cdc2 (SPBC11B10.09)


Gene Standard Namecdc2 Characterisation Statuspublished
Systematic IDSPBC11B10.09 Feature Typeprotein coding
Synonymscdk1, pi002, SPACTOKYO_453.34, swo2, tws1, wee2 Name DescriptionTWo Spored,
Cell Division Cycle
Productcyclin-dependent protein kinase Cdk1/Cdc2 Product Size297aa, 34.36 kDa
Genomic Location Chromosome II, 1500197-1502095 (1899nt); CDS:1500340-1501528 (1189nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATP binding551
Annotation ExtensionEvidenceWith/FromReference
cyclin-dependent protein kinase activity6
Annotation ExtensionEvidenceWith/FromReference
cyclin-dependent protein serine/threonine kinase activity5
protein binding900
Annotation ExtensionEvidenceWith/FromReference
protein kinase activity114
Annotation ExtensionEvidenceWith/FromReference
protein serine/threonine kinase activity105
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
correction of merotelic kinetochore attachment, mitotic5
Annotation ExtensionEvidenceWith/FromReference
negative regulation of anaphase-promoting complex-dependent catabolic process1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of attachment of mitotic spindle microtubules to kinetochore1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of conjugation with cellular fusion25
Annotation ExtensionEvidenceWith/FromReference
negative regulation of double-strand break repair via nonhomologous end joining1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of exit from mitosis1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of mitotic DNA replication initiation4
Annotation ExtensionEvidenceWith/FromReference
negative regulation of mitotic spindle elongation1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of mitotic telomere tethering at nuclear periphery1
Annotation ExtensionEvidenceWith/FromReference
positive regulation of double-strand break repair via homologous recombination2
Annotation ExtensionEvidenceWith/FromReference
positive regulation of G1/S transition of mitotic cell cycle4
Annotation ExtensionEvidenceWith/FromReference
positive regulation of G2/M transition of mitotic cell cycle20
Annotation ExtensionEvidenceWith/FromReference
positive regulation of mitotic cell cycle DNA replication3
Annotation ExtensionEvidenceWith/FromReference
positive regulation of mitotic chromosome condensation2
Annotation ExtensionEvidenceWith/FromReference
positive regulation of mitotic metaphase/anaphase transition57
Annotation ExtensionEvidenceWith/FromReference
positive regulation of septation initiation signaling7
Annotation ExtensionEvidenceWith/FromReference
regulation of cell size15
Annotation ExtensionEvidenceWith/FromReference
regulation of G2/M transition of mitotic cell cycle73
Annotation ExtensionEvidenceWith/FromReference
regulation of meiotic cell cycle51
Annotation ExtensionEvidenceWith/FromReference
response to intra-S DNA damage checkpoint signaling4
Annotation ExtensionEvidenceWith/FromReference
response to mitotic DNA integrity checkpoint signaling1
Annotation ExtensionEvidenceWith/FromReference
response to mitotic G2 DNA damage checkpoint signaling1
