cdc2 (SPBC11B10.09)


Gene Standard Namecdc2 Characterisation Statuspublished
Systematic IDSPBC11B10.09 Feature Typeprotein coding
Synonymscdk1, pi002, SPACTOKYO_453.34, swo2, tws1, wee2 Name DescriptionTWo Spored,
Cell Division Cycle
Productcyclin-dependent protein kinase Cdk1/Cdc2 Product Size297aa, 34.36 kDa
Genomic Location Chromosome II, 1500197-1502095 (1899nt); CDS:1500340-1501528 (1189nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATP binding558
Annotation ExtensionEvidenceWith/FromReference
cyclin-dependent protein kinase activity9
Annotation ExtensionEvidenceWith/FromReference
cyclin-dependent protein serine/threonine kinase activity8
Annotation ExtensionEvidenceWith/FromReference
protein binding859
Annotation ExtensionEvidenceWith/FromReference
protein kinase activity116
Annotation ExtensionEvidenceWith/FromReference
protein serine/threonine kinase activity107
Annotation ExtensionEvidenceWith/FromReference
protein serine/threonine phosphatase inhibitor activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
negative regulation of conjugation with cellular fusion24
Annotation ExtensionEvidenceWith/FromReference
negative regulation of G0 to G1 transition23
Annotation ExtensionEvidenceWith/FromReference
negative regulation of mitotic attachment of spindle microtubules to kinetochore1
Annotation ExtensionEvidenceWith/FromReference
peptidyl-serine phosphorylation21
Annotation ExtensionEvidenceWith/FromReference
peptidyl-threonine phosphorylation16
Annotation ExtensionEvidenceWith/FromReference
positive regulation of G1/S transition of mitotic cell cycle5
Annotation ExtensionEvidenceWith/FromReference
positive regulation of G2/M transition of mitotic cell cycle14
Annotation ExtensionEvidenceWith/FromReference
positive regulation of septation initiation signaling9
Annotation ExtensionEvidenceWith/FromReference
protein phosphorylation132
Annotation ExtensionEvidenceWith/FromReference
regulation of APC-fizzy related complex activity1
Annotation ExtensionEvidenceWith/FromReference
regulation of cell size5
Annotation ExtensionEvidenceWith/FromReference
regulation of meiotic cell cycle33
Annotation ExtensionEvidenceWith/FromReference
response to intra-S DNA damage checkpoint signaling3
Annotation ExtensionEvidenceWith/FromReference
traversing start control point of mitotic cell cycle5
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cyclin-dependent protein kinase holoenzyme complex7
Annotation ExtensionEvidenceWith/FromReference
cytosol2314
Annotation ExtensionEvidenceWith/FromReference
nucleus2696
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term NameAlleleExpressionCount
decreased septation indexcdc2-33 (A177T)Not specified20
increased number of cells with 1C DNA contentcdc2-3w (C67Y)Not specified40
inviable vegetative cell populationcdc2-3w (C67Y)Not specified1438
cdc2-4w (G200T)Not specified
cdc2ΔNull
loss of viability upon nitrogen starvationcdc2-974 (I35N)Not specified46
normal growth on arsenatecdc2-3w (C67Y)Not specified4
normal septation indexcdc2-3w (C67Y)Not specified7
normal vegetative cell population growth ratetws1-N22 (E42K)Not specified70
sensitive to caffeine during vegetative growthcdc2-33 (A177T)Not specified106
sensitive to ethanolcdc2-M26 (P137S)Not specified5
cdc2-M56 (P137S)Not specified
sensitive to hydroxyureacdc2-3w (C67Y)Not specified534
sensitive to methyl methanesulfonatecdc2-Y15F (Y15F)Not specified239
sensitive to plumbagincdc2+/cdc2- (heterozygous diploid)Not specified12
viable vegetative cell populationcdc2-1w (G146D)Not specified3809

Cell Phenotype

Term NameAlleleExpressionCount
abnormal meiosiscdc2-N22 (E42K)Endogenous120
abnormal mitotic cell cyclecdc2ΔNull834
abnormal mitotic cell cycle regulation during cellular response to hydroxyureacdc2-3w (C67Y)Not specified11
abnormal sporulation resulting in formation of two-spore ascuscdc2-33 (A177T)Not specified12
cdc2-59 (P248L, C67Y)
cdc2-N22 (E42K)Endogenous
tws1-N22 (E42K)Not specified
abnormally arrested mitotic cell cycle progressionAla167 (T167A)Not specified123
Arg33 (K33R)Not specified
cdc2ΔNull
Val167 (T167V)Not specified
Val177 (A177V)Not specified
abolished meiosiscdc2-M26 (P137S)Not specified17
abolished meiosis Icdc2-M26 (P137S)Not specified3
abolished meiosis IIcdc2-33 (A177T)Not specified3
cdc2-7Not specified
abolished premeiotic DNA replicationcdc2-33 (A177T)Not specified14
cdc2-M26 (P137S)Not specified
cdc2-M63 (G227C)Not specified
abolished protein binding95
affecting cdc2 and suc1cdc2-56 (G183E)Endogenous
