cdc2 (SPBC11B10.09)


Gene Standard Namecdc2 Characterisation Statuspublished
Systematic IDSPBC11B10.09 Feature Typeprotein coding
Synonymscdk1, pi002, SPACTOKYO_453.34, swo2, tws1, wee2 Name DescriptionTWo Spored,
Cell Division Cycle
Productcyclin-dependent protein kinase Cdk1/Cdc2 Product Size297aa, 34.36 kDa
Genomic Location Chromosome II, 1500197-1502095 (1899nt); CDS:1500340-1501528 (1189nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATP binding558
Annotation ExtensionEvidenceWith/FromReference
cyclin-dependent protein kinase activity9
Annotation ExtensionEvidenceWith/FromReference
cyclin-dependent protein serine/threonine kinase activity8
Annotation ExtensionEvidenceWith/FromReference
protein binding848
Annotation ExtensionEvidenceWith/FromReference
protein kinase activity117
protein serine/threonine kinase activity112
Annotation ExtensionEvidenceWith/FromReference
RNA polymerase II carboxy-terminal domain kinase activity6
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cellular response to nitrogen starvation82
Annotation ExtensionEvidenceWith/FromReference
G2/M transition of mitotic cell cycle63
Annotation ExtensionEvidenceWith/FromReference
inhibition of APC-Cdc20 complex activity2
Annotation ExtensionEvidenceWith/FromReference
negative regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of conjugation with cellular fusion20
Annotation ExtensionEvidenceWith/FromReference
negative regulation of G0 to G1 transition25
Annotation ExtensionEvidenceWith/FromReference
peptidyl-serine phosphorylation13
Annotation ExtensionEvidenceWith/FromReference
peptidyl-threonine phosphorylation13
Annotation ExtensionEvidenceWith/FromReference
positive regulation of G1/S transition of mitotic cell cycle5
Annotation ExtensionEvidenceWith/FromReference
positive regulation of G2/M transition of mitotic cell cycle12
Annotation ExtensionEvidenceWith/FromReference
positive regulation of septation initiation signaling9
Annotation ExtensionEvidenceWith/FromReference
regulation of cell size6
Annotation ExtensionEvidenceWith/FromReference
regulation of meiotic cell cycle45
Annotation ExtensionEvidenceWith/FromReference
response to intra-S DNA damage checkpoint signaling3
Annotation ExtensionEvidenceWith/FromReference
traversing start control point of mitotic cell cycle5
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cyclin-dependent protein kinase holoenzyme complex7
Annotation ExtensionEvidenceWith/FromReference
cytosol2316
Annotation ExtensionEvidenceWith/FromReference
nucleus2690
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term NameAlleleExpressionCount
decreased cell population growth at high temperaturecdc2-974 (I35N)151
decreased cell population growth during nitrogen starvationcdc2-974 (I35N)35
decreased septation indexcdc2-33 (A177T)Not specified20
increased number of cells with 1C DNA contentcdc2-3w (C67Y)Not specified39
inviable vegetative cell populationcdc2-3w (C67Y)Not specified1427
cdc2-4w (G200T)Not specified
cdc2ΔNull
normal growth on arsenatecdc2-3w (C67Y)Not specified4
normal septation indexcdc2-3w (C67Y)Not specified4
normal vegetative cell population growth ratetws1-N22 (E42K)Not specified57
sensitive to caffeinecdc2-33 (A177T)Not specified108
sensitive to ethanolcdc2-M26 (P137S)Not specified5
cdc2-M56 (P137S)Not specified
sensitive to hydroxyureacdc2-3w (C67Y)Not specified518
sensitive to methyl methanesulfonate227
expressivity FYPO_EXT:0000001cdc2-Y15F (Y15F)Not specified
sensitive to plumbagincdc2+/cdc2- (heterozygous diploid)Not specified12
viable vegetative cell populationcdc2-1w (G146D)Not specified3781

Cell Phenotype

Term NameAlleleExpressionCount
abnormal meiosiscdc2-N22 (E42K)Endogenous113
abnormal mitotic cell cyclecdc2ΔNull794