Annotation ExtensionEvidenceWith/FromReference
signal transduction involved in mitotic G2 DNA damage checkpoint2
Annotation ExtensionEvidenceWith/FromReference
traversing start control point of mitotic cell cycle4
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
chromosome, centromeric region137
Annotation ExtensionEvidenceWith/FromReference
cyclin-dependent protein kinase holoenzyme complex11
Annotation ExtensionEvidenceWith/FromReference
cytoplasm4212
cytosol2298
Annotation ExtensionEvidenceWith/FromReference
meiotic spindle pole body24
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle95
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle midzone24
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle pole body211
nuclear chromatin364
Annotation ExtensionEvidenceWith/FromReference
nucleus2690
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
abnormal mitotic cell cycle arrest with unreplicated DNAcdc2-DL5 (A48V)58
decreased cell population growth at low temperaturecdc2-r4 (D90N)96
decreased septation indexcdc2-33 (A177T)23
decreased vegetative cell population growthCdc2-F15 (T15F)745
increased frequency of apoptosiscdc2-Y15F (Y15F)15
increased number of cells with 1C DNA contentcdc2-DL50 (240 -242)66
cdc2-3w (C67Y)
inviable vegetative cell populationcdc2-3w (C67Y)1468
cdc2-4w (G200T)
cdc2-r4 (D90N)
cdc2Δ
loss of viability upon nitrogen starvationcdc2-974 (I35N)52
normal growth during cellular response to UVcdc2-1w (G146D)81
normal growth on arsenatecdc2-3w (C67Y)4
normal growth on hydroxyureacdc2-1w (G146D)76
normal septation indexcdc2-3w (C67Y)11
normal sporulation frequencytws1-N22 (E42K)14
normal vegetative cell population growthcdc2-1w (G146D)846
normal vegetative cell population growth ratetws1-N22 (E42K)85
sensitive to caffeine during vegetative growthcdc2-33 (A177T)110
sensitive to camptothecincdc2-1w (G146D)259
sensitive to ethanolcdc2-M56 (P137S)5
cdc2-M26 (P137S)
sensitive to hydroxyureacdc2-3w (C67Y)595
sensitive to methyl methanesulfonatecdc2-Y15F (Y15F)333
sensitive to plumbagincdc2+/cdc2- (heterozygous diploid)12
viable vegetative cell populationcdc2-1w (G146D)3862

Cell Phenotype

Term NameGenotypesCount
abnormal cell cycle arrest in mitotic metaphasecdc2-DL41 (P162L)20
abnormal chromosome segregationcdc2-DL5 (A48V)326
abnormal meiosiscdc2-N22 (E42K)134
abnormal mitotic cell cyclecdc2Δ903
abnormal mitotic cell cycle arrest with condensed chromosomescdc2-DL41 (P162L)10
abnormal mitotic cell cycle arrest with condensed chromosomes, septated cellcdc2-DL41 (P162L)3
abnormal mitotic cell cycle arrest with replicated DNAcdc2-DL5 (A48V)57
cdc2-L7 (P208S)
cdc2-DL41 (P162L)
cdc2-33 (A177T)
abnormal mitotic cell cycle regulation during cellular response to hydroxyureacdc2-DL50 (240 -242)15
cdc2-3w (C67Y)
cdc2+
abnormal mitotic sister chromatid separationCdc2-F15 (T15F)53
abnormal negative regulation of DNA replication initiation resulting in complete rereplication, with mitotic cell cycle arrestcdc2-DL41 (P162L)1
abnormal protein phosphorylation during vegetative growth175
affecting cdc2cdc2-1w (G146D)
abnormal septationcdc2-DL41 (P162L)300