abolished protein kinase activity20
affecting cdc2cdc2-56 (G183E)Not specified
abolished protein localization to kinetochore during vegetative growth19
affecting nsk1cdc2 analogue sensitive (analogue-sensitive)Not specified
abolished protein phosphorylation during vegetative growth33
affecting srw1cdc2-33 (A177T)Endogenous
affecting mde4cdc2-as (analog-sensitive)Endogenous
abolished re-entry into mitotic cell cycle after pheromone arrestcdc2-M26 (P137S)Not specified1
cell cycle arrest in mitotic G2 phasecdc2-33 (A177T)Not specified29
cut during cellular response to hydroxyureacdc2-3w (C67Y)Not specified43
cdc2-4w (G200T)Not specified
decreased arsenate reductase activitycdc2-3w (C67Y)Not specified2
decreased protein binding66
affecting cdc2 and suc1cdc2-33 (A177T)Not specified
affecting cdc2 and suc1cdc2-56 (G183E)Not specified
affecting cdc2 and suc1cdc2-L7 (P208S)Not specified
affecting cdc2 and suc1cdc2-L7 (P208S)Endogenous
affecting cdc2 and cdc13cdc2-L7 (P208S)Not specified
decreased protein kinase activity34
affecting cdc2cdc2-33 (A177T)Not specified
affecting cdc2cdc2-56 (G183E)Not specified
cdc2-L7 (P208S)Not specified
affecting cdc2cdc2-L7 (P208S)Not specified
cdc2-M35 (G43E)Not specified
affecting cdc2cdc2-M35 (G43E)Not specified
affecting cdc2cdc2-M55Not specified
decreased protein phosphorylation during mitotic G2 phase3
affecting srw1cdc2-M26 (P137S)Endogenous
decreased protein phosphorylation during vegetative growthcdc2-33 (A177T)Not specified74
affecting cdc13cdc2-33 (A177T)Not specified
affecting orc2cdc2-33 (A177T)Not specified
affecting cdc13cdc2-56 (G183E)Not specified
affecting cdc13cdc2-L7 (P208S)Not specified
affecting orc2cdc2-L7 (P208S)Not specified
decreased protein serine phosphorylation during vegetative growth14
affecting fkh2cdc2-tsNot specified
decreased protein threonine phosphorylation6
affecting fkh2cdc2-tsNot specified
decreased response to S-phase DNA damage checkpoint signalingcdc2-Y15F (Y15F)Not specified2
delayed protein localization to nucleoplasm during cellular response to hydrogen peroxidecdc2-F84G (F84G)Endogenous4
DNA fragmentation during nitrogen starvationcdc2-974 (I35N)Not specified13
elongated cell during nitrogen starvationcdc2-974 (I35N)Not specified18
increased mRNA splicing, via spliceosome1
affecting cdc2cdc2-I2mut (TTGACG287ACACAT)Not specified
increased RNA splicing at cryptic splice sites4
affecting cdc2cdc2-I2mut (TTGACG287ACACAT)Not specified
inviable after spore germination with elongated germ tubecdc2ΔNull164
inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cellscdc2-59 (P248L, C67Y)Endogenous88
inviable after spore germination, without cell division, with elongated germ tubecdc2ΔNull66
inviable elongated mononucleate aseptate cellcdc2-17 (G212S)Not specified34
cdc2-33 (A177T)Endogenous
cdc2-M63 (G227C)Endogenous
inviable elongated vegetative cellcdc2-17 (G212S)Endogenous401
cdc2-18 (L269S)Endogenous
cdc2-33 (A177T)Endogenous
cdc2-45 (F210L)Endogenous
cdc2-48 (Y292H)Endogenous
cdc2-56 (G183E)Endogenous
cdc2-L7 (P208S)Endogenous
cdc2-M26 (P137S)Endogenous
cdc2-M35 (G43E)Endogenous
cdc2-M63 (G227C)Endogenous
cdc2ΔNull
inviable vegetative cellL248 (P248L)Not specified1258
mitotic G1/S transition delaycdc2-33 (A177T)Endogenous13
normal cell cycle regulation during cellular response to hydroxyureacdc2-1w (G146D)Not specified14
normal cell cycle regulation during cellular response to ionizing radiationcdc2-3w (C67Y)Not specified11
normal interphase cytoplasmic microtubulescdc2-3w (C67Y)Not specified8
normal mitotic cell cycleArg34 (K34R)Not specified91
normal mitotic spindlecdc2-3w (C67Y)Not specified16
normal premeiotic DNA replicationcdc2-33 (A177T)Not specified24
normal protein binding56
affecting cdc2 and suc1cdc2-M55Endogenous
affecting cdc2 and suc1cdc2-M56 (P137S)Endogenous
normal protein kinase activity14
affecting cdc2cdc2-56 (G183E)Not specified
normal protein localization to nucleus55
affecting cdc13cdc2ΔNull
normal protein phosphorylation during vegetative growth41
affecting srw1cdc2-33 (A177T)Endogenous
normal regulation of mitotic cell cyclecdc2-59 (P248L, C67Y)Endogenous50
normal sporulationcdc2-3w (C67Y)Not specified52
normal sporulation frequencytws1-N22 (E42K)Not specified9
normal telomere lengthcdc2-3w (C67Y)Not specified17
premature protein localization to mitotic spindle2
affecting mde4cdc2-as (analog-sensitive)Endogenous
protein mislocalized to nucleus during meiosis I1
affecting rna1tws1-N22 (E42K)Not specified
