeneticPMID:22681890
csn4COP9/signalosome complex subunit Csn4 Negative GeneticPMID:22681890
SPAC144.17c6-phosphofructo-2-kinase (predicted) Negative GeneticPMID:22681890
SPBC4B4.04translation initiation factor eIF2A (predicted) Negative GeneticPMID:22681890
hus1checkpoint clamp complex protein Hus1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pex11peroxisomal biogenesis factor 11 (predicted) Positive GeneticPMID:22681890
mug27meiosis specific protein kinase Mug27/Slk1 Positive GeneticPMID:22681890
pil2meiotic eisosome BAR domain protein Pil2 Positive GeneticPMID:22681890
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
SPCC584.11cSvf1 family protein Svf1 Negative GeneticPMID:22681890
duo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
caf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
SPCC576.02hydantoin racemase family (predicted) Positive GeneticPMID:22681890
rpl160360S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:22681890
mok11alpha-1,3-glucan synthase Mok11 Negative GeneticPMID:22681890
SPCC736.13short chain dehydrogenase (predicted) Positive GeneticPMID:22681890
mad2mitotic spindle checkpoint protein Mad2 Negative GeneticPMID:22681890
nrl1NRDE-2 family protein (predicted) Positive GeneticPMID:22681890
gar1snoRNP pseudouridylase box H/ACA snoRNP complex protein Gar1 Negative GeneticPMID:22681890
car1arginase Car1 Positive GeneticPMID:22681890
atd1aldehyde dehydrogenase (predicted) Negative GeneticPMID:22681890
rxt2histone deacetylase complex subunit Rxt2 Negative GeneticPMID:22681890
rad21mitotic cohesin complex, non-SMC subunit Rad21 (kleisin) Synthetic LethalityPMID:12455694
cdc7serine/threonine protein kinase Cdc7 Negative GeneticPMID:22681890
zds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:18818364
sap14U2 snRNP-associated protein SF3B14 Sap14 Negative GeneticPMID:22681890
cut2securin, sister chromatid separation inhibitor Negative GeneticPMID:22681890
mre11Mre11 nuclease Negative GeneticPMID:18818364
SPAC18G6.13Schizosaccharomyces specific protein Positive GeneticPMID:22681890
SPCC1442.02central kinetochore associated family protein (predicted) Negative GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
nto1histone acetyltransferase complex subunit Nto1 (predicted) Negative GeneticPMID:22681890
dbl8tRNA-splicing endonuclease positive effector Dbl8 Negative GeneticPMID:22681890
gmh5alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:18818364
rad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Synthetic LethalityPMID:12455694
Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
SPCC777.04amino acid transmembrane transporter (predicted) Positive GeneticPMID:22681890
tma20RNA-binding protein Tma20 (predicted) Positive GeneticPMID:22681890
pds5mitotic cohesin-associated protein Pds5 Negative GeneticPMID:18818364
dad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
mgr2mitochondrial membrane protein Mgr2 (predicted) Negative GeneticPMID:22681890
pli1SUMO E3 ligase Pli1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
vps38phophatidylinositol 3-kinase complex subunit Vps38 Positive GeneticPMID:22681890
bmt2rRNA (adenine) methyltransferase activity Bmt2 (predicted) Positive GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Positive GeneticPMID:18818364
Negative GeneticPMID:22681890
tas3RITS complex subunit 3 Negative GeneticPMID:22681890
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:18818364
dcc1Ctf18 RFC-like complex subunit Dcc1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
skp1SCF ubiquitin ligase complex subunit Skp1 Negative GeneticPMID:22681890
atp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Negative GeneticPMID:18818364
SPAC7D4.05hydrolase (predicted) Negative GeneticPMID:22681890
bdf2BET family double bromodomain protein Bdf2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
SPBC11C11.10tRNA pseudouridine synthase (predicted) Negative GeneticPMID:22681890
hrp1ATP-dependent DNA helicase Hrp1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
bqt3bouquet formation protein Bqt3 Negative GeneticPMID:22681890
dbr1RNA lariat debranching enzyme Dbr1 Positive GeneticPMID:22681890
hop1linear element associated protein Hop1 Positive GeneticPMID:18818364
trt1telomerase reverse transcriptase 1 protein Trt1 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
ark1aurora-B kinase Ark1 Negative GeneticPMID:22681890
srb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:18818364
csn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ctf18RFC-like complex subunit Ctf18 Negative GeneticPMID:22681890
arp6actin-like protein Arp6 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
tbf1DNA binding factor Trf1 Negative GeneticPMID:22681890
csn71COP9/signalosome complex subunit 7a (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
set11ribosomal protein lysine methyltransferase Set11 Negative GeneticPMID:22681890