abnormal sporulation resulting in formation of two-spore ascuscdc2-N22 (E42K)14
cdc2-33 (A177T)
cdc2-59 (P248L, C67Y)
tws1-N22 (E42K)
abnormally arrested mitotic cell cycle progressionAla167 (T167A)179
cdc2-33 (A177T)
Val177 (A177V)
Val167 (T167V)
Arg33 (K33R)
cdc2Δ
abolished meiosiscdc2-M26 (P137S)20
abolished meiosis Icdc2-M26 (P137S)3
abolished meiosis IIcdc2-33 (A177T)5
cdc2-7
abolished premeiotic DNA replicationY15F (Y15F)15
cdc2-M26 (P137S)
cdc2-33 (A177T)
cdc2-M63 (G227C)
abolished protein kinase activity29
affecting activity of cdc2cdc2-DL2 (E215K)
affecting cdc2cdc2-56 (G183E)
abolished protein localization to kinetochore during vegetative growth22
affects localization of nsk1cdc2-as (F84G)
abolished protein phosphorylation during vegetative growth55
affecting srw1cdc2-33 (A177T)
affecting mde4cdc2-as (F84G)
abolished protein tyrosine phosphorylation during vegetative growth5
affecting cdc2Cdc2-F15 (T15F)
abolished protein-protein interaction164
affecting cdc2 and suc1cdc2-56 (G183E)
abolished re-entry into mitotic cell cycle after pheromone arrestcdc2-M26 (P137S)1
cut during cellular response to hydroxyureacdc2-4w (G200T)44
cdc2-3w (C67Y)
decreased arsenate reductase activitycdc2-3w (C67Y)2
decreased cyclin B1-CDK1 complex level2
affecting cdc2 and cdc13cdc2-DL2 (E215K)
decreased protein kinase activitycdc2-L7 (P208S)56
cdc2-A21 (D90N)
cdc2-M35 (G43E)
affecting activity of cdc2cdc2-DL5 (A48V)
affecting activity of cdc2cdc2-DL41 (P162L)
affecting activity of cdc2cdc2-DL45 (P162S)
affecting cdc2cdc2-M55
affecting cdc2cdc2-L7 (P208S)
affecting cdc2cdc2-33 (A177T)
affecting cdc2cdc2-M35 (G43E)
affecting cdc2cdc2-56 (G183E)
decreased protein localization to chromatin at replication origin10
affects localization of cdc13cdc2-33 (A177T)
decreased protein phosphorylation during mitotic G2 phase3
affecting srw1cdc2-M26 (P137S)
decreased protein phosphorylation during vegetative growthcdc2-as (F84G)105
cdc2-33 (A177T)
affecting pol1cdc2-33 (A177T)
affecting cdc13cdc2-L7 (P208S)
affecting cdc13cdc2-56 (G183E)
affecting cdc13cdc2-33 (A177T)
affecting orc2cdc2-33 (A177T)
affecting orc2cdc2-L7 (P208S)
decreased protein serine phosphorylation during vegetative growth19
affecting fkh2cdc2-ts
affecting rap1cdc2-33 (A177T)
decreased protein threonine phosphorylation during vegetative growth9
affecting activity of cdc2cdc2-DL2 (E215K)
affecting fkh2cdc2-ts
affecting rap1cdc2-33 (A177T)
decreased protein-protein interaction109
affecting cdc2 and suc1cdc2-33 (A177T)
affecting cdc2 and suc1cdc2-L7 (P208S)
affecting cdc2 and suc1cdc2-56 (G183E)
affecting cdc2 and cdc13cdc2-L7 (P208S)
decreased response to S-phase DNA damage checkpoint signalingcdc2-Y15F (Y15F)2
delayed onset of premeiotic DNA replicationY15F (Y15F)3
delayed onset of protein localization to nucleoplasm during cellular response to hydrogen peroxidecdc2-as (F84G)4
elongated cell during nitrogen starvationcdc2-974 (I35N)25
fragmented DNA during nitrogen starvationcdc2-974 (I35N)13
increased cellular reactive oxygen species level during vegetative growthcdc2-Y15F (Y15F)33
increased mRNA splicing, via spliceosome2
affecting cdc2cdc2-I2mut (TTGACG287ACACAT)