septation following abnormal chromosome segregation, with binucleate cell formation during cellular response to hydroxyureacdc2-3w (C67Y)Not specified4
cdc2-4w (G200T)Not specified
swollen sporetws1-N22 (E42K)Not specified5
viable small vegetative cellcdc2-1w (G146D)Not specified46
cdc2-1w (G146D)Endogenous
cdc2-3w (C67Y)Endogenous
cdc2-3w (C67Y)Not specified
cdc2-3w (C67Y)
cdc2-4w (G200T)Not specified
cdc2-56 (G183E)Endogenous
cdc2.1wNot specified
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in cdc10 MBF transcription factor complex subunit Cdc10
FYPO affected by mutation in cdc13 G2/M B-type cyclin Cdc13
FYPO affected by mutation in cdc18 MCM loader
FYPO affected by mutation in cdc2 cyclin-dependent protein kinase Cdk1/Cdc2
FYPO affected by mutation in cdc25 M phase inducer tyrosine phosphatase Cdc25
FYPO affected by mutation in cdc6 DNA polymerase delta catalytic subunit Cdc6
FYPO affected by mutation in cds1 replication checkpoint kinase Cds1
FYPO affected by mutation in cia1 histone chaperone Cia1
FYPO affected by mutation in clp1 Cdc14-related protein phosphatase Clp1/Flp1
FYPO affected by mutation in dim1 U4/U6 x U5 tri-snRNP complex subunit Dim1
FYPO affected by mutation in dnt1 nucleolar protein Dnt1
FYPO affected by mutation in fin1 serine/threonine protein kinase, NIMA related Fin1
FYPO affected by mutation in hsp9 heat shock protein Hsp9
FYPO affected by mutation in hub1 ubiquitin-like protein modifier Hub1
FYPO affected by mutation in mes1 meiosis II protein Mes1
FYPO affected by mutation in nap1 nucleosome assembly protein Nap1
FYPO affected by mutation in nda3 tubulin beta Nda3
FYPO affected by mutation in pim1 RCC1 family Ran GDP/GTP exchange factor
FYPO affected by mutation in prp1 U4/U6 x U5 tri-snRNP complex subunit Prp1
FYPO affected by mutation in prp10 U2 snRNP-associated protein Sap155
FYPO affected by mutation in prp2 U2AF large subunit (U2AF-59)
FYPO affected by mutation in rad3 ATR checkpoint kinase Rad3
FYPO affected by mutation in rum1 CDK inhibitor Rum1
FYPO affected by mutation in sds22 protein phosphatase regulatory subunit Sds22
FYPO affected by mutation in snu1 small nuclear RNA U1
FYPO affected by mutation in snu4 small nuclear RNA U4
FYPO affected by mutation in spo5 meiotic RNA-binding protein 1
FYPO affected by mutation in srb10 cyclin-dependent protein Srb mediator subunit kinase Srb10
FYPO affected by mutation in srw1 fizzy-related CDK inhibitor Srw1
FYPO affected by mutation in suc1 cyclin-dependent protein kinase regulatory subunit Suc1
FYPO affected by mutation in uaf2 U2AF small subunit, U2AF-23
GO binds spd1 ribonucleotide reductase (RNR) inhibitor
GO binds suc1 cyclin-dependent protein kinase regulatory subunit Suc1
GO regulated by cdc13 G2/M B-type cyclin Cdc13
GO regulated by cdc25 M phase inducer tyrosine phosphatase Cdc25
GO regulated by cig2 G1/S-specific B-type cyclin Cig2
GO regulated by clp1 Cdc14-related protein phosphatase Clp1/Flp1
GO regulated by pim1 RCC1 family Ran GDP/GTP exchange factor
GO regulated by rum1 CDK inhibitor Rum1
GO regulated by suc1 cyclin-dependent protein kinase regulatory subunit Suc1
GO regulated by wee1 M phase inhibitor protein kinase Wee1
GO substrate of cdc25 M phase inducer tyrosine phosphatase Cdc25
GO substrate of csk1 cyclin-dependent kinase/ cyclin-dependent kinase activating kinase Csk1
GO substrate of mik1 mitotic inhibitor kinase Mik1
GO substrate of pyp3 protein-tyrosine phosphatase Pyp3
GO substrate of wee1 M phase inhibitor protein kinase Wee1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1500197..1500243, 1500286..1500376, 1500445..1500613, 1500686..1500986, 1501088..1501393, 1501448..1502095
Introns1500377..1500444, 1500614..1500685, 1500987..1501087
mRNA1500197..1502095
5' UTR1500197..1500243, 1500286..1500339PMID:21511999
CDS1500340..1500376, 1500445..1500613, 1500686..1500986, 1501088..1501393, 1501448..1501528
3' UTR1501529..1502095PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00069 Pfam IPR000719 Protein kinase domain 4 293 109
SM00220 SMART IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain 4 293 107
PS00108 Prosite Patterns IPR008271 Serine/threonine-protein kinase, active site 130 142 97
PS00107 Prosite Patterns IPR017441 Protein kinase, ATP binding site 10 33 73
PS50011 Prosite Profiles IPR000719 Protein kinase domain 4 293 110
PTHR24056 HMMPANTHER 1 295 9
1.10.510.10 Gene3D 88 294 112
3.30.200.20 Gene3D 2 87 111
SSF56112 SuperFamily IPR011009 Protein kinase-like domain 1 296 127

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0003657CDK family kinaseTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0003657

