cdc2 (SPBC11B10.09)

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Gene Ontology:
Phenotype:
- Single-allele:
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- Multi-allele:
  - Population
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Protein Features
Modifications
Sequence
Gene Expression
Complementation
Taxonomic Conservation
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Gene Standard Name	cdc2	Characterisation Status	published
Systematic ID	SPBC11B10.09	Feature Type	protein coding
Synonyms	cdk1, pi002, SPACTOKYO_453.34, swo2, tws1, wee2	Name Description	TWo Spored, Cell Division Cycle
Product	cyclin-dependent protein kinase Cdk1/Cdc2	Product Size	297aa, 34.36 kDa
Genomic Location	Chromosome II, 1500197-1502095 (1899nt); CDS:1500340-1501528 (1189nt)

GO Molecular Function

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Term Name

Count

ATP binding

551

Annotation Extension	Evidence	With/From	Reference
	IEA	UniProtKB-KW:KW-0067	GO_REF:0000037

cyclin-dependent protein kinase activity

Annotation Extension	Evidence	With/From	Reference
	IDA		PMID:3322810

cyclin-dependent protein serine/threonine kinase activity

Annotation Extension	Evidence	With/From	Reference
	IGI	cdc13	PMID:2569363
has substrate hcn1, during mitotic M phase	IDA		PMID:16950791
has substrate drc1, involved in positive regulation of mitotic cell cycle DNA replication	IDA		PMID:11937031
has substrate cut3, during mitotic M phase, involved in positive regulation of mitotic chromosome condensation	IMP		PMID:10485849
has substrate cut3, during mitotic metaphase, involved in positive regulation of mitotic chromosome condensation	IMP		PMID:10485849
has substrate cdc18	IDA		PMID:9177184
has substrate rum1	IDA		PMID:11937031
has substrate dis2, during mitotic prometaphase	EXP		PMID:25487150
has substrate dis2	IDA		PMID:7957097

has substrate drc1, involved in positive regulation of mitotic cell cycle DNA replication
has substrate hcn1, during mitotic M phase
has substrate cut3, during mitotic M phase, involved in positive regulation of mitotic chromosome condensation
has substrate cut3, during mitotic metaphase, involved in positive regulation of mitotic chromosome condensation
has substrate dis2, during mitotic prometaphase
has substrate cdc18, dis2, rum1

protein binding

900

Annotation Extension	Evidence	Reference
binds cig2	IPI	PMID:8455610
binds suc1	IPI	PMID:2665944
binds cdc13, active form PR:000045539	IPI	PMID:26131711
binds cdc13, active form PR:000045540	IPI	PMID:26131711
binds cdc13, active form PR:000045541	IPI	PMID:26131711
binds cdc13, active form PR:000045542	IPI	PMID:26131711
binds cdc13	IPI	PMID:16390871
binds cdc37	IPI	PMID:16390871
binds chk1, active form PR:000045539	IPI	PMID:26131711

binds cdc13, cdc37, chk1, suc1, cig2

protein kinase activity

114

Annotation Extension	Evidence	Reference
	IDA	PMID:2665944
activated by magnesium(2+)	IDA	PMID:3516412
has substrate cdc13	IDA	PMID:2569363

activated by magnesium(2+)
has substrate cdc13

protein serine/threonine kinase activity

105

Annotation Extension	Evidence	Reference
has substrate srw1, involved in negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, during mitotic G1 phase	IMP	PMID:10921876
has substrate srw1	IDA	PMID:10921878
has substrate clp1, during negative regulation of exit from mitosis, involved in negative regulation of protein serine/threonine phosphatase activity	IDA	PMID:16950131
has substrate byr4, involved in positive regulation of septation initiation signaling	IDA	PMID:24920823
has substrate cut7	IDA	PMID:9490630
has substrate nsk1, during mitotic metaphase, involved in negative regulation of attachment of mitotic spindle microtubules to kinetochore	IDA	PMID:22065639
has substrate cdc18, during mitotic G2 phase, involved in negative regulation of mitotic DNA replication initiation	IDA	PMID:9436991
has substrate klp9, during mitotic anaphase A, involved in negative regulation of mitotic spindle elongation	IDA	PMID:19686686
has substrate fkh2, involved in negative regulation of conjugation with cellular fusion	IDA	PMID:18059475
has substrate rap1, during mitotic M phase, involved in negative regulation of mitotic telomere tethering at nuclear periphery	IDA	PMID:22959349
has substrate crb2	IDA	PMID:24074952
has substrate sds23	IDA	PMID:9242669
has substrate orc2, during mitotic G2 phase, involved in negative regulation of mitotic DNA replication initiation	IDA	PMID:11486016
has substrate mde4, during mitotic metaphase, involved in correction of merotelic kinetochore attachment, mitotic	IMP	PMID:19523829
has substrate mde4, during mitotic metaphase, involved in negative regulation of mitotic spindle elongation	IMP	PMID:19523829
has substrate xlf1, during mitotic G2 phase, involved in negative regulation of double-strand break repair via nonhomologous end joining	IDA	PMID:25533340

has substrate nsk1, during mitotic metaphase, involved in negative regulation of attachment of mitotic spindle microtubules to kinetochore
has substrate srw1, involved in negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, during mitotic G1 phase
has substrate byr4, involved in positive regulation of septation initiation signaling
has substrate clp1, during negative regulation of exit from mitosis, involved in negative regulation of protein serine/threonine phosphatase activity
has substrate mde4, during mitotic metaphase, involved in correction of merotelic kinetochore attachment, mitotic
has substrate mde4, during mitotic metaphase, involved in negative regulation of mitotic spindle elongation
has substrate cdc18, during mitotic G2 phase, involved in negative regulation of mitotic DNA replication initiation
has substrate klp9, during mitotic anaphase A, involved in negative regulation of mitotic spindle elongation
has substrate fkh2, involved in negative regulation of conjugation with cellular fusion
has substrate orc2, during mitotic G2 phase, involved in negative regulation of mitotic DNA replication initiation
has substrate rap1, during mitotic M phase, involved in negative regulation of mitotic telomere tethering at nuclear periphery
has substrate xlf1, during mitotic G2 phase, involved in negative regulation of double-strand break repair via nonhomologous end joining
has substrate crb2, srw1, cut7, sds23

Term ID	Term Name	Evidence	With/From	Reference	Count
GO:0005524	ATP binding	IEA	UniProtKB-KW:KW-0067	GO_REF:0000037	551
GO:0097472	cyclin-dependent protein kinase activity	IDA		PMID:3322810	6
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IGI	cdc13	PMID:2569363	5
has substrate hcn1, during mitotic M phase	IDA		PMID:16950791
has substrate cdc18	IDA		PMID:9177184
has substrate dis2	IDA		PMID:7957097
has substrate dis2, during mitotic prometaphase	EXP		PMID:25487150
has substrate cut3, during mitotic M phase, involved in positive regulation of mitotic chromosome condensation	IMP		PMID:10485849
has substrate rum1	IDA		PMID:11937031
has substrate drc1, involved in positive regulation of mitotic cell cycle DNA replication	IDA		PMID:11937031
has substrate cut3, during mitotic metaphase, involved in positive regulation of mitotic chromosome condensation	IMP		PMID:10485849
GO:0005515	protein binding				900
binds cdc13, active form PR:000045542	IPI		PMID:26131711
binds cdc13	IPI		PMID:16390871
binds cdc13, active form PR:000045540	IPI		PMID:26131711
binds cdc13, active form PR:000045541	IPI		PMID:26131711
binds cdc37	IPI		PMID:16390871
binds cdc13, active form PR:000045539	IPI		PMID:26131711
binds chk1, active form PR:000045539	IPI		PMID:26131711
binds suc1	IPI		PMID:2665944
binds cig2	IPI		PMID:8455610
GO:0004672	protein kinase activity	IDA		PMID:2665944	114
has substrate cdc13	IDA		PMID:2569363
activated by magnesium(2+)	IDA		PMID:3516412
GO:0004674	protein serine/threonine kinase activity				105
has substrate mde4, during mitotic metaphase, involved in negative regulation of mitotic spindle elongation	IMP		PMID:19523829
has substrate crb2	IDA		PMID:24074952
has substrate cdc18, during mitotic G2 phase, involved in negative regulation of mitotic DNA replication initiation	IDA		PMID:9436991
has substrate mde4, during mitotic metaphase, involved in correction of merotelic kinetochore attachment, mitotic	IMP		PMID:19523829
has substrate rap1, during mitotic M phase, involved in negative regulation of mitotic telomere tethering at nuclear periphery	IDA		PMID:22959349
has substrate srw1	IDA		PMID:10921878
has substrate klp9, during mitotic anaphase A, involved in negative regulation of mitotic spindle elongation	IDA		PMID:19686686
has substrate nsk1, during mitotic metaphase, involved in negative regulation of attachment of mitotic spindle microtubules to kinetochore	IDA		PMID:22065639
has substrate cut7	IDA		PMID:9490630
has substrate srw1, involved in negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, during mitotic G1 phase	IMP		PMID:10921876
has substrate fkh2, involved in negative regulation of conjugation with cellular fusion	IDA		PMID:18059475
has substrate clp1, during negative regulation of exit from mitosis, involved in negative regulation of protein serine/threonine phosphatase activity	IDA		PMID:16950131
has substrate xlf1, during mitotic G2 phase, involved in negative regulation of double-strand break repair via nonhomologous end joining	IDA		PMID:25533340
has substrate orc2, during mitotic G2 phase, involved in negative regulation of mitotic DNA replication initiation	IDA		PMID:11486016
has substrate sds23	IDA		PMID:9242669
has substrate byr4, involved in positive regulation of septation initiation signaling	IDA		PMID:24920823

GO Biological Process

GO Slim Terms

regulation of mitotic cell cycle phase transition mitotic cytokinesis signaling conjugation with cellular fusion mitotic sister chromatid segregation microtubule cytoskeleton organization DNA replication DNA repair DNA recombination protein catabolic process

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Term Name

Count

correction of merotelic kinetochore attachment, mitotic

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:19523829

negative regulation of anaphase-promoting complex-dependent catabolic process

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:10921876
during mitotic G1 phase	IMP		PMID:10921878

during mitotic G1 phase

negative regulation of attachment of mitotic spindle microtubules to kinetochore

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:22065639

negative regulation of conjugation with cellular fusion

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:18059475

negative regulation of double-strand break repair via nonhomologous end joining

Annotation Extension	Evidence	With/From	Reference
during mitotic G2 phase	IMP		PMID:25533340

during mitotic G2 phase

negative regulation of exit from mitosis

Annotation Extension	Evidence	With/From	Reference
	EXP		PMID:16950131

negative regulation of mitotic DNA replication initiation

Annotation Extension	Evidence	With/From	Reference
during mitotic G2 phase	IMP		PMID:11486016
during mitotic G2 phase	IMP		PMID:9436991

during mitotic G2 phase

negative regulation of mitotic spindle elongation

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:19523829
	IMP		PMID:19686686

negative regulation of mitotic telomere tethering at nuclear periphery

Annotation Extension	Evidence	With/From	Reference
during mitotic M phase	IPI	rap1	PMID:22959349

during mitotic M phase

positive regulation of double-strand break repair via homologous recombination

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:12023299

positive regulation of G1/S transition of mitotic cell cycle

Annotation Extension	Evidence	With/From	Reference
	IDA		PMID:9034336
	IMP		PMID:7254352

positive regulation of G2/M transition of mitotic cell cycle

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:2665944
	IMP		PMID:7254352

positive regulation of mitotic cell cycle DNA replication

Annotation Extension	Evidence	With/From	Reference
	EXP		PMID:11937031

positive regulation of mitotic chromosome condensation

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:10485849

positive regulation of mitotic metaphase/anaphase transition

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:7774573

positive regulation of septation initiation signaling

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:24920823

regulation of cell size

Annotation Extension	Evidence	With/From	Reference
	NAS		GO_REF:0000051

regulation of G2/M transition of mitotic cell cycle

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:27736299

regulation of meiotic cell cycle

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:7498766

response to intra-S DNA damage checkpoint signaling

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:15297457

response to mitotic DNA integrity checkpoint signaling

Annotation Extension	Evidence	With/From	Reference
	IGI	orc1	PMID:12186947

response to mitotic G2 DNA damage checkpoint signaling

Annotation Extension	Evidence	With/From	Reference
active form PR:000045539	IPI	chk1	PMID:26131711

