rps602 (SPAPB1E7.12)


Gene Standard Namerps602 Characterisation Statusbiological_role_inferred
Systematic IDSPAPB1E7.12 Feature Typeprotein coding
Synonymsrps6, rps6-2 Name Description
Product40S ribosomal protein S6 (predicted) Product Size239aa, 27.48 kDa
Genomic Location Chromosome I, 3319189-3320060 (872nt); CDS:3319260-3319979 (720nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0003735structural constituent of ribosomeISOSGD:S000006011GO_REF:0000024255
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0002181cytoplasmic translationISOSGD:S000006011GO_REF:0000024473
GO:0042254ribosome biogenesisISOSGD:S000005693GO_REF:0000024337
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722315
GO:0022627cytosolic small ribosomal subunitISOSGD:S000006011GO_REF:000002465
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyrps602ΔNullPECO:0000005, PECO:0000137PMID:236978063759
Microscopyrps602ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyrps602ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in isp7 2-OG-Fe(II) oxygenase superfamily protein PMID:24344203
FYPO affected by mutation in npr2 Npr2/3 complex subunit Npr2 (predicted) PMID:23934889
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
133191893320060

UTRs

Region Coordinates Reference
five_prime_UTR3319189..3319259PMID:21511999
three_prime_UTR3319980..3320060PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01092 Pfam IPR001377 Ribosomal protein S6e 1 126 2
PS00578 Prosite Patterns IPR018282 Ribosomal protein S6e, conserved site 52 63 2
PTHR11502 HMMPANTHER IPR001377 Ribosomal protein S6e 1 239 2
PIRSF002129 PIRSF IPR014401 Ribosomal protein S6, eukaryotic 1 239 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.96 Da
Charge 34.00
Isoelectric point 11.44
Molecular weight 27.48 kDa
Number of residues 239
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residueIDAPMID:239348891922
absent during cellular response to nitrogen starvation
present during single-celled organism vegetative growth phaseIDAPMID:23934889
absent during cellular response to rapamycinIDAPMID:23934889
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
98391.89during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
8129.28during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
120during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
8.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in archaea237
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
rps60140S ribosomal protein S6 Phenotypic EnhancementPMID:20144990
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cid14poly(A) polymerase Cid14 Affinity Capture-MSPMID:20403971
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
nap2nucleosome assembly protein Nap2 Two-hybridPMID:23695164
ish1LEA domain protein Two-hybridPMID:11751918
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
psk1serine/threonine protein kinase Psk1 Biochemical ActivityPMID:22976295
tea1cell end marker Tea1 Affinity Capture-MSPMID:21652630
gad8AGC family protein kinase Gad8 Affinity Capture-MSPMID:23213482
External References
Database Identifier Description
NBRP SPAPB1E7.12 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAPB1E7.12 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAPB1E7.12 BioGRID Interaction Datasets
Expression Viewer SPAPB1E7.12 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAPB1E7.12 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAPB1E7.12 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAPB1E7.12 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAPB1E7.12 Polyadenylation Viewer (Gullerova lab)
pombeTV SPAPB1E7.12 Transcriptome Viewer (Bähler Lab)
Cyclebase SPAPB1E7.12 Cell Cycle Data
GEO SPAPB1E7.12 GEO profiles
PInt SPAPB1E7.12 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPAPB1E7.12 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPAPB1E7.12 Fission yeast phenotypic data & analysis
UniProtKB/SwissProtQ9C0Z740S ribosomal protein S6-B
ModBaseQ9C0Z7Database of comparative protein structure models
STRINGQ9C0Z7Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_59413840S ribosomal protein S6
RefSeq mRNANM_001019562972h- 40S ribosomal protein S6 (rps602), mRNA
European Nucleotide ArchiveCAC36929.1ENA Protein Mapping
UniParcUPI0000135088UniProt Archive

Literature for rps602

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014