vps17 (SPAPJ696.01c)

Gene Standard Namevps17 ChromosomeI
Systematic IDSPAPJ696.01c Gene Start723684
Synonyms Gene End719090
Productretromer complex subunit Vps17 Gene Length4595
Feature Typeprotein coding CDS Start723425
Name Description CDS End721617
Characterisation Statuspublished CDS Length1809

Ensembl Gene Location
  1. sxa2
  2. mug65
  3. lcp1
  4. SPATRNAGLU.01
  5. vps17
  6. tah18
  7. SPAPJ696.02
  8. SPAC22G7.01c
  9. kap111
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000096sensitive to cadmiumCell growth assayvps17delta (deletion)deletionPECO:0000012PMID:18684775
FYPO:0000271sensitive to salt stressCell growth assayvps17delta (deletion)deletionPECO:0000012PMID:18684775
FYPO:0002060viable vegetative cell populationMicroscopyvps17delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0035091phosphatidylinositol bindingISMPFAM:PF01363GO_REF:0000001
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006886intracellular protein transportIMPPMID:16622069
GO:0030437ascospore formationIMPPMID:15189449
IGIUniProtKB:P50520PMID:15189449
GO:0042147retrograde transport, endosome to GolgiIMPPMID:16622069
GO:0071276cellular response to cadmium ionIMPPMID:18684775
GO:0071585detoxification of cadmium ionIMPPMID:18684775
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005628prospore membrane
exists_during ascospore formationIDAPMID:15189449
GO:0005634nucleusIDAPMID:16823372
GO:0005829cytosolIDAPMID:16823372
GO:0030904retromer complexIMPPMID:16622069
ISSUniProtKB:P32913GO_REF:0000001
GO:0030905retromer complex, outer shellIEAIPR014461GO_REF:0000002
GO:0031965nuclear membrane
exists_during sporulationIDAPMID:15189449
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1723684723063
2722995722542
3722493722288
4722243719090

References

Region Start End Reference
three_prime_UTR721616719090PMID:21511999
five_prime_UTR723684723426PMID:21511999
three_prime_UTR721616719090PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF09325 IPR015404 Pfam Vps5 C-terminal 258 449 2
PF00787 IPR001683 Pfam Phox homologous domain 97 208 14
SM00312 IPR001683 SMART Phox homologous domain 96 209 14
G3DSA:3.30.1520.10 IPR001683 Gene3D 97 209 14
SSF64268 IPR001683 SuperFamily 96 210 14
Coil ncoils Rabaptin coiled-coil domain 250 278 974
PIRSF011791 IPR014461 PIRSF Retromer complex, Vps17 1 549 1
PTHR10555:SF46 IPR014461 hmmpanther 9 464 1
PTHR10555 hmmpanther 9 464 8

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:19547744

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000462PX domain proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000462

