cdc2 (SPBC11B10.09)


Gene Standard Namecdc2 Characterisation Statuspublished
Systematic IDSPBC11B10.09 Feature Typeprotein coding
Synonymscdk1, pi002, SPACTOKYO_453.34, swo2, tws1, wee2 Name DescriptionTWo Spored
Productcyclin-dependent protein kinase Cdk1/Cdc2 Product Size297aa, 34.36 kDa
Genomic Location Chromosome II, 1500197-1502095 (1899nt); CDS:1500340-1501528 (1189nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005524ATP bindingIEAUniProtKB-KW:KW-0067GO_REF:0000037557
GO:0008353RNA polymerase II carboxy-terminal domain kinase activityIEA EC:2.7.11.23GO_REF:00000035
GO:0097472cyclin-dependent protein kinase activityIDAPMID:33228109
GO:0004693cyclin-dependent protein serine/threonine kinase activityIGIcdc13PMID:25693638
has substrate byr4IDAPMID:24920823
GO:0005515protein bindingIPIcdc13PMID:16390871861
IPIcdc37PMID:16390871
GO:0004672protein kinase activityIMPPMID:1372994119
has substrate cdc13IDAPMID:2569363
during mitotic metaphaseIDAPMID:2665944
IDAPMID:1756737
has substrate rum1IDAPMID:11937031
during G2/M transition of mitotic cell cycleIDAPMID:2665944
GO:0004674protein serine/threonine kinase activity112
has substrate nsk1IDAPMID:22065639
has substrate orc2IDAPMID:11486016
has substrate crb2IDAPMID:24074952
has substrate fkh2IDAPMID:18059475
has substrate cut3IDAPMID:10485849
has substrate sds23IDAPMID:9242669
has substrate drc1IDAPMID:11937031
has substrate hcn1IDAPMID:16950791
has substrate ase1IDAPMID:19686686
has substrate klp9IDAPMID:19686686
has substrate dis2IDAPMID:7957097
has substrate srw1IDAPMID:10921876
has substrate cut7IDAPMID:9490630
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000086G2/M transition of mitotic cell cycleIMPPMID:26659442
GO:0006995cellular response to nitrogen starvationIMPPMID:1936672885
GO:0033314mitotic DNA replication checkpointTASPMID:835580722
GO:0007095mitotic G2 DNA damage checkpointTASPMID:154917912
GO:0070317negative regulation of G0 to G1 transitionIMPPMID:1936672825
GO:1902424negative regulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregationIMPPMID:220656391
GO:0010515negative regulation of induction of conjugation with cellular fusionEXPPMID:1805947512
GO:1900087positive regulation of G1/S transition of mitotic cell cycleIMPPMID:72543525
GO:0010971positive regulation of G2/M transition of mitotic cell cycleIMPPMID:72543529
GO:0032467positive regulation of cytokinesisIMPPMID:2492082312
GO:0031031positive regulation of septation initiation signalingIMPPMID:249208239
GO:0051726regulation of cell cycleIGIcdc13PMID:2569363380
GO:0008361regulation of cell sizeNASGO_REF:00000016
GO:0051445regulation of meiotic cell cycleIMPPMID:749876646
GO:0007089traversing start control point of mitotic cell cycleNASGO_REF:00000015
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000307cyclin-dependent protein kinase holoenzyme complexIPIcdc13PMID:26822576
IDAPMID:3322810
GO:0005829cytosolIDAPMID:168233722316
GO:0005634nucleusIDAPMID:25345592740
except during cytokinesisIDAPMID:2569363
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000082decreased cell population growth at high temperatureCell growth assaycdc2-974 (I35N)PECO:0000004, PECO:0000099PMID:19366728141
FYPO:0000709decreased cell population growth during nitrogen starvationCell growth assaycdc2-974 (I35N)PECO:0000004, PECO:0000099PMID:1936672835
FYPO:0001128decreased septation indexMicroscopycdc2-33 (A177T)Not specifiedPMID:15633499
FYPO:0001974increased number of cells with 1C DNA contentFlow cytometry datacdc2-3w (C67Y)Not specifiedPECO:0000004PMID:888755236
Flow cytometry datacdc2-3w (C67Y)Not specifiedPECO:0000005PMID:8887552
FYPO:0002061inviable vegetative cell populationMicroscopycdc2ΔNullPECO:0000005, PECO:0000137PMID:236978061331