active form PR:000045539

signal transduction involved in mitotic G2 DNA damage checkpoint

Annotation Extension	Evidence	With/From	Reference
	IMP		PMID:9278510

traversing start control point of mitotic cell cycle

Annotation Extension	Evidence	With/From	Reference
	NAS		GO_REF:0000051

Term ID	Term Name	Evidence	With/From	Reference	Count
GO:0098783	correction of merotelic kinetochore attachment, mitotic	IMP		PMID:19523829	5
GO:1905785	negative regulation of anaphase-promoting complex-dependent catabolic process	IMP		PMID:10921876	1
during mitotic G1 phase	IMP		PMID:10921878
GO:1902424	negative regulation of attachment of mitotic spindle microtubules to kinetochore	IMP		PMID:22065639	1
GO:0031138	negative regulation of conjugation with cellular fusion	IMP		PMID:18059475	25
GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining				1
during mitotic G2 phase	IMP		PMID:25533340
GO:0001100	negative regulation of exit from mitosis	EXP		PMID:16950131	1
GO:1903467	negative regulation of mitotic DNA replication initiation				4
during mitotic G2 phase	IMP		PMID:11486016
during mitotic G2 phase	IMP		PMID:9436991
GO:1902845	negative regulation of mitotic spindle elongation	IMP		PMID:19686686	1
	IMP		PMID:19523829
GO:1904537	negative regulation of mitotic telomere tethering at nuclear periphery				1
during mitotic M phase	IPI	rap1	PMID:22959349
GO:1905168	positive regulation of double-strand break repair via homologous recombination	IMP		PMID:12023299	2
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	IDA		PMID:9034336	4
	IMP		PMID:7254352
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	IMP		PMID:2665944	20
	IMP		PMID:7254352
GO:1903465	positive regulation of mitotic cell cycle DNA replication	EXP		PMID:11937031	3
GO:1903380	positive regulation of mitotic chromosome condensation	IMP		PMID:10485849	2
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	IMP		PMID:7774573	57
GO:0031031	positive regulation of septation initiation signaling	IMP		PMID:24920823	7
GO:0008361	regulation of cell size	NAS		GO_REF:0000051	15
GO:0010389	regulation of G2/M transition of mitotic cell cycle	IMP		PMID:27736299	73
GO:0051445	regulation of meiotic cell cycle	IMP		PMID:7498766	51
GO:0072429	response to intra-S DNA damage checkpoint signaling	IMP		PMID:15297457	4
GO:1990820	response to mitotic DNA integrity checkpoint signaling	IGI	orc1	PMID:12186947	1
GO:0072435	response to mitotic G2 DNA damage checkpoint signaling				1
active form PR:000045539	IPI	chk1	PMID:26131711
GO:0072434	signal transduction involved in mitotic G2 DNA damage checkpoint	IMP		PMID:9278510	2
GO:0007089	traversing start control point of mitotic cell cycle	NAS		GO_REF:0000051	4

GO Cellular Component

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Term Name

Count

chromosome, centromeric region

137

Annotation Extension	Evidence	With/From	Reference
during meiotic prophase I	EXP		PMID:11683390

during meiotic prophase I

cyclin-dependent protein kinase holoenzyme complex

Annotation Extension	Evidence	With/From	Reference
	IDA		PMID:3322810
	IPI	cdc13	PMID:2682257

cytoplasm

4212

Annotation Extension	Evidence	Reference
during mitotic G1 phase	EXP	PMID:11683390
during mitotic S phase	EXP	PMID:11683390
during mitotic G2 phase	EXP	PMID:11683390
during mitotic prophase	EXP	PMID:11683390
during mitotic metaphase	EXP	PMID:11683390
during mitotic anaphase	EXP	PMID:11683390
during mitotic telophase	EXP	PMID:11683390

during mitotic metaphase, mitotic prophase, mitotic G2 phase, mitotic telophase, mitotic anaphase, mitotic S phase, mitotic G1 phase

cytosol

2298

Annotation Extension	Evidence	With/From	Reference
	IDA		PMID:16823372

meiotic spindle pole body

Annotation Extension	Evidence	With/From	Reference
during karyogamy involved in conjugation with cellular fusion	EXP		PMID:11683390

during karyogamy involved in conjugation with cellular fusion

mitotic spindle

Annotation Extension	Evidence	With/From	Reference
during mitotic prophase	EXP		PMID:11683390
during mitotic metaphase	EXP		PMID:11683390

during mitotic prophase, mitotic metaphase

mitotic spindle midzone

Annotation Extension	Evidence	With/From	Reference
during mitotic M phase	IDA		PMID:11084332

during mitotic M phase

mitotic spindle pole body

211

Annotation Extension	Evidence	Reference
during mitotic S phase	EXP	PMID:11683390
during mitotic G2 phase	EXP	PMID:11683390
during mitotic prophase	EXP	PMID:11683390
during mitotic metaphase	EXP	PMID:11683390

during mitotic S phase, mitotic G2 phase, mitotic metaphase, mitotic prophase

nuclear chromatin

364

Annotation Extension	Evidence	With/From	Reference
at origin_of_replication	IDA		PMID:12419251

at origin_of_replication

nucleus

2690

Annotation Extension	Evidence	Reference
	IDA	PMID:2534559
during mitotic S phase	EXP	PMID:11683390
during mitotic G2 phase	EXP	PMID:11683390
during mitotic M phase	IDA	PMID:11084332
during mitotic prophase	EXP	PMID:11683390
during mitotic metaphase	EXP	PMID:11683390
during mitotic anaphase	EXP	PMID:11683390
during mitotic telophase	EXP	PMID:11683390
during karyogamy involved in conjugation with cellular fusion	EXP	PMID:11683390
except during cytokinesis	IDA	PMID:2569363

during mitotic M phase, mitotic telophase, mitotic anaphase, mitotic G2 phase, mitotic S phase, mitotic prophase, mitotic metaphase, karyogamy involved in conjugation with cellular fusion
except during cytokinesis

Term ID	Term Name	Evidence	With/From	Reference	Count
GO:0000775	chromosome, centromeric region				137
during meiotic prophase I	EXP		PMID:11683390
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IDA		PMID:3322810	11
	IPI	cdc13	PMID:2682257
GO:0005737	cytoplasm				4212
during mitotic metaphase	EXP		PMID:11683390
during mitotic prophase	EXP		PMID:11683390
during mitotic G2 phase	EXP		PMID:11683390
during mitotic telophase	EXP		PMID:11683390
during mitotic anaphase	EXP		PMID:11683390
during mitotic S phase	EXP		PMID:11683390
during mitotic G1 phase	EXP		PMID:11683390
GO:0005829	cytosol	IDA		PMID:16823372	2298
GO:0035974	meiotic spindle pole body				24
during karyogamy involved in conjugation with cellular fusion	EXP		PMID:11683390
GO:0072686	mitotic spindle				95
during mitotic prophase	EXP		PMID:11683390
during mitotic metaphase	EXP		PMID:11683390
GO:1990023	mitotic spindle midzone				24
during mitotic M phase	IDA		PMID:11084332
GO:0044732	mitotic spindle pole body				211
during mitotic S phase	EXP		PMID:11683390
during mitotic G2 phase	EXP		PMID:11683390
during mitotic metaphase	EXP		PMID:11683390
during mitotic prophase	EXP		PMID:11683390
GO:0000790	nuclear chromatin				364
at origin_of_replication	IDA		PMID:12419251
GO:0005634	nucleus	IDA		PMID:2534559	2690
during mitotic M phase	IDA		PMID:11084332
during mitotic telophase	EXP		PMID:11683390
during mitotic anaphase	EXP		PMID:11683390
during mitotic G2 phase	EXP		PMID:11683390
during mitotic S phase	EXP		PMID:11683390
during mitotic prophase	EXP		PMID:11683390
during mitotic metaphase	EXP		PMID:11683390
except during cytokinesis	IDA		PMID:2569363
during karyogamy involved in conjugation with cellular fusion	EXP		PMID:11683390

FYPO Single-Allele Phenotypes

Gene Deletion Viability: Inviable

Population Phenotype

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Term Name

Genotypes

Count

abnormal mitotic cell cycle arrest with unreplicated DNA

cdc2-DL5 (A48V)

decreased cell population growth at low temperature

cdc2-r4 (D90N)

decreased septation index

cdc2-33 (A177T)

decreased vegetative cell population growth

Cdc2-F15 (T15F)

745

increased frequency of apoptosis

cdc2-Y15F (Y15F)

increased number of cells with 1C DNA content

cdc2-DL50 (240 -242)

cdc2-3w (C67Y)

inviable vegetative cell population

cdc2-3w (C67Y)

1468

cdc2-4w (G200T)

cdc2-r4 (D90N)

cdc2Δ

loss of viability upon nitrogen starvation

cdc2-974 (I35N)

normal growth during cellular response to UV

cdc2-1w (G146D)

normal growth on arsenate

cdc2-3w (C67Y)

normal growth on hydroxyurea

cdc2-1w (G146D)

normal septation index

cdc2-3w (C67Y)

normal sporulation frequency

tws1-N22 (E42K)

normal vegetative cell population growth

cdc2-1w (G146D)

846

normal vegetative cell population growth rate

tws1-N22 (E42K)

sensitive to caffeine during vegetative growth

cdc2-33 (A177T)

110

sensitive to camptothecin

cdc2-1w (G146D)

259

sensitive to ethanol

cdc2-M56 (P137S)

cdc2-M26 (P137S)

sensitive to hydroxyurea

cdc2-3w (C67Y)

595

sensitive to methyl methanesulfonate

cdc2-Y15F (Y15F)

333

sensitive to plumbagin

cdc2+/cdc2- (heterozygous diploid)

viable vegetative cell population

cdc2-1w (G146D)

3862

Cell Phenotype

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Term Name

Genotypes

Count

abnormal cell cycle arrest in mitotic metaphase

cdc2-DL41 (P162L)

abnormal chromosome segregation

cdc2-DL5 (A48V)

326

abnormal meiosis

cdc2-N22 (E42K)

134

abnormal mitotic cell cycle

cdc2Δ

903

abnormal mitotic cell cycle arrest with condensed chromosomes

cdc2-DL41 (P162L)

abnormal mitotic cell cycle arrest with condensed chromosomes, septated cell

cdc2-DL41 (P162L)

abnormal mitotic cell cycle arrest with replicated DNA

cdc2-DL5 (A48V)

cdc2-L7 (P208S)

cdc2-DL41 (P162L)

cdc2-33 (A177T)

abnormal mitotic cell cycle regulation during cellular response to hydroxyurea

cdc2-DL50 (240 -242)

cdc2-3w (C67Y)

cdc2+

abnormal mitotic sister chromatid separation

Cdc2-F15 (T15F)

abnormal negative regulation of DNA replication initiation resulting in complete rereplication, with mitotic cell cycle arrest

cdc2-DL41 (P162L)

abnormal protein phosphorylation during vegetative growth

175

affecting cdc2

cdc2-1w (G146D)

abnormal septation

cdc2-DL41 (P162L)

300

abnormal sporulation resulting in formation of two-spore ascus

cdc2-N22 (E42K)

cdc2-33 (A177T)

cdc2-59 (P248L, C67Y)

tws1-N22 (E42K)

abnormally arrested mitotic cell cycle progression

Ala167 (T167A)

179

cdc2-33 (A177T)

Val177 (A177V)

Val167 (T167V)

