cdc2 (SPBC11B10.09)


Gene Standard Namecdc2 Characterisation Statuspublished
Systematic IDSPBC11B10.09 Feature Typeprotein coding
Synonymscdk1, pi002, SPACTOKYO_453.34, swo2, tws1, wee2 Name DescriptionTWo Spored,
Cell Division Cycle
Productcyclin-dependent protein kinase Cdk1/Cdc2 Product Size297aa, 34.36 kDa
Genomic Location Chromosome II, 1500197-1502095 (1899nt); CDS:1500340-1501528 (1189nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATP binding559
Annotation ExtensionEvidenceWith/FromReference
cyclin-dependent protein kinase activity6
Annotation ExtensionEvidenceWith/FromReference
cyclin-dependent protein serine/threonine kinase activity5
Annotation ExtensionEvidenceWith/FromReference
protein binding863
Annotation ExtensionEvidenceWith/FromReference
protein kinase activity115
Annotation ExtensionEvidenceWith/FromReference
protein serine/threonine kinase activity105
protein serine/threonine phosphatase inhibitor activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
negative regulation of APC-fizzy related complex activity1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of conjugation with cellular fusion24
Annotation ExtensionEvidenceWith/FromReference
negative regulation of double-strand break repair via nonhomologous end joining1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of G0 to G1 transition23
Annotation ExtensionEvidenceWith/FromReference
negative regulation of mitotic attachment of spindle microtubules to kinetochore1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of mitotic telomere tethering at nuclear periphery1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of phosphoprotein phosphatase activity1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of protein dephosphorylation2
Annotation ExtensionEvidenceWith/FromReference
peptidyl-serine phosphorylation28
Annotation ExtensionEvidenceWith/FromReference
peptidyl-threonine phosphorylation18
Annotation ExtensionEvidenceWith/FromReference
positive regulation of G1/S transition of mitotic cell cycle5
Annotation ExtensionEvidenceWith/FromReference
positive regulation of G2/M transition of mitotic cell cycle17
Annotation ExtensionEvidenceWith/FromReference
positive regulation of septation initiation signaling7
Annotation ExtensionEvidenceWith/FromReference
protein phosphorylation130
Annotation ExtensionEvidenceWith/FromReference
regulation of cell size10
Annotation ExtensionEvidenceWith/FromReference
regulation of meiotic cell cycle39
Annotation ExtensionEvidenceWith/FromReference
response to intra-S DNA damage checkpoint signaling4
Annotation ExtensionEvidenceWith/FromReference
response to mitotic DNA integrity checkpoint signaling1
Annotation ExtensionEvidenceWith/FromReference
traversing start control point of mitotic cell cycle5
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cyclin-dependent protein kinase holoenzyme complex11
Annotation ExtensionEvidenceWith/FromReference
cytosol2306
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle midzone19
Annotation ExtensionEvidenceWith/FromReference
nuclear chromatin358
Annotation ExtensionEvidenceWith/FromReference
nucleus2692
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
decreased cell population growth at low temperaturecdc2-r4 (D90N)87
decreased septation indexcdc2-33 (A177T)21
increased frequency of apoptosiscdc2-Y15F (Y15F)11
increased number of cells with 1C DNA contentcdc2-3w (C67Y)39
inviable vegetative cell populationcdc2-3w (C67Y)1453
cdc2-4w (G200T)
cdc2Δ
loss of viability upon nitrogen starvationcdc2-974 (I35N)53
normal growth on arsenatecdc2-3w (C67Y)4
normal septation indexcdc2-3w (C67Y)11
normal sporulation frequencytws1-N22 (E42K)13
normal vegetative cell population growth ratetws1-N22 (E42K)78
sensitive to caffeine during vegetative growthcdc2-33 (A177T)110
sensitive to ethanolcdc2-M56 (P137S)5
cdc2-M26 (P137S)
sensitive to hydroxyureacdc2-3w (C67Y)548
sensitive to methyl methanesulfonatecdc2-Y15F (Y15F)255
sensitive to plumbagincdc2+/cdc2- (heterozygous diploid)12
viable vegetative cell populationcdc2-1w (G146D)3837

Cell Phenotype

Term NameGenotypesCount
abnormal meiosiscdc2-N22 (E42K)121
abnormal mitotic cell cyclecdc2Δ858
abnormal mitotic cell cycle regulation during cellular response to hydroxyureacdc2-3w (C67Y)13
abnormal sporulation resulting in formation of two-spore ascuscdc2-33 (A177T)13
tws1-N22 (E42K)
cdc2-N22 (E42K)
cdc2-59 (P248L, C67Y)
abnormally arrested mitotic cell cycle progressioncdc2Δ158
Arg33 (K33R)
Ala167 (T167A)
cdc2-33 (A177T)
Val167 (T167V)
Val177 (A177V)
abolished meiosiscdc2-M26 (P137S)18
abolished meiosis Icdc2-M26 (P137S)3
abolished meiosis IIcdc2-33 (A177T)3
cdc2-7
abolished premeiotic DNA replicationcdc2-M26 (P137S)15
cdc2-33 (A177T)
Y15F (Y15F)
cdc2-M63 (G227C)
abolished protein binding124
affecting cdc2 and suc1cdc2-56 (G183E)
abolished protein kinase activity26
affecting cdc2cdc2-56 (G183E)
abolished protein localization to kinetochore during vegetative growth22
affects localization of nsk1cdc2-as (F84G)
abolished protein phosphorylation during vegetative growth50
affecting srw1cdc2-33 (A177T)
affecting mde4cdc2-as (F84G)
abolished re-entry into mitotic cell cycle after pheromone arrestcdc2-M26 (P137S)1
cut during cellular response to hydroxyureacdc2-4w (G200T)44
cdc2-3w (C67Y)
decreased arsenate reductase activitycdc2-3w (C67Y)2