Protein Properties

Ave. residue weight 115.69 Da
Charge 4.50
Isoelectric point 7.68
Molecular weight 34.36 kDa
Number of residues 297
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
Annotation ExtensionEvidenceResidueReference
IDA PMID:3058333
O-phospho-L-threonine 698
present during cellular response to thiabendazoleT167
Annotation ExtensionEvidenceResidueReference
IDA PMID:1756737
IDA PMID:3058333
present during cellular response to thiabendazole IDA T167 PMID:18257517
O4'-phospho-L-tyrosine 87
absent during mitotic M phase
present during cellular response to hydroxyureaT15
added by mik1, wee1Y15
added during mitotic G2 phase, premeiotic DNA replication
present during meiosis I
present during cellular response to thiabendazole, mitotic M phaseY15
removed during meiosis II
removed during cellular response to caffeineT15
removed by cdc25
Annotation ExtensionEvidenceResidueReference
removed during meiosis II IDA PMID:10888871
removed by cdc25 IDA PMID:1756737
added during premeiotic DNA replication IDA PMID:10888871
present during meiosis I IDA PMID:10888871
added during mitotic G2 phase IDA PMID:1464318
absent during mitotic M phase IDA PMID:1464318
removed during cellular response to caffeine IDA T15 PMID:10036242
present during cellular response to hydroxyurea IDA T15 PMID:10036242
added by wee1 IDA Y15 PMID:1372994
added by mik1 IDA Y15 PMID:7982971
present during mitotic M phase experimental evidence Y15 PMID:21712547
present during cellular response to thiabendazole IDA Y15 PMID:18257517
phosphorylated residueY15 1927
added during G0 to G1 transition
removed during cellular response to nitrogen starvation
added by wee1Y15
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
added during G0 to G1 transition IDA PMID:3516412
removed during cellular response to nitrogen starvation IDA PMID:3516412
NAS Y15 PMID:9042863
added by wee1 NAS Y15 PMID:2682257
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
protein levelpresent during GO:0051321Western blot evidencePMID:10888871
constant during GO:0000278Western blot evidencePMID:3516412
increased during GO:0006279Western blot evidencePMID:10888871
constant during GO:0000278Western blot evidencePMID:2569363
unchanged during GO:0072734Western blot evidencePMID:1899230
present during GO:0072690Western blot evidencePMID:2569363

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5406.86during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
14449during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2704.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.8during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.52during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by H. sapiens CDK1full PMID:1944283 PMID:3553962
full
does not functionally complement S. cerevisiae CDC28 PMID:3796591
functionally complemented by G. gallus cdc2full PMID:1500441
functionally complements S. cerevisiae CDC28 when introns removedfull PMID:3796591
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4603
conserved in eukaryotes4514
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2501
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
modifiesalp7centrosomal transforming acidic coiled-coil (TACC) protein ortholog Alp7 Biochemical ActivityPMID:24790093
modifiesase1antiparallel microtubule cross-linking factor Ase1 Biochemical ActivityPMID:19686686
affinity captured bybgs11,3-beta-glucan synthase catalytic subunit Bgs1 Affinity Capture-WesternPMID:11937031
modifiesbub1mitotic spindle checkpoint kinase Bub1 Biochemical ActivityPMID:12606573
modifiesbyr4two-component GAP Byr4 Biochemical ActivityPMID:24920823
affinity captured bycbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
affinity captured bycdc11SIN component scaffold protein, centriolin ortholog Cdc11 Affinity Capture-WesternPMID:15062098
affinity captured bycdc13G2/M B-type cyclin Cdc13 Affinity Capture-WesternPMID:9632761
co-fractionates withcdc13G2/M B-type cyclin Cdc13 Co-fractionationPMID:2569363
modifiescdc13G2/M B-type cyclin Cdc13 Biochemical ActivityPMID:2569363
affinity captured bycdc13G2/M B-type cyclin Cdc13 Affinity Capture-WesternPMID:9790601
affinity captured bycdc13G2/M B-type cyclin Cdc13 Affinity Capture-WesternPMID:10581266
affinity capturescdc13G2/M B-type cyclin Cdc13 Affinity Capture-WesternPMID:11683390
affinity captured bycdc13G2/M B-type cyclin Cdc13 Affinity Capture-WesternPMID:16390871
affinity capturescdc13G2/M B-type cyclin Cdc13 Affinity Capture-WesternPMID:11329175
