cdc2 (SPBC11B10.09)


Gene Standard Namecdc2 Characterisation Statuspublished
Systematic IDSPBC11B10.09 Feature Typeprotein coding
Synonymscdk1, pi002, SPACTOKYO_453.34, swo2, tws1, wee2 Name DescriptionTWo Spored
Productcyclin-dependent protein kinase Cdk1/Cdc2 Product Size297aa, 34.36 kDa
Genomic Location Chromosome II, 1500197-1502095 (1899nt); CDS:1500340-1501528 (1189nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005524ATP bindingIEAUniProtKB-KW:KW-0067GO_REF:0000037559
GO:0008353RNA polymerase II carboxy-terminal domain kinase activityIEA EC:2.7.11.23GO_REF:00000035
GO:0097472cyclin-dependent protein kinase activityIDAPMID:33228108
GO:0004693cyclin-dependent protein serine/threonine kinase activityIGIcdc13PMID:25693637
GO:0005515protein bindingIPIcdc37PMID:16390871887
IPIcdc13PMID:16390871
GO:0004672protein kinase activityIDAPMID:1756737118
IMPPMID:1372994
has substrate cdc13IDAPMID:2569363
during mitotic metaphaseIDAPMID:2665944
during G2/M transition of mitotic cell cycleIDAPMID:2665944
has substrate rum1IDAPMID:11937031
GO:0004674protein serine/threonine kinase activity112
has substrate orc2IDAPMID:11486016
has substrate nsk1IDAPMID:22065639
has substrate klp9IDAPMID:19686686
has substrate ase1IDAPMID:19686686
has substrate hcn1IDAPMID:16950791
has substrate drc1IDAPMID:11937031
has substrate srw1IDAPMID:10921876
has substrate cut3IDAPMID:10485849
has substrate fkh2IDAPMID:18059475
has substrate sds23IDAPMID:9242669
has substrate cut7IDAPMID:9490630
has substrate dis2IDAPMID:7957097
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000086G2/M transition of mitotic cell cycleIMPPMID:26659443
GO:0006995cellular response to nitrogen starvationIMPPMID:1936672893
GO:0033314mitotic DNA replication checkpointTASPMID:835580722
GO:0007095mitotic G2 DNA damage checkpointTASPMID:154917912
GO:0070317negative regulation of G0 to G1 transitionIMPPMID:1936672826
GO:1902424negative regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregationIMPPMID:220656391
GO:0010515negative regulation of induction of conjugation with cellular fusionEXPPMID:1805947511
GO:1900087positive regulation of G1/S transition of mitotic cell cycleIMPPMID:72543525
GO:0010971positive regulation of G2/M transition of mitotic cell cycleIMPPMID:72543529
GO:0006468protein phosphorylationIDAPMID:3322810101
IDAPMID:1756737
IMPPMID:2569363
GO:0008361regulation of cell sizeNASGO_REF:00000016
GO:0007089traversing start control point of mitotic cell cycleNASGO_REF:00000015
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000307cyclin-dependent protein kinase holoenzyme complexIPIcdc13PMID:26822575
IDAPMID:3322810
GO:0005829cytosolIDAPMID:168233722317
GO:0005634nucleusIDAPMID:25345592730
except during cytokinesisIDAPMID:2569363
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000709decreased cell population growth during nitrogen starvationCell growth assaycdc2-974 (I35N)PECO:0000004, PECO:0000099PMID:1936672833
FYPO:0001128decreased septation indexMicroscopycdc2-33 (A177T)Not specifiedPMID:15633498
FYPO:0001974increased number of cells with 1C DNA contentFlow cytometry datacdc2-3w (C67Y)Not specifiedPECO:0000005PMID:88875528
Flow cytometry datacdc2-3w (C67Y)Not specifiedPECO:0000004PMID:8887552
FYPO:0002061inviable vegetative cell populationMicroscopycdc2ΔNullPMID:204732891309
Microscopycdc2ΔNullPECO:0000005, PECO:0000137PMID:23697806
Microscopycdc2ΔNullPMID:3796591
FYPO:0000963normal cell population growth on hydroxyureaCell growth assaycdc2-3w (C67Y)Not specifiedPMID:154917916