decreased protein binding88
affecting cdc2 and suc1cdc2-33 (A177T)
affecting cdc2 and suc1cdc2-L7 (P208S)
affecting cdc2 and suc1cdc2-56 (G183E)
affecting cdc2 and cdc13cdc2-L7 (P208S)
decreased protein kinase activitycdc2-L7 (P208S)55
cdc2-A21 (D90N)
cdc2-M35 (G43E)
affecting cdc2cdc2-L7 (P208S)
affecting cdc2cdc2-33 (A177T)
affecting cdc2cdc2-56 (G183E)
affecting cdc2cdc2-M35 (G43E)
affecting cdc2cdc2-M55
decreased protein localization to chromatin at replication origin10
affects localization of cdc13cdc2-33 (A177T)
decreased protein phosphorylation during mitotic G2 phase3
affecting srw1cdc2-M26 (P137S)
decreased protein phosphorylation during vegetative growthcdc2-as (F84G)96
cdc2-33 (A177T)
affecting cdc13cdc2-56 (G183E)
affecting cdc13cdc2-33 (A177T)
affecting cdc13cdc2-L7 (P208S)
affecting orc2cdc2-33 (A177T)
affecting orc2cdc2-L7 (P208S)
decreased protein serine phosphorylation during vegetative growth19
affecting fkh2cdc2-ts
affecting rap1cdc2-33 (A177T)
decreased protein threonine phosphorylation9
affecting fkh2cdc2-ts
affecting rap1cdc2-33 (A177T)
decreased response to S-phase DNA damage checkpoint signalingcdc2-Y15F (Y15F)2
delayed onset of premeiotic DNA replicationY15F (Y15F)2
delayed onset of protein localization to nucleoplasm during cellular response to hydrogen peroxidecdc2-as (F84G)4
elongated cell during nitrogen starvationcdc2-974 (I35N)21
fragmented DNA during nitrogen starvationcdc2-974 (I35N)13
increased cellular reactive oxygen species level during vegetative growthcdc2-Y15F (Y15F)27
increased mRNA splicing, via spliceosome1
affecting cdc2cdc2-I2mut (TTGACG287ACACAT)
increased RNA splicing at cryptic splice sites4
affecting cdc2cdc2-I2mut (TTGACG287ACACAT)
inviable after spore germination with elongated germ tubecdc2Δ164
inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cellscdc2-59 (P248L, C67Y)88
inviable after spore germination, without cell division, with elongated germ tubecdc2Δ66
inviable elongated mononucleate aseptate cellcdc2-17 (G212S)40
cdc2-M63 (G227C)
cdc2-33 (A177T)
cdc2-E8 (D213N)
cdc2-E9 (D242N)
inviable elongated mononucleate aseptate vegetative cell with cell cycle arrest in mitotic G2 phasecdc2-A21 (D90N)4
inviable elongated vegetative cellcdc2-M63 (G227C)416
cdc2-33 (A177T)
cdc2-45 (F210L)
cdc2-48 (Y292H)
cdc2-17 (G212S)
cdc2-56 (G183E)
cdc2Δ
cdc2-L7 (P208S)
cdc2-M26 (P137S)
cdc2-M35 (G43E)
cdc2-18 (L269S)
inviable vegetative cellL248 (P248L)1351
mitotic G1/S transition delaycdc2-33 (A177T)13
normal cell cycle regulation during cellular response to hydroxyureacdc2-1w (G146D)18
normal cell cycle regulation during cellular response to ionizing radiationcdc2-3w (C67Y)12
normal interphase cytoplasmic microtubulescdc2-3w (C67Y)8
normal mitotic cell cycleArg34 (K34R)111
normal mitotic spindlecdc2-3w (C67Y)16
normal premeiotic DNA replicationcdc2-33 (A177T)24
normal protein binding73
affecting cdc2 and suc1cdc2-M56 (P137S)
affecting cdc2 and suc1cdc2-M55
normal protein kinase activity20
affecting cdc2cdc2-56 (G183E)
normal protein localization to chromatin at replication origin5
affecting mrc1cdc2-33 (A177T)
normal protein localization to nucleus76
affecting cdc13cdc2Δ
normal protein phosphorylation during nitrogen starvation9
affecting ssp2cdc2-1w (G146D)
normal protein phosphorylation during vegetative growth73
affecting srw1cdc2-33 (A177T)
normal regulation of mitotic cell cyclecdc2-59 (P248L, C67Y)58
normal sporulationcdc2-3w (C67Y)52
normal telomere lengthcdc2-3w (C67Y)25
normal vegetative cell lengthcdc2-33 (A177T)7
premature protein localization to mitotic spindle2
affects localization of mde4cdc2-as (F84G)
protein mislocalized to nucleus during meiosis I1
affects localization of rna1tws1-N22 (E42K)
septation following abnormal chromosome segregation, with binucleate and anucleate compartment formation during cellular response to hydroxyureacdc2-3w (C67Y)4
cdc2-4w (G200T)
swollen sporetws1-N22 (E42K)5
viable elongated vegetative cell, elongated upon mitotic entrycdc2-33 (A177T)10
viable small vegetative cellcdc2-Y15F (Y15F)51
cdc2-3w (C67Y)
cdc2-56 (G183E)
cdc2-3w (C67Y)
cdc2-1w (G146D)
cdc2-4w (G200T)

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
abolished cell population growth at high temperaturewee1-50, cdc2-3w (C67Y)
decreased cell population growth on glucose carbon sourcemcs6-13 (L238R), cdc2-3w (C67Y)
decreased vegetative cell population growthcdc25Δ, skb1Δ, cdc2-3w (C67Y)
inviable vegetative cell populationcdc2-3w (C67Y), mcs2-75, cdc25-22 (C532Y)
cdc22-M45, cdc2-3w (C67Y)
wee1-50, sty1Δ, cdc2-3w (C67Y)
wee1-50, wis1Δ, cdc2-3w (C67Y)
cdc2-3w (C67Y), dis2+, cdc25-22 (C532Y)
cdc25::ura4, cdc2-1w (G146D)
cdc2-33 (A177T), pop1-364
cdc20-M10, cdc2-3w (C67Y)
cdc25-22 (C532Y), cdc2-3w (C67Y), mcs2-75
wee1-50, cdc2-3w (C67Y)
dis2+, cdc2-1w (G146D), cdc25-22 (C532Y)
cdc17-K42 (E298K), cdc2-3w (C67Y)
normal vegetative cell population growthskb1Δ, cdc2-3w (C67Y)
sensitive to arsenatecdc25Δ, cdc2-3w (C67Y)
viable vegetative cell populationdis2+, cdc2-1w (G146D), cdc25-22 (C532Y)
cdc2-3w (C67Y), mcs2-75, cdc25-22 (C532Y), mcs6+
cdc2-3w (C67Y), mcs2-75, cdc25-22 (C532Y), csk1+
cdc2+, cdc25-22 (C532Y), mcs4-13, wee1-50
srk1+, cdc2-3w (C67Y)
wee1+ (wild type), cdc2-3w (C67Y)
wee1-50, mcs4Δ, cdc2-3w (C67Y)
cdc2-3w (C67Y), dis2+, cdc25-22 (C532Y)
cdc25::ura4, cdc2-3w (C67Y)