affinity capturescdc18MCM loader Affinity Capture-RNAPMID:22144913
modifiescdc18MCM loader Biochemical ActivityPMID:9436991
affinity captured bycdc18MCM loader Affinity Capture-WesternPMID:9436991
modifiescdc18MCM loader Biochemical ActivityPMID:9177184
modifiescdc25M phase inducer tyrosine phosphatase Cdc25 Biochemical ActivityPMID:22665807
affinity captured bycdc37Hsp90 co-chaperone Cdc37 Affinity Capture-WesternPMID:16390871
affinity captureschk1Chk1 protein kinase Affinity Capture-WesternPMID:24861625
affinity captured bycig2G1/S-specific B-type cyclin Cig2 Affinity Capture-WesternPMID:11163211
modifiesclp1Cdc14-related protein phosphatase Clp1/Flp1 Biochemical ActivityPMID:16950131
modifiesclp1Cdc14-related protein phosphatase Clp1/Flp1 Biochemical ActivityPMID:22918952
modifiescrb2DNA repair protein Rad9 homolog Crb2 Biochemical ActivityPMID:24074952
modifiescrb2DNA repair protein Rad9 homolog Crb2 Biochemical ActivityPMID:10488332
modifiescut12spindle pole body protein Cut12 Biochemical ActivityPMID:23333317
modifiescut3condensin complex subunit Cut3 Biochemical ActivityPMID:10485849
modifiesdis2serine/threonine protein phosphatase PP1 subfamily, Dis2 Biochemical ActivityPMID:16920624
modifiesdis2serine/threonine protein phosphatase PP1 subfamily, Dis2 Biochemical ActivityPMID:7957097
forms complex withdrc1replication preinitiation complex assembly protein Reconstituted ComplexPMID:11937031
modifiesfkh2forkhead transcription factor Fkh2 Biochemical ActivityPMID:18059475
modifieshcn1anaphase-promoting complex subunit TPR lobe accessory factor Hcn1/Apc12 Biochemical ActivityPMID:16950791
affinity captureshhp1serine/threonine protein kinase Hhp1 Affinity Capture-WesternPMID:24861625
affinity captured byhsp90Hsp90 chaperone Affinity Capture-WesternPMID:22543982
modifiesmbx1MADS-box transcription factor Mbx1 Biochemical ActivityPMID:21098641
modifiesmde4microtubule-site clamp monopolin complex subunit Mde4 Biochemical ActivityPMID:19523829
modified bymik1mitotic inhibitor kinase Mik1 Biochemical ActivityPMID:7982971
affinity captured bymtl1TRAMP complex ATP-dependent RNA helicase (predicted) Affinity Capture-MSPMID:24713849
affinity capturesmus81Holliday junction resolvase subunit Mus81 Affinity Capture-WesternPMID:24861625
affinity captured bynsk1Clp1-interacting, microtubule plus-end binding Nsk1 Affinity Capture-WesternPMID:22065639
modifiesnsk1Clp1-interacting, microtubule plus-end binding Nsk1 Biochemical ActivityPMID:22065639
binds activation domain construct withorc2origin recognition complex subunit Orc2 Two-hybridPMID:8552194
affinity captured byorc2origin recognition complex subunit Orc2 Affinity Capture-WesternPMID:8552194
modifiesorc2origin recognition complex subunit Orc2 Biochemical ActivityPMID:11486016
affinity captured bypas1cyclin Pas1 Affinity Capture-WesternPMID:10982385
binds activation domain construct withpch1P-TEFB associated cyclin, cyclin T Pch1 Two-hybridPMID:9115279
affinity captured bypch1P-TEFB associated cyclin, cyclin T Pch1 Affinity Capture-WesternPMID:9115279
affinity captured bypir2zf-C2H2 type zinc finger protein, implicated in RNAi (predicted) Affinity Capture-MSPMID:24713849
affinity capturespku70Ku domain protein Pku70 Affinity Capture-WesternPMID:24861625
affinity capturespku80Ku domain protein Pku80 Affinity Capture-WesternPMID:24861625
modified bypyp3protein-tyrosine phosphatase Pyp3 Biochemical ActivityPMID:1464318
affinity capturesrad16DNA repair endonuclease XPF Affinity Capture-WesternPMID:24861625
affinity captured byred1RNA elimination defective protein Red1 Affinity Capture-MSPMID:24713849
affinity capturesrqh1RecQ type DNA helicase Rqh1 Affinity Capture-WesternPMID:24861625
modifiesrum1CDK inhibitor Rum1 Biochemical ActivityPMID:10679013
affinity capturesrum1CDK inhibitor Rum1 Affinity Capture-RNAPMID:22144913
forms complex withrum1CDK inhibitor Rum1 Reconstituted ComplexPMID:8598285
modifiesrum1CDK inhibitor Rum1 Biochemical ActivityPMID:9303310
forms complex withrum1CDK inhibitor Rum1 Reconstituted ComplexPMID:9303310
modifiesrum1CDK inhibitor Rum1 Biochemical ActivityPMID:12167173
affinity capturesrum1CDK inhibitor Rum1 Affinity Capture-WesternPMID:11329175
modifiessds23PP2A-type phosphatase inhibitor Sds23/Moc1 Biochemical ActivityPMID:9242669
binds activation domain construct withsds23PP2A-type phosphatase inhibitor Sds23/Moc1 Two-hybridPMID:9242669
affinity captured byshk1PAK-related kinase Shk1 Affinity Capture-WesternPMID:9843966
