vps17 (SPAPJ696.01c)


Gene Standard Namevps17 Characterisation Statuspublished
Systematic IDSPAPJ696.01c Feature Typeprotein coding
Synonyms Name Description
Productretromer complex subunit Vps17 Product Size549aa, 60.92 kDa
Genomic Location Chromosome I, 723684-719090 (4595nt); CDS:723425-721617 (1809nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0035091phosphatidylinositol bindingISMPFAM:PF01363GO_REF:000000135
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030437ascospore formationIMPPMID:1518944987
IGIUniProtKB:P50520PMID:15189449
GO:0006886intracellular protein transportIMPPMID:16622069330
GO:0042147retrograde transport, endosome to GolgiIMPPMID:1662206923
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722316
GO:0031965nuclear membrane51
during sporulationIDAPMID:15189449
GO:0005634nucleusIDAPMID:168233722740
GO:0005628prospore membrane24
during ascospore formationIDAPMID:15189449
GO:0030904retromer complexISSUniProtKB:P32913GO_REF:00000015
IMPPMID:16622069
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001098sensitive to 4-nitroquinoline N-oxide159
expressivity FYPO_EXT:0000003Cell growth assayvps17ΔNullPECO:0000137, PECO:0000005PMID:19264558
FYPO:0000096sensitive to cadmium246
expressivity FYPO_EXT:0000002cell growth assayvps17ΔNullPECO:0000102, PECO:0000005, PECO:0000137PMID:18684775
FYPO:0000088sensitive to hydroxyurea506
expressivity FYPO_EXT:0000003Cell Growth Assayvps17ΔNullPECO:0000137, PECO:0000102PMID:23697806
FYPO:0000271sensitive to salt stress82
expressivity FYPO_EXT:0000002cell growth assayvps17ΔNullPECO:0000207, PECO:0000137, PECO:0000102, PECO:0000005PMID:18684775
FYPO:0002060viable vegetative cell populationMicroscopyvps17ΔNullPECO:0000005, PECO:0000137PMID:236978063760
Microscopyvps17ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000708decreased mating efficiencyhigh throughput nucleotide sequencing assay evidencevps17ΔNullPECO:0000015PMID:23950735230
FYPO:0002177viable vegetative cell with normal cell morphology3086
penetrance FYPO_EXT:0000001Microscopyvps17ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
OntologyRelationshipGeneProductReference
GO localized by pik1 1-phosphatidylinositol 4-kinase Pik1 PMID:15189449
GO localized by pik3 phosphatidylinositol 3-kinase Pik3 PMID:15189449
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1723684723063
2722995722542
3722493722288
4722243719090

UTRs

Region Coordinates Reference
five_prime_UTR723684..723426PMID:21511999
three_prime_UTR721616..719090PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00787 Pfam IPR001683 Phox homologous domain 97 208 14
PF09325 Pfam IPR015404 Vps5 C-terminal 258 449 2
SM00312 SMART IPR001683 Phox homologous domain 96 209 14
PTHR10555 HMMPANTHER 1 481 8
PTHR10555:SF136 HMMPANTHER 1 481 1
3.30.1520.10 Gene3D IPR001683 Phox homologous domain 97 209 14
SSF64268 SuperFamily IPR001683 Phox homologous domain 96 210 14
Coil ncoils Rabaptin coiled-coil domain 250 278 968
PIRSF011791 PIRSF IPR014461 Vacuolar protein sorting-associated protein 17, Vps17 1 549 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000462PX domain proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000462