Cell Phenotype

Term NameGenotypes
abnormal mitotic cell cycle arrest with unreplicated DNAcdc2-Y15F (Y15F), cdc10-V50 (H362Y)
abnormal mitotic cell cycle regulation during cellular response to hydroxyureacdc17-K42 (E298K), cdc2-3w (C67Y)
cut5-T401, cdc2-3w (C67Y)
cdc20-M10, cdc2-3w (C67Y)
cdc25Δ, cdc2-3w (C67Y)
cdc22-M45, cdc2-3w (C67Y)
cdc2-1w (G146D), cut5-T401
abnormal sporulation resulting in formation of ascus with more than four sporescig2Δ, cig1Δ, puc1Δ, cdc13Δ, rem1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cdc2Δ
abnormal sporulation resulting in formation of two-spore ascuscdc2-1w (G146D), cdc25-22 (C532Y)
cdc2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc13Δ, cig2Δ, puc1Δ, cig1Δ
cdc13Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc2Δ
cdc2-M26 (P137S), suc1-210
abnormally arrested mitotic cell cycle progressioncdc2-33 (A177T), pyp3+
abolished protein localization to nucleoplasm during cellular response to hydrogen peroxide
affects localization of clp1cdc2-as (F84G), pmk1Δ
affects localization of clp1rad3Δ, cdc2-as (F84G), pmk1Δ
affects localization of clp1cdc2-as (F84G), rad3Δ
abolished protein localization to nucleoplasm during cellular response to hydroxyurea
affects localization of clp1rad3Δ, cdc2-as (F84G), pmk1Δ
abolished protein serine phosphorylation at RxxS site during cellular response to hydrogen peroxide
affecting clp1rad3Δ, cdc2-as (F84G), pmk1Δ
abolished protein serine phosphorylation at RxxS site during cellular response to hydroxyurea
affecting clp1rad3Δ, pmk1Δ, cdc2-as (F84G)
altered DNA level during vegetative growthwee1-50, cdc2-3w (C67Y)
cutorp1-4, cdc2-1w (G146D)
cdc2-3w (C67Y), orp1-4
cut during cellular response to hydroxyureacdc25Δ, cdc2-3w (C67Y)
wee1+ (wild type), cdc2-3w (C67Y)
decreased protein kinase activitycdc2-E8 (D213N), wee1-50
decreased protein threonine phosphorylation at Thr-Pro site during cellular response to hydrogen peroxide
affecting clp1rad3Δ, cdc2-as (F84G), pmk1Δ
decreased protein threonine phosphorylation at Thr-Pro site during cellular response to hydroxyurea
affecting clp1rad3Δ, cdc2-as (F84G), pmk1Δ
decreased response to S-phase DNA damage checkpoint signalingcdc2-Y15F (Y15F), cdc10-V50 (H362Y)
delayed onset of protein localization to nucleoplasm during cellular response to hydrogen peroxide
affects localization of clp1cdc2-as (F84G), rad3Δ
delayed onset of protein localization to nucleoplasm during cellular response to hydroxyurea
affects localization of clp1cdc2-as (F84G), pmk1Δ
elongated mononucleate vegetative cellcdc2-3w (C67Y), cdc10-129 (T429A)
cdc2-33 (A177T), cut5-T401
elongated multiseptate vegetative cellmcs6-13 (L238R), cdc2-3w (C67Y)
elongated vegetative cellwee1-50, mcs6-13 (L238R), cdc2-3w (C67Y)
mcs2-75, wee1-50, cdc2-3w (C67Y)
mcs2-75, cdc2-3w (C67Y)
increased duration of mitotic M phasecdc21-M68, cdc2-3w (C67Y)
inviable after spore germination, multiple cell divisionsmcs6-13 (L238R), cdc2-59 (P248L, C67Y)
mcs1-77, cdc2-59 (P248L, C67Y)
mcs4-13, cdc2-59 (P248L, C67Y)
cdc2-59 (P248L, C67Y), mcs2-75
inviable after spore germination, without cell division, elongated cellcdc25::ura4, cdc2-1w (G146D)
inviable elongated aseptate cellatf1+, cdc2-33 (A177T)
inviable elongated mononucleate aseptate cellcdc2-E8 (D213N), wee1-50
inviable elongated multiseptate vegetative cellmcs6-13 (L238R), mcs4-13, cdc2-3w (C67Y)
inviable septated mononucleate vegetative cellwee1-50, cdc2-3w (C67Y)
inviable small vegetative cellcdc17-K42 (E298K), cdc2-3w (C67Y)
cdc22-M45, cdc2-3w (C67Y)
cdc20-M10, cdc2-3w (C67Y)
inviable sporecdc2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc13Δ, cig2Δ, puc1Δ, cig1Δ
cig2Δ, cig1Δ, puc1Δ, cdc13Δ, rem1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cdc2Δ
cdc13Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc2Δ
cdc13Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cig2Δ, cig1Δ, puc1Δ, cdc2Δ
large and small daughter nucleiwee1-50, cdc2-3w (C67Y)
mitosis with unreplicated DNAcdc25Δ, cdc2-3w (C67Y)
mitotic catastrophepyp3+, cdc2-3w (C67Y)
mitotic catastrophe with cut, small cellwee1-50, cdc2-3w (C67Y)
mitotic G2/M transition delaypcn1+, cdc2-3w (C67Y)
normal cell cycle regulation during cellular response to hydroxyureacdc2-33 (A177T), cut5-T401
wee1+ (wild type), cdc2-3w (C67Y)
cdc10-129 (T429A), cdc2-3w (C67Y)
normal meiosispuc1Δ, cig1Δ, crs1Δ, rem1Δ, cdc13Δ, cdc2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cig2Δ
cig2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), rem1Δ, cig1Δ, puc1Δ
cdc13Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cig2Δ, cig1Δ, puc1Δ, cdc2Δ
cdc2Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc13Δ, cig2Δ, puc1Δ, cig1Δ
cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cig2Δ, rem1Δ, puc1Δ, cig1Δ
normal meiosis Icdc13Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cig2Δ, cig1Δ, puc1Δ, cdc2Δ
normal protein localization to chromatin at replication origin
affecting mcm4cdc2-33 (A177T), cdc13+
normal vegetative cell growthcdc2-L7 (P208S), suc1-449
cdc2-M55, suc1-210
cdc2-33 (A177T), suc1-210
cdc2-M26 (P137S), suc1-210
cdc2-M26 (P137S), suc1-449
cdc2-56 (G183E), suc1-210
cdc2-56 (G183E), suc1-449
cdc2-33 (A177T), suc1-449
cdc2-L7 (P208S), suc1-210
cdc2-M55, suc1-449
septation following abnormal chromosome segregation, with binucleate and anucleate compartment formation during cellular response to hydroxyureacdc20-M10, cdc2-3w (C67Y)