Microscopycdc2ΔNullPMID:3796591
Microscopycdc2ΔNullPMID:20473289
FYPO:0002807normal growth on arsenateCell growth assaycdc2-3w (C67Y)Not specifiedPECO:0000137, PECO:0000102, PECO:0000005PMID:229128294
FYPO:0001903normal septation indexMicroscopycdc2-3w (C67Y)Not specifiedPECO:0000137, PECO:0000005PMID:15491794
FYPO:0001420normal vegetative cell population growth rateCell growth assaytws1-N22 (E42K)Not specifiedPECO:0000201, PECO:0000005, PECO:0000103PMID:658115741
FYPO:0000842sensitive to ethanolCell growth assaycdc2-M26 (P137S)Not specifiedPECO:0000005, PECO:0000137PMID:78453615
Cell growth assaycdc2-M56 (P137S)Not specifiedPECO:0000005, PECO:0000137PMID:7845361
FYPO:0000088sensitive to hydroxyureaCell growth assaycdc2-3w (C67Y)Not specifiedPECO:0000126, PECO:0000005PMID:9560390511
Cell growth assaycdc2-3w (C67Y)Not specifiedPMID:1563349
FYPO:0003116sensitive to plumbaginCell growth assaycdc2+/cdc2- (heterozygous diploid)Not specifiedPMID:2302874211

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001005DNA fragmentation during nitrogen starvationFlow cytometry datacdc2-974 (I35N)PECO:0000090, PECO:0000004PMID:1936672813
FYPO:0001933abnormal cell cycle regulation during cellular response to hydroxyureaCell growth assaycdc2-3w (C67Y)Not specifiedPECO:0000005PMID:15633495
FYPO:0000051abnormal meiosisMicroscopycdc2-N22 (E42K)EndogenousPMID:189601795
FYPO:0000059abnormal mitotic cell cycleMicroscopycdc2ΔNullPECO:0000005, PECO:0000137PMID:23697806638
FYPO:0000681abnormal sporulation resulting in formation of two-spore ascusMicroscopycdc2-N22 (E42K)EndogenousPMID:18960178
Microscopycdc2-33 (A177T)Not specifiedPECO:0000004PMID:3870979
Microscopycdc2-59 (P248L, C67Y)PECO:0000004PMID:1934126
Microscopytws1-N22 (E42K)Not specifiedPECO:0000015PMID:6581157
FYPO:0000502abnormally arrested mitotic cell cycleCell growth assayArg33 (K33R)Not specifiedPMID:379659182
Cell growth assayVal177 (A177V)Not specifiedPMID:3796591
Cell growth assayVal167 (T167V)Not specifiedPMID:3796591
Microscopycdc2ΔNullPMID:3796591
MicroscopyAla167 (T167A)Not specifiedPMID:3796591
MicroscopyVal177 (A177V)Not specifiedPMID:3796591
Cell growth assaycdc2ΔNullPMID:3796591
Cell growth assayAla167 (T167A)Not specifiedPMID:3796591
MicroscopyArg33 (K33R)Not specifiedPMID:3796591
MicroscopyVal167 (T167V)Not specifiedPMID:3796591
FYPO:0003378abolished meiosis IMicroscopycdc2-M26 (P137S)Not specifiedPECO:0000004PMID:74987662
FYPO:0003379abolished meiosis IIMicroscopycdc2-7Not specifiedPECO:0000004PMID:74987663
Microscopycdc2-33 (A177T)Not specifiedPECO:0000004PMID:7498766
FYPO:0002044abolished premeiotic DNA replicationFlow cytometry datacdc2-M26 (P137S)Not specifiedPECO:0000004PMID:74987667
Flow cytometry datacdc2-33 (A177T)Not specifiedPECO:0000004PMID:7498766
Flow cytometry datacdc2-M63 (G227C)Not specifiedPECO:0000004PMID:7498766
FYPO:0000705abolished protein binding54
affecting suc1 and cdc2Western blot assaycdc2-56 (G183E)EndogenousPMID:3322810
FYPO:0001384abolished protein kinase activity12
affecting cdc2Enzyme assay datacdc2-56 (G183E)Not specifiedPECO:0000004PMID:3322810
affecting cdc2Enzyme assay datacdc2-56 (G183E)Not specifiedPECO:0000005PMID:3322810
FYPO:0001269abolished protein localization to kinetochore10
affecting nsk1Microscopycdc2 analogue sensitive (analogue-sensitive)Not specifiedPMID:22065639
FYPO:0000446cell cycle arrest in mitotic G2 phaseMicroscopycdc2-33 (A177T)Not specifiedPECO:0000126, PECO:0000004PMID:146431825
FYPO:0002054cut during cellular response to hydroxyureaMicroscopycdc2-3w (C67Y)Not specifiedPECO:0000005PMID:956039038
FYPO:0003476decreased arsenate reductase activitySubstance quantification evidencecdc2-3w (C67Y)Not specifiedPECO:0000141PMID:229128292