Protein Properties

Ave. residue weight 110.97 Da
Charge 5.50
Isoelectric point 7.72
Molecular weight 60.92 kDa
Number of residues 549
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineS3PMID:247631071663
level fluctuates during mitotic cell cycle
S2PMID:24763107
present during mitotic M phaseS2PMID:21712547
present during mitotic M phaseS6PMID:21712547
present during mitotic M phaseS13PMID:21712547
present during mitotic M phaseS374PMID:21712547
present during mitotic M phaseS3PMID:21712547
level fluctuates during mitotic cell cycleS374PMID:24763107
MOD:00047O-phospho-L-threonineT7PMID:21712547682
present during mitotic M phase
MOD:00696phosphorylated residueNASPMID:195477441915
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
6805during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
5729during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
4560.94during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
3428.74during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
5963during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
6844during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
6200during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2.2during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
0.87during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ubp11ubiquitin C-terminal hydrolase Ubp11 Negative GeneticPMID:22681890
tal1transaldolase (predicted) Negative GeneticPMID:22681890
pik3phosphatidylinositol 3-kinase Pik3 Dosage RescuePMID:15189449
rpp20160S acidic ribosomal protein A2 Negative GeneticPMID:22681890
rpl430260S ribosomal protein L37a (predicted) Negative GeneticPMID:22681890
SPBC2F12.05csterol binding ankyrin repeat protein (predicted) Negative GeneticPMID:22681890
SPAC27D7.11cBut2 family protein Negative GeneticPMID:22681890
ent3ENTH/VHS domain protein Ent3 (predicted) Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
SPCC663.15cconserved fungal protein Negative GeneticPMID:22681890
rds1conserved fungal protein Negative GeneticPMID:22681890
SPBC215.01GTPase activating protein (predicted) Negative GeneticPMID:22681890
SPBPB7E8.01sequence orphan, predicted GPI anchor Negative GeneticPMID:22681890
oca2serine/threonine protein kinase Oca2 Negative GeneticPMID:22681890
sgf73SAGA complex subunit Sgf73 Synthetic Growth DefectPMID:18931302
osr2potassium channel subunit/aldo-keto reductase (predicted) Negative GeneticPMID:22681890
ash2Ash2-trithorax family protein Negative GeneticPMID:22681890
msa1RNA-binding protein Msa1 Negative GeneticPMID:22681890
SPBC577.11DUF3074 family protein Negative GeneticPMID:22681890
SPCC1393.08transcription factor, zf-GATA type (predicted) Negative GeneticPMID:22681890
SPBC25B2.01elongation factor 1 alpha related protein (predicted) Negative GeneticPMID:22681890
SPCC306.11sequence orphan Negative GeneticPMID:22681890
psl1cyclin pho85 family Psl1 (predicted) Negative GeneticPMID:22681890
arg3ornithine carbamoyltransferase Arg3 Negative GeneticPMID:22681890
swr1SNF2 family helicase Swr1 Negative GeneticPMID:22681890
SPBPB2B2.19cS. pombe specific 5Tm protein family Negative GeneticPMID:22681890
far8SIP/FAR complex striatin subunit, Far8/Csc3 Negative GeneticPMID:22681890
lsd90Lsd90 protein Negative GeneticPMID:22681890
SPCC285.10cSPRY domain protein Negative GeneticPMID:22681890
atg101autophagy protein Atg101 Negative GeneticPMID:22681890
SPCC1795.10cSed5 Vesicle Protein Svp26 (predicted) Negative GeneticPMID:22681890
leo1RNA polymerase II associated Paf1 complex (predicted) Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:22681890
SPCC61.05S. pombe specific multicopy membrane protein family 1 Negative GeneticPMID:22681890
SPBC725.05cnucleotide pyrophosphatase (predicted) Negative GeneticPMID:22681890
ryh1GTPase Ryh1 Synthetic Growth DefectPMID:18931302
bro1BRO1 domain protein Bro1 (predicted) Negative GeneticPMID:22681890
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
SPAPB1E7.04cchitinase (predicted) Negative GeneticPMID:22681890
SPACUNK4.16calpha,alpha-trehalose-phosphate synthase (predicted) Negative GeneticPMID:22681890
SPBC20F10.07GRAM domain protein Negative GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:22681890
ubc16ubiquitin conjugating enzyme Ubc16 (predicted) Negative GeneticPMID:22681890