affinity captured byskb1type II protein arginine N-methyltransferase Skb1 Affinity Capture-WesternPMID:9843966
affinity capturesspd1ribonucleotide reductase (RNR) inhibitor Affinity Capture-WesternPMID:8887552
affinity capturessrs2ATP-dependent DNA helicase, UvrD subfamily Affinity Capture-WesternPMID:24861625
affinity captured bysuc1cyclin-dependent protein kinase regulatory subunit Suc1 Affinity Capture-WesternPMID:3322810
forms complex withsuc1cyclin-dependent protein kinase regulatory subunit Suc1 Reconstituted ComplexPMID:2569363
affinity captured bysuc1cyclin-dependent protein kinase regulatory subunit Suc1 Affinity Capture-WesternPMID:9790601
modified bywee1M phase inhibitor protein kinase Wee1 Biochemical ActivityPMID:7982971
modified bywee1M phase inhibitor protein kinase Wee1 Biochemical ActivityPMID:1850698
modified bywee1M phase inhibitor protein kinase Wee1 Biochemical ActivityPMID:1372994
affinity captureswos2p23 homolog, predicted co-chaperone Wos2 Affinity Capture-WesternPMID:10581266
affinity captured bywos2p23 homolog, predicted co-chaperone Wos2 Affinity Capture-WesternPMID:10581266
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
rescuesbgs11,3-beta-glucan synthase catalytic subunit Bgs1 Phenotypic SuppressionPMID:10704373
enhances phenotype ofbgs11,3-beta-glucan synthase catalytic subunit Bgs1 Phenotypic EnhancementPMID:10503548
synthetic growth defect withblt1ubiquitin domain-like protein Blt1 Synthetic Growth DefectPMID:24790095
phenotype enhanced bycdc10MBF transcription factor complex subunit Cdc10 Phenotypic EnhancementPMID:11513869
rescued by overexpression ofcdc13G2/M B-type cyclin Cdc13 Dosage RescuePMID:1533272
rescued bycdc13G2/M B-type cyclin Cdc13 Phenotypic SuppressionPMID:9790601
rescued bycdc13G2/M B-type cyclin Cdc13 Phenotypic SuppressionPMID:1934126
rescued by overexpression ofcdc13G2/M B-type cyclin Cdc13 Dosage RescuePMID:11711540
overexpression rescuescdc13G2/M B-type cyclin Cdc13 Dosage RescuePMID:2847913
rescued by overexpression ofcdc13G2/M B-type cyclin Cdc13 Dosage RescuePMID:7909513
rescuescdc13G2/M B-type cyclin Cdc13 Phenotypic SuppressionPMID:8631306
rescuescdc13G2/M B-type cyclin Cdc13 Phenotypic SuppressionPMID:1829983
synthetically rescuescdc13G2/M B-type cyclin Cdc13 Synthetic RescuePMID:3428262
overexpression rescuescdc13G2/M B-type cyclin Cdc13 Dosage RescuePMID:3428262
synthetically rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:2245912
rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:3796591
synthetically rescued bycdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:24861625
rescued bycdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:9013342
rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:1934126
synthetic growth defect withcdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic Growth DefectPMID:20444100
synthetically rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:7217015
overexpression rescuescdc37Hsp90 co-chaperone Cdc37 Dosage RescuePMID:16390871
enhances phenotype ofcdc6DNA polymerase delta catalytic subunit Cdc6 Phenotypic EnhancementPMID:9154809
synthetically rescuescdc6DNA polymerase delta catalytic subunit Cdc6 Synthetic RescuePMID:9135148
synthetic growth defect withcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic Growth DefectPMID:3448096
synthetic growth defect withcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic Growth DefectPMID:2004705
rescuescdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Phenotypic SuppressionPMID:2004705
enhances phenotype ofcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Phenotypic EnhancementPMID:2004705
synthetically rescuescdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic RescuePMID:2245912
synthetic growth defect withcdr2serine/threonine protein kinase Cdr2 Synthetic Growth DefectPMID:3448096
synthetic lethal withcdr2serine/threonine protein kinase Cdr2 Synthetic LethalityPMID:9843577
synthetically rescuescdr2serine/threonine protein kinase Cdr2 Synthetic RescuePMID:2245912
rescued bycds1replication checkpoint kinase Cds1 Phenotypic SuppressionPMID:24861625
rescued by overexpression ofchk1Chk1 protein kinase Dosage RescuePMID:8497322
rescued bychk1Chk1 protein kinase Phenotypic SuppressionPMID:10637286
rescued by overexpression ofchk1Chk1 protein kinase Dosage RescuePMID:11711540
rescued bychk1Chk1 protein kinase Phenotypic SuppressionPMID:24861625
synthetic growth defect withchk1Chk1 protein kinase Synthetic Growth DefectPMID:24861625
rescued by overexpression ofcid13poly(A) polymerase Cid13 Dosage RescuePMID:12062100
