rsv2 (SPBC1105.14)


Gene Standard Namersv2 Characterisation Statuspublished
Systematic IDSPBC1105.14 Feature Typeprotein coding
SynonymsSPNCRNA.422, SPNG1836 Name Description
Producttranscription factor Rsv2 Product Size637aa, 69.08 kDa
Genomic Location Chromosome II, 3530760-3535288 (4529nt); CDS:3532931-3534844 (1914nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
GO Cellular Component
Term NameCount
nucleus2697
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
increased cell population growth ratersv2ΔNull246
increased viability in stationary phasersv2+ (wild type)Overexpression54
viable vegetative cell populationrsv2ΔNull3783
unnamed (unrecorded)

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologyrsv2ΔNull3092
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in ecl1 extender of the chronological lifespan protein Ecl1 PMID:22212525
FYPO affected by mutation in ecl2 extender of the chronological lifespan protein Ecl2 PMID:22212525
FYPO affected by mutation in ecl3 extender of the chronological lifespan protein Ecl3 PMID:22212525
GO regulated by mei4 meiotic forkhead transcription factor Mei4 PMID:17927811
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
135307603531250
235312963535288

UTRs

Region Coordinates Reference
five_prime_UTR3530760..3531250,3531296..3532930PMID:21511999
three_prime_UTR3534845..3535288PMID:21511999
mRNA3530760..3535288
exon3532931..3534844
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00096 Pfam IPR007087 Zinc finger, C2H2 584 603 5
PF00096 Pfam IPR007087 Zinc finger, C2H2 610 635 5
SM00355 SMART IPR015880 Zinc finger, C2H2-like 610 635 19
SM00355 SMART IPR015880 Zinc finger, C2H2-like 580 603 19
PS50157 Prosite Profiles IPR007087 Zinc finger, C2H2 572 608 20
3.30.160.60 Gene3D IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain 609 636 15
SSF57667 SuperFamily 583 632 26

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000137zinc finger proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000137
PBO:0000153zf-C2H2 typeTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000153

Protein Properties

Ave. residue weight 108.45 Da
Charge 1.00
Isoelectric point 6.60
Molecular weight 69.08 kDa
Number of residues 637
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS299 1670
present during mitotic M phaseS299
present during mitotic M phaseS418
present during mitotic M phaseS420
Annotation ExtensionEvidenceResidueReference
experimental evidence S299 PMID:24763107
present during mitotic M phase experimental evidence S299 PMID:21712547
present during mitotic M phase experimental evidence S418 PMID:21712547
present during mitotic M phase experimental evidence S420 PMID:21712547
phosphorylated residue 1923
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased in presence of purvalanol A expression microarray evidencePMID:22840777