Protein Properties

Ave. residue weight 110.97 Da
Charge 5.50
Isoelectric point 7.72
Molecular weight 60.92 kDa
Number of residues 549
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide4560.94PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide3428.74PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.87PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide2.2PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPAC637.06alpha-1,2-galactosyltransferase (predicted) Synthetic Growth DefectPMID:18931302
SPCC306.11sequence orphan Negative GeneticPMID:22681890
his7phosphoribosyl-AMP cyclohydrolase/phosphoribosyl- ATP pyrophosphohydrolase His7 Negative GeneticPMID:22681890
dlc1dynein light chain Dlc1 Negative GeneticPMID:22681890
SPBC25H2.03vacuolar protein involved in phosphoinositide metabolism (predicted) Negative GeneticPMID:22681890
msy1MS ion channel protein 1 (predicted) Negative GeneticPMID:22681890
SPBC20F10.07GRAM domain protein Negative GeneticPMID:22681890
psh3ER chaperone SHR3 homologue Psh3 Negative GeneticPMID:22681890
SPAPB1E7.04cchitinase (predicted) Negative GeneticPMID:22681890
gls2glucosidase II Gls2 Synthetic Growth DefectPMID:18931302
hta1histone H2A alpha Negative GeneticPMID:22681890
SPAC27D7.11cBut2 family protein Negative GeneticPMID:22681890
SPBPB2B2.18sequence orphan Negative GeneticPMID:22681890
SPACUNK4.16calpha,alpha-trehalose-phosphate synthase (predicted) Negative GeneticPMID:22681890
SPBPB7E8.01sequence orphan Negative GeneticPMID:22681890
atg14autophagy specific phophatidylinositol 3-kinase complex subunit Atg14 (predicted) Negative GeneticPMID:22681890
SPBC21D10.09cubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:22681890
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
ngg1SAGA complex subunit Ngg1 Synthetic Growth DefectPMID:18931302
glo1glyoxalase I Negative GeneticPMID:22681890
mvp1sorting nexin Mvp1 (predicted) Negative GeneticPMID:22681890
pyp2tyrosine phosphatase Pyp2 Synthetic Growth DefectPMID:18931302
vps68vacuolar sorting protein Vps68 (predicted) Negative GeneticPMID:22681890
wtf16wtf element Wtf16 Negative GeneticPMID:22681890
rpl430260S ribosomal protein L37a (predicted) Negative GeneticPMID:22681890
SPBC2D10.04arrestin Aly1 related, implicated in endocytosis Positive GeneticPMID:22681890
pdt1Nramp family manganese ion transporter Negative GeneticPMID:22681890
SPAC4A8.10lipase (predicted) Negative GeneticPMID:22681890
SPAC3A11.13prefoldin subunit 6 (predicted) Positive GeneticPMID:22681890
psl1cyclin pho85 family (predicted) Negative GeneticPMID:22681890
SPBC25B2.01elongation factor 1 alpha related protein (predicted) Negative GeneticPMID:22681890
meu22amino acid permease, predicted Meu22 Negative GeneticPMID:22681890
ef1a-atranslation elongation factor EF-1 alpha Ef1a-a Negative GeneticPMID:22681890
SPAC9E9.04bcap family homolog (predicted) Negative GeneticPMID:22681890
ymr1phosphatidylinositol-3-phosphatase, myotubularin family (predicted) Negative GeneticPMID:22681890
SPBC1271.14glutamate N-acetyltransferase (predicted) Negative GeneticPMID:22681890
SPBC21B10.08csequence orphan Negative GeneticPMID:22681890
SPBC577.11DUF3074 family protein Negative GeneticPMID:22681890
SPBPB2B2.14cS. pombe specific DUF999 protein family 8 Negative GeneticPMID:22681890
SPBPB2B2.19cS. pombe specific 5Tm protein family Negative GeneticPMID:22681890
SPAC644.13cRab GTPase binding (predicted) Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:22681890
mug147sequence orphan Negative GeneticPMID:22681890
SPAC27D7.02cGRIP domain protein (predicted) Negative GeneticPMID:22681890
SPBC29B5.04cactin cortical patch protein (predicted) Negative GeneticPMID:22681890
SPBC1271.05czf-AN1 type zinc finger protein Negative GeneticPMID:22681890
SPCC794.01cglucose-6-phosphate 1-dehydrogenase (predicted) Negative GeneticPMID:22681890
SPBC115.03gfo/idh/mocA family oxidoreductase (predicted) Negative GeneticPMID:22681890
SPAC4A8.14ribose-phosphate pyrophosphokinase (predicted) Negative GeneticPMID:22681890