FYPO:0001645decreased protein binding30
affecting suc1Western blot assaycdc2-L7 (P208S)Not specifiedPMID:2569363
affecting suc1Western blot assaycdc2-56 (G183E)Not specifiedPMID:2569363
affecting suc1Western blot assaycdc2-33 (A177T)Not specifiedPMID:2569363
affecting cdc13Western blot assaycdc2-L7 (P208S)Not specifiedPMID:2569363
affecting suc1 and cdc2Western blot assaycdc2-L7 (P208S)EndogenousPMID:3322810
FYPO:0001382decreased protein kinase activity16
affecting cdc2Enzyme assay datacdc2-M55Not specifiedPMID:3322810
affecting cdc2Enzyme assay datacdc2-L7 (P208S)Not specifiedPMID:2665944
affecting cdc2Enzyme assay datacdc2-L7 (P208S)Not specifiedPECO:0000004PMID:3322810
affecting cdc2Enzyme assay datacdc2-33 (A177T)Not specifiedPMID:2665944
FYPO:0001838decreased protein phosphorylation during vegetative growthEnzyme assay datacdc2-33 (A177T)Not specifiedPECO:0000005PMID:256936338
affecting cdc13Enzyme assay datacdc2-L7 (P208S)Not specifiedPECO:0000005PMID:2569363
affecting cdc13Enzyme assay datacdc2-L7 (P208S)Not specifiedPECO:0000004PMID:2569363
affecting cdc13Enzyme assay datacdc2-56 (G183E)Not specifiedPECO:0000004PMID:2569363
affecting orc2Western blot assaycdc2-33 (A177T)Not specifiedPECO:0000004PMID:11486016
affecting orc2Western blot assaycdc2-L7 (P208S)Not specifiedPECO:0000004PMID:11486016
affecting cdc13Enzyme assay datacdc2-33 (A177T)Not specifiedPECO:0000004PMID:2569363
FYPO:0002536delayed protein localization to nucleoplasm during cellular response to hydrogen peroxideMicroscopycdc2-F84G (F84G)EndogenousPECO:0000005, PECO:0000137, PECO:0000223PMID:229189524
FYPO:0000998elongated cell during nitrogen starvationMicroscopycdc2-974 (I35N)PECO:0000005, PECO:0000090PMID:1936672818
FYPO:0003237increased RNA splicing at cryptic splice sites4
affecting cdc2Gel electrophoresis evidencecdc2-I2mut (TTGACG287ACACAT)PECO:0000005PMID:8665408
FYPO:0003470increased mRNA splicing, via spliceosome1
affecting cdc2Gel electrophoresis evidencecdc2-I2mut (TTGACG287ACACAT)PECO:0000005PMID:8665408
FYPO:0000314inviable after spore germination with elongated germ tubeMicroscopycdc2ΔNullPMID:3796591163
penetrance FYPO_EXT:0000001Microscopycdc2ΔNullPECO:0000005, PECO:0000137PMID:23697806
FYPO:0003529inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cellsMicroscopycdc2-59 (P248L, C67Y)EndogenousPECO:0000006PMID:34282623
FYPO:0000049inviable cellMicroscopyL248 (P248L)Not specifiedPMID:26746501385
FYPO:0000839inviable elongated mononucleate aseptate cellMicroscopycdc2-33 (A177T)EndogenousPECO:0000004PMID:725435228
Microscopycdc2-M63 (G227C)EndogenousPECO:0000004PMID:7254352
Microscopycdc2-17 (G212S)Not specifiedPECO:0000004PMID:9203579
FYPO:0001490inviable elongated vegetative cellMicroscopycdc2-18 (L269S)EndogenousPECO:0000004PMID:1896017385
Microscopycdc2-17 (G212S)EndogenousPECO:0000004PMID:1896017
Microscopycdc2-48 (Y292H)EndogenousPECO:0000004PMID:1896017
Microscopycdc2-56 (G183E)EndogenousPECO:0000004PMID:2674650
Microscopycdc2-M35 (G43E)EndogenousPECO:0000004PMID:2674650
Microscopycdc2-L7 (P208S)EndogenousPECO:0000004PMID:2674650
Microscopycdc2-M26 (P137S)EndogenousPECO:0000004PMID:2674650
Microscopycdc2-45 (F210L)EndogenousPECO:0000004PMID:1896017
Microscopycdc2ΔNullPMID:3553962
Microscopycdc2-33 (A177T)EndogenousPECO:0000004PMID:2674650
Microscopycdc2-M63 (G227C)EndogenousPECO:0000004PMID:2674650
FYPO:0000411normal cell cycleMicroscopyArg34 (K34R)Not specifiedPMID:379659137
Cell growth assayArg34 (K34R)Not specifiedPMID:3796591
FYPO:0001927normal cell cycle regulation during cellular response to ionizing radiationMicroscopycdc2-3w (C67Y)Not specifiedPECO:0000005PMID:154917912
FYPO:0002043normal premeiotic DNA replicationFlow cytometry datacdc2-33 (A177T)Not specifiedPECO:0000004PMID:38709798