FYPO:0001420normal vegetative cell population growth rateCell growth assaytws1-N22 (E42K)Not specifiedPECO:0000201, PECO:0000103, PECO:0000005PMID:658115729
penetrance FYPO_EXT:0000001
FYPO:0000842sensitive to ethanolCell growth assaycdc2-M26 (P137S)Not specifiedPECO:0000005, PECO:0000137PMID:78453615
Cell growth assaycdc2-M56 (P137S)Not specifiedPECO:0000005, PECO:0000137PMID:7845361
FYPO:0000082sensitive to heatCell growth assaycdc2-974 (I35N)PECO:0000004, PECO:0000099PMID:1936672882
FYPO:0000088sensitive to hydroxyureaCell growth assaycdc2-3w (C67Y)Not specifiedPMID:1563349233

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001005DNA fragmentation during nitrogen starvationFlow cytometry datacdc2-974 (I35N)PECO:0000090, PECO:0000004PMID:1936672813
FYPO:0001933abnormal cell cycle regulation during cellular response to hydroxyureaCell growth assaycdc2-3w (C67Y)Not specifiedPECO:0000005PMID:15633495
FYPO:0000051abnormal meiosisMicroscopycdc2-N22 (E42K)EndogenousPMID:189601735
FYPO:0000059abnormal mitotic cell cycleMicroscopycdc2ΔNullPECO:0000005, PECO:0000137PMID:23697806564
FYPO:0000681abnormal sporulation resulting in formation of two-spore ascusMicroscopycdc2-59 (P248L)PECO:0000004PMID:19341267
Microscopytws1-N22 (E42K)Not specifiedPECO:0000015PMID:6581157
Microscopycdc2-33 (A177T)Not specifiedPECO:0000004PMID:3870979
Microscopycdc2-N22 (E42K)EndogenousPMID:1896017
FYPO:0000502abnormally arrested mitotic cell cycleMicroscopyVal167 (T167V)Not specifiedPMID:379659120
Cell growth assayArg33 (K33R)Not specifiedPMID:3796591
Cell growth assayAla167 (T167A)Not specifiedPMID:3796591
MicroscopyArg33 (K33R)Not specifiedPMID:3796591
MicroscopyVal177 (A177V)Not specifiedPMID:3796591
Cell growth assaycdc2ΔNullPMID:3796591
Microscopycdc2ΔNullPMID:3796591
MicroscopyAla167 (T167A)Not specifiedPMID:3796591
Cell growth assayVal167 (T167V)Not specifiedPMID:3796591
Cell growth assayVal177 (A177V)Not specifiedPMID:3796591
FYPO:0000705abolished protein bindingWestern blot assaycdc2-56 (G183E)EndogenousPMID:332281030
affecting suc1
affecting cdc2
FYPO:0001384abolished protein kinase activityEnzyme assay datacdc2-56 (G183E)Not specifiedPECO:0000004PMID:33228109
affecting cdc2
affecting cdc2Enzyme assay datacdc2-56 (G183E)Not specifiedPECO:0000005PMID:3322810
FYPO:0001269abolished protein localization to kinetochoreMicroscopycdc2 analogue u00c2u0093sensitive (analogue-sensitive)Not specifiedPMID:220656396
affecting nsk1
FYPO:0000446cell cycle arrest in mitotic G2 phaseMicroscopycdc2-33 (A177T)Not specifiedPECO:0000126, PECO:0000004PMID:146431822
FYPO:0001645decreased protein bindingWestern blot assaycdc2-L7 (P208S)EndogenousPMID:332281021
affecting suc1
affecting cdc2
affecting suc1Western blot assaycdc2-33 (A177T)Not specifiedPMID:2569363
affecting suc1Western blot assaycdc2-L7 (P208S)Not specifiedPMID:2569363
affecting suc1Western blot assaycdc2-56 (G183E)Not specifiedPMID:2569363
affecting cdc13Western blot assaycdc2-L7 (P208S)Not specifiedPMID:2569363
FYPO:0001382decreased protein kinase activityEnzyme assay datacdc2-M55Not specifiedPMID:332281010
affecting cdc2
affecting cdc2Enzyme assay datacdc2-L7 (P208S)Not specifiedPMID:2665944
affecting cdc2Enzyme assay datacdc2-L7 (P208S)Not specifiedPECO:0000004PMID:3322810
affecting cdc2Enzyme assay datacdc2-33 (A177T)Not specifiedPMID:2665944
FYPO:0001838decreased protein phosphorylation during vegetative growthEnzyme assay datacdc2-33 (A177T)Not specifiedPECO:0000005PMID:256936319
affecting orc2Western blot assaycdc2-L7 (P208S)Not specifiedPECO:0000004PMID:11486016