increased protein kinase activity20
affecting activity of cdc2cdc2+
increased protein level146
affecting cdc25cdc2-33 (A177T)
increased RNA splicing at cryptic splice sites4
affecting cdc2cdc2-I2mut (TTGACG287ACACAT)
inviable after spore germination with elongated germ tubecdc2Δ164
inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cellscdc2-59 (P248L, C67Y)88
inviable after spore germination, without cell division, with elongated germ tubecdc2Δ66
inviable elongated mononucleate aseptate cellcdc2-M63 (G227C)44
cdc2-E9 (D242N)
cdc2-E8 (D213N)
cdc2-17 (G212S)
cdc2-33 (A177T)
cdc2-
inviable elongated mononucleate aseptate vegetative cell with cell cycle arrest in mitotic G2 phasecdc2-A21 (D90N)7
inviable elongated mononucleate vegetative cellcdc2-DL5 (A48V)55
inviable elongated septated mononucleate vegetative cellcdc2-DL5 (A48V)1
inviable elongated vegetative cellcdc2-17 (G212S)440
cdc2-M26 (P137S)
cdc2-18 (L269S)
cdc2-56 (G183E)
cdc2-33 (A177T)
cdc2-48 (Y292H)
cdc2-L7 (P208S)
cdc2Δ
cdc2-45 (F210L)
cdc2-M35 (G43E)
cdc2-M63 (G227C)
inviable vegetative cellL248 (P248L)1377
mitotic catastrophe with cut, small cellCdc2-F15 (T15F)1
mitotic G1/S transition delaycdc2-L7 (P208S)14
cdc2-33 (A177T)
mitotic spindle elongation without chromosome separationcdc2-DL41 (P162L)13
normal cell cycle regulation during cellular response to hydroxyureacdc2-1w (G146D)20
cdc2-DL45 (P162S)
normal cell cycle regulation during cellular response to ionizing radiationcdc2-3w (C67Y)17
normal interphase cytoplasmic microtubulescdc2-3w (C67Y)9
normal mitotic cell cycleArg34 (K34R)137
normal mitotic spindlecdc2-3w (C67Y)19
normal premeiotic DNA replicationcdc2-33 (A177T)25
normal protein kinase activity25
affecting activity of cdc2cdc2+
affecting cdc2cdc2-56 (G183E)
normal protein localization to chromatin at replication origin6
affecting mrc1cdc2-33 (A177T)
normal protein localization to nucleus during vegetative growth85
affecting cdc13cdc2Δ
normal protein phosphorylation during nitrogen starvation10
affecting ssp2cdc2-1w (G146D)
normal protein phosphorylation during vegetative growth97
affecting srw1cdc2-33 (A177T)
affecting pol1cdc2-33 (A177T)
normal protein tyrosine phosphorylation during vegetative growthcdc2-1w (G146D)8
affecting cdc2cdc2-F19 (Y19F)
affecting cdc2cdc2-3w (C67Y)
normal protein-protein interaction107
affecting cdc2 and suc1cdc2-M55
affecting cdc2 and suc1cdc2-M56 (P137S)
normal regulation of mitotic cell cyclecdc2-59 (P248L, C67Y)66
normal sporulationcdc2-3w (C67Y)54
normal telomere lengthcdc2-3w (C67Y)35
normal vegetative cell growthcdc2-F19 (Y19F)12
normal vegetative cell lengthcdc2-33 (A177T)10
premature mitosiscdc2-DL50 (240 -242)7
premature protein localization to mitotic spindle2
affects localization of mde4cdc2-as (F84G)
protein mislocalized to nucleus during meiosis I1
affects localization of rna1tws1-N22 (E42K)
septated vegetative cellCdc2-F15 (T15F)199
septation following abnormal chromosome segregation, with binucleate and anucleate compartment formation during cellular response to hydroxyureacdc2-3w (C67Y)4
cdc2-4w (G200T)
small vegetative cellcdc2+90
Cdc2-F15 (T15F)