abnormal mitotic cell cycle regulation during cellular response to hydroxyureacdc2-3w (C67Y)Not specified10
abnormal sporulation resulting in formation of two-spore ascuscdc2-33 (A177T)Not specified9
cdc2-59 (P248L, C67Y)
cdc2-N22 (E42K)Endogenous
tws1-N22 (E42K)Not specified
abnormally arrested mitotic cell cycle progressionAla167 (T167A)Not specified109
Arg33 (K33R)Not specified
cdc2ΔNull
Val167 (T167V)Not specified
Val177 (A177V)Not specified
abolished meiosiscdc2-M26 (P137S)Not specified18
abolished meiosis Icdc2-M26 (P137S)Not specified3
abolished meiosis IIcdc2-33 (A177T)Not specified3
cdc2-7Not specified
abolished premeiotic DNA replicationcdc2-33 (A177T)Not specified14
cdc2-M26 (P137S)Not specified
cdc2-M63 (G227C)Not specified
abolished protein binding68
affecting cdc2 and suc1cdc2-56 (G183E)Endogenous
abolished protein kinase activity17
affecting cdc2cdc2-56 (G183E)Not specified
abolished protein localization to kinetochore during vegetative growth14
affecting nsk1cdc2 analogue sensitive (analogue-sensitive)Not specified
abolished protein phosphorylation during vegetative growth30
affecting srw1cdc2-33 (A177T)Endogenous
abolished re-entry into mitotic cell cycle after pheromone arrestcdc2-M26 (P137S)Not specified1
cell cycle arrest in mitotic G2 phasecdc2-33 (A177T)Not specified26
cut during cellular response to hydroxyureacdc2-3w (C67Y)Not specified43
penetrance FYPO_EXT:0000002cdc2-3w (C67Y)Not specified
penetrance FYPO_EXT:0000002cdc2-4w (G200T)Not specified
decreased arsenate reductase activitycdc2-3w (C67Y)Not specified2
decreased protein binding51
affecting cdc2 and suc1cdc2-33 (A177T)Not specified
affecting cdc2 and suc1cdc2-56 (G183E)Not specified
affecting cdc2 and suc1cdc2-L7 (P208S)Endogenous
affecting cdc2 and suc1cdc2-L7 (P208S)Not specified
affecting cdc2 and cdc13cdc2-L7 (P208S)Not specified
decreased protein kinase activity23
affecting cdc2cdc2-33 (A177T)Not specified
affecting cdc2cdc2-56 (G183E)Not specified
cdc2-L7 (P208S)Not specified
expressivity FYPO_EXT:0000001, affecting cdc2cdc2-L7 (P208S)Not specified
affecting cdc2cdc2-L7 (P208S)Not specified
cdc2-M35 (G43E)Not specified
expressivity FYPO_EXT:0000001, affecting cdc2cdc2-M35 (G43E)Not specified
affecting cdc2cdc2-M55Not specified
decreased protein phosphorylation during mitotic G2 phase2
affecting srw1cdc2-M26 (P137S)Endogenous
decreased protein phosphorylation during vegetative growthcdc2-33 (A177T)Not specified54
affecting cdc13cdc2-33 (A177T)Not specified
affecting orc2cdc2-33 (A177T)Not specified
affecting cdc13cdc2-56 (G183E)Not specified
affecting cdc13cdc2-L7 (P208S)Not specified
affecting orc2cdc2-L7 (P208S)Not specified
decreased protein serine phosphorylation10
affecting fkh2cdc2-tsNot specified
decreased protein threonine phosphorylation6
affecting fkh2cdc2-tsNot specified
decreased response to S-phase DNA damage checkpoint signalingcdc2-Y15F (Y15F)Not specified2
delayed protein localization to nucleoplasm during cellular response to hydrogen peroxidecdc2-F84G (F84G)Endogenous4
DNA fragmentation during nitrogen starvationcdc2-974 (I35N)13
elongated cell during nitrogen starvationcdc2-974 (I35N)18
increased mRNA splicing, via spliceosome1
affecting cdc2cdc2-I2mut (TTGACG287ACACAT)
increased RNA splicing at cryptic splice sites4
affecting cdc2cdc2-I2mut (TTGACG287ACACAT)
inviable after spore germination with elongated germ tube163
penetrance FYPO_EXT:0000001cdc2ΔNull
inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cellscdc2-59 (P248L, C67Y)Endogenous87
inviable after spore germination, without cell division, with elongated germ tubecdc2ΔNull62
inviable elongated mononucleate aseptate cellcdc2-17 (G212S)Not specified37
cdc2-33 (A177T)Endogenous
cdc2-M63 (G227C)Endogenous
inviable elongated vegetative cellcdc2-17 (G212S)Endogenous405
cdc2-18 (L269S)Endogenous
