mcl1 (SPAPB1E7.02c)

Gene Standard Namemcl1 ChromosomeI
Systematic IDSPAPB1E7.02c Gene Start3285778
Synonymsslr3 Gene End3283004
ProductDNA polymerase alpha accessory factor Mcl1 Gene Length2775
Feature Typeprotein coding CDS Start3285745
Name Description CDS End3283195
Characterisation Statuspublished CDS Length2551

Ensembl Gene Location
  1. SPAC6G9.14
  2. SPAC6G9.15c
  3. SPAC6G9.16c
  4. SPAPB1E7.01c
  5. SPAC652.01
  6. mcl1
  7. rpc82
  8. SPAPB1E7.04c
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000029abnormal chromosome segregationno_name (unrecorded)unrecordedPMID:12455694
FYPO:0000229cutmcl1-1 (ntG372A)amino_acid_mutationPMID:12455694
has_penetrance FYPO_EXT:0000003
FYPO:0002060viable vegetative cell populationmcl1delta (deletion)deletionPMID:20519959
Microscopymcl1delta (deletion)deletionPMID:20473289
no_name (unrecorded)unrecordedPMID:15915339
FYPO:0002061inviable vegetative cell populationno_name (unrecorded)unrecordedPMID:15643072
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0003682chromatin bindingIDAPMID:15643072
GO:0005515protein bindingIPIpof3GO_REF:0000001
happens_during S phase of mitotic cell cycleIPIpol1PMID:15643072
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000082G1/S transition of mitotic cell cycleIMPPMID:15643072
GO:0000723telomere maintenanceIMPPMID:12455694
GO:0006261DNA-dependent DNA replicationIGIdna2PMID:15915339
GO:0006281DNA repairIEAUniProtKB:KW-0234GO_REF:0000037
GO:0006355regulation of transcription, DNA-dependentIEAUniProtKB:KW-0805GO_REF:0000037
GO:0006974response to DNA damage stimulusIGIrad26PMID:15643072
IGIrad3PMID:15643072
GO:0007064mitotic sister chromatid cohesionIMPPMID:15643072
GO:0071459protein localization to chromosome, centromeric region
has_input cnp1IMPGO_REF:0000001
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0000228nuclear chromosomeISOSGD:S000006339GO_REF:0000024
GO:0005634nucleusIDAPMID:16823372
GO:0005658alpha DNA polymerase:primase complexIDAPMID:15915339
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
132857783285554
232855083285357
332852983283004

References

Region Start End Reference
three_prime_UTR32831943283004PMID:21511999
three_prime_UTR32831943283004PMID:21511999
five_prime_UTR32857783285746PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF12341 IPR022100 Pfam Protein of unknown function DUF3639 518 544 1
PF00400 IPR001680 Pfam WD40 repeat 51 80 104
PF00400 IPR001680 Pfam WD40 repeat 229 258 104
SM00320 IPR001680 SMART WD40 repeat 44 81 120
SM00320 IPR001680 SMART WD40 repeat 126 165 120
SM00320 IPR001680 SMART WD40 repeat 3 41 120
SM00320 IPR001680 SMART WD40 repeat 217 258 120
SM00320 IPR001680 SMART WD40 repeat 175 214 120
SM00320 IPR001680 SMART WD40 repeat 84 123 120
PS50082 IPR001680 Prosite Profiles WD40 repeat 226 267 100
PS50294 IPR017986 Prosite Profiles WD40-repeat-containing domain 9 267 104
G3DSA:2.130.10.10 IPR015943 Gene3D 11 292 144
SSF50978 IPR017986 SuperFamily 10 294 135
PTHR19932 hmmpanther 1 815 1
PTHR19932:SF9 hmmpanther 1 815 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000190WD repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000190

Protein Properties

Ave. residue weight 111.64 Da
Charge -21.50
Isoelectric point 4.96
Molecular weight 90.99 kDa
Number of residues 815
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide183.3PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.52PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide1.9PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
srs2ATP-dependent DNA helicase, UvrD subfamily Negative GeneticPMID:18818364
ptc2protein phosphatase 2C Ptc2 Positive GeneticPMID:22681890
ypa1protein phosphatase type 2A regulator, PTPA family Ypa1 Negative GeneticPMID:22681890
SPAC630.10conserved eukaryotic protein, DUF3321 family Positive GeneticPMID:22681890