cdc22-M45, cdc2-3w (C67Y)
cdc17-K42 (E298K), cdc2-3w (C67Y)
small vegetative cellcdc2-1w (G146D), mcs2-75
viable cell at high temperaturecdc2-E8 (D213N), wee1-50, cdc25+ (wild type)
cdc25+ (wild type), cdc2-E9 (D242N), wee1-50
cdc2-A21 (D90N), wee1-50, cdc25+ (wild type)
viable elongated vegetative cellcdc25Δ, skb1Δ, cdc2-3w (C67Y)
cdc2-33 (A177T), cdr1-76
cdc2-3w (C67Y), cdc25-22 (C532Y), win1-1
cdc2-33 (A177T), cdr2-97
cdc25Δ, shk1+, cdc2-3w (C67Y)
wee1+ (wild type), cdc2-3w (C67Y)
cdc2-3w (C67Y), win1-1, cdc25-22 (C532Y)
cdc25-22 (C532Y), cdc2-3w (C67Y)
cdc25::ura4, cdc2-3w (C67Y)
cdc25Δ, tor1Δ, cdc2-3w (C67Y)
viable small vegetative cellcdc2-3w (C67Y), win1-1
wee1-50, mcs4-13, cdc2-3w (C67Y)
dnt1Δ, cdc2-1w (G146D)
tor1Δ, cdc2-Y15F (Y15F)
wee1-50, mcs1-77, cdc2-3w (C67Y)
viable vegetative cell with normal cell sizewin1-1, cdc2-3w (C67Y)
cdc2-3w (C67Y), cdc25-22 (C532Y)
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in cdc10 MBF transcription factor complex subunit Cdc10
FYPO affected by mutation in cdc13 G2/M B-type cyclin Cdc13
FYPO affected by mutation in cdc18 MCM loader
FYPO affected by mutation in cdc2 cyclin-dependent protein kinase Cdk1/Cdc2
FYPO affected by mutation in cdc25 M phase inducer tyrosine phosphatase Cdc25
FYPO affected by mutation in cdc6 DNA polymerase delta catalytic subunit Cdc6
FYPO affected by mutation in cds1 replication checkpoint kinase Cds1
FYPO affected by mutation in cia1 histone chaperone Cia1
FYPO affected by mutation in clp1 Cdc14-related protein phosphatase Clp1/Flp1
FYPO affected by mutation in dim1 U4/U6 x U5 tri-snRNP complex subunit Dim1
FYPO affected by mutation in dnt1 nucleolar protein Dnt1
FYPO affected by mutation in fin1 serine/threonine protein kinase, NIMA related Fin1
FYPO affected by mutation in hsp9 heat shock protein Hsp9
FYPO affected by mutation in hub1 ubiquitin-like protein modifier Hub1
FYPO affected by mutation in mei4 meiotic forkhead transcription factor Mei4
FYPO affected by mutation in mes1 meiosis II protein Mes1
FYPO affected by mutation in nap1 nucleosome assembly protein Nap1
FYPO affected by mutation in nda3 tubulin beta Nda3
FYPO affected by mutation in pim1 RCC1 family Ran GDP/GTP exchange factor
FYPO affected by mutation in prp1 U4/U6 x U5 tri-snRNP complex subunit Prp1
FYPO affected by mutation in prp10 U2 snRNP-associated protein Sap155
FYPO affected by mutation in prp2 U2AF large subunit (U2AF-59)
FYPO affected by mutation in rad3 ATR checkpoint kinase Rad3
FYPO affected by mutation in rum1 CDK inhibitor Rum1
FYPO affected by mutation in sds22 protein phosphatase regulatory subunit Sds22
FYPO affected by mutation in snu1 small nuclear RNA U1
FYPO affected by mutation in snu4 small nuclear RNA U4
FYPO affected by mutation in spo5 meiotic RNA-binding protein 1
FYPO affected by mutation in srb10 cyclin-dependent protein Srb mediator subunit kinase Srb10
FYPO affected by mutation in srw1 fizzy-related CDK inhibitor Srw1
FYPO affected by mutation in suc1 cyclin-dependent protein kinase regulatory subunit Suc1
FYPO affected by mutation in uaf2 U2AF small subunit, U2AF-23
FYPO affected by mutation in xlf1 XRCC4-like nonhomologous end joining factor, Cernunnon Xlf1/Nej1
FYPO localization affected by mutation in atf1 transcription factor, Atf-CREB family Atf1
FYPO localization affected by mutation in cdc13 G2/M B-type cyclin Cdc13
GO binds spd1 ribonucleotide reductase (RNR) inhibitor
GO binds suc1 cyclin-dependent protein kinase regulatory subunit Suc1
GO regulated by cdc13 G2/M B-type cyclin Cdc13
GO regulated by cdc16 two-component GAP Cdc16
GO regulated by cdc25 M phase inducer tyrosine phosphatase Cdc25
GO regulated by cig2 G1/S-specific B-type cyclin Cig2
GO regulated by clp1 Cdc14-related protein phosphatase Clp1/Flp1
GO regulated by csk1 cyclin-dependent kinase/ cyclin-dependent kinase activating kinase Csk1
GO regulated by mcs2 TFIIH complex cyclin Mcs2
GO regulated by mcs6 TFIIH associated cyclin-dependent protein kinase Mcs6
GO regulated by rum1 CDK inhibitor Rum1
GO regulated by suc1 cyclin-dependent protein kinase regulatory subunit Suc1
GO regulated by wee1 M phase inhibitor protein kinase Wee1
GO substrate of cdc25 M phase inducer tyrosine phosphatase Cdc25
GO substrate of csk1 cyclin-dependent kinase/ cyclin-dependent kinase activating kinase Csk1
GO substrate of mcs6 TFIIH associated cyclin-dependent protein kinase Mcs6
GO substrate of mik1 mitotic inhibitor kinase Mik1
GO substrate of pyp3 protein-tyrosine phosphatase Pyp3
GO substrate of wee1 M phase inhibitor protein kinase Wee1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1500197..1500243, 1500286..1500376, 1500445..1500613, 1500686..1500986, 1501088..1501393, 1501448..1502095
Intron1500244..1500285, 1500377..1500444, 1500614..1500685, 1500987..1501087, 1501394..1501447
5' UTR1500197..1500243, 1500286..1500339PMID:21511999
3' UTR1501529..1502095PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00069 Pfam IPR000719 Protein kinase domain 4 293 108
SM00220 SMART IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain 4 293 107
PS00108 Prosite Patterns IPR008271 Serine/threonine-protein kinase, active site 130 142 97
PS00107 Prosite Patterns IPR017441 Protein kinase, ATP binding site 10 33 73