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.2during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
1.9during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Misc
DescriptionQualifierReferenceCount
deletion mutant expression profiling PMID:1792781178
Warning
DescriptionQualifierReferenceCount
previously annotated as ncRNA21
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi only619
conserved in fungi4604
conserved in eukaryotes4516
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withadn2transcription factor (predicted) Negative GeneticPMID:22681890
positive genetic interaction withair1zinc knuckle TRAMP complex subunit Air1 Positive GeneticPMID:18818364
negative genetic interaction withamo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
negative genetic interaction withamt1ammonium transmembrane transporter Amt1 Negative GeneticPMID:22681890
positive genetic interaction withamt2ammonium transmembrane transporter Amt2 Positive GeneticPMID:22681890
negative genetic interaction withany1arrestin-related endocytic adaptor Any1 Negative GeneticPMID:22681890
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
positive genetic interaction withatg1801WD repeat protein involved in autophagy Atg18a Positive GeneticPMID:22681890
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withcip2RNA-binding protein Cip2 Positive GeneticPMID:22681890
negative genetic interaction withcoq5C-methyltransferase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
negative genetic interaction withcsr102sec14 cytosolic factor family phosphatidylinositol transmembrane transporter (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcwf16splicing factor Cwf16 Negative GeneticPMID:22681890
negative genetic interaction withcwf21complexed with Cdc5 protein Cwf21 Negative GeneticPMID:18818364
positive genetic interaction withdad2DASH complex subunit Dad2 Positive GeneticPMID:22681890
negative genetic interaction withddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:22681890
positive genetic interaction withelp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:18818364
negative genetic interaction witheme1Holliday junction resolvase subunit Eme1 Negative GeneticPMID:22681890
negative genetic interaction witherf4palmitoyltransferase complex subunit Erf4 Negative GeneticPMID:22681890
negative genetic interaction withest1telomerase regulator Est1 Negative GeneticPMID:18818364
negative genetic interaction withfas1fatty acid synthase beta subunit Fas1 Negative GeneticPMID:22681890
negative genetic interaction withfep1iron-sensing transcription factor Fep1 Negative GeneticPMID:22681890
synthetic growth defect withfor3formin For3 Synthetic Growth DefectPMID:18931302
negative genetic interaction withftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:18818364
negative genetic interaction withgcs2glutamate-cysteine ligase regulatory subunit Gcs2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withgdh1NADP-specific glutamate dehydrogenase Gdh1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withget1GET complex subunit Get1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withgim3prefoldin subunit 4, Gim3 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withgit5heterotrimeric G protein beta subunit Git5 Positive GeneticPMID:22681890
negative genetic interaction withgld1mitochondrial glycerol dehydrogenase Gld1 Negative GeneticPMID:22681890
negative genetic interaction withgmh5alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withgpa2heterotrimeric G protein alpha-2 subunit Gpa2 Positive GeneticPMID:22681890
negative genetic interaction withgpd3glyceraldehyde 3-phosphate dehydrogenase Gpd3 Negative GeneticPMID:22681890
negative genetic interaction withgsk3serine/threonine protein kinase Gsk3 Negative GeneticPMID:22681890
negative genetic interaction withgyp1GTPase activating protein Gyp1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withhip4histone promoter control protein Hip4 Positive GeneticPMID:18818364
negative genetic interaction withhob3BAR adaptor protein Hob3 Negative GeneticPMID:22681890
negative genetic interaction withhrp3ATP-dependent DNA helicase Hrp3 Negative GeneticPMID:22681890
negative genetic interaction withidp1isocitrate dehydrogenase Idp1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withiwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withmad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:18818364
negative genetic interaction withmad1mitotic spindle checkpoint protein Mad1 Negative GeneticPMID:22681890
negative genetic interaction withmei2RNA-binding protein involved in meiosis Mei2 Negative GeneticPMID:22681890
negative genetic interaction withmga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
negative genetic interaction withmkh1MEK kinase (MEKK) Mkh1 Negative GeneticPMID:22681890
negative genetic interaction withmoe1translation initiation factor eIF3d Moe1 Negative GeneticPMID:22681890
negative genetic interaction withmrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
negative genetic interaction withmrf1mitochondrial peptide chain release factor (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmrpl1mitochondrial ribosomal protein subunit L1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmug14adducin Negative GeneticPMID:22681890
negative genetic interaction withmug151mouse transcriptional regulator, HCNGP-like (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmug154conserved fungal protein Negative GeneticPMID:18818364
negative genetic interaction withmug166Schizosaccharomyces specific protein Mug166 Negative GeneticPMID:22681890
negative genetic interaction withmug20Schizosaccharomyces specific protein Mug20 Negative GeneticPMID:22681890
positive genetic interaction withmyp2myosin II heavy chain Myo3 Positive GeneticPMID:18818364
synthetic growth defect withnse5Smc5-6 complex non-SMC subunit Nse5 Synthetic Growth DefectPMID:18931302
negative genetic interaction withnse6Smc5-6 complex non-SMC subunit Nse6 Negative GeneticPMID:22681890
positive genetic interaction withotu1ubiquitin-specific cysteine protease, OTU family, Otu1 Positive GeneticPMID:22681890
positive genetic interaction withpdi5protein disulfide isomerase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:18818364
positive genetic interaction withpkp1mitochondrial pyruvate dehydrogenase (lipoamide) kinase Pkp1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withppk38Ark1/Prk1 family protein kinase Ppk38 Negative GeneticPMID:22681890
negative genetic interaction withppr8mitochondrial PPR repeat protein Ppr8 Negative GeneticPMID:22681890
enhances phenotype ofpst2Clr6 histone deacetylase complex subunit Pst2 Phenotypic EnhancementPMID:19547744
positive genetic interaction withpuf3RNA-binding protein Puf3 (predicted) Positive GeneticPMID:18818364
synthetic growth defect withpyp1tyrosine phosphatase Pyp1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withpyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:22681890
negative genetic interaction withpzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
negative genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:18818364
negative genetic interaction withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:18818364
negative genetic interaction withreb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:22681890
negative genetic interaction withrer1Rer1 family protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrho3Rho family GTPase Rho3 Negative GeneticPMID:22681890
negative genetic interaction withrok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withrpl170260S ribosomal protein L17 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withrpl35b60S ribosomal protein L35a (predicted) Positive GeneticPMID:22681890