pol1DNA polymerase alpha catalytic subunit Synthetic Growth DefectPMID:12455694
Synthetic LethalityPMID:15915339
rrg9mitochondrial genome maintenance protein Rrg9 (predicted) Negative GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
pli1SUMO E3 ligase Pli1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPCC553.01cmeiotic chromosome segregation protein (predicted) Negative GeneticPMID:22681890
dna2DNA replication endonuclease-helicase Dna2 Dosage RescuePMID:12455694
Synthetic LethalityPMID:15915339
SPCC736.13short chain dehydrogenase (predicted) Positive GeneticPMID:22681890
atp11F1-ATPase chaperone Atp11 (predicted) Negative GeneticPMID:18818364
pmc2mediator complex subunit Pmc2/Med1 Negative GeneticPMID:18818364
ase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPBPB2B2.18sequence orphan Positive GeneticPMID:22681890
bdf1Swr1 complex bromodomain subunit Brf1 Negative GeneticPMID:22681890
SPAC144.17c6-phosphofructo-2-kinase (predicted) Negative GeneticPMID:22681890
mgr2mitochondrial membrane protein Mgr2 (predicted) Negative GeneticPMID:22681890
set11ribosomal protein lysine methyltransferase Set11 Negative GeneticPMID:22681890
dnm1dynamin Dnm1 Negative GeneticPMID:22681890
caf1CCR4-Not complex CAF1 family ribonuclease subunit Caf1 Negative GeneticPMID:18818364
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
mrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
poz1Pot1 associated protein Poz1 Positive GeneticPMID:22681890
dpb4DNA polymerase epsilon subunit Dpb4 Negative GeneticPMID:22681890
tel1ATM checkpoint kinase Negative GeneticPMID:22681890
SPBC19F8.02nuclear distribution protein NUDC homolog Positive GeneticPMID:22681890
SPBC1703.11optic atrophy 3 family protein Positive GeneticPMID:18818364
pmc3mediator complex subunit Pmc3/Med27 Positive GeneticPMID:18818364
mhf2FANCM-MHF complex subunit Mhf2 Negative GeneticPMID:22681890
jmj1histone demethylase Jmj1 (predicted) Positive GeneticPMID:22681890
SPAC821.05translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
pob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
pms1MutL family mismatch-repair protein Pms1 Negative GeneticPMID:22681890
ubp3ubiquitin C-terminal hydrolase Ubp3 Positive GeneticPMID:22681890
bob1prefoldin subunit 5 (predicted) Positive GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
bzz1diacylglycerol binding protein Bzz1 (predicted) Negative GeneticPMID:22681890
hif2Set3 complex subunit Hif2 Negative GeneticPMID:22681890
nup60nucleoporin Nup60 Negative GeneticPMID:22681890
SPBC1778.03cNADH pyrophosphatase (predicted) Negative GeneticPMID:22681890
bio2biotin synthase Negative GeneticPMID:22681890
rem1meiosis-specific cyclin Rem1 Negative GeneticPMID:22681890
mtr4ATP-dependent RNA helicase, TRAMP complex subunit Mtr4 Positive GeneticPMID:22681890
mlo2ubiquitin protein ligase E3 component human N-recognin 7 homolog Mlo2 Positive GeneticPMID:18818364
ptn1phosphatidylinositol-3,4,5-trisphosphate3-phosphatase Ptn1 Negative GeneticPMID:22681890
hop1linear element associated protein Hop1 Positive GeneticPMID:18818364
SPAC7D4.05hydrolase (predicted) Negative GeneticPMID:22681890
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
hus1checkpoint clamp complex protein Hus1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
sty1MAP kinase Sty1 Negative GeneticPMID:22681890
tfs1transcription elongation factor TFIIS Negative GeneticPMID:22681890
ppk26serine/threonine protein kinase, PAN complex subunit, Ppk26 Negative GeneticPMID:22681890
rdp1RNA-directed RNA polymerase Rdp1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
dbr1RNA lariat debranching enzyme Dbr1 Positive GeneticPMID:22681890
trm10tRNA m(1)G methyltransferase Trm10 (predicted) Negative GeneticPMID:22681890
tma20RNA-binding protein Tma20 (predicted) Positive GeneticPMID:22681890
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