Arg33 (K33R)

cdc2Δ

abolished meiosis

cdc2-M26 (P137S)

abolished meiosis I

cdc2-M26 (P137S)

abolished meiosis II

cdc2-33 (A177T)

cdc2-7

abolished premeiotic DNA replication

Y15F (Y15F)

cdc2-M26 (P137S)

cdc2-33 (A177T)

cdc2-M63 (G227C)

abolished protein kinase activity

affecting activity of cdc2

cdc2-DL2 (E215K)

affecting cdc2

cdc2-56 (G183E)

abolished protein localization to kinetochore during vegetative growth

affects localization of nsk1

cdc2-as (F84G)

abolished protein phosphorylation during vegetative growth

affecting srw1

cdc2-33 (A177T)

affecting mde4

cdc2-as (F84G)

abolished protein tyrosine phosphorylation during vegetative growth

affecting cdc2

Cdc2-F15 (T15F)

abolished protein-protein interaction

164

affecting cdc2 and suc1

cdc2-56 (G183E)

abolished re-entry into mitotic cell cycle after pheromone arrest

cdc2-M26 (P137S)

cut during cellular response to hydroxyurea

cdc2-4w (G200T)

cdc2-3w (C67Y)

decreased arsenate reductase activity

cdc2-3w (C67Y)

decreased cyclin B1-CDK1 complex level

affecting cdc2 and cdc13

cdc2-DL2 (E215K)

decreased protein kinase activity

cdc2-L7 (P208S)

cdc2-A21 (D90N)

cdc2-M35 (G43E)

affecting activity of cdc2

cdc2-DL5 (A48V)

affecting activity of cdc2

cdc2-DL41 (P162L)

affecting activity of cdc2

cdc2-DL45 (P162S)

affecting cdc2

cdc2-M55

affecting cdc2

cdc2-L7 (P208S)

affecting cdc2

cdc2-33 (A177T)

affecting cdc2

cdc2-M35 (G43E)

affecting cdc2

cdc2-56 (G183E)

decreased protein localization to chromatin at replication origin

affects localization of cdc13

cdc2-33 (A177T)

decreased protein phosphorylation during mitotic G2 phase

affecting srw1

cdc2-M26 (P137S)

decreased protein phosphorylation during vegetative growth

cdc2-as (F84G)

105

cdc2-33 (A177T)

affecting pol1

cdc2-33 (A177T)

affecting cdc13

cdc2-L7 (P208S)

affecting cdc13

cdc2-56 (G183E)

affecting cdc13

cdc2-33 (A177T)

affecting orc2

cdc2-33 (A177T)

affecting orc2

cdc2-L7 (P208S)

decreased protein serine phosphorylation during vegetative growth

affecting fkh2

cdc2-ts

affecting rap1

cdc2-33 (A177T)

decreased protein threonine phosphorylation during vegetative growth

affecting activity of cdc2

cdc2-DL2 (E215K)

affecting fkh2

cdc2-ts

affecting rap1

cdc2-33 (A177T)

decreased protein-protein interaction

109

affecting cdc2 and suc1

cdc2-33 (A177T)

affecting cdc2 and suc1

cdc2-L7 (P208S)

affecting cdc2 and suc1

cdc2-56 (G183E)

affecting cdc2 and cdc13

cdc2-L7 (P208S)

decreased response to S-phase DNA damage checkpoint signaling

cdc2-Y15F (Y15F)

delayed onset of premeiotic DNA replication

Y15F (Y15F)

delayed onset of protein localization to nucleoplasm during cellular response to hydrogen peroxide

cdc2-as (F84G)

elongated cell during nitrogen starvation

cdc2-974 (I35N)

fragmented DNA during nitrogen starvation

cdc2-974 (I35N)

increased cellular reactive oxygen species level during vegetative growth

cdc2-Y15F (Y15F)

increased mRNA splicing, via spliceosome

affecting cdc2

cdc2-I2mut (TTGACG287ACACAT)

increased protein kinase activity

affecting activity of cdc2

cdc2+

increased protein level

146

affecting cdc25

cdc2-33 (A177T)

increased RNA splicing at cryptic splice sites

affecting cdc2

cdc2-I2mut (TTGACG287ACACAT)

inviable after spore germination with elongated germ tube

cdc2Δ

164

inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

cdc2-59 (P248L, C67Y)

inviable after spore germination, without cell division, with elongated germ tube

cdc2Δ

inviable elongated mononucleate aseptate cell

cdc2-M63 (G227C)

cdc2-E9 (D242N)

cdc2-E8 (D213N)

cdc2-17 (G212S)

cdc2-33 (A177T)

cdc2-

inviable elongated mononucleate aseptate vegetative cell with cell cycle arrest in mitotic G2 phase

cdc2-A21 (D90N)

inviable elongated mononucleate vegetative cell

cdc2-DL5 (A48V)

inviable elongated septated mononucleate vegetative cell

cdc2-DL5 (A48V)

inviable elongated vegetative cell

cdc2-17 (G212S)

440

cdc2-M26 (P137S)

cdc2-18 (L269S)

cdc2-56 (G183E)

cdc2-33 (A177T)

cdc2-48 (Y292H)

cdc2-L7 (P208S)

cdc2Δ

cdc2-45 (F210L)

cdc2-M35 (G43E)

cdc2-M63 (G227C)

inviable vegetative cell

L248 (P248L)

1377

mitotic catastrophe with cut, small cell

Cdc2-F15 (T15F)

mitotic G1/S transition delay

cdc2-L7 (P208S)

cdc2-33 (A177T)

mitotic spindle elongation without chromosome separation

cdc2-DL41 (P162L)

normal cell cycle regulation during cellular response to hydroxyurea

cdc2-1w (G146D)

cdc2-DL45 (P162S)

normal cell cycle regulation during cellular response to ionizing radiation

cdc2-3w (C67Y)

normal interphase cytoplasmic microtubules

cdc2-3w (C67Y)

normal mitotic cell cycle

Arg34 (K34R)

137

normal mitotic spindle

cdc2-3w (C67Y)

normal premeiotic DNA replication

cdc2-33 (A177T)

normal protein kinase activity

affecting activity of cdc2

cdc2+

affecting cdc2

cdc2-56 (G183E)

normal protein localization to chromatin at replication origin

affecting mrc1

cdc2-33 (A177T)

normal protein localization to nucleus during vegetative growth

affecting cdc13

cdc2Δ

normal protein phosphorylation during nitrogen starvation

affecting ssp2

cdc2-1w (G146D)

normal protein phosphorylation during vegetative growth

affecting srw1

cdc2-33 (A177T)

affecting pol1

cdc2-33 (A177T)

normal protein tyrosine phosphorylation during vegetative growth

cdc2-1w (G146D)

affecting cdc2

cdc2-F19 (Y19F)

affecting cdc2

cdc2-3w (C67Y)

normal protein-protein interaction

107

affecting cdc2 and suc1

cdc2-M55

affecting cdc2 and suc1

cdc2-M56 (P137S)

normal regulation of mitotic cell cycle

cdc2-59 (P248L, C67Y)

normal sporulation

cdc2-3w (C67Y)

normal telomere length

cdc2-3w (C67Y)

normal vegetative cell growth

cdc2-F19 (Y19F)

normal vegetative cell length

cdc2-33 (A177T)

premature mitosis

cdc2-DL50 (240 -242)

premature protein localization to mitotic spindle

affects localization of mde4

cdc2-as (F84G)

protein mislocalized to nucleus during meiosis I

affects localization of rna1

tws1-N22 (E42K)

septated vegetative cell

Cdc2-F15 (T15F)

199

septation following abnormal chromosome segregation, with binucleate and anucleate compartment formation during cellular response to hydroxyurea

cdc2-3w (C67Y)

cdc2-4w (G200T)

small vegetative cell

cdc2+

Cdc2-F15 (T15F)

cdc2-DL50 (240 -242)

swollen spore

tws1-N22 (E42K)

viable elongated vegetative cell

cdc2-M35 (G43E)

329

cdc2-M63 (G227C)

viable elongated vegetative cell, elongated upon mitotic entry

cdc2-33 (A177T)

viable small vegetative cell

cdc2-3w (C67Y)

cdc2Δ

cdc2-Y15F (Y15F)

cdc2-130

cdc2-56 (G183E)

cdc2-4w (G200T)

cdc2-1w (G146D)

cdc2-3w (C67Y)

Extensions	Evidence	Genotype		Condition	Reference
Extensions	Evidence	Allele	Expression	Condition	Reference
	Microscopy	cdc2-3w (C67Y)	Not assayed		PMID:8887552
	Microscopy	cdc2-3w (C67Y)	Not assayed	PECO:0000005	PMID:1756736
	Microscopy	cdc2-1w (G146D)	Wild type product level		PMID:2674650
	Microscopy	cdc2-1w (G146D)	Not assayed	PECO:0000263	PMID:17952063
	Microscopy	cdc2-1w (G146D)	Wild type product level	PECO:0000005	PMID:1756736
	Microscopy	cdc2-Y15F (Y15F)	Not assayed		PMID:19546237
	Microscopy	cdc2-1w (G146D)	Not assayed	PECO:0000004	PMID:672898
	Microscopy	cdc2-3w (C67Y)	Not assayed	PECO:0000126, PECO:0000005	PMID:1464318
	Microscopy	cdc2-4w (G200T)	Not assayed	PECO:0000005	PMID:7813446
	Microscopy	cdc2-4w (G200T)	Not assayed	PECO:0000004	PMID:7813446
	Microscopy	cdc2-56 (G183E)	Wild type product level	PECO:0000006	PMID:2674650
	Microscopy	cdc2-3w (C67Y)	Wild type product level		PMID:2674650
	Microscopy	cdc2-1w (G146D)	Not assayed		PMID:3032459
	Microscopy	cdc2-3w (C67Y)	Not assayed	PECO:0000263	PMID:17952063
	Microscopy	cdc2-3w (C67Y)		PECO:0000004	PMID:8631307
	Microscopy	cdc2-1w (G146D)	Not assayed		PMID:3796591
penetrance FYPO_EXT:0000001	Microscopy	cdc2-3w (C67Y)	Not assayed	PECO:0000005, PECO:0000126	PMID:1703321
penetrance FYPO_EXT:0000001	Microscopy	cdc2Δ	Null	PECO:0000005, PECO:0000126	PMID:2038306
penetrance FYPO_EXT:0000001	Microscopy	cdc2-1w (G146D)	Not assayed	PECO:0000005, PECO:0000126	PMID:1703321
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000001	Microscopy	cdc2-1w (G146D)	Not assayed	PECO:0000126, PECO:0000004	PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000001	Microscopy	cdc2-56 (G183E)	Not assayed	PECO:0000126, PECO:0000227	PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000001	Microscopy	cdc2-56 (G183E)	Not assayed	PECO:0000126, PECO:0000227	PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000001	Microscopy	cdc2-130	Not assayed	PECO:0000126, PECO:0000227	PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000001	Microscopy	cdc2-1w (G146D)	Not assayed		PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000001	Microscopy	cdc2-130	Not assayed	PECO:0000126, PECO:0000227	PMID:7262540
expressivity FYPO_EXT:0000001	Microscopy	cdc2-3w (C67Y)	Not assayed	PECO:0000004, PECO:0000126	PMID:3442828
expressivity FYPO_EXT:0000002	Microscopy	cdc2-3w (C67Y)	Not assayed	PECO:0000005, PECO:0000126	PMID:3442828

viable vegetative cell

Cdc2-F15 (T15F)