negative genetic interaction withrps00140S ribosomal protein S0A (p40) Negative GeneticPMID:22681890
negative genetic interaction withrrg9mitochondrial genome maintenance protein Rrg9 (predicted) Negative GeneticPMID:22681890
enhances phenotype ofrxt2histone deacetylase complex subunit Rxt2 Phenotypic EnhancementPMID:19547744
positive genetic interaction withsaw1recombination protein Saw1 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withscs7sphingosine hydroxylase Scs7 Negative GeneticPMID:18818364
negative genetic interaction withscs7sphingosine hydroxylase Scs7 Negative GeneticPMID:22681890
negative genetic interaction withsde2silencing defective protein Sde2 Negative GeneticPMID:22681890
positive genetic interaction withsec28coatomer epsilon subunit (predicted) Positive GeneticPMID:18818364
negative genetic interaction withset1histone lysine methyltransferase Set1 Negative GeneticPMID:18818364
negative genetic interaction withsgf73SAGA complex subunit Sgf73 Negative GeneticPMID:25076038
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
negative genetic interaction withSPAC1296.01cphosphoacetylglucosamine mutase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC13A11.06pyruvate decarboxylase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPAC17H9.08mitochondrial coenzyme A transmembrane transporter (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC186.09pyruvate decarboxylase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC19A8.11crecombination protein Irc6 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC1A6.03cphospholipase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC212.06cDNA helicase in rearranged telomeric region, truncated Negative GeneticPMID:22681890
positive genetic interaction withSPAC23A1.07ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
negative genetic interaction withSPAC24B11.12cP-type ATPase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPAC26A3.11amidohydrolase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPAC27D7.02cGRIP domain protein (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPAC29E6.07Schizosaccharomyces pombe specific protein Positive GeneticPMID:22681890
negative genetic interaction withSPAC3A12.06csodium/calcium exchanger (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPAC5D6.04auxin family transmembrane transporter (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPAC6G9.14RNA-binding protein (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPAC6G9.15cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
positive genetic interaction withSPAC823.09cthreonine aspartase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPAC977.17MIP water channel (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPAC9G1.07Schizosaccharomyces specific protein Positive GeneticPMID:22681890
positive genetic interaction withSPBC1271.09glycerophosphodiester transmembrane transporter (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPBC1271.14glutamate N-acetyltransferase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC12C2.03cmethionine synthase reductase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC1347.08cribonuclease H2 complex subunit (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPBC1348.01S. pombe specific DUF999 protein family 5 Negative GeneticPMID:22681890
positive genetic interaction withSPBC1685.05serine protease (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPBC16H5.12cconserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:18818364
positive genetic interaction withSPBC1709.14peptide N-glycanase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPBC1861.07elongin C (predicted) Negative GeneticPMID:18818364
positive genetic interaction withSPBC21D10.08cconserved fungal protein Positive GeneticPMID:22681890
negative genetic interaction withSPBC29A10.16ccytochrome b5 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC365.16conserved protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC3E7.11cDNAJ protein Caj1/Djp1-type (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBPB2B2.05peptidase family C26 protein Negative GeneticPMID:22681890
negative genetic interaction withSPBPB2B2.09c2-dehydropantoate 2-reductase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC1235.01Schizosaccharomyces specific protein Negative GeneticPMID:22681890
positive genetic interaction withSPCC132.03Schizosaccharomyces specific protein Positive GeneticPMID:22681890
positive genetic interaction withSPCC1393.09cRWD domain protein, implicated in translation Positive GeneticPMID:22681890
positive genetic interaction withSPCC1840.07cphosphoprotein phosphatase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPCC24B10.02cNAD/NADH kinase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC569.06S. pombe specific multicopy membrane protein family 1 Negative GeneticPMID:22681890
positive genetic interaction withSPCC584.01csulfite reductase NADPH flavoprotein subunit (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPCPB16A4.06cSchizosaccharomyces specific protein Positive GeneticPMID:22681890
negative genetic interaction withspf38U5 snRNP complex subunit Spf38 Negative GeneticPMID:22681890
positive genetic interaction withssa1heat shock protein Ssa1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withssr3SWI/SNF and RSC complex subunit Ssr3 Positive GeneticPMID:22681890
positive genetic interaction withthi4bifunctional thiamine-phosphate dipyrophosphorylase/hydroxyethylthiazole kinase Positive GeneticPMID:22681890
negative genetic interaction withtos4FHA domain protein Tos4 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withtrm10tRNA m(1)G methyltransferase Trm10 Positive GeneticPMID:18818364
negative genetic interaction withubp11ubiquitin C-terminal hydrolase Ubp11 Negative GeneticPMID:22681890
negative genetic interaction withulp1SUMO deconjugating enzyme Ulp1 Negative GeneticPMID:22681890
synthetic growth defect withupf3up-frameshift suppressor 3 family protein (predicted) Synthetic Growth DefectPMID:18931302
positive genetic interaction withura3dihydroorotate dehydrogenase Ura3 Positive GeneticPMID:22681890
positive genetic interaction withure2urease Ure2 Positive GeneticPMID:22681890
negative genetic interaction withvph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withvps3CORVET complex subunit, GTPase regulator Vps3 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withyar1ribosome biogenesis protein Yar1 (predicted) Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC1105.14 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1105.14 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1105.14 BioGRID Interaction Datasets
Expression Viewer SPBC1105.14 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1105.14 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1105.14 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1105.14 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1105.14 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1105.14 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC1105.14 Cell Cycle Data
GEO SPBC1105.14 GEO profiles
PInt SPBC1105.14 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1105.14 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC1105.14 Fission yeast phenotypic data & analysis
SPD / RIKEN26/26F12Orfeome Localization Data
UniProtKB/SwissProtQ9Y815Zinc finger protein rsv2
ModBaseQ9Y815Database of comparative protein structure models
STRINGQ9Y815Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596470transcription factor Rsv2
European Nucleotide ArchiveCAB50977.1ENA Protein Mapping
UniParcUPI000006994DUniProt Archive

Literature for rsv2

Search: Europe PMC or PubMed

Release Version: PomBase:25_49 - 02 Feb 2015