affecting orc2Western blot assaycdc2-33 (A177T)Not specifiedPECO:0000004PMID:11486016
affecting cdc13Enzyme assay datacdc2-33 (A177T)Not specifiedPECO:0000004PMID:2569363
affecting cdc13Enzyme assay datacdc2-56 (G183E)Not specifiedPECO:0000004PMID:2569363
affecting cdc13Enzyme assay datacdc2-L7 (P208S)Not specifiedPECO:0000004PMID:2569363
affecting cdc13Enzyme assay datacdc2-L7 (P208S)Not specifiedPECO:0000005PMID:2569363
FYPO:0002536delayed protein localization to nucleoplasm during cellular response to hydrogen peroxideMicroscopycdc2-F84G (F84G)EndogenousPECO:0000005, PECO:0000137, PECO:0000223PMID:229189524
FYPO:0000998elongated cell during nitrogen starvationMicroscopycdc2-974 (I35N)PECO:0000005, PECO:0000090PMID:1936672814
FYPO:0000314inviable after spore germination with elongated germ tubeMicroscopycdc2ΔNullPECO:0000005, PECO:0000137PMID:23697806162
penetrance FYPO_EXT:0000001
Microscopycdc2ΔNullPMID:3796591
FYPO:0000049inviable cellMicroscopycdc2-59 (P248L)EndogenousPMID:26746501356
FYPO:0000839inviable elongated mononucleate aseptate cellMicroscopycdc2-17 (G212S)Not specifiedPECO:0000004PMID:920357919
Microscopycdc2-M63 (G227C)EndogenousPECO:0000004PMID:7254352
Microscopycdc2-33 (A177T)EndogenousPECO:0000004PMID:7254352
FYPO:0001490inviable elongated vegetative cellMicroscopycdc2-33 (A177T)EndogenousPECO:0000004PMID:2674650368
Microscopycdc2-M35 (G43E)EndogenousPECO:0000004PMID:2674650
Microscopycdc2-M63 (G227C)EndogenousPECO:0000004PMID:2674650
Microscopycdc2-L7 (P208S)EndogenousPECO:0000004PMID:2674650
Microscopycdc2ΔNullPMID:3553962
Microscopycdc2-56 (G183E)EndogenousPECO:0000004PMID:2674650
Microscopycdc2-M26 (P137S)EndogenousPECO:0000004PMID:2674650
Microscopycdc2-45 (F210L)EndogenousPECO:0000004PMID:1896017
Microscopycdc2-17 (G212S)EndogenousPECO:0000004PMID:1896017
Microscopycdc2-48 (Y292H)EndogenousPECO:0000004PMID:1896017
Microscopycdc2-18 (L269S)EndogenousPECO:0000004PMID:1896017
FYPO:0000411normal cell cycleMicroscopyArg34 (K34R)Not specifiedPMID:379659124
Cell growth assayArg34 (K34R)Not specifiedPMID:3796591
FYPO:0001927normal cell cycle regulation during cellular response to ionizing radiationCell growth assaycdc2-3w (C67Y)Not specifiedPMID:15491798
FYPO:0002043normal premeiotic DNA replicationFlow cytometry datacdc2-33 (A177T)Not specifiedPECO:0000004PMID:38709793
FYPO:0000703normal protein bindingWestern blot assaycdc2-M56 (P137S)EndogenousPMID:332281018
affecting suc1
affecting cdc2
affecting suc1Western blot assaycdc2-M55EndogenousPMID:3322810
affecting cdc2
FYPO:0000838normal protein localization to nucleusMicroscopycdc2ΔNullPMID:256936324
affecting cdc13
FYPO:0000673normal septationMicroscopycdc2-3w (C67Y)Not specifiedPECO:0000137PMID:15491792
FYPO:0000590normal sporulationCell growth assaycdc2-3w (C67Y)PECO:0000004PMID:193412633
Cell growth assaycdc22-M45PECO:0000005PMID:1934126
FYPO:0002052normal sporulation frequencyCell growth assaytws1-N22 (E42K)Not specifiedPECO:0000015PMID:65811573
FYPO:0000997pear-shaped cell during nitrogen starvationMicroscopycdc2-974 (I35N)PECO:0000005, PECO:0000090PMID:193667286
FYPO:0003116sensitive to plumbaginCell growth assaycdc2+/cdc2- (heterozygous diploid)Not specifiedPMID:2302874211
FYPO:0000347swollen sporeMicroscopytws1-N22 (E42K)Not specifiedPMID:65811575
FYPO:0000648viable small vegetative cellMicroscopycdc2-1w (G146D)Not specifiedPECO:0000004PMID:67289828
Microscopycdc2-3w (C67Y)Not specifiedPECO:0000126, PECO:0000005PMID:1464318
Microscopycdc2-1w (G146D)EndogenousPMID:2674650
Microscopycdc2-3w (C67Y)Not specifiedPECO:0000005PMID:1756736
Microscopycdc2-3w (C67Y)Not specifiedPMID:8887552