3680

viable vegetative cell with normal cell size

cdc2+

FYPO Multi-allele Phenotypes

Population Phenotype

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Term Name

Genotypes

abnormal mitotic cell cycle arrest with unreplicated DNA

cdc2-Y15F (Y15F), cdc10-V50 (H362Y)

abolished cell population growth at high temperature

cdc2-3w (C67Y), wee1-50

decreased cell population growth on glucose carbon source

mcs6-13 (L238R), cdc2-3w (C67Y)

decreased conjugation frequency

srw1::ura4, cdc2-M35 (G43E)

decreased vegetative cell population growth

slx8-29, cdc2-1w (G146D)

cdc2-4w (G200T), wee1-50

skb1Δ, cdc25Δ, cdc2-3w (C67Y)

increased septation index

cdc2-M63 (G227C), T167E (T167E)

inviable vegetative cell population

cdc2-3w (C67Y), wee1-50

cdc2-3w (C67Y), cdc25-22 (C532Y), dis2+

cdc17-K42 (E298K), cdc2-3w (C67Y)

cdc2-3w (C67Y), wis1Δ, wee1-50

mcs2-75, cdc2-3w (C67Y)

mcs2-75, cdc25-22 (C532Y), cdc2-3w (C67Y)

cdc2-M63 (G227C), T167E (T167E)

cdc22-M45, cdc2-3w (C67Y)

cdc2-33 (A177T), pop1-364

cdc2-1w (G146D), cdc25::ura4

cdc20-M10, cdc2-3w (C67Y)

cdc2-3w (C67Y), sty1Δ, wee1-50

cdc25-22 (C532Y), cdc2-1w (G146D), dis2+

normal vegetative cell population growth

skb1Δ, cdc2-3w (C67Y)

sensitive to arsenate

cdc25Δ, cdc2-3w (C67Y)

sensitive to camptothecin

cdc2-1w (G146D), wee1Δ

sensitive to hydroxyurea

cdc2-1w (G146D), wee1Δ

slx8-29, cdc2-1w (G146D)

sensitive to UV during vegetative growth

cdc2-1w (G146D), wee1Δ

slow vegetative cell population growth

E167 (T167E), cdc2-33 (A177T)

cdc2-DL41 (P162L), suc1+

viable vegetative cell population

mcs2-75, cdc2-3w (C67Y), cdc25-22 (C532Y), csk1+

cdc2-3w (C67Y), cdc25::ura4

wee1+ (wild type), cdc2-3w (C67Y)

cdc2-3w (C67Y), cdc25-22 (C532Y), dis2+

cdc25-22 (C532Y), cdc2-1w (G146D), dis2+

cdc2+, wee1-50, mcs4-13, cdc25-22 (C532Y)

cdc25-22 (C532Y), cdc2-3w (C67Y), mcs6+, mcs2-75

cdc2-3w (C67Y), mcs4Δ, wee1-50

cdc2-3w (C67Y), srk1+

cdc25Δ, Cdc2-F15 (T15F)

cdc25-22 (C532Y), Cdc2-F15 (T15F)

mcs2-75, cdc2-3w (C67Y)

cdc2-3w (C67Y), mcs2-75, mcs6::ura4+

Cell Phenotype

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Term Name

Genotypes

abnormal mitosis

cdc2-33 (A177T), cdc2-DL45 (P162S)

cdc2-DL41 (P162L), cdc2-33 (A177T)

abnormal mitotic cell cycle arrest with replicated DNA

A167 (T167A), cdc2-L7 (P208S)

abnormal mitotic cell cycle regulation during cellular response to hydroxyurea

cdc2-3w (C67Y), cdc25Δ

cdc20-M10, cdc2-3w (C67Y)

cdc2-1w (G146D), cut5-T401

cdc17-K42 (E298K), cdc2-3w (C67Y)

cdc2-3w (C67Y), cut5-T401

cdc22-M45, cdc2-3w (C67Y)

abnormal mitotic sister chromatid segregation

E167 (T167E), cdc2::huCDC2 (gene replacement)

abnormal protein phosphorylation during vegetative growth

affecting cdc2

cdc2-1w (G146D), mik1Δ

affecting cdc2

cdc2-1w (G146D), wee1Δ

affecting cdc2

cdc2-1w (G146D), cdc13-245 (E255R)

abnormal sporulation resulting in formation of ascus with more than four spores

cig2Δ, puc1Δ, rem1Δ, cdc2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cig1Δ, cdc13Δ

abnormal sporulation resulting in formation of two-spore ascus

cdc2-1w (G146D), cdc25-22 (C532Y)

cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc13Δ, cdc2Δ

cdc2Δ, cig2Δ, cig1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), puc1Δ, cdc13Δ

cdc2-M26 (P137S), suc1-210

abnormally arrested mitotic cell cycle progression

pyp3+, cdc2-33 (A177T)

abolished activation of bipolar cell growth

orb2-34, cdc2-33 (A177T)

abolished mitotic G2 DNA damage checkpoint

chk1+ (wild type), cdc25Δ, cdc2-3w (C67Y)

cdc25Δ, cdc2-3w (C67Y)

abolished protein kinase activity

affecting cdc2

A167,F15 (T167A, Y15F), cdc2::huCDC2 (gene replacement)

affecting cdc2

A167 (T167A), cdc2::huCDC2 (gene replacement)

affecting cdc2

E167 (T167E), cdc2::huCDC2 (gene replacement)

affecting cdc2

(Y15F, T167E), cdc2::huCDC2 (gene replacement)

affecting cdc2

cdc2-M63 (G227C), T167E (T167E)

abolished protein localization to nucleoplasm during cellular response to hydrogen peroxide

affects localization of clp1

pmk1Δ, rad3Δ, cdc2-as (F84G)

affects localization of clp1

cdc2-as (F84G), pmk1Δ

affects localization of clp1

cdc2-as (F84G), rad3Δ

abolished protein localization to nucleoplasm during cellular response to hydroxyurea

affects localization of clp1

pmk1Δ, rad3Δ, cdc2-as (F84G)

abolished protein phosphorylation

affecting cdc2

A167,F15 (T167A, Y15F), cdc2::huCDC2 (gene replacement)

abolished protein serine phosphorylation at RxxS site during cellular response to hydrogen peroxide

affecting clp1

pmk1Δ, rad3Δ, cdc2-as (F84G)

abolished protein serine phosphorylation at RxxS site during cellular response to hydroxyurea

affecting clp1

pmk1Δ, rad3Δ, cdc2-as (F84G)

abolished protein threonine phosphorylation

affecting cdc2

Y167 (T167Y), cdc2::huCDC2 (gene replacement)

affecting cdc2

A167 (T167A), cdc2::huCDC2 (gene replacement)

affecting cdc2

E167 (T167E), cdc2::huCDC2 (gene replacement)

altered DNA level during vegetative growth

cdc2-3w (C67Y), wee1-50

cell cycle arrest at mitotic G1/S phase transition

cdc2+, cdc13+, cdc10-129 (T429A)

cell cycle arrest in mitotic G2 phase

cdc25-22 (C532Y), cdc2-DL45 (P162S)

cdc2-DL2 (E215K), cdc2+

cut

orp1-4, cdc2-1w (G146D)

cdc2-3w (C67Y), orp1-4

cut during cellular response to hydroxyurea

wee1+ (wild type), cdc2-3w (C67Y)

cdc2-3w (C67Y), cdc25Δ

decreased protein kinase activity

cdc2-E8 (D213N), wee1-50

decreased protein level during vegetative growth

affecting cdc2

cdc2Δ, cdc2 (wild type)

decreased protein phosphorylation during vegetative growth

affecting cut9

cdc2-M63 (G227C), T167E (T167E)

decreased protein threonine phosphorylation at Thr-Pro site during cellular response to hydrogen peroxide

affecting clp1

pmk1Δ, rad3Δ, cdc2-as (F84G)

decreased protein threonine phosphorylation at Thr-Pro site during cellular response to hydroxyurea

affecting clp1

pmk1Δ, rad3Δ, cdc2-as (F84G)

decreased protein-protein interaction

affecting cdc2 and cdc13

A167 (T167A), cdc2::huCDC2 (gene replacement)

decreased response to S-phase DNA damage checkpoint signaling

cdc2-Y15F (Y15F), cdc10-V50 (H362Y)

delayed onset of protein localization to nucleoplasm during cellular response to hydrogen peroxide

affects localization of clp1

cdc2-as (F84G), rad3Δ

delayed onset of protein localization to nucleoplasm during cellular response to hydroxyurea

affects localization of clp1

cdc2-as (F84G), pmk1Δ

DNA content increased during vegetative growth

E167 (T167E), cdc2-33 (A177T)

elongated mononucleate vegetative cell

cdc10-129 (T429A), cdc2-3w (C67Y)

cdc2-33 (A177T), cut5-T401

elongated multinucleate multiseptate vegetative cell, single septa between nuclei

E167 (T167E), cdc2-33 (A177T)

elongated multiseptate vegetative cell

mcs6-13 (L238R), cdc2-3w (C67Y)

elongated vegetative cell

mcs2-75, cdc2-3w (C67Y)

cdc2-3w (C67Y), mcs2-75, wee1-50

cdc2-3w (C67Y), mcs6-13 (L238R), wee1-50

increased duration of mitotic M phase

cdc21-M68, cdc2-3w (C67Y)

inviable after spore germination, multiple cell divisions

mcs4-13, cdc2-59 (P248L, C67Y)

cdc2-59 (P248L, C67Y), mcs2-75

mcs1-77, cdc2-59 (P248L, C67Y)

cdc2-59 (P248L, C67Y), mcs6-13 (L238R)

inviable after spore germination, without cell division, elongated cell

cdc2-1w (G146D), cdc25::ura4

inviable cell

cdc2-33 (A177T), cdc2-DL5 (A48V)

cdc2Δ, cdc2-DL5 (A48V)

inviable curved elongated vegetative cell

tea1-3, cdc2-33 (A177T)

inviable elongated aseptate cell

atf1+, cdc2-33 (A177T)

inviable elongated mononucleate aseptate cell

cdc2-E8 (D213N), wee1-50

D167 (T167D), cdc2-33 (A177T)

Y167 (T167Y), cdc2-33 (A177T)

cdc2-, cut1-

cdc2-33 (A177T), orb5-19

A167,F15 (T167A, Y15F), cdc2-33 (A177T)

A167 (T167A), cdc2-33 (A177T)

cdc2-DL2 (E215K), cdc2+

cdc2-33 (A177T), orb3-167

inviable elongated multiseptate vegetative cell

mcs6-13 (L238R), mcs4-13, cdc2-3w (C67Y)

inviable elongated vegetative cell

mcs2-75, cdc2-3w (C67Y)

inviable septated mononucleate vegetative cell

cdc2-3w (C67Y), wee1-50

inviable small vegetative cell

cdc17-K42 (E298K), cdc2-3w (C67Y)

cdc20-M10, cdc2-3w (C67Y)

cdc22-M45, cdc2-3w (C67Y)

inviable spore

cig2Δ, puc1Δ, rem1Δ, cdc2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cig1Δ, cdc13Δ

cdc2Δ, cig2Δ, cig1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), puc1Δ, cdc13Δ

cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc13Δ, cdc2Δ

inviable vegetative cell

cdc2-M63 (G227C), T167E (T167E)

large and small daughter nuclei

cdc2-3w (C67Y), wee1-50

lemon-shaped cell

orb6-25, cdc2-33 (A177T)

mitosis with unreplicated DNA

cdc2-3w (C67Y), cdc25Δ

mitotic catastrophe

pyp3+, cdc2-3w (C67Y)

mitotic catastrophe with cut, small cell

cdc2+, cdc13+, cdc10-129 (T429A)

cdc2-3w (C67Y), wee1-50

mitotic G1/S transition delay

A167 (T167A), cdc2-L7 (P208S)

mitotic G2/M transition delay

cdc2-3w (C67Y), pcn1+

multiple mitotic spindles

E167 (T167E), cdc2-33 (A177T)

normal actin cortical patch localization

cdc2-33 (A177T), orb5-19

normal actin cytoskeleton morphology during vegetative growth

cdc2-33 (A177T), orb3-167

normal cell cycle regulation during cellular response to hydroxyurea

wee1+ (wild type), cdc2-3w (C67Y)

cdc2-3w (C67Y), cdc10-129 (T429A)

cdc2-33 (A177T), cut5-T401

normal meiosis

cig2Δ, puc1Δ, rem1Δ, cdc2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cig1Δ, cdc13Δ

cig2Δ, cig1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), puc1Δ, rem1Δ

cdc2Δ, cig2Δ, cig1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), puc1Δ, cdc13Δ