rad9checkpoint clamp complex protein Rad9 Synthetic Growth DefectPMID:12455694
Negative GeneticPMID:18818364
cdm1DNA polymerase delta subunit Cdm1 Negative GeneticPMID:22681890
not3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
arp6actin-like protein Arp6 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
csn5COP9/signalosome complex subunit Csn5 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ppa2serine/threonine protein phosphatase Ppa2 Negative GeneticPMID:22681890
SPBC336.05csmall RNA 2'-O-methyltransferase activity (predicted) Positive GeneticPMID:18818364
pub1HECT-type ubiquitin-protein ligase E3 Pub1 Negative GeneticPMID:22681890
SPBC29A10.10ctRNA-splicing endonuclease positive effector (predicted) Negative GeneticPMID:22681890
car1arginase Car1 Positive GeneticPMID:22681890
pcf2CAF assembly factor (CAF-1) complex subunit B, Pcf2 Negative GeneticPMID:22681890
rqh1RecQ type DNA helicase Rqh1 Synthetic LethalityPMID:12455694
Synthetic LethalityPMID:15643072
pds5cohesin-associated protein Pds5 Negative GeneticPMID:18818364
SPBC28F2.11HMG box protein Negative GeneticPMID:18818364
rad2FEN-1 endonuclease Rad2 Synthetic Growth DefectPMID:15915339
sap10splicing factor 3B Negative GeneticPMID:22681890
cdc24DNA replication protein Cdc24 Synthetic LethalityPMID:12455694
mto1MT organizer Mto1 Negative GeneticPMID:22681890
hht1histone H3 h3.1 Negative GeneticPMID:22681890
dcc1Ctf18 RFC-like complex subunit Dcc1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
mug27meiosis specific protein kinase Mug27/Slk1 Positive GeneticPMID:22681890
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
spc34DASH complex subunit Spc34 Negative GeneticPMID:22681890
sts5RNB-like protein Negative GeneticPMID:22681890
wee1M phase inhibitor protein kinase Wee1 Synthetic Growth DefectPMID:12455694
SPBC15C4.06cubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:22681890
rad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
cdc7serine/threonine protein kinase Cdc7 Negative GeneticPMID:22681890
swr1SNF2 family helicase Swr1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
sir2Sir2 family histone deacetylase Sir2 Negative GeneticPMID:22681890
bdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
php3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
csk1cyclin-dependent kinase activating kinase Csk1 Positive GeneticPMID:22681890
grx3monothiol glutaredoxin Grx3 Positive GeneticPMID:22681890
ers1RNA-silencing factor Ers1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
chp1chromodomain protein Chp1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
zds1zds family protein phosphatase type A regulator Zds1 (predicted) Negative GeneticPMID:18818364
rxt2histone deacetylase complex subunit Rxt2 Negative GeneticPMID:22681890
hrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:22681890
ssp2serine/threonine protein kinase Ssp2 Negative GeneticPMID:22681890
swc5Swr1 complex subunit Swc5 Negative GeneticPMID:18818364
swc2Swr1 complex complex subunit Swc2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
fft3fun thirty related protein Fft3 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPCC576.02hydantoin racemase family (predicted) Positive GeneticPMID:22681890
swd1Set1C complex subunit Swd1 Negative GeneticPMID:18818364
phf2Lsd1/2 complex PHD finger containing protein Phf2 Positive GeneticPMID:22681890
SPCC777.04amino acid transporter (predicted) Positive GeneticPMID:22681890
mre11Mre11 nuclease Negative GeneticPMID:18818364
cdt2WD repeat protein Cdt2 Negative GeneticPMID:22681890
srp2mRNA export factor Srp2 Positive GeneticPMID:22681890
rad1checkpoint clamp complex protein Rad1 Synthetic Growth DefectPMID:12455694
Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
mms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:18818364
far10SIP/FAR complex FHA domain subunit Far10/Csc1 Negative GeneticPMID:22681890
