rav1 (SPBC1105.10)

Gene Standard Namerav1 ChromosomeII
Systematic IDSPBC1105.10 Gene Start3524531
Synonyms Gene End3528845
ProductRAVE complex subunit Rav1 Gene Length4315
Feature Typeprotein coding CDS Start3524673
Name Description CDS End3528681
Characterisation Statuspublished CDS Length4009

Ensembl Gene Location
  1. SPBC1105.07c
  2. SPBC1105.08
  3. ubc15
  4. rav1
  5. SPNCRNA.1610
  6. hht3
  7. SPNCRNA.1611
  8. hhf3
  9. rsv2
  10. SPBC1105.13c
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000096sensitive to cadmiumCell growth assayrav1delta (deletion)deletionPECO:0000012PMID:18684775
FYPO:0001491viable vegetative cellMicroscopyrav1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0032403protein complex bindingIPIvma2PMID:18441123
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0007035vacuolar acidificationIMPPMID:18441123
GO:0042493response to drugIMPPMID:18441123
GO:0045324late endosome to vacuole transportTASPMID:18441123
GO:0070072vacuolar proton-transporting V-type ATPase complex assemblyTASPMID:18441123
GO:0071276cellular response to cadmium ionIMPPMID:18684775
GO:0071277cellular response to calcium ionIMPPMID:18441123
GO:0071294cellular response to zinc ionIMPPMID:18441123
GO:0071585detoxification of cadmium ionIMPPMID:18684775
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005737cytoplasmIDAPMID:18441123
GO:0005829cytosolIDAPMID:16823372
GO:0010008endosome membraneIDAPMID:18441123
GO:0012505endomembrane systemIEASL-0147GO_REF:0000039
GO:0043291RAVE complexIPIskp1PMID:18441123
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
135245313524759
235248753528845

References

Region Start End Reference
three_prime_UTR35286823528845PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF12234 IPR022033 Pfam RAVE complex protein Rav1 C-terminal 574 1231 1
G3DSA:2.130.10.10 IPR015943 Gene3D 549 670 144
G3DSA:2.130.10.10 IPR015943 Gene3D 389 435 144
G3DSA:2.130.10.10 IPR015943 Gene3D 98 241 144
SSF101908 SuperFamily 24 270 4
SSF50978 IPR017986 SuperFamily 382 726 135
PTHR13950:SF2 hmmpanther 1 1296 1
PTHR13950 hmmpanther 1 1296 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000190WD repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000190

Protein Properties

Ave. residue weight 114.68 Da
Charge 6.50
Isoelectric point 6.82
Molecular weight 148.74 kDa
Number of residues 1297
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide239.65PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide526.23PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.44PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide1.3PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
prp43ATP-dependent RNA helicase Prp43 (predicted) Negative GeneticPMID:22681890
erg31C-5 sterol desaturase Erg31 Positive GeneticPMID:22681890
sdc1Dpy-30 domain protein Sdc1 Positive GeneticPMID:22681890
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
mcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
sfp1transcription factor Sfp1 (predicted) Negative GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
arp8actin-like protein, Ino80 complex subunit Arp8 Positive GeneticPMID:22681890
lag1sphingosine N-acyltransferase Lag1 Phenotypic EnhancementPMID:18441123
ste20Rictor homolog, Ste20 Positive GeneticPMID:22681890
rad51RecA family recombinase Rad51/Rhp51 Negative GeneticPMID:22681890
sif1Sad1 interacting factor 1 Negative GeneticPMID:22681890
lac1sphingosine N-acyltransferase Lac1 Phenotypic EnhancementPMID:18441123
cut2securin, sister chromatid separation inhibitor Negative GeneticPMID:22681890
dad5DASH complex subunit Dad5 Phenotypic EnhancementPMID:23365689
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
hta1histone H2A alpha Negative GeneticPMID:22681890
mpr1histidine-containing response regulator phosphotransferase Mpr1 Negative GeneticPMID:22681890
iec1Ino80 complex subunit Iec1 Phenotypic EnhancementPMID:23365689
ubp2ubiquitin C-terminal hydrolase Ubp2 Positive GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
rad55RecA family ATPase Rad55/Rhp55 Phenotypic EnhancementPMID:23365689
Synthetic Growth Defect
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
skp1SCF ubiquitin ligase complex subunit Skp1 Affinity Capture-WesternPMID:18441123
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External References
Database Identifier Description
NBRP SPBC1105.10 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1105.10 Retrieval of eukaryotic orthologs
BioGrid SPBC1105.10 BioGRID Interaction Datasets
Bähler Lab SPBC1105.10 Cell Cycle Expression Profile
Bähler Lab SPBC1105.10 Meiosis/Sporulation Expression Profies
Bähler Lab SPBC1105.10 Pheromone response/mating expression profiles
Bähler Lab SPBC1105.10 Environmental stress expression profiles
Bähler Lab SPBC1105.10 Bähler Lab Transcriptome Viewer
Cyclebase SPBC1105.10 Cell Cycle Data
PInt SPBC1105.10 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC1105.10 Entrez Gene
SPD / RIKEN48/48F07Orfeome Localization Data
WikiGene2539705RAVE complex subunit Rav1
Uniprot_genenameRAV1
EntrezGene2539705RAVE complex subunit Rav1
UniProtKB/SwissProtQ9Y817Putative regulator of V-ATPase in vacuolar membrane protein 1
ModBaseQ9Y817Database of comparative protein structure models
Pfam Protein DomainsQ9Y817Pfam Domain Arrangement
RefSeq PeptideNP_596466RAVE complex subunit Rav1
RefSeq mRNANM_001022385972h- RAVE complex subunit Rav1 (rav1), mRNA
European Nucleotide ArchiveCAB50973ENA Protein Mapping
SPD / RIKEN48/48F07Orfeome Localization Data

Literature for rav1
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Release Version: PomBase:18.34 - 04 Apr 2013