FYPO:0000703normal protein binding31
affecting suc1 and cdc2Western blot assaycdc2-M56 (P137S)EndogenousPMID:3322810
affecting suc1 and cdc2Western blot assaycdc2-M55EndogenousPMID:3322810
FYPO:0000838normal protein localization to nucleus28
affecting cdc13Microscopycdc2ΔNullPMID:2569363
FYPO:0001928normal regulation of mitotic cell cycleMicroscopycdc2-59 (P248L, C67Y)EndogenousPECO:0000005PMID:342826218
FYPO:0000590normal sporulationMicroscopycdc2-3w (C67Y)Not specifiedPECO:0000005PMID:193412645
Microscopycdc2-3w (C67Y)Not specifiedPECO:0000004PMID:1934126
FYPO:0002052normal sporulation frequencyCell growth assaytws1-N22 (E42K)Not specifiedPECO:0000015PMID:65811577
FYPO:0000997pear-shaped cell during nitrogen starvationMicroscopycdc2-974 (I35N)PECO:0000005, PECO:0000090PMID:193667286
FYPO:0003454protein mislocalized to nucleus during meiosis I1
affecting rna1Microscopytws1-N22 (E42K)Not specifiedPMID:20970342
FYPO:0000347swollen sporeMicroscopytws1-N22 (E42K)Not specifiedPMID:65811575
FYPO:0000648viable small vegetative cellMicroscopycdc2-3w (C67Y)Not specifiedPECO:0000005PMID:175673632
Microscopycdc2-3w (C67Y)Not specifiedPMID:8887552
Microscopycdc2-3w (C67Y)Not specifiedPECO:0000126, PECO:0000005PMID:1464318
Microscopycdc2.1wNot specifiedPECO:0000005PMID:1756736
Microscopycdc2-56 (G183E)EndogenousPECO:0000006PMID:2674650
Microscopycdc2-3w (C67Y)EndogenousPMID:2674650
Microscopycdc2-1w (G146D)Not specifiedPMID:3796591
Microscopycdc2-1w (G146D)EndogenousPMID:2674650
Microscopycdc2-3w (C67Y)PECO:0000004PMID:8631307
Microscopycdc2-1w (G146D)Not specifiedPECO:0000004PMID:672898
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in cdc10 MBF transcription factor complex subunit Cdc10 PMID:8631306
FYPO affected by mutation in cdc13 G2/M B-type cyclin Cdc13 PMID:2569363
FYPO affected by mutation in cdc13 G2/M B-type cyclin Cdc13 PMID:2665944
FYPO affected by mutation in cdc2 cyclin-dependent protein kinase Cdk1/Cdc2 PMID:8665408
FYPO affected by mutation in cdc2 cyclin-dependent protein kinase Cdk1/Cdc2 PMID:2665944
FYPO affected by mutation in cdc2 cyclin-dependent protein kinase Cdk1/Cdc2 PMID:3322810
FYPO affected by mutation in cdc25 M phase inducer tyrosine phosphatase Cdc25 PMID:2665944
FYPO affected by mutation in cdc28 ATP-dependent RNA helicase Cdc28 PMID:11350031
FYPO affected by mutation in cia1 histone chaperone Cia1 PMID:22291963
FYPO affected by mutation in dnt1 nucleolar protein Dnt1 PMID:24006256
FYPO affected by mutation in drc1 DNA replication checkpoint protein Drc1 PMID:11937031
FYPO affected by mutation in nap1 nucleosome assembly protein Nap1 PMID:18474252
FYPO affected by mutation in nda3 tubulin beta Nda3 PMID:2665944
FYPO affected by mutation in pim1 Ran GDP/GTP exchange factor PMID:1855255
FYPO affected by mutation in prp1 U4/U6 x U5 tri-snRNP complex subunit Prp1 PMID:11350031
FYPO affected by mutation in prp10 U2 snRNP-associated protein Sap155 PMID:11350031
FYPO affected by mutation in prp11 ATP-dependent RNA helicase Prp11 PMID:11350031
FYPO affected by mutation in prp12 U2 snRNP-associated protein Sap130 PMID:11350031
FYPO affected by mutation in prp2 U2AF large subunit (U2AF-59) PMID:11350031
FYPO affected by mutation in prp2 U2AF large subunit (U2AF-59) PMID:9917066
FYPO affected by mutation in ran1 serine/threonine protein kinase Ran1 PMID:3058333
FYPO affected by mutation in rum1 CDK inhibitor Rum1 PMID:9552380
FYPO affected by mutation in snu1 small nuclear RNA U1 PMID:8665408
FYPO affected by mutation in spo5 meiotic RNA-binding protein 1 PMID:16896214
FYPO affected by mutation in srb10 cyclin-dependent protein Srb mediator subunit kinase Srb10 PMID:22451489