synthetically rescued bycig2G1/S-specific B-type cyclin Cig2 Synthetic RescuePMID:8455610
enhances phenotype ofcig2G1/S-specific B-type cyclin Cig2 Phenotypic EnhancementPMID:8455610
synthetically rescued byclp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic RescuePMID:23297348
synthetic lethal withclp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic LethalityPMID:16950131
rescued byclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic SuppressionPMID:15128870
rescuesclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic SuppressionPMID:11683392
enhances phenotype ofclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic EnhancementPMID:11683392
rescued bycmk2MAPK-activated protein kinase Cmk2 Phenotypic SuppressionPMID:12135745
synthetic growth defect withcrb2DNA repair protein Rad9 homolog Crb2 Synthetic Growth DefectPMID:24861625
synthetic growth defect withctu1cytosolic thiouridylase subunit Ctu1 Synthetic Growth DefectPMID:22768388
rescuescut1separase/separin Phenotypic SuppressionPMID:16453724
synthetically rescued bycut12spindle pole body protein Cut12 Synthetic RescuePMID:23333317
rescued bycut12spindle pole body protein Cut12 Phenotypic SuppressionPMID:2245912
synthetic growth defect withdim1U4/U6 x U5 tri-snRNP complex subunit Dim1 Synthetic Growth DefectPMID:9182666
synthetic growth defect withelp3elongator complex subunit Elp3 (predicted) Synthetic Growth DefectPMID:22768388
rescuesfin1serine/threonine protein kinase, NIMA related Fin1 Phenotypic SuppressionPMID:12065422
synthetically rescueshhp1serine/threonine protein kinase Hhp1 Synthetic RescuePMID:24861625
rescued by overexpression ofhsp9heat shock protein Hsp9 Dosage RescuePMID:22182414
enhances phenotype ofhsp90Hsp90 chaperone Phenotypic EnhancementPMID:22543982
phenotype enhanced byhsp90Hsp90 chaperone Phenotypic EnhancementPMID:10102358
phenotype enhanced byhta1histone H2A alpha Phenotypic EnhancementPMID:16314498
phenotype enhanced byhta2histone H2A beta Phenotypic EnhancementPMID:16314498
rescuesmcm4MCM complex subunit Mcm4/Cdc21 Phenotypic SuppressionPMID:8631307
synthetic lethal withmcs2TFIIH complex cyclin Mcs2 Synthetic LethalityPMID:2474475
synthetic lethal withmcs4response regulator Mcs4 Synthetic LethalityPMID:2474475
synthetic lethal withmcs6TFIIH associated cyclin-dependent protein kinase Mcs6 Synthetic LethalityPMID:2474475
synthetic growth defect withmcs6TFIIH associated cyclin-dependent protein kinase Mcs6 Synthetic Growth DefectPMID:2474475
rescued by overexpression ofmcs6TFIIH associated cyclin-dependent protein kinase Mcs6 Dosage RescuePMID:8557037
rescued bymik1mitotic inhibitor kinase Mik1 Phenotypic SuppressionPMID:10637286
synthetically rescued bymik1mitotic inhibitor kinase Mik1 Synthetic RescuePMID:24861625
enhances phenotype oforc1origin recognition complex subunit Orc1 Phenotypic EnhancementPMID:12186947
phenotype enhanced byorc2origin recognition complex subunit Orc2 Phenotypic EnhancementPMID:8552194
rescuespab1protein phosphatase regulatory subunit Pab1 Phenotypic SuppressionPMID:20876564
enhances phenotype ofpmk1MAP kinase Pmk1 Phenotypic EnhancementPMID:22918952
phenotype enhanced bypmk1MAP kinase Pmk1 Phenotypic EnhancementPMID:22918952
synthetic lethal withpop1cullin 1 adaptor protein Pop1 Synthetic LethalityPMID:9203581
rescuespyp1tyrosine phosphatase Pyp1 Phenotypic SuppressionPMID:1448087
rescued by overexpression ofpyp1tyrosine phosphatase Pyp1 Dosage RescuePMID:9560390
rescuespyp2tyrosine phosphatase Pyp2 Phenotypic SuppressionPMID:1448087
inviable in presence of overexpressedpyp3protein-tyrosine phosphatase Pyp3 Dosage LethalityPMID:1464318
enhances phenotype ofrad3ATR checkpoint kinase Rad3 Phenotypic EnhancementPMID:22918952
rescuesrad4BRCT domain protein Rad4 Phenotypic SuppressionPMID:7957098
synthetic lethal withrad54DNA-dependent ATPase Rad54/Rhp54 Synthetic LethalityPMID:8834792
synthetically rescued byres2MBF transcription factor complex subunit Res2 Synthetic RescuePMID:11029045
synthetic lethal withres2MBF transcription factor complex subunit Res2 Synthetic LethalityPMID:2474475
negative genetic interaction withria1GTPase Ria1 (predicted) Negative GeneticPMID:22681890
phenotype enhanced byrum1CDK inhibitor Rum1 Phenotypic EnhancementPMID:7593289
enhances phenotype ofsep1forkhead transcription factor Sep1 Phenotypic EnhancementPMID:9473044
synthetic growth defect withslp1substrate-specific APC activator Slp1 Synthetic Growth DefectPMID:9001228