SPBC16G5.06sequence orphan Positive GeneticPMID:22681890
pil2meiotic eisosome BAR domain protein Pil2 Positive GeneticPMID:22681890
dcr1dicer Negative GeneticPMID:18818364
SPBC19F8.04cnuclease Positive GeneticPMID:22681890
csn4COP9/signalosome complex subunit Csn4 Negative GeneticPMID:22681890
SPAC2F3.11exopolyphosphatase (predicted) Negative GeneticPMID:22681890
hsk1Dbf4(Dfp1)-dependent protein kinase Hsk1 Synthetic LethalityPMID:12455694
Synthetic LethalityPMID:15643072
Negative GeneticPMID:22681890
cwf21complexed with Cdc5 protein Cwf21 Negative GeneticPMID:18818364
trt1telomerase reverse transcriptase 1 protein Trt1 Negative GeneticPMID:22681890
SPAC637.06alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:18818364
hhp2serine/threonine protein kinase Hhp2 Negative GeneticPMID:22681890
rtn1reticulon-like protein Rtn1 Negative GeneticPMID:22681890
SPAC222.14cGTP binding protein Sey1 (predicted) Negative GeneticPMID:22681890
SPAC26F1.08cconserved protein Positive GeneticPMID:22681890
hhf2histone H4 h4.2 Negative GeneticPMID:22681890
fbp1fructose-1,6-bisphosphatase Fbp1 Positive GeneticPMID:22681890
cgi121EKC/KEOPS complex subunit Cgi121 (predicted) Positive GeneticPMID:22681890
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:22681890
mug154conserved fungal protein Negative GeneticPMID:22681890
ppk8serine/threonine protein kinase Ppk8 (predicted) Positive GeneticPMID:22681890
rhp14XP-A family homolog Rhp14 Negative GeneticPMID:22681890
ask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
pof3F-box protein Pof3 Negative GeneticPMID:22681890
Synthetic LethalityPMID:16997270
spf1Set1C PHD Finger protein Spf1 Negative GeneticPMID:18818364
atg14autophagy specific phophatidylinositol 3-kinase complex subunit Atg14 (predicted) Positive GeneticPMID:22681890
pnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:18818364
skp1SCF ubiquitin ligase complex subunit Skp1 Negative GeneticPMID:22681890
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
pex11peroxisomal biogenesis factor 11 (predicted) Positive GeneticPMID:22681890
rcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Positive GeneticPMID:18818364
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
SPBC29A3.09cAAA family ATPase Gcn20 (predicted) Negative GeneticPMID:22681890
pzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
SPBC36B7.08cnucleosome assembly protein (predicted) Negative GeneticPMID:18818364
rad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Synthetic LethalityPMID:12455694
Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
php5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
srp1SR family protein, human SRFS2 ortholog Srp1 Negative GeneticPMID:22681890
arb1argonaute binding protein 1 Negative GeneticPMID:22681890
psl1cyclin pho85 family (predicted) Negative GeneticPMID:22681890
ark1aurora-B kinase Ark1 Negative GeneticPMID:22681890
SPCC757.12alpha-amylase homolog (predicted) Positive GeneticPMID:22681890
dad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
swd3WD repeat protein Swd3 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
ctf18RFC-like complex subunit Ctf18 Negative GeneticPMID:22681890
rsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
klp5kinesin-like protein Klp5 Negative GeneticPMID:22681890
sap14U2 snRNP-associated protein SF3B14 Sap14 Negative GeneticPMID:22681890
SPCC4B3.13MatE family transporter (predicted) Positive GeneticPMID:22681890
tas3RITS complex subunit 3 Negative GeneticPMID:22681890
cut2securin, sister chromatid separation inhibitor Negative GeneticPMID:22681890
SPCC70.03cproline dehydrogenase (predicted) Positive GeneticPMID:22681890
SPCC1442.02central kinetochore associated family protein (predicted) Negative GeneticPMID:22681890
raf1Rik1-associated factor Raf1 Negative GeneticPMID:22681890
SPBC4B4.04translation initiation factor eIF2A (predicted) Negative GeneticPMID:22681890