cdc2-DL50 (240 -242)
swollen sporetws1-N22 (E42K)5
viable elongated vegetative cellcdc2-M35 (G43E)329
cdc2-M63 (G227C)
viable elongated vegetative cell, elongated upon mitotic entrycdc2-33 (A177T)13
viable small vegetative cellcdc2-3w (C67Y)56
cdc2Δ
cdc2-Y15F (Y15F)
cdc2-130
cdc2-56 (G183E)
cdc2-4w (G200T)
cdc2-1w (G146D)
cdc2-3w (C67Y)
viable vegetative cellCdc2-F15 (T15F)3680
viable vegetative cell with normal cell sizecdc2+5

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
abnormal mitotic cell cycle arrest with unreplicated DNAcdc2-Y15F (Y15F), cdc10-V50 (H362Y)
abolished cell population growth at high temperaturecdc2-3w (C67Y), wee1-50
decreased cell population growth on glucose carbon sourcemcs6-13 (L238R), cdc2-3w (C67Y)
decreased conjugation frequencysrw1::ura4, cdc2-M35 (G43E)
decreased vegetative cell population growthslx8-29, cdc2-1w (G146D)
cdc2-4w (G200T), wee1-50
skb1Δ, cdc25Δ, cdc2-3w (C67Y)
increased septation indexcdc2-M63 (G227C), T167E (T167E)
inviable vegetative cell populationcdc2-3w (C67Y), wee1-50
cdc2-3w (C67Y), cdc25-22 (C532Y), dis2+
cdc17-K42 (E298K), cdc2-3w (C67Y)
cdc2-3w (C67Y), wis1Δ, wee1-50
mcs2-75, cdc2-3w (C67Y)
mcs2-75, cdc25-22 (C532Y), cdc2-3w (C67Y)
cdc2-M63 (G227C), T167E (T167E)
cdc22-M45, cdc2-3w (C67Y)
cdc2-33 (A177T), pop1-364
cdc2-1w (G146D), cdc25::ura4
cdc20-M10, cdc2-3w (C67Y)
cdc2-3w (C67Y), sty1Δ, wee1-50
cdc25-22 (C532Y), cdc2-1w (G146D), dis2+
normal vegetative cell population growthskb1Δ, cdc2-3w (C67Y)
sensitive to arsenatecdc25Δ, cdc2-3w (C67Y)
sensitive to camptothecincdc2-1w (G146D), wee1Δ
sensitive to hydroxyureacdc2-1w (G146D), wee1Δ
slx8-29, cdc2-1w (G146D)
sensitive to UV during vegetative growthcdc2-1w (G146D), wee1Δ
slow vegetative cell population growthE167 (T167E), cdc2-33 (A177T)
cdc2-DL41 (P162L), suc1+
viable vegetative cell populationmcs2-75, cdc2-3w (C67Y), cdc25-22 (C532Y), csk1+
cdc2-3w (C67Y), cdc25::ura4
wee1+ (wild type), cdc2-3w (C67Y)
cdc2-3w (C67Y), cdc25-22 (C532Y), dis2+
cdc25-22 (C532Y), cdc2-1w (G146D), dis2+
cdc2+, wee1-50, mcs4-13, cdc25-22 (C532Y)
cdc25-22 (C532Y), cdc2-3w (C67Y), mcs6+, mcs2-75
cdc2-3w (C67Y), mcs4Δ, wee1-50
cdc2-3w (C67Y), srk1+
cdc25Δ, Cdc2-F15 (T15F)
cdc25-22 (C532Y), Cdc2-F15 (T15F)
mcs2-75, cdc2-3w (C67Y)
cdc2-3w (C67Y), mcs2-75, mcs6::ura4+

Cell Phenotype

Term NameGenotypes
abnormal mitosiscdc2-33 (A177T), cdc2-DL45 (P162S)
cdc2-DL41 (P162L), cdc2-33 (A177T)
abnormal mitotic cell cycle arrest with replicated DNAA167 (T167A), cdc2-L7 (P208S)
abnormal mitotic cell cycle regulation during cellular response to hydroxyureacdc2-3w (C67Y), cdc25Δ
cdc20-M10, cdc2-3w (C67Y)
cdc2-1w (G146D), cut5-T401
cdc17-K42 (E298K), cdc2-3w (C67Y)
cdc2-3w (C67Y), cut5-T401
cdc22-M45, cdc2-3w (C67Y)
abnormal mitotic sister chromatid segregationE167 (T167E), cdc2::huCDC2 (gene replacement)
abnormal protein phosphorylation during vegetative growth
affecting cdc2cdc2-1w (G146D), mik1Δ
affecting cdc2cdc2-1w (G146D), wee1Δ
affecting cdc2cdc2-1w (G146D), cdc13-245 (E255R)
abnormal sporulation resulting in formation of ascus with more than four sporescig2Δ, puc1Δ, rem1Δ, cdc2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cig1Δ, cdc13Δ