Microscopycdc2-3w (C67Y)PECO:0000004PMID:8631307
Microscopycdc2.1wNot specifiedPECO:0000005PMID:1756736
Microscopycdc2-56 (G183E)EndogenousPECO:0000006PMID:2674650
Cell growth assaycdc2-1w (G146D)Not specifiedPMID:3796591
Microscopycdc2-1w (G146D)Not specifiedPMID:3796591
Microscopycdc2-3w (C67Y)EndogenousPMID:2674650
Target Of
RelationshipGeneProductReference
regulated by cdc13 G2/M B-type cyclin Cdc13 PMID:2569363
regulated by cdc25 M phase inducer phosphatase Cdc25 PMID:1756737
substrate of cdc25 M phase inducer phosphatase Cdc25 PMID:1756737
substrate of cdc25 M phase inducer phosphatase Cdc25 PMID:1819507
substrate of csk1 cyclin-dependent kinase activating kinase Csk1 PMID:10226032
substrate of mik1 mitotic inhibitor kinase Mik1 PMID:7982971
regulated by pim1 Ran GDP/GTP exchange factor PMID:1855255
substrate of pyp3 protein-tyrosine phosphatase Pyp3 PMID:1464318
binds spd1 ribonucleotide reductase (RNR) inhibitor PMID:8887552
binds suc1 cyclin-dependent protein kinase regulatory subunit Suc1 PMID:2569363
regulated by suc1 cyclin-dependent protein kinase regulatory subunit Suc1 PMID:2569363
regulated by suc1 cyclin-dependent protein kinase regulatory subunit Suc1 PMID:3322810
regulated by wee1 M phase inhibitor protein kinase Wee1 PMID:1372994
substrate of wee1 M phase inhibitor protein kinase Wee1 PMID:1372994
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
115001971500243
215002861500376
315004451500613
415006861500986
515010881501393
615014481502095

UTRs

Region Start End Reference
three_prime_UTR15015291502095PMID:21511999
five_prime_UTR15002861500339PMID:21511999
five_prime_UTR15001971500243PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00069 Pfam IPR000719 Protein kinase domain 4 293 109
SM00220 SMART IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain 4 293 73
PS50011 Prosite Profiles IPR000719 Protein kinase domain 4 293 110
PS00107 Prosite Patterns IPR017441 Protein kinase, ATP binding site 10 33 73
PS00108 Prosite Patterns IPR008271 Serine/threonine-protein kinase, active site 130 142 97
PTHR24056 HMMPANTHER 1 296 9
G3DSA:3.30.200.20 Gene3D 2 87 109
G3DSA:1.10.510.10 Gene3D 88 294 112
SSF56112 SuperFamily IPR011009 1 296 127

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0003657CDK family kinaseTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0003657

Protein Properties

Ave. residue weight 115.69 Da
Charge 4.50
Isoelectric point 7.68
Molecular weight 34.36 kDa
Number of residues 297
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00048O4'-phospho-L-tyrosineIDAPMID:17567374
removed_by cdc25
not_during mitotic M phaseIDAPMID:1464318
during mitotic G2 phaseIDAPMID:1464318
added_by mik1IDAY15PMID:7982971
added_by wee1IDAY15PMID:1372994
MOD:00046O-phospho-L-serineIDAPMID:305833312
MOD:00047O-phospho-L-threonineIDAPMID:305833312
IDAPMID:1756737
MOD:00696phosphorylated residueY15PMID:90428631192
added_by wee1Y15PMID:2682257
PMID:18257517
PMID:19547744
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
protein levelpresentWestern blot evidencePMID:2569363
during GO:0072690
unchangedWestern blot evidencePMID:1899230
during GO:0072734

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2704.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
5406.86during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.8during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.52during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReferenceCount
functionally complemented by H. sapiens CDK1full PMID:3553962 PMID:19442831
full