normal meiosis I

cdc2Δ, cig2Δ, cig1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), puc1Δ, cdc13Δ

normal microtubule cytoskeleton morphology during vegetative growth

cdc2-33 (A177T), orb3-167

normal mitotic cell cycle

cdc2+, cdc2-DL45 (P162S)

cdc2-DL41 (P162L), cdc2-33 (A177T)

cdc2-33 (A177T), cdc2-DL45 (P162S)

cdc2-DL41 (P162L), cdc2+

normal protein level during mitotic metaphase

affecting cdc13

cdc2-M63 (G227C), T167E (T167E)

normal protein localization to chromatin at replication origin

affecting mcm4

cdc13+, cdc2-33 (A177T)

normal protein tyrosine phosphorylation during vegetative growth

affecting cdc2

Y167 (T167Y), cdc2::huCDC2 (gene replacement)

affecting cdc2

E167 (T167E), cdc2::huCDC2 (gene replacement)

affecting cdc2

A167 (T167A), cdc2::huCDC2 (gene replacement)

normal protein-protein interaction

affecting cdc2 and suc1

E167 (T167E), cdc2::huCDC2 (gene replacement)

affecting cdc2 and cdc13

E167 (T167E), cdc2::huCDC2 (gene replacement)

normal vegetative cell growth

cdc2-M26 (P137S), suc1-210

cdc2-M55, suc1-449

suc1-210, cdc2-33 (A177T)

cdc2-56 (G183E), suc1-449

cdc2-33 (A177T), suc1-449

cdc2-M26 (P137S), suc1-449

cdc2-L7 (P208S), suc1-449

cdc2-M55, suc1-210

suc1-210, cdc2-56 (G183E)

suc1-210, cdc2-L7 (P208S)

normal vegetative cell size

cdc2-3w (C67Y), mcs2-75, mcs6::ura4+

premature mitosis

cdc2-33 (A177T), cdc2-DL50 (240 -242)

septation following abnormal chromosome segregation, with binucleate and anucleate compartment formation during cellular response to hydroxyurea

cdc20-M10, cdc2-3w (C67Y)

cdc22-M45, cdc2-3w (C67Y)

cdc17-K42 (E298K), cdc2-3w (C67Y)

small vegetative cell

cdc2-1w (G146D), mcs2-75

sterile

srw1::ura4, cdc2-M35 (G43E)

viable cell at high temperature

cdc2-E8 (D213N), cdc25+ (wild type), wee1-50

cdc2-A21 (D90N), cdc25+ (wild type), wee1-50

cdc2-E9 (D242N), cdc25+ (wild type), wee1-50

viable elongated vegetative cell

cdc2-3w (C67Y), cdc25::ura4

cdc25Δ, tor1Δ, cdc2-3w (C67Y)

cdc2-M72, cdc2+

win1-1, cdc25-22 (C532Y), cdc2-3w (C67Y)

wee1+ (wild type), cdc2-3w (C67Y)

cdc2Δ, cdc2 (wild type)

cdc2-33 (A177T), cdr1-76

cdc2+, cdc2-M55

cdc2+, cdc2-M76

cdc2-L7 (P208S), cdc2+

cdc2-M35 (G43E), cdc2+

cdc2-M63 (G227C), cdc2+

cdc2-M26 (P137S), cdc2+

cdc2-56 (G183E), cdc2+

cdc2-33 (A177T), cdc2+

cdc2+, cdc2-130

cdc2-3w (C67Y), cdc25-22 (C532Y)

skb1Δ, cdc25Δ, cdc2-3w (C67Y)

cdc25Δ, shk1+, cdc2-3w (C67Y)

cdr2-97, cdc2-33 (A177T)

Extensions	Evidence	Genotype			Condition	Reference
Extensions	Evidence	Genes	Allele	Expression	Condition	Reference
	Cell growth assay	wee1	wee1+ (wild type)	Overexpression	PECO:0000005	PMID:3032459
	Cell growth assay	cdc2	cdc2-3w (C67Y)	Not assayed	PECO:0000005	PMID:3032459
	Cell growth assay	cdc2	cdc2-3w (C67Y)	Not assayed	PECO:0000005	PMID:3032459
	Cell growth assay	cdc25	cdc25::ura4	Null	PECO:0000005	PMID:3032459
	Microscopy	cdr2	cdr2-97	Not assayed	PECO:0000005	PMID:3448096
	Microscopy	cdc2	cdc2-33 (A177T)	Not assayed	PECO:0000005	PMID:3448096
	Microscopy	cdc2	cdc2-33 (A177T)	Not assayed	PECO:0000005	PMID:3448096
	Microscopy	cdr1	cdr1-76	Not assayed	PECO:0000005	PMID:3448096
	Microscopy	cdc25	cdc25Δ	Null		PMID:19546237
		tor1	tor1Δ	Null
		cdc2	cdc2-3w (C67Y)	Not assayed
penetrance FYPO_EXT:0000001 expressivity FYPO_EXT:0000002	Microscopy	cdc2	cdc2-56 (G183E)	Not assayed	PECO:0000229, PECO:0000126	PMID:7262540
	Microscopy	cdc2	cdc2+	Wild type product level	PECO:0000229, PECO:0000126	PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000001	Microscopy	cdc2	cdc2+	Wild type product level	PECO:0000229, PECO:0000126	PMID:7262540
	Microscopy	cdc2	cdc2-M76	Not assayed	PECO:0000229, PECO:0000126	PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000001	Microscopy	cdc2	cdc2-M35 (G43E)	Not assayed	PECO:0000229, PECO:0000126	PMID:7262540
	Microscopy	cdc2	cdc2+	Wild type product level	PECO:0000229, PECO:0000126	PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000001	Microscopy	cdc2	cdc2-L7 (P208S)	Not assayed	PECO:0000229, PECO:0000126	PMID:7262540
	Microscopy	cdc2	cdc2+	Wild type product level	PECO:0000229, PECO:0000126	PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000001	Microscopy	cdc2	cdc2-M26 (P137S)	Not assayed	PECO:0000229, PECO:0000126	PMID:7262540
	Microscopy	cdc2	cdc2+	Wild type product level	PECO:0000229, PECO:0000126	PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000001	Microscopy	cdc2	cdc2-33 (A177T)	Not assayed	PECO:0000229, PECO:0000126	PMID:7262540
	Microscopy	cdc2	cdc2+	Wild type product level	PECO:0000229, PECO:0000126	PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000002	Microscopy	cdc2	cdc2+	Wild type product level	PECO:0000229, PECO:0000126	PMID:7262540
	Microscopy	cdc2	cdc2-130	Not assayed	PECO:0000229, PECO:0000126	PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000002	Microscopy	cdc2	cdc2-M63 (G227C)	Not assayed	PECO:0000229, PECO:0000126	PMID:7262540
	Microscopy	cdc2	cdc2+	Wild type product level	PECO:0000229, PECO:0000126	PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000002	Microscopy	cdc2	cdc2-M72	Not assayed	PECO:0000229, PECO:0000126	PMID:7262540
	Microscopy	cdc2	cdc2+	Wild type product level	PECO:0000229, PECO:0000126	PMID:7262540
penetrance FYPO_EXT:0000004 expressivity FYPO_EXT:0000002	Microscopy	cdc2	cdc2+	Wild type product level	PECO:0000229, PECO:0000126	PMID:7262540
	Microscopy	cdc2	cdc2-M55	Not assayed	PECO:0000229, PECO:0000126	PMID:7262540
expressivity FYPO_EXT:0000001	Microscopy	skb1	skb1Δ	Null	PECO:0000005	PMID:9843966
		cdc25	cdc25Δ	Null
		cdc2	cdc2-3w (C67Y)	Not assayed
expressivity FYPO_EXT:0000001	Microscopy	cdc2	cdc2Δ	Null	PECO:0000137, PECO:0000125, PECO:0000005	PMID:27736299
expressivity FYPO_EXT:0000001	Microscopy	cdc2	cdc2 (wild type)	Wild type product level	PECO:0000137, PECO:0000125, PECO:0000005	PMID:27736299
expressivity FYPO_EXT:0000002	Microscopy	win1	win1-1	Not assayed	PECO:0000126, PECO:0000005	PMID:3442828
		cdc25	cdc25-22 (C532Y)	Not assayed
		cdc2	cdc2-3w (C67Y)	Not assayed
expressivity FYPO_EXT:0000002	Microscopy	win1	win1-1	Not assayed	PECO:0000126, PECO:0000004	PMID:3442828
		cdc25	cdc25-22 (C532Y)	Not assayed
		cdc2	cdc2-3w (C67Y)	Not assayed
expressivity FYPO_EXT:0000002	Microscopy	cdc25	cdc25Δ	Null	PECO:0000005	PMID:9843966
		shk1	shk1+	Knockdown
		cdc2	cdc2-3w (C67Y)	Not assayed
expressivity FYPO_EXT:0000003	Microscopy	cdc2	cdc2-3w (C67Y)	Not assayed	PECO:0000126, PECO:0000005	PMID:3442828
expressivity FYPO_EXT:0000003	Microscopy	cdc25	cdc25-22 (C532Y)	Not assayed	PECO:0000126, PECO:0000005	PMID:3442828

viable elongated vegetative cell, elongated upon mitotic entry

chk1+ (wild type), cdc2-3w (C67Y)

chk1+ (wild type), cdc25Δ, cdc2-3w (C67Y)

viable small vegetative cell

Cdc2-F15 (T15F), cdc25-22 (C532Y)

cdc2-3w (C67Y), win1-1

cdc2-3w (C67Y), mcs4-13, wee1-50

cdc25Δ, Cdc2-F15 (T15F)

cdc2-3w (C67Y), mcs1-77, wee1-50

cdc2+, cdc2-130

cdc2-Y15F (Y15F), tor1Δ

dnt1Δ, cdc2-1w (G146D)

cdc2-56 (G183E), cdc2+

cdc2-1w (G146D), cdc2+

viable vegetative cell

E167 (T167E), cdc2-33 (A177T)

cdc2+, cdc13+, cdc2-DL2 (E215K)

viable vegetative cell with normal cell size

win1-1, cdc2-3w (C67Y)

cdc2+, cdc2-33 (A177T)

cdc2-M63 (G227C), T167E (T167E)

cdc25-22 (C532Y), cdc2-3w (C67Y)

S167 (T167S), cdc2-33 (A177T)