cdc2-33 (A177T)Endogenous
cdc2-45 (F210L)Endogenous
cdc2-48 (Y292H)Endogenous
cdc2-56 (G183E)Endogenous
cdc2-L7 (P208S)Endogenous
cdc2-M26 (P137S)Endogenous
cdc2-M35 (G43E)Endogenous
cdc2-M63 (G227C)Endogenous
cdc2ΔNull
inviable vegetative cellL248 (P248L)Not specified1268
mitotic G1/S transition delaycdc2-33 (A177T)Endogenous10
normal cell cycle regulation during cellular response to hydroxyureacdc2-1w (G146D)Not specified12
normal cell cycle regulation during cellular response to ionizing radiationcdc2-3w (C67Y)Not specified15
normal interphase cytoplasmic microtubulescdc2-3w (C67Y)Not specified7
normal mitotic cell cycleArg34 (K34R)Not specified74
normal mitotic spindlecdc2-3w (C67Y)Not specified11
normal premeiotic DNA replicationcdc2-33 (A177T)Not specified16
normal protein binding49
affecting cdc2 and suc1cdc2-M55Endogenous
affecting cdc2 and suc1cdc2-M56 (P137S)Endogenous
normal protein kinase activity12
affecting cdc2cdc2-56 (G183E)Not specified
normal protein localization to nucleus47
affecting cdc13cdc2ΔNull
normal protein phosphorylation34
affecting srw1cdc2-33 (A177T)Endogenous
normal regulation of mitotic cell cyclecdc2-59 (P248L, C67Y)Endogenous45
normal sporulationcdc2-3w (C67Y)Not specified49
normal sporulation frequencytws1-N22 (E42K)Not specified8
normal telomere lengthcdc2-3w (C67Y)Not specified15
pear-shaped cell during nitrogen starvationcdc2-974 (I35N)6
protein mislocalized to nucleus during meiosis I1
affecting rna1tws1-N22 (E42K)Not specified
septation following abnormal chromosome segregation, with binucleate cell formation during cellular response to hydroxyurea2
penetrance FYPO_EXT:0000002cdc2-3w (C67Y)Not specified
penetrance FYPO_EXT:0000002cdc2-4w (G200T)Not specified
swollen sporetws1-N22 (E42K)Not specified5
viable small vegetative cellcdc2-1w (G146D)Endogenous38
cdc2-1w (G146D)Not specified
cdc2-3w (C67Y)Endogenous
cdc2-3w (C67Y)
cdc2-3w (C67Y)Not specified
cdc2-4w (G200T)Not specified
cdc2-56 (G183E)Endogenous
cdc2.1wNot specified
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in cdc10 MBF transcription factor complex subunit Cdc10 PMID:8631306
FYPO affected by mutation in cdc13 G2/M B-type cyclin Cdc13 PMID:2569363
FYPO affected by mutation in cdc13 G2/M B-type cyclin Cdc13 PMID:2665944
FYPO affected by mutation in cdc18 MCM loader PMID:9177184
FYPO affected by mutation in cdc2 cyclin-dependent protein kinase Cdk1/Cdc2 PMID:2569363
FYPO affected by mutation in cdc2 cyclin-dependent protein kinase Cdk1/Cdc2 PMID:3322810
FYPO affected by mutation in cdc2 cyclin-dependent protein kinase Cdk1/Cdc2 PMID:8665408
FYPO affected by mutation in cdc2 cyclin-dependent protein kinase Cdk1/Cdc2 PMID:3516412
FYPO affected by mutation in cdc2 cyclin-dependent protein kinase Cdk1/Cdc2 PMID:2665944
FYPO affected by mutation in cdc25 M phase inducer tyrosine phosphatase Cdc25 PMID:2665944
FYPO affected by mutation in cds1 replication checkpoint kinase Cds1 PMID:15347659
FYPO affected by mutation in cia1 histone chaperone Cia1 PMID:22291963
FYPO affected by mutation in clp1 Cdc14-related protein phosphatase Clp1/Flp1 PMID:11448769
FYPO affected by mutation in dnt1 nucleolar protein Dnt1 PMID:24006256
FYPO affected by mutation in fin1 serine/threonine protein kinase, NIMA related Fin1 PMID:9490640
FYPO affected by mutation in hub1 ubiquitin-like protein modifier Hub1 PMID:15620657
FYPO affected by mutation in nap1 nucleosome assembly protein Nap1 PMID:18474252
FYPO affected by mutation in nda3 tubulin beta Nda3 PMID:2665944
FYPO affected by mutation in pim1 RCC1 family Ran GDP/GTP exchange factor PMID:1855255
FYPO affected by mutation in prp1 U4/U6 x U5 tri-snRNP complex subunit Prp1 PMID:11350031
FYPO affected by mutation in prp10 U2 snRNP-associated protein Sap155 PMID:11350031
