mfr1 (SPBC1198.12)

Gene Standard Namemfr1 ChromosomeII
Systematic IDSPBC1198.12 Gene Start194678
SynonymsSPBC660.02 Gene End195989
Productfizzy-related protein Mfr1 Gene Length1312
Feature Typeprotein coding CDS Start194678
Name Description CDS End195989
Characterisation Statuspublished CDS Length1312

Ensembl Gene Location
  1. SPBC1198.08
  2. slm5
  3. ubc16
  4. reb1
  5. tfg2
  6. mfr1
  7. SPNCRNA.1324
  8. fbp1
  9. SPNCRNA.1325
  10. SPNCRNA.1326
  11. SPBC660.05
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopymfr1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPImes1PMID:15791259
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0007126meiosisIEPPMID:12161753
GO:0030437ascospore formationIMPPMID:15791259
GO:0051487activation of anaphase-promoting complex activity involved in meiotic cell cycleIGIcdc13GO_REF:0000001
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:15791259
GO:0043234protein complexNASGO_REF:0000051
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1194678194798
2194845195989
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00400 IPR001680 Pfam WD40 repeat 372 407 104
PF00400 IPR001680 Pfam WD40 repeat 283 311 104
PF00400 IPR001680 Pfam WD40 repeat 166 194 104
PF00400 IPR001680 Pfam WD40 repeat 199 227 104
PF00400 IPR001680 Pfam WD40 repeat 243 277 104
SM00320 IPR001680 SMART WD40 repeat 238 277 120
SM00320 IPR001680 SMART WD40 repeat 325 365 120
SM00320 IPR001680 SMART WD40 repeat 280 322 120
SM00320 IPR001680 SMART WD40 repeat 368 407 120
SM00320 IPR001680 SMART WD40 repeat 197 234 120
SM00320 IPR001680 SMART WD40 repeat 154 194 120
PS50082 IPR001680 Prosite Profiles WD40 repeat 245 286 100
PS50082 IPR001680 Prosite Profiles WD40 repeat 162 203 100
PS50082 IPR001680 Prosite Profiles WD40 repeat 375 416 100
PS50294 IPR017986 Prosite Profiles WD40-repeat-containing domain 121 416 104
G3DSA:2.130.10.10 IPR015943 Gene3D 129 407 144
SSF50978 IPR017986 SuperFamily 111 408 135
PTHR19918 hmmpanther 1 421 5
PTHR19918:SF0 hmmpanther 1 421 5

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:18257517

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000189Cdc20/Fizzy subfamilyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000189
PBO:0000190WD repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000190

Protein Properties

Ave. residue weight 112.20 Da
Charge 19.50
Isoelectric point 9.80
Molecular weight 47.24 kDa
Number of residues 421
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
meiosis-specific splicing PMID:15893732
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencePECO:0000005,
PECO:0000014		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.012PMID:23101633
experimental evidencePECO:0000014,
PECO:0000005		population_wide0.063PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
png2ING family homolog Png2 Phenotypic EnhancementPMID:19547744
dsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:21504829
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Positive GeneticPMID:22681890
swr1SNF2 family helicase Swr1 Negative GeneticPMID:22681890
ubp8SAGA complex ubiquitin C-terminal hydrolase Ubp8 Positive GeneticPMID:22681890
dma1mitotic spindle checkpoint protein Dma1 Phenotypic EnhancementPMID:20826461
rpb9DNA-directed RNA polymerase II complex subunit Rpb9 Negative GeneticPMID:22681890
mes1meiosis II protein Mes1 Phenotypic SuppressionPMID:21389117
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
slp1sleepy homolog Slp1 Phenotypic EnhancementPMID:21389117
eso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
clr1cryptic loci regulator Clr1 Negative GeneticPMID:22681890
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
tel2Tel2/Rad-5/Clk-2 family protein Tel2 Negative GeneticPMID:22681890
ufd2ubiquitin-protein ligase E4 (predicted) Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
mes1meiosis II protein Mes1 Reconstituted ComplexPMID:15791259
Reconstituted ComplexPMID:21389117
cdc13G2/M B-type cyclin Cdc13 Biochemical ActivityPMID:21389117
cut20anaphase-promoting complex subunit Apc4 Affinity Capture-WesternPMID:11493649
cut2securin, sister chromatid separation inhibitor Biochemical ActivityPMID:21389117
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External References
Database Identifier Description
NBRP SPBC1198.12 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1198.12 Retrieval of eukaryotic orthologs
BioGrid SPBC1198.12 BioGRID Interaction Datasets
Bähler Lab SPBC1198.12 Cell Cycle Expression Profile
Bähler Lab SPBC1198.12 Meiosis/Sporulation Expression Profies
Bähler Lab SPBC1198.12 Pheromone response/mating expression profiles
Bähler Lab SPBC1198.12 Environmental stress expression profiles
Bähler Lab SPBC1198.12 Bähler Lab Transcriptome Viewer
Cyclebase SPBC1198.12 Cell Cycle Data
PInt SPBC1198.12 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC1198.12 Entrez Gene
EntrezGene2540043fizzy-related protein Mfr1
Uniprot_genenameMFR1
WikiGene2540043fizzy-related protein Mfr1
UniProtKB/SwissProtO94423Meiotic fizzy-related protein 1
ModBaseO94423Database of comparative protein structure models
Pfam Protein DomainsO94423Pfam Domain Arrangement
RefSeq PeptideNP_595081fizzy-related protein Mfr1
RefSeq mRNANM_001020987972h- fizzy-related protein Mfr1 (mfr1), mRNA
European Nucleotide ArchiveCAB91187ENA Protein Mapping
SPD / RIKEN22/22H02Orfeome Localization Data
UniParcUPI000012F049UniProt Archive

Literature for mfr1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013