rdp1RNA-directed RNA polymerase Rdp1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ash2Ash2-trithorax family protein Negative GeneticPMID:18818364
SPBPB2B2.18Schizosaccharomyces specific protein Positive GeneticPMID:22681890
SPBC336.05csmall RNA 2'-O-methyltransferase activity (predicted) Positive GeneticPMID:18818364
rnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Negative GeneticPMID:22681890
ppa2serine/threonine protein phosphatase Ppa2 Negative GeneticPMID:22681890
bdf1Swr1 complex bromodomain subunit Brf1 Negative GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
trm10tRNA m(1)G methyltransferase Trm10 Negative GeneticPMID:22681890
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
ase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
prp4serine/threonine protein kinase Prp4 Positive GeneticPMID:22681890
set1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:22681890
rtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:18818364
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
mtr4ATP-dependent RNA helicase, TRAMP complex subunit Mtr4 Positive GeneticPMID:22681890
SPBC16G5.06Schizosaccharomyces specific protein Positive GeneticPMID:22681890
tel1ATM checkpoint kinase Negative GeneticPMID:22681890
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
srp1SR family protein, human SRFS2 ortholog Srp1 Negative GeneticPMID:22681890
SPAC222.14cGTP binding protein Sey1 (predicted) Negative GeneticPMID:22681890
wee1M phase inhibitor protein kinase Wee1 Synthetic Growth DefectPMID:12455694
rad3ATR checkpoint kinase Rad3 Synthetic LethalityPMID:12455694
Negative GeneticPMID:22681890
Synthetic LethalityPMID:15643072
ers1RNA-silencing factor Ers1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
nup60nucleoporin Nup60 Negative GeneticPMID:22681890
hmo1HMG box protein Hmo1 Negative GeneticPMID:18818364
mhf2CENP-X homolog, FANCM-MHF complex subunit Mhf2 Negative GeneticPMID:22681890
sty1MAP kinase Sty1 Negative GeneticPMID:22681890
atg6beclin family protein, involved in autophagy Positive GeneticPMID:22681890
SPAC26F1.08cconserved protein Positive GeneticPMID:22681890
bub1mitotic spindle checkpoint kinase Bub1 Synthetic Growth DefectPMID:12455694
srp2mRNA export factor Srp2 Positive GeneticPMID:22681890
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
dcr1dicer Negative GeneticPMID:18818364
crb2DNA repair protein Rad9 homolog, Rhp9 Negative GeneticPMID:18818364
pmc2mediator complex subunit Pmc2/Med1 Negative GeneticPMID:18818364
csn5COP9/signalosome complex subunit Csn5 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
snt2Lid2 complex subunit Snt2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
lsg1Lsk1 complex gamma subunit Lsg1 Positive GeneticPMID:22681890
srs2ATP-dependent DNA helicase, UvrD subfamily Negative GeneticPMID:18818364
ptc2protein phosphatase 2C Ptc2 Positive GeneticPMID:22681890
chp1chromodomain protein Chp1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
lcl3mitochondrial endonuclease, possibly DNA damage related (predicted) Positive GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
swd3WD repeat protein Swd3 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
spf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
SPBC1348.03S. pombe specific 5Tm protein family Negative GeneticPMID:22681890
dsc5UBX domain containing protein required for Sre1 cleavage Positive GeneticPMID:22681890
mrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
hrd1synviolin family ubiquitin-protein ligase E3, Hrd1 Negative GeneticPMID:22681890
vps71Swr1 complex subunit Vps71 Negative GeneticPMID:18818364
mms1E3 ubiquitin ligase complex subunit Mms1 (predicted) Negative GeneticPMID:22681890
pub1HECT-type ubiquitin-protein ligase E3 Pub1 Negative GeneticPMID:22681890
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
hhp2serine/threonine protein kinase Hhp2 Negative GeneticPMID:22681890
grx3monothiol glutaredoxin Grx3 Positive GeneticPMID:22681890
mfm1M-factor precursor Mfm1 Negative GeneticPMID:22681890
ppk8serine/threonine protein kinase Ppk8 (predicted) Positive GeneticPMID:22681890
cdt2WD repeat protein Cdt2 Negative GeneticPMID:22681890
rhp18Rad18 homolog ubiquitin protein ligase E3, Rhp18 Synthetic Growth DefectPMID:12455694
ubp3ubiquitin C-terminal hydrolase Ubp3 Positive GeneticPMID:22681890
cdc22ribonucleoside reductase large subunit Cdc22 Synthetic Growth DefectPMID:12455694
SPAC2F3.11exopolyphosphatase (predicted) Negative GeneticPMID:22681890
phf2Lsd1/2 complex PHD finger containing protein Phf2 Positive GeneticPMID:22681890
rec8meiotic cohesin complex subunit Rec8 Negative GeneticPMID:22681890
tor1phosphatidylinositol kinase Tor1 Negative GeneticPMID:22681890
mik1mitotic inhibitor kinase Mik1 Synthetic Growth DefectPMID:12455694
Negative GeneticPMID:22681890
SPCC4B3.13MatE family transmembrane transporter (predicted) Positive GeneticPMID:22681890
cwf21complexed with Cdc5 protein Cwf21 Negative GeneticPMID:18818364