abnormal sporulation resulting in formation of two-spore ascuscdc2-1w (G146D), cdc25-22 (C532Y)
cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc13Δ, cdc2Δ
cdc2Δ, cig2Δ, cig1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), puc1Δ, cdc13Δ
cdc2-M26 (P137S), suc1-210
abnormally arrested mitotic cell cycle progressionpyp3+, cdc2-33 (A177T)
abolished activation of bipolar cell growthorb2-34, cdc2-33 (A177T)
abolished mitotic G2 DNA damage checkpointchk1+ (wild type), cdc25Δ, cdc2-3w (C67Y)
cdc25Δ, cdc2-3w (C67Y)
abolished protein kinase activity
affecting cdc2A167,F15 (T167A, Y15F), cdc2::huCDC2 (gene replacement)
affecting cdc2A167 (T167A), cdc2::huCDC2 (gene replacement)
affecting cdc2E167 (T167E), cdc2::huCDC2 (gene replacement)
affecting cdc2 (Y15F, T167E), cdc2::huCDC2 (gene replacement)
affecting cdc2cdc2-M63 (G227C), T167E (T167E)
abolished protein localization to nucleoplasm during cellular response to hydrogen peroxide
affects localization of clp1pmk1Δ, rad3Δ, cdc2-as (F84G)
affects localization of clp1cdc2-as (F84G), pmk1Δ
affects localization of clp1cdc2-as (F84G), rad3Δ
abolished protein localization to nucleoplasm during cellular response to hydroxyurea
affects localization of clp1pmk1Δ, rad3Δ, cdc2-as (F84G)
abolished protein phosphorylation
affecting cdc2A167,F15 (T167A, Y15F), cdc2::huCDC2 (gene replacement)
abolished protein serine phosphorylation at RxxS site during cellular response to hydrogen peroxide
affecting clp1pmk1Δ, rad3Δ, cdc2-as (F84G)
abolished protein serine phosphorylation at RxxS site during cellular response to hydroxyurea
affecting clp1pmk1Δ, rad3Δ, cdc2-as (F84G)
abolished protein threonine phosphorylation
affecting cdc2Y167 (T167Y), cdc2::huCDC2 (gene replacement)
affecting cdc2A167 (T167A), cdc2::huCDC2 (gene replacement)
affecting cdc2E167 (T167E), cdc2::huCDC2 (gene replacement)
altered DNA level during vegetative growthcdc2-3w (C67Y), wee1-50
cell cycle arrest at mitotic G1/S phase transitioncdc2+, cdc13+, cdc10-129 (T429A)
cell cycle arrest in mitotic G2 phasecdc25-22 (C532Y), cdc2-DL45 (P162S)
cdc2-DL2 (E215K), cdc2+
cutorp1-4, cdc2-1w (G146D)
cdc2-3w (C67Y), orp1-4
cut during cellular response to hydroxyureawee1+ (wild type), cdc2-3w (C67Y)
cdc2-3w (C67Y), cdc25Δ
decreased protein kinase activitycdc2-E8 (D213N), wee1-50
decreased protein level during vegetative growth
affecting cdc2cdc2Δ, cdc2 (wild type)
decreased protein phosphorylation during vegetative growth
affecting cut9cdc2-M63 (G227C), T167E (T167E)
decreased protein threonine phosphorylation at Thr-Pro site during cellular response to hydrogen peroxide
affecting clp1pmk1Δ, rad3Δ, cdc2-as (F84G)
decreased protein threonine phosphorylation at Thr-Pro site during cellular response to hydroxyurea
affecting clp1pmk1Δ, rad3Δ, cdc2-as (F84G)
decreased protein-protein interaction
affecting cdc2 and cdc13A167 (T167A), cdc2::huCDC2 (gene replacement)
decreased response to S-phase DNA damage checkpoint signalingcdc2-Y15F (Y15F), cdc10-V50 (H362Y)
delayed onset of protein localization to nucleoplasm during cellular response to hydrogen peroxide