FYPO affected by mutation in prp2 U2AF large subunit (U2AF-59) PMID:11350031
FYPO affected by mutation in prp2 U2AF large subunit (U2AF-59) PMID:9917066
FYPO affected by mutation in prp2 U2AF large subunit (U2AF-59) PMID:15548596
FYPO affected by mutation in rad3 ATR checkpoint kinase Rad3 PMID:15347659
FYPO affected by mutation in rum1 CDK inhibitor Rum1 PMID:9552380
FYPO affected by mutation in snu1 small nuclear RNA U1 PMID:8665408
FYPO affected by mutation in snu4 small nuclear RNA U4 PMID:20018856
FYPO affected by mutation in spo5 meiotic RNA-binding protein 1 PMID:16896214
FYPO affected by mutation in srb10 cyclin-dependent protein Srb mediator subunit kinase Srb10 PMID:22451489
FYPO affected by mutation in srw1 fizzy-related CDK inhibitor Srw1 PMID:10921878
FYPO affected by mutation in suc1 cyclin-dependent protein kinase regulatory subunit Suc1 PMID:2665944
FYPO affected by mutation in uaf2 U2AF small subunit, U2AF-23 PMID:15548596
GO binds spd1 ribonucleotide reductase (RNR) inhibitor PMID:8887552
GO binds suc1 cyclin-dependent protein kinase regulatory subunit Suc1 PMID:2569363
GO regulated by cdc13 G2/M B-type cyclin Cdc13 PMID:2569363
GO regulated by cdc13 G2/M B-type cyclin Cdc13 PMID:2665944
GO regulated by cdc25 M phase inducer tyrosine phosphatase Cdc25 PMID:1756737
GO regulated by cdc25 M phase inducer tyrosine phosphatase Cdc25 PMID:2665944
GO regulated by cig2 G1/S-specific B-type cyclin Cig2 PMID:8631306
GO regulated by cig2 G1/S-specific B-type cyclin Cig2 PMID:9552380
GO regulated by clp1 Cdc14-related protein phosphatase Clp1/Flp1 PMID:11448769
GO regulated by pim1 RCC1 family Ran GDP/GTP exchange factor PMID:1855255
GO regulated by rum1 CDK inhibitor Rum1 PMID:9552380
GO regulated by rum1 CDK inhibitor Rum1 PMID:8598285
GO regulated by suc1 cyclin-dependent protein kinase regulatory subunit Suc1 PMID:3322810
GO regulated by suc1 cyclin-dependent protein kinase regulatory subunit Suc1 PMID:2569363
GO regulated by wee1 M phase inhibitor protein kinase Wee1 PMID:1372994
GO substrate of cdc25 M phase inducer tyrosine phosphatase Cdc25 PMID:1756737
GO substrate of cdc25 M phase inducer tyrosine phosphatase Cdc25 PMID:1819507
GO substrate of csk1 cyclin-dependent kinase/ cyclin-dependent kinase activating kinase Csk1 PMID:10226032
GO substrate of mik1 mitotic inhibitor kinase Mik1 PMID:7982971
GO substrate of pyp3 protein-tyrosine phosphatase Pyp3 PMID:1464318
GO substrate of wee1 M phase inhibitor protein kinase Wee1 PMID:1372994
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
115001971500243
215002861500376
315004451500613
415006861500986
515010881501393
615014481502095

UTRs

Region Coordinates Reference
five_prime_UTR1500197..1500243,1500286..1500339PMID:21511999
three_prime_UTR1501529..1502095PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00069 Pfam IPR000719 Protein kinase domain 4 293 109
SM00220 SMART IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain 4 293 107
PS00107 Prosite Patterns IPR017441 Protein kinase, ATP binding site 10 33 73
PS00108 Prosite Patterns IPR008271 Serine/threonine-protein kinase, active site 130 142 97
PS50011 Prosite Profiles IPR000719 Protein kinase domain 4 293 110
PTHR24056 HMMPANTHER 1 295 9
1.10.510.10 Gene3D 88 294 112
3.30.200.20 Gene3D 2 87 111
SSF56112 SuperFamily IPR011009 Protein kinase-like domain 1 296 127

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0003657CDK family kinaseTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0003657

Protein Properties

Ave. residue weight 115.69 Da
Charge 4.50
Isoelectric point 7.68
Molecular weight 34.36 kDa
Number of residues 297
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1670
Annotation ExtensionEvidenceResidueReference
IDA PMID:3058333
O-phospho-L-threonine 693
present during cellular response to thiabendazoleT167