SPBP8B7.10cU3 snoRNP-associated protein Utp16 (predicted) Negative GeneticPMID:22681890
crb2DNA repair protein Rad9 homolog, Rhp9 Negative GeneticPMID:18818364
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
cds1replication checkpoint kinase Cds1 Synthetic RescuePMID:12455694
rad3ATR checkpoint kinase Rad3 Synthetic LethalityPMID:12455694
Synthetic LethalityPMID:15643072
Negative GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
csn71COP9/signalosome complex subunit 7a (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
hhf1histone H4 h4.1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:18818364
Synthetic LethalityPMID:15915339
ddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:18818364
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:22681890
gnr1heterotrimeric G protein beta subunit Gnr1 Positive GeneticPMID:18818364
swi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rad21mitotic cohesin complex, non-SMC subunit Rad21 (kleisin) Synthetic LethalityPMID:12455694
csn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
mfm1M-factor precursor Mfm1 Negative GeneticPMID:22681890
meu7alpha-amylase homolog Aah4 Positive GeneticPMID:22681890
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
duo1DASH complex subunit Duo1 Negative GeneticPMID:22681890
ppk21serine/threonine protein kinase Ppk21 Negative GeneticPMID:22681890
ssb3DNA replication factor A subunit Ssb3 Negative GeneticPMID:22681890
dad4DASH complex subunit Dad4 Negative GeneticPMID:22681890
rad17RFC related checkpoint protein Rad17 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
prp4serine/threonine protein kinase Prp4 Positive GeneticPMID:22681890
puf3RNA-binding protein Puf3 (predicted) Positive GeneticPMID:22681890
ash2Ash2-trithorax family protein Negative GeneticPMID:18818364
dsc5UBX domain containing protein required for Sre1 cleavage Positive GeneticPMID:22681890
bqt3bouquet formation protein Bqt3 Negative GeneticPMID:22681890
set1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
mph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
SPCC584.11cSvf1 family protein Svf1 Negative GeneticPMID:22681890
lsg1Lsk1 complex gamma subunit (predicted) Positive GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
atg6beclin family protein, involved in autophagy Positive GeneticPMID:22681890
pmc1mediator complex subunit Pmc1 Negative GeneticPMID:22681890
rtt109RTT109 family histone lysine acetyltransferase Negative GeneticPMID:18818364
nrl1NRDE-2 family protein (predicted) Positive GeneticPMID:22681890
tbf1DNA binding factor Trf1 Negative GeneticPMID:22681890
rec8meiotic cohesin complex subunit Rec8 Negative GeneticPMID:22681890
mad2spindle checkpoint protein Mad2 Negative GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
SPAP14E8.02FHA domain protein Tos4 (predicted) Negative GeneticPMID:22681890
rad57RecA family ATPase Rad57/Rhp57 Negative GeneticPMID:18818364
gar1snoRNP pseudouridylase box H/ACA snoRNP complex protein Gar1 Negative GeneticPMID:22681890
SPBC839.03cneddylation protein Dcn1 (predicted) Negative GeneticPMID:22681890
rpl160360S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:22681890
SPAC9E9.09caldehyde dehydrogenase (predicted) Negative GeneticPMID:22681890
rnc1RNA-binding protein that suppresses calcineurin deletion Rnc1 Negative GeneticPMID:22681890
mik1mitotic inhibitor kinase Mik1 Synthetic Growth DefectPMID:12455694
Negative GeneticPMID:22681890
swi3replication fork protection complex subunit Swi3 Negative GeneticPMID:18818364
SPBC1348.03S. pombe specific 5Tm protein family Negative GeneticPMID:22681890
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
SPAC18G6.13sequence orphan Positive GeneticPMID:22681890
vps71Swr1 complex subunit Vps71 Negative GeneticPMID:18818364
cdc22ribonucleoside reductase large subunit Cdc22 Synthetic Growth DefectPMID:12455694