FYPO affected by mutation in suc1 cyclin-dependent protein kinase regulatory subunit Suc1 PMID:2665944
FYPO affected by mutation in wee1 M phase inhibitor protein kinase Wee1 PMID:3058333
GO regulated by cdc13 G2/M B-type cyclin Cdc13 PMID:2569363
GO regulated by cdc25 M phase inducer tyrosine phosphatase Cdc25 PMID:2665944
GO regulated by cdc25 M phase inducer tyrosine phosphatase Cdc25 PMID:1756737
GO substrate of cdc25 M phase inducer tyrosine phosphatase Cdc25 PMID:1756737
GO substrate of cdc25 M phase inducer tyrosine phosphatase Cdc25 PMID:1819507
GO regulated by cig2 G1/S-specific B-type cyclin Cig2 PMID:8631306
GO regulated by cig2 G1/S-specific B-type cyclin Cig2 PMID:9552380
GO substrate of csk1 cyclin-dependent kinase activating kinase Csk1 PMID:10226032
GO substrate of mik1 mitotic inhibitor kinase Mik1 PMID:7982971
GO regulated by pim1 Ran GDP/GTP exchange factor PMID:1855255
GO substrate of pyp3 protein-tyrosine phosphatase Pyp3 PMID:1464318
GO regulated by rum1 CDK inhibitor Rum1 PMID:9552380
GO binds spd1 ribonucleotide reductase (RNR) inhibitor PMID:8887552
GO binds suc1 cyclin-dependent protein kinase regulatory subunit Suc1 PMID:2569363
GO regulated by suc1 cyclin-dependent protein kinase regulatory subunit Suc1 PMID:3322810
GO regulated by suc1 cyclin-dependent protein kinase regulatory subunit Suc1 PMID:2569363
GO regulated by wee1 M phase inhibitor protein kinase Wee1 PMID:1372994
GO substrate of wee1 M phase inhibitor protein kinase Wee1 PMID:1372994
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
115001971500243
215002861500376
315004451500613
415006861500986
515010881501393
615014481502095

UTRs

Region Coordinates Reference
five_prime_UTR1500197..1500243,1500286..1500339PMID:21511999
three_prime_UTR1501529..1502095PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00069 Pfam IPR000719 Protein kinase domain 4 293 109
SM00220 SMART IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain 4 293 107
PS00108 Prosite Patterns IPR008271 Serine/threonine-protein kinase, active site 130 142 97
PS00107 Prosite Patterns IPR017441 Protein kinase, ATP binding site 10 33 73
PS50011 Prosite Profiles IPR000719 Protein kinase domain 4 293 110
PTHR24056 HMMPANTHER 1 295 9
1.10.510.10 Gene3D 88 294 112
3.30.200.20 Gene3D 2 87 111
SSF56112 SuperFamily IPR011009 Protein kinase-like domain 1 296 127

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0003657CDK family kinaseTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0003657

Protein Properties

Ave. residue weight 115.69 Da
Charge 4.50
Isoelectric point 7.68
Molecular weight 34.36 kDa
Number of residues 297
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineIDAPMID:30583331669
MOD:00047O-phospho-L-threonineIDAT167PMID:18257517689
present during cellular response to thiabendazole
MOD:00048O4'-phospho-L-tyrosineY15PMID:2171254782
present during mitotic M phase
present during cellular response to thiabendazoleIDAY15PMID:18257517
MOD:00696phosphorylated residueNASY15PMID:90428631921
added by wee1NASY15PMID:2682257
NASPMID:19547744
NASPMID:18257517
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
protein levelunchanged during GO:0072734Western blot evidencePMID:1899230
present during GO:0072690Western blot evidencePMID:2569363
constant during GO:0000278Western blot evidencePMID:2569363

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
14449during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
5406.86during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
2704.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.8during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
0.52during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by H. sapiens CDK1full PMID:1944283 PMID:3553962