PS50011 Prosite Profiles IPR000719 Protein kinase domain 4 293 110
PTHR24056 HMMPANTHER 1 295 9
PTHR24056:SF11 HMMPANTHER 1 295 1
1.10.510.10 Gene3D AGC-kinase, C-terminal 88 294 112
3.30.200.20 Gene3D AGC-kinase, C-terminal 2 87 111
SSF56112 SuperFamily IPR011009 Protein kinase-like domain 1 296 127

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0003657CDK family kinaseTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0003657

Protein Properties

Ave. residue weight 115.69 Da
Charge 4.50
Codon Adaptation Index 0.43
Isoelectric point 7.68
Molecular weight 34.36 kDa
Number of residues 297
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1676
Annotation ExtensionEvidenceResidueReference
IDA PMID:3058333
O-phospho-L-threonine 700
present during cellular response to thiabendazoleT167
Annotation ExtensionEvidenceResidueReference
present during cellular response to thiabendazole IDA T167 PMID:18257517
IDA PMID:1756737
IDA PMID:3058333
O4'-phospho-L-tyrosine 88
added by mik1, wee1Y15
added during mitotic G2 phase, premeiotic DNA replication
present during meiosis I
present during cellular response to hydroxyureaT15
present during cellular response to nitrosative stress, cellular response to thiabendazole, mitotic M phaseY15
removed by cdc25
removed during meiosis II
removed during cellular response to caffeineT15
absent during mitotic M phase
Annotation ExtensionEvidenceResidueReference
added by mik1 IDA Y15 PMID:7982971
added by wee1 IDA Y15 PMID:1372994
added during premeiotic DNA replication IDA PMID:10888871
added during mitotic G2 phase IDA PMID:1464318
present during meiosis I IDA PMID:10888871
present during cellular response to hydroxyurea IDA T15 PMID:10036242
present during cellular response to nitrosative stress IDA Y15 PMID:22561704
present during cellular response to thiabendazole IDA Y15 PMID:18257517
present during mitotic M phase experimental evidence Y15 PMID:21712547
removed by cdc25 IDA PMID:1756737
removed during meiosis II IDA PMID:10888871
removed during cellular response to caffeine IDA T15 PMID:10036242
absent during mitotic M phase IDA PMID:1464318
phosphorylated residue 1930
added by wee1Y15
added during cellular response to UV, G0 to G1 transition
removed during cellular response to nitrogen starvation
Y15
Annotation ExtensionEvidenceResidueReference
added by wee1 NAS Y15 PMID:2682257
added during cellular response to UV IDA PMID:12960401
added during G0 to G1 transition IDA PMID:3516412
removed during cellular response to nitrogen starvation IDA PMID:3516412
NAS Y15 PMID:9042863
IDA PMID:19547744
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
protein levelconstant during GO:0000278Western blot evidencePMID:2569363
unchanged during GO:0072734Western blot evidencePMID:1899230
present during GO:0051321Western blot evidencePMID:10888871
present during GO:0072690Western blot evidencePMID:2569363
constant during GO:0000278Western blot evidencePMID:3516412
increased during GO:0006279Western blot evidencePMID:10888871

Quantitative Gene Expression

View graphical display of gene expression data for cdc2 (SPBC11B10.09)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
14449during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
5406.86during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
2704.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000005,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.8during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.52during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by H. sapiens CDK1full PMID:3553962 PMID:1944283
full
does not functionally complement S. cerevisiae CDC28 PMID:3796591
functionally complemented by G. gallus cdc2full PMID:1500441
functionally complements S. cerevisiae CDC28 when introns removedfull PMID:3796591
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4605
conserved in eukaryotes4515
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2505
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC11B10.09 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
modifiescrb2DNA repair protein Rad9 homolog Crb2 Biochemical ActivityPMID:24074952
modifieshcn1anaphase-promoting complex subunit TPR lobe accessory factor Hcn1/Apc12 Biochemical ActivityPMID:16950791
modifiesalp7centrosomal transforming acidic coiled-coil (TACC) protein ortholog Alp7 Biochemical ActivityPMID:24790093
modifiesmde4microtubule-site clamp monopolin complex subunit Mde4 Biochemical ActivityPMID:19523829
modifiesrum1CDK inhibitor Rum1 Biochemical ActivityPMID:10679013
modifiesdis2serine/threonine protein phosphatase PP1, Dis2 Biochemical ActivityPMID:7957097
modifiescut3condensin complex SMC subunit Smc4 Biochemical ActivityPMID:10485849
modifiesclp1Cdc14-related protein phosphatase Clp1/Flp1 Biochemical ActivityPMID:16950131
modifiesnsk1Clp1-interacting, microtubule plus-end binding Nsk1 Biochemical ActivityPMID:22065639
modifiesfkh2forkhead transcription factor Fkh2 Biochemical ActivityPMID:18059475
modifiesbyr4two-component GAP Byr4 Biochemical ActivityPMID:24920823
modifiescdc18MCM loader Biochemical ActivityPMID:9177184
modifiescdc25M phase inducer tyrosine phosphatase Cdc25 Biochemical ActivityPMID:22665807
modifiesorc2origin recognition complex subunit Orc2 Biochemical ActivityPMID:11486016