rescuesslp1substrate-specific APC activator Slp1 Phenotypic SuppressionPMID:9001228
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
rescued bySPAC29A4.02ctranslation elongation factor EF-1 gamma subunit Phenotypic SuppressionPMID:14985109
rescued byspd1ribonucleotide reductase (RNR) inhibitor Phenotypic SuppressionPMID:8887552
rescuesspo4serine/threonine protein kinase Spo4 Phenotypic SuppressionPMID:23370392
rescuesspo5meiotic RNA-binding protein 1 Phenotypic SuppressionPMID:24506453
synthetically rescuessrk1MAPK-activated protein kinase Srk1 Synthetic RescuePMID:15629716
synthetic growth defect withsrw1fizzy-related CDK inhibitor Srw1 Synthetic Growth DefectPMID:14985109
rescuessrw1fizzy-related CDK inhibitor Srw1 Phenotypic SuppressionPMID:14985109
rescuessrw1fizzy-related CDK inhibitor Srw1 Phenotypic SuppressionPMID:9398669
overexpression lethal tosrw1fizzy-related CDK inhibitor Srw1 Dosage LethalityPMID:9398669
synthetically rescued bysty1MAP kinase Sty1 Synthetic RescuePMID:9560390
rescued by overexpression ofsuc1cyclin-dependent protein kinase regulatory subunit Suc1 Dosage RescuePMID:3322810
rescued bysuc1cyclin-dependent protein kinase regulatory subunit Suc1 Phenotypic SuppressionPMID:16453733
rescued by overexpression ofsuc1cyclin-dependent protein kinase regulatory subunit Suc1 Dosage RescuePMID:1896017
rescued bysuc1cyclin-dependent protein kinase regulatory subunit Suc1 Phenotypic SuppressionPMID:9790601
rescued bysuc1cyclin-dependent protein kinase regulatory subunit Suc1 Phenotypic SuppressionPMID:3010051
rescued by overexpression ofsum1translation initiation factor eIF3i Dosage RescuePMID:9560390
rescued by overexpression ofsum3translation initiation RNA helicase Sum3 Dosage RescuePMID:11711540
rescued by overexpression ofsum3translation initiation RNA helicase Sum3 Dosage RescuePMID:9832516
phenotype enhanced byswr1SNF2 family ATP-dependent DNA helicase Swr1 Phenotypic EnhancementPMID:9571240
rescuestor1phosphatidylinositol kinase Tor1 Phenotypic SuppressionPMID:19546237
synthetic growth defect withwee1M phase inhibitor protein kinase Wee1 Synthetic Growth DefectPMID:11029045
synthetically rescueswee1M phase inhibitor protein kinase Wee1 Synthetic RescuePMID:24861625
rescued by overexpression ofwee1M phase inhibitor protein kinase Wee1 Dosage RescuePMID:1427071
phenotype enhanced bywee1M phase inhibitor protein kinase Wee1 Phenotypic EnhancementPMID:9013342
synthetic lethal withwee1M phase inhibitor protein kinase Wee1 Synthetic LethalityPMID:2474475
enhances phenotype ofwee1M phase inhibitor protein kinase Wee1 Phenotypic EnhancementPMID:3116001
synthetic lethal withwee1M phase inhibitor protein kinase Wee1 Synthetic LethalityPMID:9188094
rescued bywis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:1756736
rescueswis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:1756736
phenotype enhanced bywos2p23 homolog, predicted co-chaperone Wos2 Phenotypic EnhancementPMID:10581266
External References
Database Identifier Description
NBRP SPBC11B10.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC11B10.09 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC11B10.09 BioGRID Interaction Datasets
Expression Viewer SPBC11B10.09 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC11B10.09 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC11B10.09 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC11B10.09 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC11B10.09 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC11B10.09 Transcriptome Viewer (Bähler Lab)
GEO SPBC11B10.09 GEO profiles
PInt SPBC11B10.09 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC11B10.09 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC11B10.09 Fission yeast phenotypic data & analysis
Cyclebase SPBC11B10.09.1 Cell Cycle Data
PUBMED8313892
SPD / RIKEN50/50D08Orfeome Localization Data
PUBMED2665944
PUBMED9552380
UniProtKB/SwissProtP04551Cyclin-dependent kinase 1
ModBaseP04551Database of comparative protein structure models
STRINGP04551Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595629cyclin-dependent protein kinase Cdk1/Cdc2
RefSeq mRNANM_001021523972h- cyclin-dependent protein kinase Cdk1/Cdc2 (cdc2), mRNA
European Nucleotide ArchiveAAA35293.1ENA Protein Mapping
European Nucleotide ArchiveBAA21379.1ENA Protein Mapping
European Nucleotide ArchiveCAC37513.1ENA Protein Mapping
UniParcUPI00001273F9UniProt Archive

Literature for cdc2

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Release Version: PomBase:26_53 - 27 May 2015