full
does not functionally complement S. cerevisiae CDC28 PMID:3796591
functionally complemented by G. gallus cdc2full PMID:1500441
functionally complements S. cerevisiae CDC28 when introns removedfull PMID:3796591
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
res2MBF transcription factor complex subunit Res2 Synthetic RescuePMID:11029045
Synthetic LethalityPMID:2474475
rad4BRCT domain protein Rad4 Phenotypic SuppressionPMID:7957098
wis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:1756736
dim1U4/U6 x U5 tri-snRNP complex subunit Dim1 Synthetic Growth DefectPMID:9182666
sum3translation initiation RNA helicase Sum3 Dosage RescuePMID:11711540
Dosage RescuePMID:9832516
hta1histone H2A alpha Phenotypic EnhancementPMID:16314498
spd1ribonucleotide reductase (RNR) inhibitor Phenotypic SuppressionPMID:8887552
ria1GTPase Ria1 (predicted) Negative GeneticPMID:22681890
slp1sleepy homolog Slp1 Phenotypic SuppressionPMID:9001228
Synthetic Growth Defect
cmk2MAPK-activated protein kinase Cmk2 Phenotypic SuppressionPMID:12135745
cdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic Growth DefectPMID:3448096
Phenotypic EnhancementPMID:2004705
Synthetic RescuePMID:2245912
pyp1tyrosine phosphatase Pyp1 Phenotypic SuppressionPMID:1448087
Dosage RescuePMID:9560390
SPAC29A4.02ctranslation elongation factor EF-1 gamma subunit Phenotypic SuppressionPMID:14985109
cdr2serine/threonine protein kinase Cdr2 Synthetic Growth DefectPMID:3448096
Synthetic LethalityPMID:9843577
Synthetic RescuePMID:2245912
tor1phosphatidylinositol kinase Tor1 Phenotypic SuppressionPMID:19546237
sty1MAP kinase Sty1 Synthetic RescuePMID:9560390
ctu1cytosolic thiouridylase subunit Ctu1 Synthetic Growth DefectPMID:22768388
wee1M phase inhibitor protein kinase Wee1 Phenotypic EnhancementPMID:3116001
Synthetic LethalityPMID:9188094
Phenotypic EnhancementPMID:9013342
Synthetic Growth DefectPMID:11029045
Synthetic LethalityPMID:2474475
elp3elongator complex subunit Elp3 (predicted) Synthetic Growth DefectPMID:22768388
clp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic RescuePMID:23297348
Synthetic LethalityPMID:16950131
Phenotypic EnhancementPMID:11683392
Phenotypic Suppression
mik1mitotic inhibitor kinase Mik1 Phenotypic SuppressionPMID:10637286
cig2G1/S-specific B-type cyclin Cig2 Synthetic LethalityPMID:8455610
Synthetic Rescue
Phenotypic Enhancement
Phenotypic EnhancementPMID:9552380
pmk1MAP kinase Pmk1 Phenotypic EnhancementPMID:22918952
rum1CDK inhibitor Rum1 Phenotypic EnhancementPMID:7593289
hta2histone H2A beta Phenotypic EnhancementPMID:16314498
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
blt1Blt1 Synthetic Growth DefectPMID:24790095
sum1translation initiation factor eIF3i Dosage RescuePMID:9560390
chk1Chk1 protein kinase Dosage RescuePMID:8497322
Phenotypic SuppressionPMID:10637286
Dosage RescuePMID:11711540
rad3ATR checkpoint kinase Rad3 Phenotypic EnhancementPMID:22918952
swr1SNF2 family helicase Swr1 Phenotypic EnhancementPMID:9571240
cdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:2245912
Phenotypic SuppressionPMID:3796591
Phenotypic SuppressionPMID:9013342
Phenotypic SuppressionPMID:1934126
Synthetic Growth DefectPMID:20444100
Synthetic RescuePMID:7217015
suc1cyclin-dependent protein kinase regulatory subunit Suc1 Phenotypic SuppressionPMID:3010051
Dosage RescuePMID:3322810
Phenotypic SuppressionPMID:9790601
Dosage RescuePMID:2665944
Phenotypic SuppressionPMID:16453733
Dosage RescuePMID:1896017
rad54DNA-dependent ATPase Rad54/Rhp54 Synthetic LethalityPMID:8834792
fin1serine/threonine protein kinase, NIMA related Fin1 Phenotypic SuppressionPMID:12065422
hsp9heat shock protein Hsp9 Dosage RescuePMID:22182414
