fmd2 (SPBC1198.01)


Gene Standard Namefmd2 Characterisation Statusbiological_role_inferred
Systematic IDSPBC1198.01 Feature Typeprotein coding
Synonyms Name DescriptionForMaldehyde Dehydrogenase
Productglutathione-dependent formaldehyde dehydrogenase (predicted) Product Size423aa, 46.44 kDa
Genomic Location Chromosome II, 172378-174315 (1938nt); CDS:172991-174262 (1272nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
oxidoreductase activity277
Annotation ExtensionEvidenceWith/FromReference
zinc ion binding241
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Golgi apparatus357
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationfmd2ΔNull3809

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologyfmd2ΔNull3093
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons172378..174315
mRNA172378..174315
5' UTR172378..172990PMID:21511999
CDS172991..174262
3' UTR174263..174315PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08240 Pfam IPR013154 Alcohol dehydrogenase GroES-like 61 188 9
PF00107 Pfam IPR013149 Alcohol dehydrogenase, C-terminal 232 308 12
PS00059 Prosite Patterns IPR002328 Alcohol dehydrogenase, zinc-type, conserved site 96 110 5
PTHR11695 HMMPANTHER IPR002085 Alcohol dehydrogenase superfamily, zinc-type 28 421 12
PTHR11695:SF281 HMMPANTHER 28 421 1
3.40.50.720 Gene3D IPR016040 NAD(P)-binding domain 223 376 100
3.90.180.10 Gene3D IPR011032 GroES (chaperonin 10)-like 35 222 12
SSF51735 SuperFamily 201 383 88
SSF50129 SuperFamily IPR011032 GroES (chaperonin 10)-like 36 215 13

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.79 Da
Charge -7.00
Isoelectric point 5.44
Molecular weight 46.44 kDa
Number of residues 423
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1977.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.67during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.55during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog600
conserved in fungi4603
conserved in eukaryotes4514
Orthologs

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
positive genetic interaction withhip1hira protein, histone chaperone Hip1 Positive GeneticPMID:22681890
negative genetic interaction withkin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
positive genetic interaction withpab2poly(A) binding protein Pab2 Positive GeneticPMID:22681890
negative genetic interaction withpob3FACT complex subunit Pob3 Negative GeneticPMID:22681890
positive genetic interaction withppk21serine/threonine protein kinase Ppk21 Positive GeneticPMID:22681890
negative genetic interaction withprw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
negative genetic interaction withsep1forkhead transcription factor Sep1 Negative GeneticPMID:22681890
positive genetic interaction withSPAC17H9.13cglutamate 5-kinase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withsrb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
positive genetic interaction withvps35retromer complex subunit Vps35 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC1198.01 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1198.01 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1198.01 BioGRID Interaction Datasets
Expression Viewer SPBC1198.01 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1198.01 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1198.01 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1198.01 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1198.01 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1198.01 Transcriptome Viewer (Bähler Lab)
GEO SPBC1198.01 GEO profiles
PInt SPBC1198.01 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1198.01 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC1198.01 Fission yeast phenotypic data & analysis
Cyclebase SPBC1198.01.1 Cell Cycle Data
SPD / RIKEN20/20D04Orfeome Localization Data
UniProtKB/SwissProtQ9P6I8Zinc-type alcohol dehydrogenase-like protein C1198.01
ModBaseQ9P6I8Database of comparative protein structure models
STRINGQ9P6I8Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595070glutathione-dependent formaldehyde dehydrogenase (predicted)
RefSeq mRNANM_001020976972h- glutathione-dependent formaldehyde dehydrogenase (predicted) (SPBC1198.01), mRNA
European Nucleotide ArchiveCAB91176.1ENA Protein Mapping
UniParcUPI0000069AC0UniProt Archive

Literature for fmd2

Search: Europe PMC or PubMed

Release Version: PomBase:26_52 - 11 May 2015