Annotation ExtensionEvidenceResidueReference
IDA PMID:1756737
IDA PMID:3058333
present during cellular response to thiabendazole IDA T167 PMID:18257517
O4'-phospho-L-tyrosine 85
added during premeiotic DNA replication
added by wee1, mik1Y15
during mitotic G2 phase
not during mitotic M phase
removed during cellular response to caffeineT15
present during meiosis I
present during mitotic M phase, cellular response to thiabendazoleY15
present during cellular response to hydroxyureaT15
removed by cdc25
removed during meiosis II
Annotation ExtensionEvidenceResidueReference
not during mitotic M phase IDA PMID:1464318
removed by cdc25 IDA PMID:1756737
during mitotic G2 phase IDA PMID:1464318
removed during meiosis II IDA PMID:10888871
present during meiosis I IDA PMID:10888871
added during premeiotic DNA replication IDA PMID:10888871
present during cellular response to hydroxyurea IDA T15 PMID:10036242
removed during cellular response to caffeine IDA T15 PMID:10036242
present during cellular response to thiabendazole IDA Y15 PMID:18257517
added by mik1 IDA Y15 PMID:7982971
present during mitotic M phase experimental evidence Y15 PMID:21712547
added by wee1 IDA Y15 PMID:1372994
phosphorylated residue 1922
added during G0 to G1 transition
Y15
added by wee1Y15
removed during cellular response to nitrogen starvation
Annotation ExtensionEvidenceResidueReference
NAS PMID:18257517
IDA PMID:19547744
removed during cellular response to nitrogen starvation IDA PMID:3516412
added during G0 to G1 transition IDA PMID:3516412
NAS Y15 PMID:9042863
added by wee1 NAS Y15 PMID:2682257
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
protein levelconstant during GO:0000278Western blot evidencePMID:3516412
increased during GO:0006279Western blot evidencePMID:10888871
present during GO:0051321Western blot evidencePMID:10888871
unchanged during GO:0072734Western blot evidencePMID:1899230
present during GO:0072690Western blot evidencePMID:2569363
constant during GO:0000278Western blot evidencePMID:2569363

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5406.86during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
14449during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2704.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.8during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.52during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by H. sapiens CDK1full PMID:1944283 PMID:3553962
full
does not functionally complement S. cerevisiae CDC28 PMID:3796591
functionally complemented by G. gallus cdc2full PMID:1500441
functionally complements S. cerevisiae CDC28 when introns removedfull PMID:3796591
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in eukaryotes only2503
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
ase1antiparallel microtubule cross-linking factor Ase1 Biochemical ActivityPMID:19686686
cig2G1/S-specific B-type cyclin Cig2 Affinity Capture-WesternPMID:11163211
hsp90Hsp90 chaperone Affinity Capture-WesternPMID:22543982
spd1ribonucleotide reductase (RNR) inhibitor Affinity Capture-WesternPMID:8887552
pku70Ku domain protein Pku70 Affinity Capture-WesternPMID:24861625
pku80Ku domain protein Pku80 Affinity Capture-WesternPMID:24861625
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Two-hybridPMID:9242669
Biochemical Activity
rad16DNA repair endonuclease XPF Affinity Capture-WesternPMID:24861625
mik1mitotic inhibitor kinase Mik1 Biochemical ActivityPMID:7982971
wee1M phase inhibitor protein kinase Wee1 Biochemical ActivityPMID:7982971
Biochemical ActivityPMID:1850698
Biochemical ActivityPMID:1372994
cdc11SIN component scaffold protein, centriolin ortholog Cdc11 Affinity Capture-WesternPMID:15062098
clp1Cdc14-related protein phosphatase Clp1/Flp1 Biochemical ActivityPMID:16950131