affects localization of clp1cdc2-as (F84G), rad3Δ
delayed onset of protein localization to nucleoplasm during cellular response to hydroxyurea
affects localization of clp1cdc2-as (F84G), pmk1Δ
DNA content increased during vegetative growthE167 (T167E), cdc2-33 (A177T)
elongated mononucleate vegetative cellcdc10-129 (T429A), cdc2-3w (C67Y)
cdc2-33 (A177T), cut5-T401
elongated multinucleate multiseptate vegetative cell, single septa between nucleiE167 (T167E), cdc2-33 (A177T)
elongated multiseptate vegetative cellmcs6-13 (L238R), cdc2-3w (C67Y)
elongated vegetative cellmcs2-75, cdc2-3w (C67Y)
cdc2-3w (C67Y), mcs2-75, wee1-50
cdc2-3w (C67Y), mcs6-13 (L238R), wee1-50
increased duration of mitotic M phasecdc21-M68, cdc2-3w (C67Y)
inviable after spore germination, multiple cell divisionsmcs4-13, cdc2-59 (P248L, C67Y)
cdc2-59 (P248L, C67Y), mcs2-75
mcs1-77, cdc2-59 (P248L, C67Y)
cdc2-59 (P248L, C67Y), mcs6-13 (L238R)
inviable after spore germination, without cell division, elongated cellcdc2-1w (G146D), cdc25::ura4
inviable cellcdc2-33 (A177T), cdc2-DL5 (A48V)
cdc2Δ, cdc2-DL5 (A48V)
inviable curved elongated vegetative celltea1-3, cdc2-33 (A177T)
inviable elongated aseptate cellatf1+, cdc2-33 (A177T)
inviable elongated mononucleate aseptate cellcdc2-E8 (D213N), wee1-50
D167 (T167D), cdc2-33 (A177T)
Y167 (T167Y), cdc2-33 (A177T)
cdc2-, cut1-
cdc2-33 (A177T), orb5-19
A167,F15 (T167A, Y15F), cdc2-33 (A177T)
A167 (T167A), cdc2-33 (A177T)
cdc2-DL2 (E215K), cdc2+
cdc2-33 (A177T), orb3-167
inviable elongated multiseptate vegetative cellmcs6-13 (L238R), mcs4-13, cdc2-3w (C67Y)
inviable elongated vegetative cellmcs2-75, cdc2-3w (C67Y)
inviable septated mononucleate vegetative cellcdc2-3w (C67Y), wee1-50
inviable small vegetative cellcdc17-K42 (E298K), cdc2-3w (C67Y)
cdc20-M10, cdc2-3w (C67Y)
cdc22-M45, cdc2-3w (C67Y)
inviable sporecig2Δ, puc1Δ, rem1Δ, cdc2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cig1Δ, cdc13Δ
cdc2Δ, cig2Δ, cig1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), puc1Δ, cdc13Δ
cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc13Δ, cdc2Δ
inviable vegetative cellcdc2-M63 (G227C), T167E (T167E)
large and small daughter nucleicdc2-3w (C67Y), wee1-50
lemon-shaped cellorb6-25, cdc2-33 (A177T)
mitosis with unreplicated DNAcdc2-3w (C67Y), cdc25Δ
mitotic catastrophepyp3+, cdc2-3w (C67Y)
mitotic catastrophe with cut, small cellcdc2+, cdc13+, cdc10-129 (T429A)
cdc2-3w (C67Y), wee1-50
mitotic G1/S transition delayA167 (T167A), cdc2-L7 (P208S)
mitotic G2/M transition delaycdc2-3w (C67Y), pcn1+
multiple mitotic spindlesE167 (T167E), cdc2-33 (A177T)
normal actin cortical patch localizationcdc2-33 (A177T), orb5-19
normal actin cytoskeleton morphology during vegetative growthcdc2-33 (A177T), orb3-167
normal cell cycle regulation during cellular response to hydroxyureawee1+ (wild type), cdc2-3w (C67Y)
cdc2-3w (C67Y), cdc10-129 (T429A)
cdc2-33 (A177T), cut5-T401
normal meiosiscig2Δ, puc1Δ, rem1Δ, cdc2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cig1Δ, cdc13Δ
cig2Δ, cig1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), puc1Δ, rem1Δ