Target Of

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Ontology	Relationship	Gene	Product
FYPO	affected by mutation in	cdc10	MBF transcription factor complex subunit Cdc10
FYPO	affected by mutation in	cdc13	G2/M B-type cyclin Cdc13
FYPO	affected by mutation in	cdc18	MCM loader
FYPO	affected by mutation in	cdc2	cyclin-dependent protein kinase Cdk1/Cdc2
FYPO	affected by mutation in	cdc25	M phase inducer tyrosine phosphatase Cdc25
FYPO	affected by mutation in	cdc6	DNA polymerase delta catalytic subunit Cdc6
FYPO	affected by mutation in	cds1	replication checkpoint kinase Cds1
FYPO	affected by mutation in	cia1	histone chaperone Cia1
FYPO	affected by mutation in	cig1	cyclin Cig1
FYPO	affected by mutation in	cig2	G1/S-specific B-type cyclin Cig2
FYPO	affected by mutation in	clp1	Cdc14-related protein phosphatase Clp1/Flp1
FYPO	affected by mutation in	csk1	cyclin-dependent kinase/ cyclin-dependent kinase activating kinase Csk1
FYPO	affected by mutation in	dim1	U4/U6 x U5 tri-snRNP complex subunit Dim1
FYPO	affected by mutation in	dma1	mitotic spindle checkpoint ubiquitin ligase Dma1
FYPO	affected by mutation in	dnt1	nucleolar protein Dnt1
FYPO	affected by mutation in	fin1	serine/threonine protein kinase, NIMA related Fin1
FYPO	affected by mutation in	hsp9	heat shock protein Hsp9
FYPO	affected by mutation in	hub1	ubiquitin-like protein modifier Hub1
FYPO	affected by mutation in	mcs6	TFIIH associated cyclin-dependent protein kinase Mcs6
FYPO	affected by mutation in	mei4	meiotic forkhead transcription factor Mei4
FYPO	affected by mutation in	mes1	meiotic APC inhibitor Mes1
FYPO	affected by mutation in	mik1	mitotic inhibitor kinase Mik1
FYPO	affected by mutation in	nap1	nucleosome assembly protein Nap1
FYPO	affected by mutation in	nda3	tubulin beta Nda3
FYPO	affected by mutation in	pim1	RCC1 family Ran GDP/GTP exchange factor
FYPO	affected by mutation in	prp1	U4/U6 x U5 tri-snRNP complex subunit Prp1
FYPO	affected by mutation in	prp10	U2 snRNP-associated protein Sap155
FYPO	affected by mutation in	prp2	U2AF large subunit (U2AF-59)
FYPO	affected by mutation in	rad3	ATR checkpoint kinase Rad3
FYPO	affected by mutation in	rum1	CDK inhibitor Rum1
FYPO	affected by mutation in	sds22	protein phosphatase regulatory subunit Sds22
FYPO	affected by mutation in	snu1	small nuclear RNA U1
FYPO	affected by mutation in	snu4	small nuclear RNA U4
FYPO	affected by mutation in	spo5	meiotic RNA-binding protein 1
FYPO	affected by mutation in	srb10	cyclin-dependent protein Srb mediator subunit kinase Srb10
FYPO	affected by mutation in	srw1	substrate-specific mitotic G1 APC coactivator Srw1/Ste9
FYPO	affected by mutation in	suc1	cyclin-dependent protein kinase regulatory subunit Suc1
FYPO	affected by mutation in	uaf2	U2AF small subunit, U2AF-23
FYPO	affected by mutation in	wee1	M phase inhibitor protein kinase Wee1
FYPO	affected by mutation in	xlf1	XRCC4-like nonhomologous end joining factor, Cernunnon Xlf1/Nej1
FYPO	localization affected by mutation in	atf1	transcription factor, Atf-CREB family Atf1
FYPO	localization affected by mutation in	cdc10	MBF transcription factor complex subunit Cdc10
FYPO	localization affected by mutation in	cdc13	G2/M B-type cyclin Cdc13
FYPO	localization affected by mutation in	cig1	cyclin Cig1
FYPO	localization affected by mutation in	cig2	G1/S-specific B-type cyclin Cig2
GO	binds	spd1	ribonucleotide reductase (RNR) inhibitor
GO	binds	suc1	cyclin-dependent protein kinase regulatory subunit Suc1
GO	regulated by	cdc13	G2/M B-type cyclin Cdc13
GO	regulated by	cdc16	two-component GAP Cdc16
GO	regulated by	cdc25	M phase inducer tyrosine phosphatase Cdc25
GO	regulated by	cig2	G1/S-specific B-type cyclin Cig2
GO	regulated by	clp1	Cdc14-related protein phosphatase Clp1/Flp1
GO	regulated by	csk1	cyclin-dependent kinase/ cyclin-dependent kinase activating kinase Csk1
GO	regulated by	mcs2	TFIIH complex cyclin Mcs2
GO	regulated by	mcs6	TFIIH associated cyclin-dependent protein kinase Mcs6
GO	regulated by	rum1	CDK inhibitor Rum1
GO	regulated by	srw1	substrate-specific mitotic G1 APC coactivator Srw1/Ste9
GO	regulated by	suc1	cyclin-dependent protein kinase regulatory subunit Suc1
GO	substrate of	cdc25	M phase inducer tyrosine phosphatase Cdc25
GO	substrate of	csk1	cyclin-dependent kinase/ cyclin-dependent kinase activating kinase Csk1
GO	substrate of	mcs6	TFIIH associated cyclin-dependent protein kinase Mcs6
GO	substrate of	mik1	mitotic inhibitor kinase Mik1
GO	substrate of	pyp3	protein-tyrosine phosphatase Pyp3

Transcript

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Transcript Structure

Region	Coordinates	Reference
Exons	1500197..1500243, 1500286..1500376, 1500445..1500613, 1500686..1500986, 1501088..1501393, 1501448..1502095
Intron	1500244..1500285, 1500377..1500444, 1500614..1500685, 1500987..1501087, 1501394..1501447
mRNA	1500197..1502095
5' UTR	1500197..1500243, 1500286..1500339	PMID:21511999
CDS	1500340..1500376, 1500445..1500613, 1500686..1500986, 1501088..1501393, 1501448..1501528
3' UTR	1501529..1502095	PMID:21511999

Protein Features

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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID	Database	InterPro	Description	Start	End	Count
PF00069	Pfam	IPR000719	Protein kinase domain	4	293	108
SM00220	SMART	IPR000719	Protein kinase domain	4	293	107
PS00108	Prosite Patterns	IPR008271	Serine/threonine-protein kinase, active site	130	142	91
PS00107	Prosite Patterns	IPR017441	Protein kinase, ATP binding site	10	33	70
PS50011	Prosite Profiles	IPR000719	Protein kinase domain	4	293	108
PTHR24056	HMMPANTHER			1	295	9
PTHR24056:SF11	HMMPANTHER			1	295	1
1.10.510.10	Gene3D		Immunoglobulin-like fold	88	294	112
3.30.200.20	Gene3D		Immunoglobulin-like fold	2	87	111
SSF56112	SuperFamily	IPR011009	Protein kinase-like domain	1	296	127

View domain organization at Pfam

Term ID	Term Name	Reference	Count
PBO:0003657	CDK family kinase

Protein Properties

Ave. residue weight	115.69 Da
Charge	4.50
Codon Adaptation Index	0.43
Isoelectric point	7.68
Molecular weight	34.36 kDa
Number of residues	297

Modifications

Protein Modifications

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Term Name

Residue

Count

O-phospho-L-serine

2293

Annotation Extension	Evidence	Residue	Reference
	IDA		PMID:3058333

O-phospho-L-threonine

1087

present during cellular response to thiabendazole, mitotic S phase

T167

T14, T167

Annotation Extension	Evidence	Residue	Reference
present during cellular response to thiabendazole	IDA	T167	PMID:18257517
present during mitotic S phase	IDA	T167	PMID:1655416
	IDA	T167	PMID:26131711
	IDA		PMID:3058333
	IDA	T167	PMID:25720772
	IDA		PMID:1756737
	IDA	T14	PMID:26131711
	IDA	T14	PMID:25720772

O4'-phospho-L-tyrosine

281

added by mik1, wee1

Y15

added during mitotic G2 phase, premeiotic DNA replication

present during cellular response to hydroxyurea, cellular response to nitrosative stress, cellular response to thiabendazole, mitotic M phase, mitotic S phase

Y15

present during mitotic G2 phase, absent during mitotic M phase

Y15

present during meiosis I

removed by cdc25

removed during cellular response to caffeine

Y15

removed during meiosis II

absent during mitotic M phase

Y15

Annotation Extension	Evidence	Residue	Reference
added by mik1	IDA	Y15	PMID:7982971
added by wee1	IDA	Y15	PMID:1372994
added during premeiotic DNA replication	IDA		PMID:10888871
added during mitotic G2 phase	IDA		PMID:1464318
present during mitotic M phase	experimental evidence	Y15	PMID:21712547
present during mitotic S phase	IDA	Y15	PMID:1655416
present during cellular response to thiabendazole	IDA	Y15	PMID:18257517
present during cellular response to nitrosative stress	IDA	Y15	PMID:22561704
present during mitotic G2 phase absent during mitotic M phase	IDA	Y15	PMID:2682257
present during meiosis I	IDA		PMID:10888871
present during cellular response to hydroxyurea	IDA	Y15	PMID:10036242
removed by cdc25	IDA		PMID:1756737
removed during cellular response to caffeine	IDA	Y15	PMID:10036242
removed during meiosis II	IDA		PMID:10888871
absent during mitotic M phase	IDA		PMID:1464318
	IDA	Y15	PMID:25720772
	IDA	Y15	PMID:26131711

phosphorylated residue

2515

added during G0 to G1 transition, cellular response to UV

removed during cellular response to nitrogen starvation

Annotation Extension	Evidence	Reference
added during G0 to G1 transition	IDA	PMID:3516412
added during cellular response to UV	IDA	PMID:12960401
removed during cellular response to nitrogen starvation	IDA	PMID:3516412

Sequence

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Gene Expression

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Qualitative Gene Expression

Description	Level	Evidence	Reference
protein level	constant during GO:0000278	Western blot evidence	PMID:2569363
	present during GO:0051321	Western blot evidence	PMID:10888871
	present during GO:0072690	Western blot evidence	PMID:2569363
	constant during GO:0000278	Western blot evidence	PMID:3516412
	unchanged during GO:0072734	Western blot evidence	PMID:1899230
	increased during GO:0006279	Western blot evidence	PMID:10888871

Quantitative Gene Expression

View graphical display of gene expression data for cdc2 (SPBC11B10.09)

Protein Level

Molecules/Cell (average)	Extension	Condition	Scale	Evidence	Reference
5406.86	during GO:0072690	PECO:0000126, PECO:0000005	population wide	experimental evidence	PMID:23101633
14449	during GO:0072690	PECO:0000005, PECO:0000126	single cell	mass spectrometry evidence	PMID:24763107
2704.8	during cell quiescence following G1 arrest due to nitrogen limitation	PECO:0000127, PECO:0000126, PECO:0000005	population wide	experimental evidence	PMID:23101633

RNA Level

Molecules/Cell (average)	Extension	Condition	Scale	Evidence	Reference
1.8	during GO:0072690	PECO:0000126, PECO:0000005	population wide	experimental evidence	PMID:23101633
0.52	during cell quiescence following G1 arrest due to nitrogen limitation	PECO:0000127, PECO:0000126, PECO:0000005	population wide	experimental evidence	PMID:23101633

Complementation

Description	Qualifier	Reference
functionally complemented by H. sapiens CDK1	full	PMID:3553962 PMID:1944283
	full	PMID:3553962 PMID:1944283
does not functionally complement S. cerevisiae CDC28		PMID:3796591
functionally complemented by G. gallus cdc2	full	PMID:1500441
functionally complements S. cerevisiae CDC28 when introns removed	full	PMID:3796591

Taxonomic Conservation

Description	Qualifier	Reference	Count
predominantly single copy (one to one)			3087
conserved in fungi			4608
conserved in eukaryotes			4516
conserved in metazoa			3498
conserved in vertebrates			3473
conserved in eukaryotes only			2525

Orthologs

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Manually curated orthologous groups

Species	Gene	Description	Links	Count

Orthologs in Compara

Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC11B10.09 into the Query Builder
View all interactions in esyN View network in esyN
View the HCPIN interactions in esyN