Biochemical ActivityPMID:22918952
pir2zf-C2H2 type zinc finger protein, implicated in RNAi (predicted) Affinity Capture-MSPMID:24713849
pch1P-TEFB associated cyclin, cyclin T Pch1 Affinity Capture-WesternPMID:9115279
Two-hybrid
rum1CDK inhibitor Rum1 Biochemical ActivityPMID:10679013
Affinity Capture-RNAPMID:22144913
Affinity Capture-WesternPMID:8598285
Reconstituted ComplexPMID:9303310
Biochemical Activity
Biochemical ActivityPMID:12167173
Affinity Capture-WesternPMID:11329175
cdc18MCM loader Affinity Capture-RNAPMID:22144913
Affinity Capture-WesternPMID:9436991
Biochemical Activity
Biochemical ActivityPMID:9177184
mbx1MADS-box transcription factor Mbx1 Biochemical ActivityPMID:21098641
hcn1anaphase-promoting complex subunit Hcn1 Biochemical ActivityPMID:16950791
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-WesternPMID:24861625
mde4monopolin-like complex subunit Mde4 Biochemical ActivityPMID:19523829
cut3condensin complex subunit Cut3 Biochemical ActivityPMID:10485849
bub1mitotic spindle checkpoint kinase Bub1 Biochemical ActivityPMID:12606573
cdc25M phase inducer tyrosine phosphatase Cdc25 Biochemical ActivityPMID:22665807
suc1cyclin-dependent protein kinase regulatory subunit Suc1 Affinity Capture-WesternPMID:3322810
Reconstituted ComplexPMID:2665944
Reconstituted ComplexPMID:2569363
Affinity Capture-WesternPMID:9790601
mus81Holliday junction resolvase subunit Mus81 Affinity Capture-WesternPMID:24861625
pas1cyclin Pas1 Affinity Capture-WesternPMID:10982385
skb1type II protein arginine N-methyltransferase Skb1 Affinity Capture-WesternPMID:9843966
chk1Chk1 protein kinase Affinity Capture-WesternPMID:24861625
rqh1RecQ type DNA helicase Rqh1 Affinity Capture-WesternPMID:24861625
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
drc1replication preinitiation complex assembly protein Reconstituted ComplexPMID:11937031
cut12spindle pole body protein Cut12 Biochemical ActivityPMID:23333317
srs2ATP-dependent DNA helicase, UvrD subfamily Affinity Capture-WesternPMID:24861625
dis2serine/threonine protein phosphatase PP1 subfamily, Dis2 Biochemical ActivityPMID:16920624
Biochemical ActivityPMID:7957097
fkh2forkhead transcription factor Fkh2 Biochemical ActivityPMID:18059475
bgs11,3-beta-glucan synthase catalytic subunit Bgs1 Affinity Capture-WesternPMID:11937031
cdc37Hsp90 co-chaperone Cdc37 Affinity Capture-WesternPMID:16390871
mtl1TRAMP complex ATP-dependent RNA helicase (predicted) Affinity Capture-MSPMID:24713849
orc2origin recognition complex subunit Orc2 Two-hybridPMID:8552194
Affinity Capture-Western
Biochemical ActivityPMID:11486016
byr4two-component GAP Byr4 Biochemical ActivityPMID:24920823
nsk1Clp1-interacting, microtubule plus-end binding Nsk1 Biochemical ActivityPMID:22065639
Affinity Capture-Western
alp7centrosomal transforming acidic coiled-coil (TACC) protein ortholog Alp7 Biochemical ActivityPMID:24790093
pyp3protein-tyrosine phosphatase Pyp3 Biochemical ActivityPMID:1464318
cdc13G2/M B-type cyclin Cdc13 Affinity Capture-WesternPMID:9632761
Co-fractionationPMID:2569363
Biochemical Activity
Affinity Capture-WesternPMID:9790601
Affinity Capture-WesternPMID:10581266
Affinity Capture-WesternPMID:11683390
Affinity Capture-WesternPMID:16390871
Affinity Capture-WesternPMID:11329175
crb2DNA repair protein Rad9 homolog, Rhp9 Biochemical ActivityPMID:24074952
Biochemical ActivityPMID:10488332
red1RNA elimination defective protein Red1 Affinity Capture-MSPMID:24713849
wos2p23 homolog, predicted co-chaperone Wos2 Affinity Capture-WesternPMID:10581266
shk1PAK-related kinase Shk1 Affinity Capture-WesternPMID:9843966
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
res2MBF transcription factor complex subunit Res2 Synthetic RescuePMID:11029045
Synthetic LethalityPMID:2474475
rad4BRCT domain protein Rad4 Phenotypic SuppressionPMID:7957098