modifiesase1antiparallel microtubule cross-linking factor Ase1 Biochemical ActivityPMID:19686686
modifiesmbx1MADS-box transcription factor Mbx1 Biochemical ActivityPMID:21098641
modifiesbub1mitotic spindle checkpoint kinase Bub1 Biochemical ActivityPMID:12606573
modifiescdc13G2/M B-type cyclin Cdc13 Biochemical ActivityPMID:2569363
modifiescut12spindle pole body protein Cut12 Biochemical ActivityPMID:23333317
modifiessds23PP2A-type phosphatase inhibitor Sds23/Moc1 Biochemical ActivityPMID:9242669
affinity captured bycdc18MCM loader Affinity Capture-WesternPMID:9436991
affinity captured bycdc13G2/M B-type cyclin Cdc13 Affinity Capture-WesternPMID:16390871
affinity captured bycbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
affinity captured bynsk1Clp1-interacting, microtubule plus-end binding Nsk1 Affinity Capture-WesternPMID:22065639
affinity captured bycig2G1/S-specific B-type cyclin Cig2 Affinity Capture-WesternPMID:11163211
affinity captured bypas1cyclin Pas1 Affinity Capture-WesternPMID:10982385
affinity captured bysuc1cyclin-dependent protein kinase regulatory subunit Suc1 Affinity Capture-WesternPMID:9790601
affinity captured byhsp90Hsp90 chaperone Affinity Capture-WesternPMID:22543982
affinity captured bycdc11SIN component scaffold protein, centriolin ortholog Cdc11 Affinity Capture-WesternPMID:15062098
affinity captured byskb1type II protein arginine N-methyltransferase Skb1 Affinity Capture-WesternPMID:9843966
affinity captured bymtl1TRAMP complex ATP-dependent RNA helicase (predicted) Affinity Capture-MSPMID:24713849
affinity captured bypir2zf-C2H2 type zinc finger protein, implicated in RNAi (predicted) Affinity Capture-MSPMID:24713849
affinity captured bypch1P-TEFB associated cyclin, cyclin T Pch1 Affinity Capture-WesternPMID:9115279
affinity captured bywos2p23 homolog, predicted co-chaperone Wos2 Affinity Capture-WesternPMID:10581266
affinity captured bychk1Chk1 protein kinase Affinity Capture-WesternPMID:26131711
affinity captured byshk1PAK-related kinase Shk1 Affinity Capture-WesternPMID:9843966
affinity captured bycdc37Hsp90 co-chaperone Cdc37 Affinity Capture-WesternPMID:16390871
affinity captured bybgs11,3-beta-glucan synthase catalytic subunit Bgs1 Affinity Capture-WesternPMID:11937031
affinity captured byred1RNA elimination defective protein Red1 Affinity Capture-MSPMID:24713849
affinity captured byorc2origin recognition complex subunit Orc2 Affinity Capture-WesternPMID:8552194
affinity capturesrad16DNA repair endonuclease XPF Affinity Capture-WesternPMID:24861625
affinity captureswos2p23 homolog, predicted co-chaperone Wos2 Affinity Capture-WesternPMID:10581266
affinity capturespku80Ku domain protein Pku80 Affinity Capture-WesternPMID:24861625
affinity capturesspd1ribonucleotide reductase (RNR) inhibitor Affinity Capture-WesternPMID:8887552
affinity capturesrum1CDK inhibitor Rum1 Affinity Capture-WesternPMID:11329175
affinity captureshhp1serine/threonine protein kinase Hhp1 Affinity Capture-WesternPMID:24861625
affinity capturescdc13G2/M B-type cyclin Cdc13 Affinity Capture-WesternPMID:11683390
affinity capturessrs2ATP-dependent DNA helicase, UvrD subfamily Affinity Capture-WesternPMID:24861625
affinity capturesrqh1RecQ type DNA helicase Rqh1 Affinity Capture-WesternPMID:24861625
affinity capturespku70Ku domain protein Pku70 Affinity Capture-WesternPMID:24861625
affinity captureschk1Chk1 protein kinase Affinity Capture-WesternPMID:24861625
affinity capturesmus81Holliday junction resolvase subunit Mus81 Affinity Capture-WesternPMID:24861625
affinity capturescdc18MCM loader Affinity Capture-RNAPMID:22144913
modified bywee1M phase inhibitor protein kinase Wee1 Biochemical ActivityPMID:7982971
modified bymik1mitotic inhibitor kinase Mik1 Biochemical ActivityPMID:7982971
modified bypyp3protein-tyrosine phosphatase Pyp3 Biochemical ActivityPMID:1464318
binds activation domain construct withdis2serine/threonine protein phosphatase PP1, Dis2 Two-hybridPMID:26771498
binds activation domain construct withsds23PP2A-type phosphatase inhibitor Sds23/Moc1 Two-hybridPMID:9242669
binds activation domain construct withcdc13G2/M B-type cyclin Cdc13 Two-hybridPMID:26771498
binds activation domain construct withsuc1cyclin-dependent protein kinase regulatory subunit Suc1 Two-hybridPMID:26771498
binds activation domain construct withpch1P-TEFB associated cyclin, cyclin T Pch1 Two-hybridPMID:9115279
binds activation domain construct withorc2origin recognition complex subunit Orc2 Two-hybridPMID:8552194
forms complex withrum1CDK inhibitor Rum1 Reconstituted ComplexPMID:9303310
forms complex withdrc1replication preinitiation complex assembly protein Reconstituted ComplexPMID:11937031
forms complex withsuc1cyclin-dependent protein kinase regulatory subunit Suc1 Reconstituted ComplexPMID:2569363
interacts withsuc1cyclin-dependent protein kinase regulatory subunit Suc1 PCAPMID:26771498
co-fractionates withcdc13G2/M B-type cyclin Cdc13 Co-fractionationPMID:2569363
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC11B10.09 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
synthetic growth defect withcrb2DNA repair protein Rad9 homolog Crb2 Synthetic Growth DefectPMID:24861625
synthetic growth defect withelp3elongator complex subunit Elp3 (predicted) Synthetic Growth DefectPMID:22768388
synthetic growth defect withwee1M phase inhibitor protein kinase Wee1 Synthetic Growth DefectPMID:11029045