	Gene	Product	Evidence	Reference
co-purifies with	chk1	Chk1 protein kinase	Co-purification	PMID:26131711
co-purifies with	cdc13	G2/M B-type cyclin Cdc13	Co-purification	PMID:2038306
affinity captured by	orc2	origin recognition complex subunit Orc2	Affinity Capture-Western	PMID:8552194
affinity captured by	suc1	cyclin-dependent protein kinase regulatory subunit Suc1	Affinity Capture-Western	PMID:3297353
affinity captured by	chk1	Chk1 protein kinase	Affinity Capture-Western	PMID:26131711
affinity captured by	shk1	PAK-related kinase Shk1	Affinity Capture-Western	PMID:9843966
affinity captured by	cdc18	MCM loader	Affinity Capture-Western	PMID:9436991
affinity captured by	wos2	p23 homolog, predicted co-chaperone Wos2	Affinity Capture-Western	PMID:10581266
affinity captured by	nsk1	Clp1-interacting, microtubule plus-end binding Nsk1	Affinity Capture-Western	PMID:22065639
affinity captured by	hsp90	Hsp90 chaperone	Affinity Capture-Western	PMID:22543982
affinity captured by	cdc13	G2/M B-type cyclin Cdc13	Affinity Capture-Western	PMID:26131711
affinity captured by	pch1	P-TEFB associated cyclin, cyclin T Pch1	Affinity Capture-Western	PMID:9115279
affinity captured by	cig2	G1/S-specific B-type cyclin Cig2	Affinity Capture-Western	PMID:11163211
affinity captured by	cdc37	Hsp90 co-chaperone Cdc37	Affinity Capture-Western	PMID:16390871
affinity captured by	pas1	cyclin Pas1	Affinity Capture-Western	PMID:10982385
affinity captured by	pir2	zf-C2H2 type zinc finger protein, implicated in RNAi (predicted)	Affinity Capture-MS	PMID:24713849
affinity captured by	bgs1	primary septum and spore wall linear 1,3-beta-glucan synthase catalytic subunit Bgs1	Affinity Capture-Western	PMID:11937031
affinity captured by	skb1	type II protein arginine N-methyltransferase Skb1	Affinity Capture-Western	PMID:9843966
affinity captured by	mtl1	TRAMP/MTREC complex subunit, ATP-dependent RNA helicase (predicted)	Affinity Capture-MS	PMID:24713849
affinity captured by	cbf11	CBF1/Su(H)/LAG-1 family transcription factor Cbf11	Affinity Capture-MS	PMID:22540037
affinity captured by	red1	RNA elimination defective protein Red1	Affinity Capture-MS	PMID:24713849
affinity captured by	cdc11	SIN component scaffold protein, centriolin ortholog Cdc11	Affinity Capture-Western	PMID:15062098
forms complex with	suc1	cyclin-dependent protein kinase regulatory subunit Suc1	Reconstituted Complex	PMID:2569363
forms complex with	rum1	CDK inhibitor Rum1	Reconstituted Complex	PMID:8598285
forms complex with	drc1	replication preinitiation complex assembly protein	Reconstituted Complex	PMID:11937031
co-fractionates with	cdc13	G2/M B-type cyclin Cdc13	Co-fractionation	PMID:2569363
binds activation domain construct with	orc2	origin recognition complex subunit Orc2	Two-hybrid	PMID:8552194
binds activation domain construct with	suc1	cyclin-dependent protein kinase regulatory subunit Suc1	Two-hybrid	PMID:26771498
binds activation domain construct with	cdc13	G2/M B-type cyclin Cdc13	Two-hybrid	PMID:26771498
binds activation domain construct with	sds23	PP2A-type phosphatase inhibitor Sds23/Moc1	Two-hybrid	PMID:9242669
binds activation domain construct with	pch1	P-TEFB associated cyclin, cyclin T Pch1	Two-hybrid	PMID:9115279
binds activation domain construct with	dis2	serine/threonine protein phosphatase PP1, Dis2	Two-hybrid	PMID:26771498
modifies	dis2	serine/threonine protein phosphatase PP1, Dis2	Biochemical Activity	PMID:16920624
modifies	bub1	mitotic spindle checkpoint kinase Bub1	Biochemical Activity	PMID:12606573
modifies	clp1	Cdc14-related protein phosphatase Clp1/Flp1	Biochemical Activity	PMID:22918952
modifies	cut3	condensin complex SMC subunit Smc4	Biochemical Activity	PMID:10485849
modifies	byr4	two-component GAP Byr4	Biochemical Activity	PMID:24920823
modifies	hcn1	anaphase-promoting complex subunit TPR lobe accessory factor Hcn1/Apc12	Biochemical Activity	PMID:16950791
modifies	crb2	DNA repair protein Rad9 homolog Crb2	Biochemical Activity	PMID:24074952
modifies	cdc18	MCM loader	Biochemical Activity	PMID:9436991
modifies	mde4	microtubule-site clamp monopolin complex subunit Mde4	Biochemical Activity	PMID:19523829
modifies	rum1	CDK inhibitor Rum1	Biochemical Activity	PMID:12167173
modifies	cdc13	G2/M B-type cyclin Cdc13	Biochemical Activity	PMID:2569363
modifies	alp7	centrosomal transforming acidic coiled-coil (TACC) protein ortholog Alp7	Biochemical Activity	PMID:24790093
modifies	orc2	origin recognition complex subunit Orc2	Biochemical Activity	PMID:11486016
modifies	fkh2	forkhead transcription factor Fkh2	Biochemical Activity	PMID:18059475
modifies	sds23	PP2A-type phosphatase inhibitor Sds23/Moc1	Biochemical Activity	PMID:9242669
modifies	mbx1	MADS-box transcription factor Mbx1	Biochemical Activity	PMID:21098641
modifies	nsk1	Clp1-interacting, microtubule plus-end binding Nsk1	Biochemical Activity	PMID:22065639
modifies	ase1	antiparallel microtubule cross-linking factor Ase1	Biochemical Activity	PMID:19686686
modifies	cdc25	M phase inducer tyrosine phosphatase Cdc25	Biochemical Activity	PMID:22665807
modifies	cut12	spindle pole body protein Cut12	Biochemical Activity	PMID:23333317
affinity captures	mus81	Holliday junction resolvase subunit Mus81	Affinity Capture-Western	PMID:24861625
affinity captures	cdc13	G2/M B-type cyclin Cdc13	Affinity Capture-Western	PMID:11683390
affinity captures	hhp1	serine/threonine protein kinase Hhp1	Affinity Capture-Western	PMID:24861625
affinity captures	rqh1	RecQ type DNA helicase Rqh1	Affinity Capture-Western	PMID:24861625
affinity captures	chk1	Chk1 protein kinase	Affinity Capture-Western	PMID:24861625
affinity captures	cdc18	MCM loader	Affinity Capture-RNA	PMID:22144913
affinity captures	gad8	AGC family protein kinase Gad8	Affinity Capture-Western	PMID:26912660
affinity captures	wos2	p23 homolog, predicted co-chaperone Wos2	Affinity Capture-Western	PMID:10581266
affinity captures	rum1	CDK inhibitor Rum1	Affinity Capture-RNA	PMID:22144913
affinity captures	spd1	ribonucleotide reductase (RNR) inhibitor	Affinity Capture-Western	PMID:8887552
affinity captures	rad16	DNA repair endonuclease XPF	Affinity Capture-Western	PMID:24861625
affinity captures	srs2	ATP-dependent DNA helicase, UvrD subfamily	Affinity Capture-Western	PMID:24861625
affinity captures	pku70	Ku domain protein Pku70	Affinity Capture-Western	PMID:24861625
affinity captures	pku80	Ku domain protein Pku80	Affinity Capture-Western	PMID:24861625
modified by	wee1	M phase inhibitor protein kinase Wee1	Biochemical Activity	PMID:1850698
modified by	mik1	mitotic inhibitor kinase Mik1	Biochemical Activity	PMID:7982971
modified by	pyp3	protein-tyrosine phosphatase Pyp3	Biochemical Activity	PMID:1464318
interacts with	suc1	cyclin-dependent protein kinase regulatory subunit Suc1	PCA	PMID:26771498