los1karyopherin exportin T Los1 (predicted) Negative GeneticPMID:22681890
gmh5alpha-1,2-galactosyltransferase (predicted) Synthetic Growth DefectPMID:18931302
rav2RAVE complex subunit Rav2 Negative GeneticPMID:22681890
SPBC1271.14glutamate N-acetyltransferase (predicted) Negative GeneticPMID:22681890
vps38phophatidylinositol 3-kinase complex subunit Vps38 Negative GeneticPMID:22681890
SPAC9E9.04bcap family homolog (predicted) Negative GeneticPMID:22681890
SPBC1604.03cconserved fungal protein Negative GeneticPMID:22681890
SPBPB2B2.14cS. pombe specific DUF999 protein family 8 Negative GeneticPMID:22681890
SPCC584.11cSvf1 family protein Svf1 Positive GeneticPMID:22681890
his7phosphoribosyl-AMP cyclohydrolase/phosphoribosyl- ATP pyrophosphohydrolase His7 Negative GeneticPMID:22681890
SPBC16H5.12cconserved fungal protein Negative GeneticPMID:22681890
rkr1RQC complex ubiquitin-protein ligase E3 Rkr1 (predicted) Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:22681890
wtf16wtf element Wtf16 Negative GeneticPMID:22681890
pyp2tyrosine phosphatase Pyp2 Synthetic Growth DefectPMID:18931302
SPAC644.13cRab GTPase binding (predicted) Negative GeneticPMID:22681890
srk1MAPK-activated protein kinase Srk1 Negative GeneticPMID:22681890
pdt1Nramp family manganese ion transporter Negative GeneticPMID:22681890
fis1mitochondrial fission protein Fis1 (predicted) Negative GeneticPMID:22681890
apm3AP-3 adaptor complex subunit Apm3 (predicted) Negative GeneticPMID:22681890
for3formin For3 Synthetic Growth DefectPMID:18931302
SPBCPT2R1.01cS. pombe specific DUF999 protein family 9 Negative GeneticPMID:22681890
mug122PX/PXA domain protein Negative GeneticPMID:22681890
sde2silencing defective protein Sde2 Negative GeneticPMID:22681890
SPBPB2B2.18sequence orphan Negative GeneticPMID:22681890
ctl1choline transmembrane transporter family protein Ctl1 Negative GeneticPMID:22681890
spn3septin Spn3 Negative GeneticPMID:22681890
tef101translation elongation factor EF-1 alpha Ef1a-a Negative GeneticPMID:22681890
hta1histone H2A alpha Negative GeneticPMID:22681890
zwf2glucose-6-phosphate 1-dehydrogenase Zwf2 (predicted) Negative GeneticPMID:22681890
ppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:22681890
ftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:22681890
dlc1dynein light chain Dlc1 Negative GeneticPMID:22681890
pmr1P-type ATPase, calcium transporting Pmr1 Synthetic Growth DefectPMID:18931302
SPBC21B10.08csequence orphan Negative GeneticPMID:22681890
vps1dynamin family protein Vps1 Negative GeneticPMID:22681890
acp2F-actin capping protein beta subunit Acp2 Positive GeneticPMID:22681890
mug147sequence orphan Negative GeneticPMID:22681890
cek1serine/threonine protein kinase Cek1 Negative GeneticPMID:22681890
atg16autophagy protein Atg16 Negative GeneticPMID:22681890
xap5xap-5-like protein Negative GeneticPMID:22681890
SPCC1442.11csequence orphan Negative GeneticPMID:22681890
ymr1phosphatidylinositol-3-phosphatase, myotubularin family (predicted) Negative GeneticPMID:22681890
SPBC6B1.03cPal1 family protein Negative GeneticPMID:22681890
SPBC2D10.04arrestin Aly1 related, implicated in endocytosis Positive GeneticPMID:22681890
uge1UDP-glucose 4-epimerase Uge1 Negative GeneticPMID:22681890
SPAC27D7.02cGRIP domain protein (predicted) Negative GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Synthetic Growth DefectPMID:18931302
SPBC12C2.03cmethionine synthase reductase (predicted) Negative GeneticPMID:22681890
nta1protein N-terminal amidase Nta1 (predicted) Negative GeneticPMID:22681890
SPBC115.03gfo/idh/mocA family oxidoreductase (predicted) Negative GeneticPMID:22681890
vps8WD repeat protein Vps8 (predicted) Synthetic Growth DefectPMID:18931302
SPCC16A11.01plasma membrane protein involved in inositol lipid-mediated signaling (predicted) Negative GeneticPMID:22681890
cat1cationic amino acid transporter Cat1 Negative GeneticPMID:22681890
SPAC3A11.13prefoldin subunit 6 (predicted) Positive GeneticPMID:22681890
SPAC922.04sequence orphan Negative GeneticPMID:22681890
SPCC4B3.02cGolgi transport protein Got1 (predicted) Negative GeneticPMID:22681890
SPAC6C3.06cP-type ATPase, calcium transporting (predicted) Negative GeneticPMID:22681890
SPCC1884.01sequence orphan Negative GeneticPMID:22681890