mcs4response regulator Mcs4 Synthetic LethalityPMID:2474475
pyp2tyrosine phosphatase Pyp2 Phenotypic SuppressionPMID:1448087
orc1origin recognition complex subunit Orc1 Phenotypic EnhancementPMID:12186947
cdc6DNA polymerase delta catalytic subunit Cdc6 Phenotypic EnhancementPMID:9154809
Synthetic RescuePMID:9135148
srw1CDK inhibitor Srw1 Phenotypic SuppressionPMID:14985109
Synthetic Growth Defect
Dosage LethalityPMID:9398669
Phenotypic Suppression
bgs11,3-beta-glucan synthase catalytic subunit Bgs1 Phenotypic SuppressionPMID:10704373
Phenotypic EnhancementPMID:10503548
pab1protein phosphatase regulatory subunit Pab1 Phenotypic SuppressionPMID:20876564
cut12spindle pole body protein Cut12 Synthetic RescuePMID:23333317
Phenotypic SuppressionPMID:2245912
pop1cullin 1 adaptor protein Pop1 Synthetic LethalityPMID:9203581
cdc5splicing factor, Prp19 complex subunit Cdc5 Negative GeneticPMID:8313892
cdc37Hsp90 co-chaperone Cdc37 Dosage RescuePMID:16390871
spo4serine/threonine protein kinase Spo4 Phenotypic SuppressionPMID:23370392
cut1separase/separin Phenotypic SuppressionPMID:16453724
cdc10MBF transcription factor complex subunit Cdc10 Phenotypic EnhancementPMID:11513869
cid13poly(A) polymerase Cid13 Dosage RescuePMID:12062100
mcs2TFIIH complex cyclin Mcs2 Synthetic LethalityPMID:2474475
orc2origin recognition complex subunit Orc2 Phenotypic EnhancementPMID:8552194
hsp90Hsp90 chaperone Phenotypic EnhancementPMID:22543982
Phenotypic EnhancementPMID:10102358
pyp3protein-tyrosine phosphatase Pyp3 Dosage LethalityPMID:1464318
cdc13G2/M B-type cyclin Cdc13 Dosage RescuePMID:1533272
Phenotypic SuppressionPMID:9790601
Phenotypic SuppressionPMID:1934126
Dosage RescuePMID:11711540
Dosage RescuePMID:2847913
Dosage RescuePMID:7909513
Phenotypic SuppressionPMID:8631306
Phenotypic SuppressionPMID:1829983
Dosage RescuePMID:3428262
Phenotypic Suppression
Phenotypic Enhancement
sep1forkhead transcription factor Sep1 Phenotypic EnhancementPMID:9473044
mcs6cyclin-dependent protein kinase/CDK-activating kinase Mcs6 Synthetic LethalityPMID:2474475
Synthetic Growth Defect
Dosage RescuePMID:8557037
wos2p23 homolog, predicted co-chaperone Wos2 Phenotypic EnhancementPMID:10581266
mcm4MCM complex subunit Mcm4/Cdc21 Phenotypic SuppressionPMID:8631307
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
ase1antiparallel microtubule cross-linking factor Ase1 Biochemical ActivityPMID:19686686
cig2G1/S-specific B-type cyclin Cig2 Affinity Capture-WesternPMID:11163211
hsp90Hsp90 chaperone Affinity Capture-WesternPMID:22543982
spd1ribonucleotide reductase (RNR) inhibitor Affinity Capture-WesternPMID:8887552
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Biochemical ActivityPMID:9242669
Two-hybrid
mik1mitotic inhibitor kinase Mik1 Biochemical ActivityPMID:7982971
cdc25M phase inducer tyrosine phosphatase Cdc25 Biochemical ActivityPMID:22665807
cdc11SIN component scaffold protein, centriolin ortholog Cdc11 Affinity Capture-WesternPMID:15062098
clp1Cdc14-related protein phosphatase Clp1/Flp1 Biochemical ActivityPMID:16950131
Biochemical ActivityPMID:22918952
pch1P-TEFB associated cyclin, cyclin T Pch1 Affinity Capture-WesternPMID:9115279
Two-hybrid
rum1CDK inhibitor Rum1 Biochemical ActivityPMID:10679013
Biochemical ActivityPMID:9303310
Reconstituted Complex
Biochemical ActivityPMID:12167173
Affinity Capture-RNAPMID:22144913
Affinity Capture-WesternPMID:11329175
mbx1MADS-box transcription factor Mbx1 Biochemical ActivityPMID:21098641
hcn1anaphase-promoting complex subunit Hcn1 Biochemical ActivityPMID:16950791
cdc18MCM loader Affinity Capture-RNAPMID:22144913
Affinity Capture-WesternPMID:9436991
Biochemical Activity
Biochemical ActivityPMID:9177184
mde4monopolin-like complex subunit Mde4 Biochemical ActivityPMID:19523829