msa1RNA-binding protein Msa1 Negative GeneticPMID:22681890
SPAC6C3.06cP-type ATPase, calcium transporting (predicted) Negative GeneticPMID:22681890
SPCC1682.11ccholine transmembrane transporter family protein (predicted) Negative GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
Synthetic Growth DefectPMID:18931302
rav2RAVE complex subunit Rav2 Negative GeneticPMID:22681890
SPBCPT2R1.01cS. pombe specific DUF999 protein family 9 Negative GeneticPMID:22681890
SPCC1020.05phosphoprotein phosphatase (predicted) Negative GeneticPMID:22681890
ftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:22681890
arg3ornithine carbamoyltransferase Arg3 Negative GeneticPMID:22681890
srk1MAPK-activated protein kinase Srk1 Negative GeneticPMID:22681890
SPCC285.10cSPRY domain protein Negative GeneticPMID:22681890
alg6glucosyltransferase Alg6 (predicted) Synthetic Growth DefectPMID:18931302
SPAC922.04sequence orphan Negative GeneticPMID:22681890
ubp11ubiquitin C-terminal hydrolase Ubp11 Negative GeneticPMID:22681890
mug122PX/PXA domain protein Negative GeneticPMID:22681890
SPCC1442.11csequence orphan Negative GeneticPMID:22681890
nta1protein N-terminal amidase Nta1 (predicted) Negative GeneticPMID:22681890
acp2F-actin capping protein beta subunit (predicted) Positive GeneticPMID:22681890
SPBC12C2.03cmethionine synthase reductase (predicted) Negative GeneticPMID:22681890
ash2Ash2-trithorax family protein Negative GeneticPMID:22681890
ght1hexose transporter Ght1 Negative GeneticPMID:22681890
fis1mitochondrial fission protein Fis1 (predicted) Negative GeneticPMID:22681890
emp24COPII-coated vesicle component Emp24 (predicted) Negative GeneticPMID:22681890
SPCC965.06potassium channel subunit/aldo-keto reductase (predicted) Negative GeneticPMID:22681890
cxr1mRNA processing factor Negative GeneticPMID:22681890
tal1transaldolase (predicted) Negative GeneticPMID:22681890
SPCC584.11cSvf1 family protein Svf1 Positive GeneticPMID:22681890
spn3septin Spn3 Negative GeneticPMID:22681890
spa1ornithine decarboxylase antizyme with +1 programmed ribosomal frameshift Spa1 Negative GeneticPMID:22681890
bro1BRO1 domain protein Bro1 (predicted) Negative GeneticPMID:22681890
arg6acetylglutamate synthase Arg6 (predicted) Negative GeneticPMID:22681890
SPBP35G2.14RNA-binding protein Negative GeneticPMID:22681890
SPBC25B2.10Usp (universal stress protein) family protein Negative GeneticPMID:22681890
alm1medial ring protein Alm1 Positive GeneticPMID:22681890
SPBC6B1.03cPal1 family protein Negative GeneticPMID:22681890
sde2silencing defective protein Sde2 Negative GeneticPMID:22681890
ppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:22681890
swr1SNF2 family helicase Swr1 Negative GeneticPMID:22681890
skb5Shk1 kinase binding protein 5 Negative GeneticPMID:22681890
rpp20160S acidic ribosomal protein P2A subunit (predicted) Negative GeneticPMID:22681890
SPCC1235.01sequence orphan Negative GeneticPMID:22681890
los1karyopherin exportin T Los1 (predicted) Negative GeneticPMID:22681890
SPCC794.11cENTH/VHS domain protein Ent3 (predicted) Negative GeneticPMID:22681890
ubc16ubiquitin conjugating enzyme Ubc16 (predicted) Negative GeneticPMID:22681890
are2acyl-coA-sterol acyltransferase Are2 (predicted) Negative GeneticPMID:22681890
far8SIP/FAR complex striatin subunit, Far8/Csc3 Negative GeneticPMID:22681890
SPBC215.01GTPase activating protein (predicted) Negative GeneticPMID:22681890
SPCC663.15cconserved fungal protein Negative GeneticPMID:22681890
crn1actin binding protein, coronin Crn1 Synthetic Growth DefectPMID:18931302
mug66meiotically upregulated gene Mug66 Negative GeneticPMID:22681890
SPBC13E7.08cRNA polymerase II associated Paf1 complex (predicted) Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:22681890
SPCC1884.01sequence orphan Negative GeneticPMID:22681890
wis2cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 Negative GeneticPMID:22681890
SPCC61.05S. pombe specific multicopy membrane protein family 1 Negative GeneticPMID:22681890
