alg2 (SPBC11B10.01)

Gene Standard Namealg2 Characterisation Statusbiological_role_inferred
Systematic IDSPBC11B10.01 Feature Typeprotein coding
Synonymspi010, SPACTOKYO_453.27, SPBC32H8.14 Name Description
Productmannosyltransferase complex subunit Alg2 (predicted) Product Size506aa, 57.17 kDa
Genomic Location Chromosome II, 1486094-1489535 (3442nt); CDS:1486152-1487938 (1787nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004378GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activityISOSGD:S000003033GO_REF:00000241
GO:0033164glycolipid 6-alpha-mannosyltransferase activityISOSGD:S000003033GO_REF:00000242
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006490oligosaccharide-lipid intermediate biosynthetic processISOSGD:S000003033GO_REF:00000245
GO:0006486protein glycosylationIEA UniPathway:UPA00378GO_REF:000004164
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005783endoplasmic reticulumISOSGD:S000003033GO_REF:0000024594
GO:0030176integral component of endoplasmic reticulum membraneNASGO_REF:0000000167
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyalg2ΔNullPMID:204732891309
Microscopyalg2ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002148inviable after spore germination, multiple cell divisions, abnormal morphologyMicroscopyalg2ΔNullPECO:0000005, PECO:0000137PMID:23697806177
penetrance FYPO_EXT:0000001
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Start End Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00534 Pfam IPR001296 Glycosyl transferase, family 1 305 375 8
PF00534 Pfam IPR001296 Glycosyl transferase, family 1 216 289 8
TMhelix TMHMM 82 104 959
TMhelix TMHMM 444 466 959
TMhelix TMHMM 114 136 959
TMhelix TMHMM 481 503 959
PTHR12526 HMMPANTHER 1 479 8
PTHR12526:SF22 HMMPANTHER IPR027054 1 479 1
G3DSA: Gene3D 220 397 15
SSF53756 SuperFamily 17 422 15

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.98 Da
Charge 19.00
Isoelectric point 9.58
Molecular weight 57.17 kDa
Number of residues 506
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
13412.07during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
2333.23during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2.6during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.85during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Disease Association
CDG-Ii PMID:126845071
gene structure updated PMID:21511999426
Species Distribution
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPBC11B10.01 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC11B10.01 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC11B10.01 BioGRID Interaction Datasets
Expression Viewer SPBC11B10.01 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC11B10.01 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC11B10.01 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC11B10.01 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC11B10.01 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC11B10.01 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC11B10.01 Cell Cycle Data
GEO SPBC11B10.01 GEO profiles
PInt SPBC11B10.01 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2539854mannosyltransferase complex subunit Alg2 (predicted)
EntrezGene2539854mannosyltransferase complex subunit Alg2 (predicted)
SPD / RIKEN49/49C05Orfeome Localization Data
UniProtKB/SwissProtQ96WW6Alpha-1,3/1,6-mannosyltransferase alg2
ModBaseQ96WW6Database of comparative protein structure models
StringQ96WW6Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595621mannosyltransferase complex subunit Alg2 (predicted)
RefSeq mRNANM_001021515972h- mannosyltransferase complex subunit Alg2 (predicted) (alg2), mRNA
European Nucleotide ArchiveBAA21387ENA Protein Mapping
European Nucleotide ArchiveCAC37504ENA Protein Mapping
UniParcUPI000006AE20UniProt Archive

Literature for alg2

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014