fmd2 (SPBC1198.01)


Gene Standard Namefmd2 Characterisation Statusbiological_role_inferred
Systematic IDSPBC1198.01 Feature Typeprotein coding
Synonyms Name DescriptionForMaldehyde Dehydrogenase
Productglutathione-dependent formaldehyde dehydrogenase (predicted) Product Size423aa, 46.44 kDa
Genomic Location Chromosome II, 172378-174315 (1938nt); CDS:172991-174262 (1272nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016491oxidoreductase activityIEAUniProtKB-KW:KW-0560GO_REF:0000037286
GO:0008270zinc ion bindingIEAIPR002085GO_REF:0000002249
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005794Golgi apparatusIDAPMID:16823372355
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopyfmd2ΔNullPMID:204732893751
Microscopyfmd2ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001Microscopyfmd2ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1172378174315
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00107 Pfam IPR013149 Alcohol dehydrogenase, C-terminal 232 308 12
PF08240 Pfam IPR013154 Alcohol dehydrogenase GroES-like 61 188 9
PS00059 Prosite Patterns IPR002328 Alcohol dehydrogenase, zinc-type, conserved site 96 110 5
PTHR11695 HMMPANTHER IPR002085 Alcohol dehydrogenase superfamily, zinc-type 17 423 12
PTHR11695:SF281 HMMPANTHER 17 423 1
3.90.180.10 Gene3D IPR011032 GroES (chaperonin 10)-like 35 222 12
3.40.50.720 Gene3D IPR016040 NAD(P)-binding domain 223 376 100
SSF50129 SuperFamily IPR011032 GroES (chaperonin 10)-like 36 215 13
SSF51735 SuperFamily 201 383 88

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.79 Da
Charge -7.00
Isoelectric point 5.44
Molecular weight 46.44 kDa
Number of residues 423
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1977.3during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.67during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.55during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog601
conserved in fungi4599
conserved in eukaryotes4514
Orthologs

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
vps35retromer complex subunit Vps35 Positive GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
SPAC17H9.13cglutamate 5-kinase (predicted) Positive GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
pob3FACT complex subunit Pob3 Negative GeneticPMID:22681890
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Positive GeneticPMID:22681890
sep1forkhead transcription factor Sep1 Negative GeneticPMID:22681890
ppk21serine/threonine protein kinase Ppk21 Positive GeneticPMID:22681890
hip1hira protein, histone chaperone Hip1 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC1198.01 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1198.01 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1198.01 BioGRID Interaction Datasets
Expression Viewer SPBC1198.01 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1198.01 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1198.01 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1198.01 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1198.01 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1198.01 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC1198.01 Cell Cycle Data
GEO SPBC1198.01 GEO profiles
PInt SPBC1198.01 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1198.01 Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN20/20D04Orfeome Localization Data
UniProtKB/SwissProtQ9P6I8Zinc-type alcohol dehydrogenase-like protein C1198.01
ModBaseQ9P6I8Database of comparative protein structure models
STRINGQ9P6I8Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595070glutathione-dependent formaldehyde dehydrogenase (predicted)
RefSeq mRNANM_001020976972h- glutathione-dependent formaldehyde dehydrogenase (predicted) (SPBC1198.01), mRNA
European Nucleotide ArchiveCAB91176.1ENA Protein Mapping
UniParcUPI0000069AC0UniProt Archive

Literature for fmd2

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014