puf3RNA-binding protein Puf3 (predicted) Positive GeneticPMID:22681890
pms1MutL family mismatch-repair protein Pms1 Negative GeneticPMID:22681890
tif452translation initiation factor eIF4E, 4F complex E subunit isoform 2, stress response factor Positive GeneticPMID:22681890
pzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
rcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Positive GeneticPMID:18818364
ssb3DNA replication factor A subunit Ssb3 Negative GeneticPMID:22681890
apc10anaphase-promoting complex subunit Apc10 Negative GeneticPMID:22681890
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
cgi121EKC/KEOPS complex subunit Cgi121 (predicted) Positive GeneticPMID:22681890
hht1histone H3 h3.1 Negative GeneticPMID:22681890
mms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:18818364
SPCC757.12alpha-amylase homolog (predicted) Positive GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
hrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:22681890
dna2DNA replication endonuclease-helicase Dna2 Dosage RescuePMID:12455694
Synthetic LethalityPMID:15915339
swr1SNF2 family ATP-dependent DNA helicase Swr1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
mto1MT organizer Mto1 Negative GeneticPMID:22681890
dbl2meiotic chromosome segregation protein Dbl2 Negative GeneticPMID:22681890
mug154conserved fungal protein Negative GeneticPMID:22681890
klp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
gcn20AAA family ATPase Gcn20 (predicted) Negative GeneticPMID:22681890
msc1multi-copy suppressor of Chk1 Negative GeneticPMID:18818364
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
ptn1phosphatidylinositol-3,4,5-trisphosphate3-phosphatase Ptn1 Negative GeneticPMID:22681890
pob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
mit1SHREC complex ATP-dependent DNA helicase subunit Mit1 Positive GeneticPMID:22681890
dad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
cds1replication checkpoint kinase Cds1 Synthetic RescuePMID:12455694
fbp1fructose-1,6-bisphosphatase Fbp1 Positive GeneticPMID:22681890
hif2Set3 complex subunit Hif2 Negative GeneticPMID:22681890
rhp14XP-A family homolog Rhp14 Negative GeneticPMID:22681890
rad2FEN-1 endonuclease Rad2 Synthetic Growth DefectPMID:15915339
SPBC15C4.06cubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:22681890
bio2biotin synthase Negative GeneticPMID:22681890
utp16U3 snoRNP-associated protein Utp16 (predicted) Negative GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
klp5kinesin-like protein Klp5 Negative GeneticPMID:22681890
tos4FHA domain protein Tos4 (predicted) Negative GeneticPMID:22681890
raf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:22681890
ppk26protein kinase like PAN complex subunit Ppk26 Negative GeneticPMID:22681890
SPBC1683.06curidine ribohydrolase (predicted) Positive GeneticPMID:22681890
dpb4DNA polymerase epsilon subunit Dpb4 Negative GeneticPMID:22681890
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:18818364
swi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
tfs1transcription elongation factor TFIIS Negative GeneticPMID:22681890
ppk21serine/threonine protein kinase Ppk21 Negative GeneticPMID:22681890
mlo2ubiquitin protein ligase E3 component human N-recognin 7 homolog Mlo2 Positive GeneticPMID:18818364
mcs6TFIIH associated cyclin-dependent protein kinase Mcs6 Negative GeneticPMID:22681890
poz1Pot1 associated protein Poz1 Positive GeneticPMID:22681890
sir2Sir2 family histone deacetylase Sir2 Negative GeneticPMID:22681890
gnr1heterotrimeric G protein beta subunit Gnr1 Positive GeneticPMID:18818364
SPBC19F8.02nuclear distribution protein NUDC homolog Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAPB1E7.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAPB1E7.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAPB1E7.02c BioGRID Interaction Datasets
Expression Viewer SPAPB1E7.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAPB1E7.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAPB1E7.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAPB1E7.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAPB1E7.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAPB1E7.02c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAPB1E7.02c Cell Cycle Data
GEO SPAPB1E7.02c GEO profiles
PInt SPAPB1E7.02c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAPB1E7.02c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAPB1E7.02c Fission yeast phenotypic data & analysis
UniProtKB/SwissProtQ9C107Minichromosome loss protein 1
ModBaseQ9C107Database of comparative protein structure models
STRINGQ9C107Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_594128DNA polymerase alpha accessory factor Mcl1
RefSeq mRNANM_001019552972h- DNA polymerase alpha accessory factor Mcl1 (mcl1), mRNA
European Nucleotide ArchiveCAC36919.1ENA Protein Mapping
UniParcUPI000006C769UniProt Archive

Literature for mcl1

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015