wis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:1756736
dim1U4/U6 x U5 tri-snRNP complex subunit Dim1 Synthetic Growth DefectPMID:9182666
hsp90Hsp90 chaperone Phenotypic EnhancementPMID:22543982
Phenotypic EnhancementPMID:10102358
hta1histone H2A alpha Phenotypic EnhancementPMID:16314498
spd1ribonucleotide reductase (RNR) inhibitor Phenotypic SuppressionPMID:8887552
cdr2serine/threonine protein kinase Cdr2 Synthetic Growth DefectPMID:3448096
Synthetic LethalityPMID:9843577
Synthetic RescuePMID:2245912
ria1GTPase Ria1 (predicted) Negative GeneticPMID:22681890
slp1mitotic spindle checkpoint component/ APC activator Slp1 Synthetic Growth DefectPMID:9001228
Phenotypic Suppression
rum1CDK inhibitor Rum1 Phenotypic EnhancementPMID:7593289
cdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic Growth DefectPMID:3448096
Phenotypic EnhancementPMID:2004705
Synthetic RescuePMID:2245912
pyp1tyrosine phosphatase Pyp1 Phenotypic SuppressionPMID:1448087
Dosage RescuePMID:9560390
SPAC29A4.02ctranslation elongation factor EF-1 gamma subunit Phenotypic SuppressionPMID:14985109
tor1phosphatidylinositol kinase Tor1 Phenotypic SuppressionPMID:19546237
cmk2MAPK-activated protein kinase Cmk2 Phenotypic SuppressionPMID:12135745
mik1mitotic inhibitor kinase Mik1 Phenotypic SuppressionPMID:10637286
Synthetic RescuePMID:24861625
ctu1cytosolic thiouridylase subunit Ctu1 Synthetic Growth DefectPMID:22768388
wee1M phase inhibitor protein kinase Wee1 Synthetic Growth DefectPMID:11029045
Synthetic RescuePMID:24861625
Dosage RescuePMID:1427071
Phenotypic EnhancementPMID:9013342
Synthetic LethalityPMID:2474475
Phenotypic EnhancementPMID:3116001
Synthetic LethalityPMID:9188094
hsp9heat shock protein Hsp9 Dosage RescuePMID:22182414
clp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic RescuePMID:23297348
Synthetic LethalityPMID:16950131
Phenotypic EnhancementPMID:11683392
Phenotypic Suppression
cut1separase/separin Phenotypic SuppressionPMID:16453724
sum1translation initiation factor eIF3i Dosage RescuePMID:9560390
spo4serine/threonine protein kinase Spo4 Phenotypic SuppressionPMID:23370392
hta2histone H2A beta Phenotypic EnhancementPMID:16314498
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
blt1ubiquitin domain-like protein Blt1 Synthetic Growth DefectPMID:24790095
pmk1MAP kinase Pmk1 Phenotypic EnhancementPMID:22918952
hhp1serine/threonine protein kinase Hhp1 Synthetic RescuePMID:24861625
chk1Chk1 protein kinase Dosage RescuePMID:8497322
Phenotypic SuppressionPMID:10637286
Dosage RescuePMID:11711540
Phenotypic SuppressionPMID:24861625
Synthetic Growth Defect
rad3ATR checkpoint kinase Rad3 Phenotypic EnhancementPMID:22918952
swr1SNF2 family ATP-dependent DNA helicase Swr1 Phenotypic EnhancementPMID:9571240
cdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:2245912
Phenotypic SuppressionPMID:3796591
Synthetic RescuePMID:24861625
Phenotypic SuppressionPMID:9013342
Phenotypic SuppressionPMID:1934126
Synthetic Growth DefectPMID:20444100
Synthetic RescuePMID:7217015
cds1replication checkpoint kinase Cds1 Phenotypic SuppressionPMID:24861625
suc1cyclin-dependent protein kinase regulatory subunit Suc1 Phenotypic SuppressionPMID:3010051
Dosage RescuePMID:3322810
Phenotypic SuppressionPMID:9790601
Dosage RescuePMID:2665944
Phenotypic SuppressionPMID:16453733
Dosage RescuePMID:1896017
rad54DNA-dependent ATPase Rad54/Rhp54 Synthetic LethalityPMID:8834792
fin1serine/threonine protein kinase, NIMA related Fin1 Phenotypic SuppressionPMID:12065422
elp3elongator complex subunit Elp3 (predicted) Synthetic Growth DefectPMID:22768388
mcs4response regulator Mcs4 Synthetic LethalityPMID:2474475
pyp2tyrosine phosphatase Pyp2 Phenotypic SuppressionPMID:1448087
orc1origin recognition complex subunit Orc1 Phenotypic EnhancementPMID:12186947