does not functionally complement S. cerevisiae CDC28 PMID:37965911
functionally complemented by G. gallus cdc2full PMID:15004411
functionally complements S. cerevisiae CDC28 when introns removedfull PMID:37965911
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
res2MBF transcription factor complex subunit Res2 Synthetic RescuePMID:11029045
Synthetic LethalityPMID:2474475
rad4BRCT domain protein Rad4 Phenotypic SuppressionPMID:7957098
wis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:1756736
dim1U4/U6 x U5 tri-snRNP complex subunit Dim1 Synthetic Growth DefectPMID:9182666
sum3translation initiation RNA helicase Sum3 Dosage RescuePMID:11711540
Dosage RescuePMID:9832516
hta1histone H2A alpha Phenotypic EnhancementPMID:16314498
spd1ribonucleotide reductase (RNR) inhibitor Phenotypic SuppressionPMID:8887552
SPCC553.08cGTPase Ria1 (predicted) Negative GeneticPMID:22681890
slp1sleepy homolog Slp1 Phenotypic SuppressionPMID:9001228
Synthetic Growth Defect
cmk2MAPK-activated protein kinase Cmk2 Phenotypic SuppressionPMID:12135745
cdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic Growth DefectPMID:3448096
Phenotypic EnhancementPMID:2004705
Synthetic RescuePMID:2245912
pyp1tyrosine phosphatase Pyp1 Phenotypic SuppressionPMID:1448087
Dosage RescuePMID:9560390
SPAC29A4.02ctranslation elongation factor EF-1 gamma subunit Phenotypic SuppressionPMID:14985109
cdr2serine/threonine protein kinase Cdr2 Synthetic Growth DefectPMID:3448096
Synthetic LethalityPMID:9843577
Synthetic RescuePMID:2245912
tor1phosphatidylinositol kinase Tor1 Phenotypic SuppressionPMID:19546237
mik1mitotic inhibitor kinase Mik1 Phenotypic SuppressionPMID:10637286
ctu1cytosolic thiouridylase subunit Ctu1 Synthetic Growth DefectPMID:22768388
wee1M phase inhibitor protein kinase Wee1 Phenotypic EnhancementPMID:3116001
Synthetic Growth DefectPMID:11029045
Phenotypic EnhancementPMID:9013342
Synthetic LethalityPMID:9188094
Synthetic LethalityPMID:2474475
elp3elongator complex, histone acetyltransferase subunit Elp3 (predicted) Synthetic Growth DefectPMID:22768388
clp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic RescuePMID:23297348
Synthetic LethalityPMID:16950131
Phenotypic EnhancementPMID:11683392
Phenotypic Suppression
cig2G1/S-specific B-type cyclin Cig2 Synthetic LethalityPMID:8455610
pmk1MAP kinase Pmk1 Phenotypic EnhancementPMID:22918952
rum1CDK inhibitor Rum1 Phenotypic EnhancementPMID:7593289
hta2histone H2A beta Phenotypic EnhancementPMID:16314498
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
sty1MAP kinase Sty1 Synthetic RescuePMID:9560390
sum1translation initiation factor eIF3i Dosage RescuePMID:9560390
chk1Chk1 protein kinase Dosage RescuePMID:8497322
Phenotypic SuppressionPMID:10637286
Dosage RescuePMID:11711540
rad3ATR checkpoint kinase Rad3 Phenotypic EnhancementPMID:22918952
swr1SNF2 family helicase Swr1 Phenotypic EnhancementPMID:9571240
cdc25M phase inducer phosphatase Cdc25 Synthetic RescuePMID:2245912
Phenotypic SuppressionPMID:3796591
Phenotypic SuppressionPMID:9013342
Phenotypic SuppressionPMID:1934126
Synthetic Growth DefectPMID:20444100
Synthetic RescuePMID:7217015
suc1cyclin-dependent protein kinase regulatory subunit Suc1 Phenotypic SuppressionPMID:3010051
Dosage RescuePMID:3322810
Phenotypic SuppressionPMID:9790601
Dosage RescuePMID:2665944
Phenotypic SuppressionPMID:16453733
Dosage RescuePMID:1896017
rad54DNA-dependent ATPase Rad54/Rhp54 Synthetic LethalityPMID:8834792
fin1serine/threonine protein kinase, NIMA related Fin1 Phenotypic SuppressionPMID:12065422
hsp9heat shock protein Hsp9 Dosage RescuePMID:22182414