for3formin For3 Synthetic Growth DefectPMID:18931302
SPAC3C7.01cinositol polyphosphate phosphatase (predicted) Negative GeneticPMID:22681890
cat1cationic amino acid transporter Cat1 Negative GeneticPMID:22681890
apm3AP-3 adaptor complex subunit Apm3 (predicted) Negative GeneticPMID:22681890
SPBC2F12.05csterol binding ankyrin repeat protein (predicted) Negative GeneticPMID:22681890
swi10DNA repair endonuclease Swi10 Synthetic Growth DefectPMID:18931302
SPCC306.02cRab GTPase binding involved in ER to Golgi vesicle transport (predicted) Negative GeneticPMID:22681890
vps8WD repeat protein Vps8 (predicted) Synthetic Growth DefectPMID:18931302
cek1serine/threonine protein kinase Cek1 Negative GeneticPMID:22681890
tcg1single-stranded telomeric binding protein Tgc1 Negative GeneticPMID:22681890
xap5xap-5-like protein Negative GeneticPMID:22681890
lsd90Lsd90 protein Negative GeneticPMID:22681890
pex5peroxisomal targeting signal receptor Pex5 Negative GeneticPMID:22681890
SPCC584.15carrestin/PY protein 2 Negative GeneticPMID:22681890
SPBC16H5.12cconserved fungal protein Negative GeneticPMID:22681890
fcf2rRNA processing protein Fcf2 (predicted) Negative GeneticPMID:22681890
SPCC16A11.01plasma membrane protein involved in inositol lipid-mediated signaling (predicted) Negative GeneticPMID:22681890
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
SPBC405.05sequence orphan Negative GeneticPMID:22681890
SPBC1604.03cconserved fungal protein Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:22681890
ryh1GTPase Ryh1 Synthetic Growth DefectPMID:18931302
pik3phosphatidylinositol 3-kinase Pik3 Dosage RescuePMID:15189449
sgf73SAGA complex subunit Sgf73 Synthetic Growth DefectPMID:18931302
SPCC1795.10cSed5 Vesicle Protein Svp26 (predicted) Negative GeneticPMID:22681890
pmr1P-type ATPase, calcium transporting Pmr1 Synthetic Growth DefectPMID:18931302
oca2serine/threonine protein kinase Oca2 Negative GeneticPMID:22681890
mni1Mago Nashi interacting protein (predicted) Negative GeneticPMID:22681890
SPCC4B3.02cGolgi transport protein Got1 (predicted) Negative GeneticPMID:22681890
vps1dynamin family protein Vps1 Negative GeneticPMID:22681890
SPCC1393.08transcription factor, zf-GATA type (predicted) Negative GeneticPMID:22681890
SPBC3E7.11cDNAJ protein Caj1/Djp1-type (predicted) Negative GeneticPMID:22681890
SPBC725.05cnucleotide pyrophosphatase (predicted) Negative GeneticPMID:22681890
SPBC106.13ubiquitin ligase complex subunit, involved in proteasome-dependent catabolite inactivation of FBPase (predicted) Negative GeneticPMID:22681890
rds1conserved fungal protein Negative GeneticPMID:22681890
uge1UDP-glucose 4-epimerase Uge1 Negative GeneticPMID:22681890
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External References
Database Identifier Description
NBRP SPAPJ696.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPAPJ696.01c Retrieval of eukaryotic orthologs
BioGrid SPAPJ696.01c BioGRID Interaction Datasets
Bähler Lab SPAPJ696.01c Cell Cycle Expression Profile
Bähler Lab SPAPJ696.01c Meiosis/Sporulation Expression Profies
Bähler Lab SPAPJ696.01c Pheromone response/mating expression profiles
Bähler Lab SPAPJ696.01c Environmental stress expression profiles
Bähler Lab SPAPJ696.01c Bähler Lab Transcriptome Viewer
Cyclebase SPAPJ696.01c Cell Cycle Data
PInt SPAPJ696.01c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPAPJ696.01c Entrez Gene
WikiGene2543324retromer complex subunit Vps17
Uniprot_genenameVPS17
EntrezGene2543324retromer complex subunit Vps17
UniProtKB/SwissProtQ9URW7Vacuolar protein sorting-associated protein 17
ModBaseQ9URW7Database of comparative protein structure models
Pfam Protein DomainsQ9URW7Pfam Domain Arrangement
RefSeq PeptideNP_593047retromer complex subunit Vps17
RefSeq mRNANM_001018446972h- retromer complex subunit Vps17 (vps17), mRNA
European Nucleotide ArchiveCAB62421ENA Protein Mapping
UniParcUPI000006BD10UniProt Archive

Literature for vps17
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013