cdc6DNA polymerase delta catalytic subunit Cdc6 Phenotypic EnhancementPMID:9154809
Synthetic RescuePMID:9135148
srw1fizzy-related CDK inhibitor Srw1 Phenotypic SuppressionPMID:14985109
Synthetic Growth Defect
Phenotypic SuppressionPMID:9398669
Dosage Lethality
spo5meiotic RNA-binding protein 1 Phenotypic SuppressionPMID:24506453
bgs11,3-beta-glucan synthase catalytic subunit Bgs1 Phenotypic SuppressionPMID:10704373
Phenotypic EnhancementPMID:10503548
pab1protein phosphatase regulatory subunit Pab1 Phenotypic SuppressionPMID:20876564
cut12spindle pole body protein Cut12 Synthetic RescuePMID:23333317
Phenotypic SuppressionPMID:2245912
sty1MAP kinase Sty1 Synthetic RescuePMID:9560390
pop1cullin 1 adaptor protein Pop1 Synthetic LethalityPMID:9203581
cdc5splicing factor, Prp19 complex subunit Cdc5 Negative GeneticPMID:8313892
cdc37Hsp90 co-chaperone Cdc37 Dosage RescuePMID:16390871
cdc10MBF transcription factor complex subunit Cdc10 Phenotypic EnhancementPMID:11513869
cid13poly(A) polymerase Cid13 Dosage RescuePMID:12062100
mcs2TFIIH complex cyclin Mcs2 Synthetic LethalityPMID:2474475
orc2origin recognition complex subunit Orc2 Phenotypic EnhancementPMID:8552194
cig2G1/S-specific B-type cyclin Cig2 Synthetic RescuePMID:8455610
Phenotypic Enhancement
Synthetic Lethality
Phenotypic EnhancementPMID:9552380
sum3translation initiation RNA helicase Sum3 Dosage RescuePMID:11711540
Dosage RescuePMID:9832516
pyp3protein-tyrosine phosphatase Pyp3 Dosage LethalityPMID:1464318
cdc13G2/M B-type cyclin Cdc13 Dosage RescuePMID:1533272
Phenotypic SuppressionPMID:9790601
Phenotypic SuppressionPMID:1934126
Dosage RescuePMID:11711540
Dosage RescuePMID:2847913
Dosage RescuePMID:7909513
Phenotypic SuppressionPMID:8631306
Phenotypic SuppressionPMID:1829983
Dosage RescuePMID:3428262
Phenotypic Suppression
Phenotypic Enhancement
crb2DNA repair protein Rad9 homolog, Rhp9 Synthetic Growth DefectPMID:24861625
sep1forkhead transcription factor Sep1 Phenotypic EnhancementPMID:9473044
mcs6TFIIH associated cyclin-dependent protein kinase Mcs6 Synthetic Growth DefectPMID:2474475
Synthetic Lethality
Dosage RescuePMID:8557037
wos2p23 homolog, predicted co-chaperone Wos2 Phenotypic EnhancementPMID:10581266
mcm4MCM complex subunit Mcm4/Cdc21 Phenotypic SuppressionPMID:8631307
External References
Database Identifier Description
NBRP SPBC11B10.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC11B10.09 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC11B10.09 BioGRID Interaction Datasets
Expression Viewer SPBC11B10.09 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC11B10.09 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC11B10.09 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC11B10.09 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC11B10.09 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC11B10.09 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC11B10.09 Cell Cycle Data
GEO SPBC11B10.09 GEO profiles
PInt SPBC11B10.09 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC11B10.09 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC11B10.09 Fission yeast phenotypic data & analysis
SPD / RIKEN50/50D08Orfeome Localization Data
UniProtKB/SwissProtP04551Cyclin-dependent kinase 1
ModBaseP04551Database of comparative protein structure models
STRINGP04551Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595629cyclin-dependent protein kinase Cdk1/Cdc2
RefSeq mRNANM_001021523972h- cyclin-dependent protein kinase Cdk1/Cdc2 (cdc2), mRNA
European Nucleotide ArchiveAAA35293.1ENA Protein Mapping
European Nucleotide ArchiveBAA21379.1ENA Protein Mapping
European Nucleotide ArchiveCAC37513.1ENA Protein Mapping
UniParcUPI00001273F9UniProt Archive

Literature for cdc2

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015