mcs4response regulator Mcs4 Synthetic LethalityPMID:2474475
orc1origin recognition complex subunit Orc1 Phenotypic EnhancementPMID:12186947
cdc6DNA polymerase delta catalytic subunit Cdc6 Phenotypic EnhancementPMID:9154809
Synthetic RescuePMID:9135148
srw1CDK inhibitor Srw1 Synthetic Growth DefectPMID:14985109
Phenotypic Suppression
Phenotypic SuppressionPMID:9398669
Dosage Lethality
bgs11,3-beta-glucan synthase catalytic subunit Bgs1 Phenotypic SuppressionPMID:10704373
Phenotypic EnhancementPMID:10503548
pab1protein phosphatase regulatory subunit Pab1 Phenotypic SuppressionPMID:20876564
cut12spindle pole body protein Cut12 Synthetic RescuePMID:23333317
Phenotypic SuppressionPMID:2245912
pop1cullin 1 adaptor protein Pop1 Synthetic LethalityPMID:9203581
pyp2tyrosine phosphatase Pyp2 Phenotypic SuppressionPMID:1448087
cdc37Hsp90 co-chaperone Cdc37 Dosage RescuePMID:16390871
spo4serine/threonine protein kinase Spo4 Phenotypic SuppressionPMID:23370392
cut1separase/separin Phenotypic SuppressionPMID:16453724
cdc10MBF transcription factor complex subunit Cdc10 Phenotypic EnhancementPMID:11513869
cid13poly(A) polymerase Cid13 Dosage RescuePMID:12062100
mcs2TFIIH complex cyclin Mcs2 Synthetic LethalityPMID:2474475
orc2origin recognition complex subunit Orc2 Phenotypic EnhancementPMID:8552194
hsp90Hsp90 chaperone Phenotypic EnhancementPMID:22543982
Phenotypic EnhancementPMID:10102358
pyp3protein-tyrosine phosphatase Pyp3 Dosage LethalityPMID:1464318
cdc13G2/M B-type cyclin Cdc13 Dosage RescuePMID:1533272
Phenotypic SuppressionPMID:1829983
Phenotypic SuppressionPMID:9790601
Dosage RescuePMID:11711540
Dosage RescuePMID:2847913
Dosage RescuePMID:7909513
Phenotypic SuppressionPMID:1934126
Phenotypic SuppressionPMID:3428262
sep1forkhead transcription factor Sep1 Phenotypic EnhancementPMID:9473044
mcs6cyclin-dependent protein kinase/CDK-activating kinase Mcs6 Synthetic LethalityPMID:2474475
Synthetic Growth Defect
Dosage RescuePMID:8557037
wos2p23 homolog, predicted co-chaperone Wos2 Phenotypic EnhancementPMID:10581266
mcm4MCM complex subunit Mcm4/Cdc21 Phenotypic SuppressionPMID:8631307
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
ase1antiparallel microtubule cross-linking factor Ase1 Biochemical ActivityPMID:19686686
cig2G1/S-specific B-type cyclin Cig2 Affinity Capture-WesternPMID:11163211
hsp90Hsp90 chaperone Affinity Capture-WesternPMID:22543982
spd1ribonucleotide reductase (RNR) inhibitor Affinity Capture-WesternPMID:8887552
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Two-hybridPMID:9242669
Biochemical Activity
mik1mitotic inhibitor kinase Mik1 Biochemical ActivityPMID:7982971
cdc25M phase inducer phosphatase Cdc25 Biochemical ActivityPMID:22665807
cdc11SIN component scaffold protein, centriolin ortholog Cdc11 Affinity Capture-WesternPMID:15062098
clp1Cdc14-related protein phosphatase Clp1/Flp1 Biochemical ActivityPMID:16950131
Biochemical ActivityPMID:22918952
pch1P-TEFB associated cyclin, cyclin T Pch1 Affinity Capture-WesternPMID:9115279
Two-hybrid
rum1CDK inhibitor Rum1 Biochemical ActivityPMID:10679013
Reconstituted ComplexPMID:9303310
Biochemical Activity
Biochemical ActivityPMID:12167173
Affinity Capture-RNAPMID:22144913
Affinity Capture-WesternPMID:11329175
mbx1MADS-box transcription factor Mbx1 Biochemical ActivityPMID:21098641
hcn1anaphase-promoting complex subunit Hcn1 Biochemical ActivityPMID:16950791
cdc18MCM loader Affinity Capture-RNAPMID:22144913
Biochemical ActivityPMID:9436991
Affinity Capture-Western
Biochemical ActivityPMID:9177184