Genetic Interactions

Source: BioGRID

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	Gene	Product	Evidence	Reference
synthetically rescues	cdr1	NIM1 family serine/threonine protein kinase Cdr1/Nim1	Synthetic Rescue	PMID:2245912
synthetically rescues	cdr2	serine/threonine protein kinase Cdr2	Synthetic Rescue	PMID:2245912
synthetically rescues	pot1	telomere end-binding protein Pot1	Synthetic Rescue	PMID:26093291
synthetically rescues	rqh1	RecQ type DNA helicase Rqh1	Synthetic Rescue	PMID:26093291
synthetically rescues	cdc25	M phase inducer tyrosine phosphatase Cdc25	Synthetic Rescue	PMID:7217015
synthetically rescues	hhp1	serine/threonine protein kinase Hhp1	Synthetic Rescue	PMID:24861625
synthetically rescues	cdc6	DNA polymerase delta catalytic subunit Cdc6	Synthetic Rescue	PMID:9135148
synthetically rescues	wee1	M phase inhibitor protein kinase Wee1	Synthetic Rescue	PMID:24861625
synthetically rescues	cdc13	G2/M B-type cyclin Cdc13	Synthetic Rescue	PMID:3428262
synthetically rescues	srk1	MAPK-activated protein kinase Srk1	Synthetic Rescue	PMID:15629716
rescued by overexpression of	suc1	cyclin-dependent protein kinase regulatory subunit Suc1	Dosage Rescue	PMID:3322810
rescued by overexpression of	cdc13	G2/M B-type cyclin Cdc13	Dosage Rescue	PMID:11711540
rescued by overexpression of	pyp1	tyrosine phosphatase Pyp1	Dosage Rescue	PMID:9560390
rescued by overexpression of	sum3	translation initiation RNA helicase Sum3	Dosage Rescue	PMID:11711540
rescued by overexpression of	cid13	poly(A) polymerase Cid13	Dosage Rescue	PMID:12062100
rescued by overexpression of	hsp9	heat shock protein Hsp9	Dosage Rescue	PMID:22182414
rescued by overexpression of	chk1	Chk1 protein kinase	Dosage Rescue	PMID:8497322
rescued by overexpression of	sum1	translation initiation factor eIF3i	Dosage Rescue	PMID:9560390
rescued by overexpression of	mcs6	TFIIH associated cyclin-dependent protein kinase Mcs6	Dosage Rescue	PMID:8557037
rescued by overexpression of	wee1	M phase inhibitor protein kinase Wee1	Dosage Rescue	PMID:1427071
rescued by	suc1	cyclin-dependent protein kinase regulatory subunit Suc1	Phenotypic Suppression	PMID:3010051
rescued by	chk1	Chk1 protein kinase	Phenotypic Suppression	PMID:10637286
rescued by	cds1	replication checkpoint kinase Cds1	Phenotypic Suppression	PMID:24861625
rescued by	cdc25	M phase inducer tyrosine phosphatase Cdc25	Phenotypic Suppression	PMID:9013342
rescued by	spd1	ribonucleotide reductase (RNR) inhibitor	Phenotypic Suppression	PMID:8887552
rescued by	cut12	spindle pole body protein Cut12	Phenotypic Suppression	PMID:2245912
rescued by	cdc13	G2/M B-type cyclin Cdc13	Phenotypic Suppression	PMID:9790601
rescued by	mik1	mitotic inhibitor kinase Mik1	Phenotypic Suppression	PMID:10637286
rescued by	cmk2	MAPK-activated protein kinase Cmk2	Phenotypic Suppression	PMID:12135745
rescued by	SPAC29A4.02c	translation elongation factor EF-1 gamma subunit	Phenotypic Suppression	PMID:14985109
rescued by	clp1	Cdc14-related protein phosphatase Clp1/Flp1	Phenotypic Suppression	PMID:15128870
rescued by	wee1	M phase inhibitor protein kinase Wee1	Phenotypic Suppression	PMID:3032459
rescued by	wis1	MAP kinase kinase Wis1	Phenotypic Suppression	PMID:1756736
rescues	pyp2	tyrosine phosphatase Pyp2	Phenotypic Suppression	PMID:1448087
rescues	srw1	substrate-specific mitotic G1 APC coactivator Srw1/Ste9	Phenotypic Suppression	PMID:9398669
rescues	spo5	meiotic RNA-binding protein 1	Phenotypic Suppression	PMID:24506453
rescues	spo4	serine/threonine protein kinase Spo4	Phenotypic Suppression	PMID:23370392
rescues	fin1	serine/threonine protein kinase, NIMA related Fin1	Phenotypic Suppression	PMID:12065422
rescues	wis1	MAP kinase kinase Wis1	Phenotypic Suppression	PMID:1756736
rescues	clp1	Cdc14-related protein phosphatase Clp1/Flp1	Phenotypic Suppression	PMID:11683392
rescues	bgs1	primary septum and spore wall linear 1,3-beta-glucan synthase catalytic subunit Bgs1	Phenotypic Suppression	PMID:10704373
rescues	pyp1	tyrosine phosphatase Pyp1	Phenotypic Suppression	PMID:1448087
rescues	tor1	serine/threonine protein kinase Tor1	Phenotypic Suppression	PMID:19546237
rescues	rad4	BRCT domain protein Rad4	Phenotypic Suppression	PMID:7957098
rescues	cut1	separase/separin	Phenotypic Suppression	PMID:16453724
rescues	pab1	protein phosphatase PP2A regulatory subunit B-55 Pab1	Phenotypic Suppression	PMID:20876564
rescues	slp1	substrate-specific mitotic metaphase/anaphase APC coactivator Slp1	Phenotypic Suppression	PMID:9001228
rescues	cdc13	G2/M B-type cyclin Cdc13	Phenotypic Suppression	PMID:8631306
rescues	mcm4	MCM complex subunit Mcm4/Cdc21	Phenotypic Suppression	PMID:8631307
rescues	cdc25	M phase inducer tyrosine phosphatase Cdc25	Phenotypic Suppression	PMID:1934126
rescues	cdr1	NIM1 family serine/threonine protein kinase Cdr1/Nim1	Phenotypic Suppression	PMID:2004705
phenotype enhanced by	wos2	p23 homolog, predicted co-chaperone Wos2	Phenotypic Enhancement	PMID:10581266
phenotype enhanced by	swr1	SNF2 family ATP-dependent DNA helicase Swr1	Phenotypic Enhancement	PMID:9571240
phenotype enhanced by	wee1	M phase inhibitor protein kinase Wee1	Phenotypic Enhancement	PMID:9013342
phenotype enhanced by	hta2	histone H2A beta	Phenotypic Enhancement	PMID:16314498
phenotype enhanced by	cdc10	MBF transcription factor complex subunit Cdc10	Phenotypic Enhancement	PMID:11513869
phenotype enhanced by	rum1	CDK inhibitor Rum1	Phenotypic Enhancement	PMID:7593289
phenotype enhanced by	pmk1	MAP kinase Pmk1	Phenotypic Enhancement	PMID:22918952
phenotype enhanced by	hta1	histone H2A alpha	Phenotypic Enhancement	PMID:16314498
phenotype enhanced by	hsp90	Hsp90 chaperone	Phenotypic Enhancement	PMID:10102358
phenotype enhanced by	orc2	origin recognition complex subunit Orc2	Phenotypic Enhancement	PMID:8552194
synthetic lethal with	rad54	DNA-dependent ATPase Rad54/Rhp54	Synthetic Lethality	PMID:8834792
synthetic lethal with	res2	MBF transcription factor complex subunit Res2	Synthetic Lethality	PMID:2474475
synthetic lethal with	pop1	cullin 1 adaptor protein Pop1	Synthetic Lethality	PMID:9203581
synthetic lethal with	cdr2	serine/threonine protein kinase Cdr2	Synthetic Lethality	PMID:9843577
synthetic lethal with	mcs6	TFIIH associated cyclin-dependent protein kinase Mcs6	Synthetic Lethality	PMID:2474475
synthetic lethal with	mcs2	TFIIH complex cyclin Mcs2	Synthetic Lethality	PMID:2474475
synthetic lethal with	wee1	M phase inhibitor protein kinase Wee1	Synthetic Lethality	PMID:2474475
synthetic lethal with	clp1	Cdc14-related protein phosphatase Clp1/Flp1	Synthetic Lethality	PMID:16950131
synthetic lethal with	mcs4	response regulator Mcs4	Synthetic Lethality	PMID:2474475
enhances phenotype of	bgs1	primary septum and spore wall linear 1,3-beta-glucan synthase catalytic subunit Bgs1	Phenotypic Enhancement	PMID:10503548
enhances phenotype of	rad3	ATR checkpoint kinase Rad3	Phenotypic Enhancement	PMID:22918952
enhances phenotype of	cdc6	DNA polymerase delta catalytic subunit Cdc6	Phenotypic Enhancement	PMID:9154809
enhances phenotype of	pmk1	MAP kinase Pmk1	Phenotypic Enhancement	PMID:22918952
enhances phenotype of	orc1	origin recognition complex subunit Orc1	Phenotypic Enhancement	PMID:12186947
enhances phenotype of	hsp90	Hsp90 chaperone	Phenotypic Enhancement	PMID:22543982
enhances phenotype of	wee1	M phase inhibitor protein kinase Wee1	Phenotypic Enhancement	PMID:3116001
enhances phenotype of	cdr1	NIM1 family serine/threonine protein kinase Cdr1/Nim1	Phenotypic Enhancement	PMID:2004705
enhances phenotype of	sep1	forkhead transcription factor Sep1	Phenotypic Enhancement	PMID:9473044
enhances phenotype of	clp1	Cdc14-related protein phosphatase Clp1/Flp1	Phenotypic Enhancement	PMID:11683392
enhances phenotype of	cig2	G1/S-specific B-type cyclin Cig2	Phenotypic Enhancement	PMID:8455610
enhances phenotype of	cdc14	SIN component Cdc14	Phenotypic Enhancement	PMID:8334307
synthetic growth defect with	mcs6	TFIIH associated cyclin-dependent protein kinase Mcs6	Synthetic Growth Defect	PMID:2474475
synthetic growth defect with	dim1	U4/U6 x U5 tri-snRNP complex subunit Dim1	Synthetic Growth Defect	PMID:9182666
synthetic growth defect with	cdc25	M phase inducer tyrosine phosphatase Cdc25	Synthetic Growth Defect	PMID:20444100
synthetic growth defect with	srw1	substrate-specific mitotic G1 APC coactivator Srw1/Ste9	Synthetic Growth Defect	PMID:14985109
synthetic growth defect with	crb2	DNA repair protein Rad9 homolog Crb2	Synthetic Growth Defect	PMID:24861625
synthetic growth defect with	wee1	M phase inhibitor protein kinase Wee1	Synthetic Growth Defect	PMID:11029045
synthetic growth defect with	elp3	elongator complex subunit Elp3 (predicted)	Synthetic Growth Defect	PMID:22768388
synthetic growth defect with	blt1	ubiquitin domain-like protein Blt1	Synthetic Growth Defect	PMID:24790095
synthetic growth defect with	chk1	Chk1 protein kinase	Synthetic Growth Defect	PMID:24861625
synthetic growth defect with	ctu1	cytosolic thiouridylase subunit Ctu1	Synthetic Growth Defect	PMID:22768388
synthetic growth defect with	slp1	substrate-specific mitotic metaphase/anaphase APC coactivator Slp1	Synthetic Growth Defect	PMID:9001228
synthetic growth defect with	cdr2	serine/threonine protein kinase Cdr2	Synthetic Growth Defect	PMID:3448096
synthetic growth defect with	cdr1	NIM1 family serine/threonine protein kinase Cdr1/Nim1	Synthetic Growth Defect	PMID:3448096
negative genetic interaction with	ria1	GTPase Ria1 (predicted)	Negative Genetic	PMID:22681890
negative genetic interaction with	snf5	SWI/SNF complex subunit Snf5	Negative Genetic	PMID:22681890
synthetically rescued by	mik1	mitotic inhibitor kinase Mik1	Synthetic Rescue	PMID:24861625
synthetically rescued by	cut12	spindle pole body protein Cut12	Synthetic Rescue	PMID:23333317
synthetically rescued by	cdc25	M phase inducer tyrosine phosphatase Cdc25	Synthetic Rescue	PMID:24861625
synthetically rescued by	res2	MBF transcription factor complex subunit Res2	Synthetic Rescue	PMID:11029045
synthetically rescued by	clp1	Cdc14-related protein phosphatase Clp1/Flp1	Synthetic Rescue	PMID:23297348
synthetically rescued by	sty1	MAP kinase Sty1	Synthetic Rescue	PMID:9560390
synthetically rescued by	cig2	G1/S-specific B-type cyclin Cig2	Synthetic Rescue	PMID:8455610
overexpression lethal to	srw1	substrate-specific mitotic G1 APC coactivator Srw1/Ste9	Dosage Lethality	PMID:9398669
overexpression rescues	cdc37	Hsp90 co-chaperone Cdc37	Dosage Rescue	PMID:16390871
overexpression rescues	cdc13	G2/M B-type cyclin Cdc13	Dosage Rescue	PMID:2847913
overexpression rescues	cdc25	M phase inducer tyrosine phosphatase Cdc25	Dosage Rescue	PMID:3796591
inviable in presence of overexpressed	pyp3	protein-tyrosine phosphatase Pyp3	Dosage Lethality	PMID:1464318

External References

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Database	Identifier	Description
NBRP	SPBC11B10.09	Fission yeast strain database, National BioResource Project (Japan)
YOGY	SPBC11B10.09	Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid	SPBC11B10.09	BioGRID Interaction Datasets
Expression Viewer	SPBC11B10.09	Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer	SPBC11B10.09	Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer	SPBC11B10.09	Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer	SPBC11B10.09	Environmental stress expression profiles (Bähler Lab)
Pomb(A)	SPBC11B10.09	Polyadenylation Viewer (Gullerova lab)
pombeTV	SPBC11B10.09	Transcriptome Viewer (Bähler Lab)
GEO	SPBC11B10.09	GEO profiles
PInt	SPBC11B10.09	Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas	SPBC11B10.09	Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO	SPBC11B10.09	Fission yeast phenotypic data & analysis
Cyclebase	SPBC11B10.09.1	Cell Cycle Data
SPD / RIKEN	50/50D08	Orfeome Localization Data
UniProtKB/SwissProt	P04551	Cyclin-dependent kinase 1
ModBase	P04551	Database of comparative protein structure models
STRING	P04551	Network display of known and predicted interactions and functional associations
RefSeq Peptide	NP_595629	cyclin-dependent protein kinase Cdk1/Cdc2
RefSeq mRNA	NM_001021523	972h- cyclin-dependent protein kinase Cdk1/Cdc2 (cdc2), mRNA
European Nucleotide Archive	AAA35293.1	ENA Protein Mapping
European Nucleotide Archive	BAA21379.1	ENA Protein Mapping
European Nucleotide Archive	CAC37513.1	ENA Protein Mapping
UniParc	UPI00001273F9	UniProt Archive

Literature for cdc2

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Release Version: PomBase:30_62 - 30 Jan 2017

Term ID	Term Name	Evidence	Residue	Reference	Count
MOD:00046	O-phospho-L-serine				2293
MOD:00046		IDA		PMID:3058333	2293
MOD:00047	O-phospho-L-threonine				1087
	present during cellular response to thiabendazole	IDA	T167	PMID:18257517
	present during mitotic S phase	IDA	T167	PMID:1655416
		IDA	T167	PMID:26131711
		IDA		PMID:3058333
		IDA	T167	PMID:25720772
		IDA		PMID:1756737
		IDA	T14	PMID:26131711
		IDA	T14	PMID:25720772
MOD:00048	O4'-phospho-L-tyrosine				281
	added by mik1	IDA	Y15	PMID:7982971
	added by wee1	IDA	Y15	PMID:1372994
	added during premeiotic DNA replication	IDA		PMID:10888871
	added during mitotic G2 phase	IDA		PMID:1464318
	present during mitotic M phase	experimental evidence	Y15	PMID:21712547
	present during mitotic S phase	IDA	Y15	PMID:1655416
	present during cellular response to thiabendazole	IDA	Y15	PMID:18257517
	present during cellular response to nitrosative stress	IDA	Y15	PMID:22561704
	present during mitotic G2 phase absent during mitotic M phase	IDA	Y15	PMID:2682257
	present during meiosis I	IDA		PMID:10888871
	present during cellular response to hydroxyurea	IDA	Y15	PMID:10036242
	removed by cdc25	IDA		PMID:1756737
	removed during cellular response to caffeine	IDA	Y15	PMID:10036242
	removed during meiosis II	IDA		PMID:10888871
	absent during mitotic M phase	IDA		PMID:1464318
		IDA	Y15	PMID:25720772
		IDA	Y15	PMID:26131711
MOD:00696	phosphorylated residue				2515
	added during G0 to G1 transition	IDA		PMID:3516412
	added during cellular response to UV	IDA		PMID:12960401
	removed during cellular response to nitrogen starvation	IDA		PMID:3516412