rps602 (SPAPB1E7.12)


Gene Standard Namerps602 Characterisation Statuspublished
Systematic IDSPAPB1E7.12 Feature Typeprotein coding
Synonymsp27, rps6, rps6-2 Name Description
Product40S ribosomal protein S6 Product Size239aa, 27.48 kDa
Genomic Location Chromosome I, 3319189-3320060 (872nt); CDS:3319260-3319979 (720nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
structural constituent of ribosome257
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cytoplasmic translation470
Annotation ExtensionEvidenceWith/FromReference
ribosome biogenesis338
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
cytosolic small ribosomal subunit64
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationrps602Δ3844

Cell Phenotype

Term NameGenotypesCount
abolished protein phosphorylation during vegetative growth53
affecting rps602S235A,S236A (S235A, S236A)
abolished protein serine phosphorylation at RxxS site3
affecting substrate rps602, affecting activity of psk1SSAA (both RxxS phosphorylation sites disrupted)
viable vegetative cell with normal cell morphologyrps602Δ3100

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
viable vegetative cell populationS235A,S236A (S235A, S236A), rps601Δ

Cell Phenotype

Term NameGenotypes
abolished protein phosphorylation during vegetative growth
affecting rps602S235A,S236A (S235A, S236A), rps601Δ
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in fkh1 FKBP12 peptidyl-prolyl cis-trans isomerase Fkh1
FYPO affected by mutation in isp7 2-OG-Fe(II) oxygenase superfamily protein
FYPO affected by mutation in ksg1 serine/threonine protein kinase Ksg1
FYPO affected by mutation in leu1 3-isopropylmalate dehydrogenase Leu1
FYPO affected by mutation in npr2 SEA/Iml1/Npr2/3 complex subunit Npr2 (predicted)
FYPO affected by mutation in psk1 ribosomal protein S6 kinase Psk1
FYPO affected by mutation in rhb1 Rheb GTPase Rhb1
FYPO affected by mutation in rps601 40S ribosomal protein S6
FYPO affected by mutation in rps602 40S ribosomal protein S6
FYPO affected by mutation in sck2 serine/threonine protein kinase Sck2
FYPO affected by mutation in tor2 serine/threonine protein kinase Tor2
FYPO affected by mutation in tsc2 tuberin
GO substrate of psk1 ribosomal protein S6 kinase Psk1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3319189..3320060
mRNA3319189..3320060
5' UTR3319189..3319259PMID:21511999
CDS3319260..3319979
3' UTR3319980..3320060PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01092 Pfam IPR001377 Ribosomal protein S6e 1 126 2
PS00578 Prosite Patterns IPR018282 Ribosomal protein S6e, conserved site 52 63 2
PTHR11502 HMMPANTHER IPR001377 Ribosomal protein S6e 2 236 2
PIRSF002129 PIRSF IPR014401 Ribosomal protein S6, eukaryotic 1 239 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.96 Da
Charge 34.00
Codon Adaptation Index 0.73
Isoelectric point 11.44
Molecular weight 27.48 kDa
Number of residues 239
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1677
present during cellular response to cycloheximide, cellular response to ammonium ion
absent during cellular response to nitrogen starvation
Annotation ExtensionEvidenceResidueReference
present during cellular response to cycloheximide IDA PMID:22976295
present during cellular response to ammonium ion IDA PMID:22976295
absent during cellular response to nitrogen starvation IDA PMID:22976295
phosphorylated residue 1932
present during single-celled organism vegetative growth phase
removed during cellular response to glucose starvation, cellular response to hydrogen peroxide, cellular response to nitrogen starvation, cellular response to osmotic stress
absent during cellular response to nitrogen starvation, cellular response to rapamycin
sumoylated lysine 173
Annotation ExtensionEvidenceResidueReference
IDA PMID:26404184
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for rps602 (SPAPB1E7.12)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
98391.89during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
8129.28during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
120during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
8.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4606
conserved in eukaryotes4516
conserved in metazoa3424
conserved in vertebrates3399
conserved in archaea238
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPAPB1E7.12 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bycid14poly(A) polymerase Cid14 Affinity Capture-MSPMID:20403971
affinity captured bytea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
affinity captured bygad8AGC family protein kinase Gad8 Affinity Capture-MSPMID:23213482
modified bypsk1ribosomal protein S6 kinase Psk1 Biochemical ActivityPMID:22976295
binds activation domain construct withnap2nucleosome assembly protein Nap2 Two-hybridPMID:26771498
binds DNA-binding domain construct withish1LEA domain protein Two-hybridPMID:11751918
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPAPB1E7.12 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
enhances phenotype ofrps60140S ribosomal protein S6 Phenotypic EnhancementPMID:20144990
External References
Database Identifier Description
NBRP SPAPB1E7.12 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAPB1E7.12 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAPB1E7.12 BioGRID Interaction Datasets
Expression Viewer SPAPB1E7.12 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAPB1E7.12 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAPB1E7.12 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAPB1E7.12 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAPB1E7.12 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAPB1E7.12 Transcriptome Viewer (Bähler Lab)
GEO SPAPB1E7.12 GEO profiles
PInt SPAPB1E7.12 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAPB1E7.12 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAPB1E7.12 Fission yeast phenotypic data & analysis
Cyclebase SPAPB1E7.12.1 Cell Cycle Data
SPD / RIKEN41/E05Orfeome Localization Data
UniProtKB/SwissProtQ9C0Z740S ribosomal protein S6-B
ModBaseQ9C0Z7Database of comparative protein structure models
STRINGQ9C0Z7Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_59413840S ribosomal protein S6
RefSeq mRNANM_001019562972h- 40S ribosomal protein S6 (rps602), mRNA
European Nucleotide ArchiveCAC36929.1ENA Protein Mapping
UniParcUPI0000135088UniProt Archive

Literature for rps602

Search: Europe PMC or PubMed

Release Version: PomBase:30_60 - 12 May 2016