mde4monopolin-like complex subunit Mde4 Biochemical ActivityPMID:19523829
cut3condensin complex subunit Cut3 Biochemical ActivityPMID:10485849
bub1serine/threonine protein kinase Bub1 Biochemical ActivityPMID:12606573
wee1M phase inhibitor protein kinase Wee1 Biochemical ActivityPMID:7982971
Biochemical ActivityPMID:1850698
Biochemical ActivityPMID:1372994
suc1cyclin-dependent protein kinase regulatory subunit Suc1 Affinity Capture-WesternPMID:3322810
Reconstituted ComplexPMID:2665944
Co-fractionationPMID:2569363
Affinity Capture-WesternPMID:9790601
crb2DNA repair protein Rad9 homolog, Rhp9 Biochemical ActivityPMID:24074952
Biochemical ActivityPMID:10488332
pas1cyclin Pas1 Affinity Capture-WesternPMID:10982385
skb1type II protein arginine N-methyltransferase Skb1 Affinity Capture-WesternPMID:9843966
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
drc1DNA replication checkpoint protein Drc1 Reconstituted ComplexPMID:11937031
cut12spindle pole body protein Cut12 Biochemical ActivityPMID:23333317
dis2serine/threonine protein phosphatase PP1 Biochemical ActivityPMID:16920624
Biochemical ActivityPMID:7957097
fkh2forkhead transcription factor Fkh2 Biochemical ActivityPMID:18059475
bgs11,3-beta-glucan synthase catalytic subunit Bgs1 Affinity Capture-WesternPMID:11937031
cdc37Hsp90 co-chaperone Cdc37 Affinity Capture-WesternPMID:16390871
wos2p23 homolog, predicted co-chaperone Wos2 Affinity Capture-WesternPMID:10581266
nsk1Clp1-interacting protein Nsk1 Affinity Capture-WesternPMID:22065639
Biochemical Activity
pyp3protein-tyrosine phosphatase Pyp3 Biochemical ActivityPMID:1464318
cdc13G2/M B-type cyclin Cdc13 Affinity Capture-WesternPMID:9632761
Co-fractionationPMID:2569363
Biochemical Activity
Affinity Capture-WesternPMID:9790601
Affinity Capture-WesternPMID:10581266
Affinity Capture-WesternPMID:11683390
Affinity Capture-WesternPMID:16390871
Affinity Capture-WesternPMID:11329175
orc2origin recognition complex subunit Orc2 Affinity Capture-WesternPMID:8552194
Two-hybrid
Biochemical ActivityPMID:11486016
shk1PAK-related kinase Shk1 Affinity Capture-WesternPMID:9843966
External References
Database Identifier Description
NBRP SPBC11B10.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC11B10.09 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC11B10.09 BioGRID Interaction Datasets
Expression Viewer SPBC11B10.09 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC11B10.09 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC11B10.09 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC11B10.09 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC11B10.09 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC11B10.09 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC11B10.09 Cell Cycle Data
GEO SPBC11B10.09 GEO profiles
PInt SPBC11B10.09 Protein-Protein Interaction Predictor (Bähler Lab)
EntrezGene2539869cyclin-dependent protein kinase Cdc2
WikiGene2539869cyclin-dependent protein kinase Cdc2
SPD / RIKEN50/50D08Orfeome Localization Data
UniProtKB/SwissProtP04551Cyclin-dependent kinase 1
ModBaseP04551Database of comparative protein structure models
StringP04551Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595629cyclin-dependent protein kinase Cdc2
RefSeq mRNANM_001021523972h- cyclin-dependent protein kinase Cdc2 (cdc2), mRNA
European Nucleotide ArchiveAAA35293ENA Protein Mapping
European Nucleotide ArchiveBAA21379ENA Protein Mapping
European Nucleotide ArchiveCAC37513ENA Protein Mapping
UniParcUPI00001273F9UniProt Archive

Literature for cdc2

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014