synthetic growth defect withsrw1fizzy-related CDK inhibitor Srw1 Synthetic Growth DefectPMID:14985109
synthetic growth defect withslp1substrate-specific APC activator Slp1 Synthetic Growth DefectPMID:9001228
synthetic growth defect withdim1U4/U6 x U5 tri-snRNP complex subunit Dim1 Synthetic Growth DefectPMID:9182666
synthetic growth defect withctu1cytosolic thiouridylase subunit Ctu1 Synthetic Growth DefectPMID:22768388
synthetic growth defect withcdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic Growth DefectPMID:20444100
synthetic growth defect withblt1ubiquitin domain-like protein Blt1 Synthetic Growth DefectPMID:24790095
synthetic growth defect withmcs6TFIIH associated cyclin-dependent protein kinase Mcs6 Synthetic Growth DefectPMID:2474475
synthetic growth defect withchk1Chk1 protein kinase Synthetic Growth DefectPMID:24861625
synthetic growth defect withcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic Growth DefectPMID:3448096
synthetic growth defect withcdr2serine/threonine protein kinase Cdr2 Synthetic Growth DefectPMID:3448096
enhances phenotype ofcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Phenotypic EnhancementPMID:2004705
enhances phenotype ofclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic EnhancementPMID:11683392
enhances phenotype oforc1origin recognition complex subunit Orc1 Phenotypic EnhancementPMID:12186947
enhances phenotype ofhsp90Hsp90 chaperone Phenotypic EnhancementPMID:22543982
enhances phenotype ofpmk1MAP kinase Pmk1 Phenotypic EnhancementPMID:22918952
enhances phenotype ofwee1M phase inhibitor protein kinase Wee1 Phenotypic EnhancementPMID:3116001
enhances phenotype ofrad3ATR checkpoint kinase Rad3 Phenotypic EnhancementPMID:22918952
enhances phenotype ofcdc6DNA polymerase delta catalytic subunit Cdc6 Phenotypic EnhancementPMID:9154809
enhances phenotype ofbgs11,3-beta-glucan synthase catalytic subunit Bgs1 Phenotypic EnhancementPMID:10503548
enhances phenotype ofsep1forkhead transcription factor Sep1 Phenotypic EnhancementPMID:9473044
enhances phenotype ofcig2G1/S-specific B-type cyclin Cig2 Phenotypic EnhancementPMID:8455610
synthetic lethal withmcs6TFIIH associated cyclin-dependent protein kinase Mcs6 Synthetic LethalityPMID:2474475
synthetic lethal withmcs4response regulator Mcs4 Synthetic LethalityPMID:2474475
synthetic lethal withwee1M phase inhibitor protein kinase Wee1 Synthetic LethalityPMID:9188094
synthetic lethal withmcs2TFIIH complex cyclin Mcs2 Synthetic LethalityPMID:2474475
synthetic lethal withrad54DNA-dependent ATPase Rad54/Rhp54 Synthetic LethalityPMID:8834792
synthetic lethal withcdr2serine/threonine protein kinase Cdr2 Synthetic LethalityPMID:9843577
synthetic lethal withres2MBF transcription factor complex subunit Res2 Synthetic LethalityPMID:2474475
synthetic lethal withclp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic LethalityPMID:16950131
synthetic lethal withpop1cullin 1 adaptor protein Pop1 Synthetic LethalityPMID:9203581
rescuesfin1serine/threonine protein kinase, NIMA related Fin1 Phenotypic SuppressionPMID:12065422
rescuesspo4serine/threonine protein kinase Spo4 Phenotypic SuppressionPMID:23370392
rescuespyp2tyrosine phosphatase Pyp2 Phenotypic SuppressionPMID:1448087
rescuessrw1fizzy-related CDK inhibitor Srw1 Phenotypic SuppressionPMID:14985109
rescuesrad4BRCT domain protein Rad4 Phenotypic SuppressionPMID:7957098
rescuesbgs11,3-beta-glucan synthase catalytic subunit Bgs1 Phenotypic SuppressionPMID:10704373
rescuesslp1substrate-specific APC activator Slp1 Phenotypic SuppressionPMID:9001228
rescuesclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic SuppressionPMID:11683392
rescueswis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:1756736
rescuespyp1tyrosine phosphatase Pyp1 Phenotypic SuppressionPMID:1448087
rescuescut1separase/separin Phenotypic SuppressionPMID:16453724
rescuesspo5meiotic RNA-binding protein 1 Phenotypic SuppressionPMID:24506453
rescuestor1serine/threonine protein kinase Tor1 Phenotypic SuppressionPMID:19546237
rescuespab1protein phosphatase PP2A regulatory subunit B-55 Pab1 Phenotypic SuppressionPMID:20876564
rescuescdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Phenotypic SuppressionPMID:2004705
rescuesmcm4MCM complex subunit Mcm4/Cdc21 Phenotypic SuppressionPMID:8631307
rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:3796591
rescuescdc13G2/M B-type cyclin Cdc13 Phenotypic SuppressionPMID:1829983
rescued bychk1Chk1 protein kinase Phenotypic SuppressionPMID:10637286
rescued bycds1replication checkpoint kinase Cds1 Phenotypic SuppressionPMID:24861625
rescued bysuc1cyclin-dependent protein kinase regulatory subunit Suc1 Phenotypic SuppressionPMID:3010051
rescued bySPAC29A4.02ctranslation elongation factor EF-1 gamma subunit Phenotypic SuppressionPMID:14985109
rescued bymik1mitotic inhibitor kinase Mik1 Phenotypic SuppressionPMID:10637286
rescued bycmk2MAPK-activated protein kinase Cmk2 Phenotypic SuppressionPMID:12135745
rescued bycdc13G2/M B-type cyclin Cdc13 Phenotypic SuppressionPMID:9790601
rescued bycut12spindle pole body protein Cut12 Phenotypic SuppressionPMID:2245912
rescued byspd1ribonucleotide reductase (RNR) inhibitor Phenotypic SuppressionPMID:8887552
rescued bycdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:9013342