fcf2rRNA processing protein Fcf2 (predicted) Negative GeneticPMID:22681890
mni1Mago Nashi interacting protein Mni1 (predicted) Negative GeneticPMID:22681890
gls2glucosidase II alpha subunit Gls2 Synthetic Growth DefectPMID:18931302
SPBC25H2.03vacuolar protein involved in phosphoinositide metabolism (predicted) Negative GeneticPMID:22681890
emp24COPII-coated vesicle component Emp24 (predicted) Negative GeneticPMID:22681890
SPAC4A8.10lipase (predicted) Negative GeneticPMID:22681890
skb5Shk1 kinase binding protein 5 Negative GeneticPMID:22681890
are2acyl-coA-sterol acyltransferase Are2 (predicted) Negative GeneticPMID:22681890
SPAC4A8.14ribose-phosphate pyrophosphokinase (predicted) Negative GeneticPMID:22681890
SPBC1271.05czf-AN1 type zinc finger protein Negative GeneticPMID:22681890
vps68vacuolar sorting protein Vps68 (predicted) Negative GeneticPMID:22681890
pex5peroxisomal targeting signal receptor Pex5 Negative GeneticPMID:22681890
glo1glyoxalase I Negative GeneticPMID:22681890
SPBC29B5.04cactin cortical patch protein (predicted) Negative GeneticPMID:22681890
mvp1sorting nexin Mvp1 (predicted) Negative GeneticPMID:22681890
swi10DNA repair endonuclease Swi10 Synthetic Growth DefectPMID:18931302
tcg1single-stranded telomeric binding protein Tgc1 Negative GeneticPMID:22681890
SPCC306.02cRab GTPase binding involved in ER to Golgi vesicle transport (predicted) Negative GeneticPMID:22681890
alm1medial ring protein Alm1 Positive GeneticPMID:22681890
sac12inositol polyphosphate phosphatase (predicted) Negative GeneticPMID:22681890
crn1actin binding protein, coronin Crn1 Synthetic Growth DefectPMID:18931302
meu22amino acid permease, predicted Meu22 Negative GeneticPMID:22681890
msy1MS calcium ion channel protein Msy1 Negative GeneticPMID:22681890
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
SPBC106.13ubiquitin ligase complex subunit, involved in proteasome-dependent catabolite inactivation of FBPase (predicted) Negative GeneticPMID:22681890
ght1hexose transporter Ght1 Negative GeneticPMID:22681890
SPBC3E7.11cDNAJ protein Caj1/Djp1-type (predicted) Negative GeneticPMID:22681890
SPCC1235.01sequence orphan Negative GeneticPMID:22681890
SPCC584.15carrestin/PY protein 2 Negative GeneticPMID:22681890
psh3ER chaperone SHR3 homologue Psh3 Negative GeneticPMID:22681890
cxr1mRNA processing factor Negative GeneticPMID:22681890
SPBP35G2.14RNA-binding protein Negative GeneticPMID:22681890
arg6acetylglutamate synthase Arg6 (predicted) Negative GeneticPMID:22681890
wis2cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 Negative GeneticPMID:22681890
SPCC1020.05phosphoprotein phosphatase (predicted) Negative GeneticPMID:22681890
spa1ornithine decarboxylase antizyme with +1 programmed ribosomal frameshift Spa1 Negative GeneticPMID:22681890
alg6glucosyltransferase Alg6 Synthetic Growth DefectPMID:18931302
SPBC25B2.10Usp (universal stress protein) family protein Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPAPJ696.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAPJ696.01c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPAPJ696.01c BioGRID Interaction Datasets
Expression Viewer SPAPJ696.01c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPAPJ696.01c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPAPJ696.01c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPAPJ696.01c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPAPJ696.01c Polyadenylation Viewer (Gullerova lab)
pombeTV SPAPJ696.01c Transcriptome Viewer (Bähler Lab)
Cyclebase SPAPJ696.01c Cell Cycle Data
GEO SPAPJ696.01c GEO profiles
PInt SPAPJ696.01c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2543324retromer complex subunit Vps17
EntrezGene2543324retromer complex subunit Vps17
UniProtKB/SwissProtQ9URW7Vacuolar protein sorting-associated protein 17
ModBaseQ9URW7Database of comparative protein structure models
STRINGQ9URW7Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_593047retromer complex subunit Vps17
RefSeq mRNANM_001018446972h- retromer complex subunit Vps17 (vps17), mRNA
European Nucleotide ArchiveCAB62421ENA Protein Mapping
European Nucleotide ArchiveCAB62421.1ENA Protein Mapping
UniParcUPI000006BD10UniProt Archive

Literature for vps17

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014