cdc2Δ, cig2Δ, cig1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), puc1Δ, cdc13Δ
normal meiosis Icdc2Δ, cig2Δ, cig1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), puc1Δ, cdc13Δ
normal microtubule cytoskeleton morphology during vegetative growthcdc2-33 (A177T), orb3-167
normal mitotic cell cyclecdc2+, cdc2-DL45 (P162S)
cdc2-DL41 (P162L), cdc2-33 (A177T)
cdc2-33 (A177T), cdc2-DL45 (P162S)
cdc2-DL41 (P162L), cdc2+
normal protein level during mitotic metaphase
affecting cdc13cdc2-M63 (G227C), T167E (T167E)
normal protein localization to chromatin at replication origin
affecting mcm4cdc13+, cdc2-33 (A177T)
normal protein tyrosine phosphorylation during vegetative growth
affecting cdc2Y167 (T167Y), cdc2::huCDC2 (gene replacement)
affecting cdc2E167 (T167E), cdc2::huCDC2 (gene replacement)
affecting cdc2A167 (T167A), cdc2::huCDC2 (gene replacement)
normal protein-protein interaction
affecting cdc2 and suc1E167 (T167E), cdc2::huCDC2 (gene replacement)
affecting cdc2 and cdc13E167 (T167E), cdc2::huCDC2 (gene replacement)
normal vegetative cell growthcdc2-M26 (P137S), suc1-210
cdc2-M55, suc1-449
suc1-210, cdc2-33 (A177T)
cdc2-56 (G183E), suc1-449
cdc2-33 (A177T), suc1-449
cdc2-M26 (P137S), suc1-449
cdc2-L7 (P208S), suc1-449
cdc2-M55, suc1-210
suc1-210, cdc2-56 (G183E)
suc1-210, cdc2-L7 (P208S)
normal vegetative cell sizecdc2-3w (C67Y), mcs2-75, mcs6::ura4+
premature mitosiscdc2-33 (A177T), cdc2-DL50 (240 -242)
septation following abnormal chromosome segregation, with binucleate and anucleate compartment formation during cellular response to hydroxyureacdc20-M10, cdc2-3w (C67Y)
cdc22-M45, cdc2-3w (C67Y)
cdc17-K42 (E298K), cdc2-3w (C67Y)
small vegetative cellcdc2-1w (G146D), mcs2-75
sterilesrw1::ura4, cdc2-M35 (G43E)
viable cell at high temperaturecdc2-E8 (D213N), cdc25+ (wild type), wee1-50
cdc2-A21 (D90N), cdc25+ (wild type), wee1-50
cdc2-E9 (D242N), cdc25+ (wild type), wee1-50
viable elongated vegetative cellcdc2-3w (C67Y), cdc25::ura4
cdc25Δ, tor1Δ, cdc2-3w (C67Y)
cdc2-M72, cdc2+
win1-1, cdc25-22 (C532Y), cdc2-3w (C67Y)
wee1+ (wild type), cdc2-3w (C67Y)
cdc2Δ, cdc2 (wild type)
cdc2-33 (A177T), cdr1-76
cdc2+, cdc2-M55
cdc2+, cdc2-M76
cdc2-L7 (P208S), cdc2+
cdc2-M35 (G43E), cdc2+
cdc2-M63 (G227C), cdc2+
cdc2-M26 (P137S), cdc2+
cdc2-56 (G183E), cdc2+
cdc2-33 (A177T), cdc2+
cdc2+, cdc2-130
cdc2-3w (C67Y), cdc25-22 (C532Y)
skb1Δ, cdc25Δ, cdc2-3w (C67Y)
cdc25Δ, shk1+, cdc2-3w (C67Y)
cdr2-97, cdc2-33 (A177T)
viable elongated vegetative cell, elongated upon mitotic entrychk1+ (wild type), cdc2-3w (C67Y)
chk1+ (wild type), cdc25Δ, cdc2-3w (C67Y)
viable small vegetative cellCdc2-F15 (T15F), cdc25-22 (C532Y)
cdc2-3w (C67Y), win1-1
cdc2-3w (C67Y), mcs4-13, wee1-50
cdc25Δ, Cdc2-F15 (T15F)
cdc2-3w (C67Y), mcs1-77, wee1-50
cdc2+, cdc2-130
cdc2-Y15F (Y15F), tor1Δ
dnt1Δ, cdc2-1w (G146D)
cdc2-56 (G183E), cdc2+
cdc2-1w (G146D), cdc2+
viable vegetative cellE167 (T167E), cdc2-33 (A177T)
cdc2+, cdc13+, cdc2-DL2 (E215K)
viable vegetative cell with normal cell sizewin1-1, cdc2-3w (C67Y)
cdc2+, cdc2-33 (A177T)
cdc2-M63 (G227C), T167E (T167E)
cdc25-22 (C532Y), cdc2-3w (C67Y)
S167 (T167S), cdc2-33 (A177T)