rescued byclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic SuppressionPMID:15128870
rescued bywee1M phase inhibitor protein kinase Wee1 Phenotypic SuppressionPMID:3032459
rescued bywis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:1756736
synthetically rescueswee1M phase inhibitor protein kinase Wee1 Synthetic RescuePMID:24861625
synthetically rescuescdc6DNA polymerase delta catalytic subunit Cdc6 Synthetic RescuePMID:9135148
synthetically rescuescdr2serine/threonine protein kinase Cdr2 Synthetic RescuePMID:2245912
synthetically rescuescdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic RescuePMID:2245912
synthetically rescueshhp1serine/threonine protein kinase Hhp1 Synthetic RescuePMID:24861625
synthetically rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:7217015
synthetically rescuescdc13G2/M B-type cyclin Cdc13 Synthetic RescuePMID:3428262
synthetically rescuessrk1MAPK-activated protein kinase Srk1 Synthetic RescuePMID:15629716
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
negative genetic interaction withria1GTPase Ria1 (predicted) Negative GeneticPMID:22681890
rescued by overexpression ofchk1Chk1 protein kinase Dosage RescuePMID:8497322
rescued by overexpression ofmcs6TFIIH associated cyclin-dependent protein kinase Mcs6 Dosage RescuePMID:8557037
rescued by overexpression ofsum1translation initiation factor eIF3i Dosage RescuePMID:9560390
rescued by overexpression ofcdc13G2/M B-type cyclin Cdc13 Dosage RescuePMID:11711540
rescued by overexpression ofsum3translation initiation RNA helicase Sum3 Dosage RescuePMID:11711540
rescued by overexpression ofsuc1cyclin-dependent protein kinase regulatory subunit Suc1 Dosage RescuePMID:3322810
rescued by overexpression ofpyp1tyrosine phosphatase Pyp1 Dosage RescuePMID:9560390
rescued by overexpression ofcid13poly(A) polymerase Cid13 Dosage RescuePMID:12062100
rescued by overexpression ofhsp9heat shock protein Hsp9 Dosage RescuePMID:22182414
rescued by overexpression ofwee1M phase inhibitor protein kinase Wee1 Dosage RescuePMID:1427071
synthetically rescued byclp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic RescuePMID:23297348
synthetically rescued bycut12spindle pole body protein Cut12 Synthetic RescuePMID:23333317
synthetically rescued bycig2G1/S-specific B-type cyclin Cig2 Synthetic RescuePMID:8455610
synthetically rescued bycdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:24861625
synthetically rescued bymik1mitotic inhibitor kinase Mik1 Synthetic RescuePMID:24861625
synthetically rescued bysty1MAP kinase Sty1 Synthetic RescuePMID:9560390
synthetically rescued byres2MBF transcription factor complex subunit Res2 Synthetic RescuePMID:11029045
inviable in presence of overexpressedpyp3protein-tyrosine phosphatase Pyp3 Dosage LethalityPMID:1464318
overexpression lethal tosrw1fizzy-related CDK inhibitor Srw1 Dosage LethalityPMID:9398669
overexpression rescuescdc37Hsp90 co-chaperone Cdc37 Dosage RescuePMID:16390871
overexpression rescuescdc13G2/M B-type cyclin Cdc13 Dosage RescuePMID:2847913
overexpression rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Dosage RescuePMID:3796591
phenotype enhanced byhta2histone H2A beta Phenotypic EnhancementPMID:16314498
phenotype enhanced bypmk1MAP kinase Pmk1 Phenotypic EnhancementPMID:22918952
phenotype enhanced byhta1histone H2A alpha Phenotypic EnhancementPMID:16314498
phenotype enhanced bycdc10MBF transcription factor complex subunit Cdc10 Phenotypic EnhancementPMID:11513869
phenotype enhanced byswr1SNF2 family ATP-dependent DNA helicase Swr1 Phenotypic EnhancementPMID:9571240
phenotype enhanced byrum1CDK inhibitor Rum1 Phenotypic EnhancementPMID:7593289
phenotype enhanced bywos2p23 homolog, predicted co-chaperone Wos2 Phenotypic EnhancementPMID:10581266
phenotype enhanced byhsp90Hsp90 chaperone Phenotypic EnhancementPMID:10102358
phenotype enhanced bywee1M phase inhibitor protein kinase Wee1 Phenotypic EnhancementPMID:9013342
phenotype enhanced byorc2origin recognition complex subunit Orc2 Phenotypic EnhancementPMID:8552194
External References
Database Identifier Description
NBRP SPBC11B10.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC11B10.09 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC11B10.09 BioGRID Interaction Datasets
Expression Viewer SPBC11B10.09 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC11B10.09 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC11B10.09 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC11B10.09 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC11B10.09 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC11B10.09 Transcriptome Viewer (Bähler Lab)
GEO SPBC11B10.09 GEO profiles
PInt SPBC11B10.09 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC11B10.09 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC11B10.09 Fission yeast phenotypic data & analysis
Cyclebase SPBC11B10.09.1 Cell Cycle Data
SPD / RIKEN50/50D08Orfeome Localization Data
UniProtKB/SwissProtP04551Cyclin-dependent kinase 1
ModBaseP04551Database of comparative protein structure models
STRINGP04551Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595629cyclin-dependent protein kinase Cdk1/Cdc2
RefSeq mRNANM_001021523972h- cyclin-dependent protein kinase Cdk1/Cdc2 (cdc2), mRNA

Literature for cdc2

Search: Europe PMC or PubMed

Release Version: PomBase:30_58 - 11 Mar 2016