bub1serine/threonine protein kinase Bub1 Synthetic Growth DefectPMID:12455694
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
Positive GeneticPMID:18818364
nto1histone acetyltransferase complex subunit Nto1 (predicted) Negative GeneticPMID:22681890
ppk27serine/threonine protein kinase Ppk27 (predicted) Negative GeneticPMID:22681890
hrd1ubiquitin-protein ligase Hrd1, synviolin family Negative GeneticPMID:22681890
rhp18Rad18 homolog Rhp18 Synthetic Growth DefectPMID:12455694
apc10anaphase-promoting complex subunit Apc10 Negative GeneticPMID:22681890
mcs6cyclin-dependent protein kinase/CDK-activating kinase Mcs6 Negative GeneticPMID:22681890
SPBC1683.06curidine ribohydrolase (predicted) Positive GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC732.02cfructose-2,6-bisphosphate 2-phosphatase activity (predicted) Negative GeneticPMID:22681890
klp6kinesin-like protein Klp6 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPBC11C11.11cATP helicase Irc3 (predicted) Negative GeneticPMID:22681890
SPBC29A10.16ccytochrome b5 (predicted) Negative GeneticPMID:22681890
tor1phosphatidylinositol kinase Tor1 Negative GeneticPMID:22681890
snt2Lid2 complex subunit Snt2 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
srb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:18818364
nrc1bromodomain protein (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
mms1E3 ubiquitin ligase complex subunit Mms1 (predicted) Negative GeneticPMID:22681890
SPBC11C11.10tRNA pseudouridine synthase (predicted) Negative GeneticPMID:22681890
mit1SHREC complex subunit Mit1 Positive GeneticPMID:22681890
mok11alpha-1,3-glucan synthase Mok11 Negative GeneticPMID:22681890
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:22681890
msc1multi-copy suppressor of Chk1 Negative GeneticPMID:18818364
rik1silencing protein Rik1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
csn3COP9/signalosome complex subunit Csn3 (predicted) Negative GeneticPMID:22681890
tif452translation initiation factor eIF4E 4F complex subunit Positive GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
hrp1ATP-dependent DNA helicase Hrp1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hsk1Dbf4(Dfp1)-dependent protein kinase Hsk1 Co-localizationPMID:15643072
pof3F-box protein Pof3 Affinity Capture-WesternPMID:16997270
Two-hybrid
pol1DNA polymerase alpha catalytic subunit Reconstituted ComplexPMID:15643072
Affinity Capture-Western
cds1replication checkpoint kinase Cds1 Co-localizationPMID:15643072
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External References
Database Identifier Description
NBRP SPAPB1E7.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAPB1E7.02c Retrieval of eukaryotic orthologs
BioGrid SPAPB1E7.02c BioGRID Interaction Datasets
Bähler Lab SPAPB1E7.02c Cell Cycle Expression Profile
Bähler Lab SPAPB1E7.02c Meiosis/Sporulation Expression Profies
Bähler Lab SPAPB1E7.02c Pheromone response/mating expression profiles
Bähler Lab SPAPB1E7.02c Environmental stress expression profiles
Bähler Lab SPAPB1E7.02c Bähler Lab Transcriptome Viewer
Cyclebase SPAPB1E7.02c Cell Cycle Data
PInt SPAPB1E7.02c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAPB1E7.02c Entrez Gene
WikiGene2543387DNA polymerase alpha accessory factor Mcl1
Uniprot_genenameMCL1
EntrezGene2543387DNA polymerase alpha accessory factor Mcl1
UniProtKB/SwissProtQ9C107Minichromosome loss protein 1
ModBaseQ9C107Database of comparative protein structure models
Pfam Protein DomainsQ9C107Pfam Domain Arrangement
RefSeq PeptideNP_594128DNA polymerase alpha accessory factor Mcl1
RefSeq mRNANM_001019552972h- DNA polymerase alpha accessory factor Mcl1 (mcl1), mRNA
European Nucleotide ArchiveCAC36919ENA Protein Mapping
UniParcUPI000006C769UniProt Archive

Literature for mcl1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013