cut3condensin complex subunit Cut3 Biochemical ActivityPMID:10485849
bub1serine/threonine protein kinase Bub1 Biochemical ActivityPMID:12606573
wee1M phase inhibitor protein kinase Wee1 Biochemical ActivityPMID:7982971
Biochemical ActivityPMID:1850698
Biochemical ActivityPMID:1372994
suc1cyclin-dependent protein kinase regulatory subunit Suc1 Affinity Capture-WesternPMID:3322810
Reconstituted ComplexPMID:2665944
Co-fractionationPMID:2569363
Affinity Capture-WesternPMID:9790601
crb2DNA repair protein Rad9 homolog, Rhp9 Biochemical ActivityPMID:24074952
Biochemical ActivityPMID:10488332
pas1cyclin Pas1 Affinity Capture-WesternPMID:10982385
skb1type II protein arginine N-methyltransferase Skb1 Affinity Capture-WesternPMID:9843966
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
drc1DNA replication checkpoint protein Drc1 Reconstituted ComplexPMID:11937031
cut12spindle pole body protein Cut12 Biochemical ActivityPMID:23333317
dis2serine/threonine protein phosphatase PP1 subfamily, Dis2 Biochemical ActivityPMID:16920624
Biochemical ActivityPMID:7957097
fkh2forkhead transcription factor Fkh2 Biochemical ActivityPMID:18059475
bgs11,3-beta-glucan synthase catalytic subunit Bgs1 Affinity Capture-WesternPMID:11937031
cdc37Hsp90 co-chaperone Cdc37 Affinity Capture-WesternPMID:16390871
wos2p23 homolog, predicted co-chaperone Wos2 Affinity Capture-WesternPMID:10581266
nsk1Clp1-interacting protein Nsk1 Affinity Capture-WesternPMID:22065639
Biochemical Activity
pyp3protein-tyrosine phosphatase Pyp3 Biochemical ActivityPMID:1464318
cdc13G2/M B-type cyclin Cdc13 Affinity Capture-WesternPMID:9632761
Biochemical ActivityPMID:2569363
Co-fractionation
Affinity Capture-WesternPMID:9790601
Affinity Capture-WesternPMID:10581266
Affinity Capture-WesternPMID:11683390
Affinity Capture-WesternPMID:16390871
Affinity Capture-WesternPMID:11329175
orc2origin recognition complex subunit Orc2 Affinity Capture-WesternPMID:8552194
Two-hybrid
Biochemical ActivityPMID:11486016
shk1PAK-related kinase Shk1 Affinity Capture-WesternPMID:9843966
External References
Database Identifier Description
NBRP SPBC11B10.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC11B10.09 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC11B10.09 BioGRID Interaction Datasets
Expression Viewer SPBC11B10.09 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC11B10.09 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC11B10.09 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC11B10.09 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC11B10.09 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC11B10.09 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC11B10.09 Cell Cycle Data
GEO SPBC11B10.09 GEO profiles
PInt SPBC11B10.09 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC11B10.09 Peptides identified in tandem mass spectrometry proteomics experiments
EntrezGene2539869cyclin-dependent protein kinase Cdc2
WikiGene2539869cyclin-dependent protein kinase Cdc2
SPD / RIKEN50/50D08Orfeome Localization Data
UniProtKB/SwissProtP04551Cyclin-dependent kinase 1
ModBaseP04551Database of comparative protein structure models
STRINGP04551Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595629cyclin-dependent protein kinase Cdc2
RefSeq mRNANM_001021523972h- cyclin-dependent protein kinase Cdc2 (cdc2), mRNA
European Nucleotide ArchiveAAA35293ENA Protein Mapping
European Nucleotide ArchiveAAA35293.1ENA Protein Mapping
European Nucleotide ArchiveBAA21379ENA Protein Mapping
European Nucleotide ArchiveBAA21379.1ENA Protein Mapping
European Nucleotide ArchiveCAC37513ENA Protein Mapping
European Nucleotide ArchiveCAC37513.1ENA Protein Mapping
ReactomeREACT_188254
ReactomeREACT_188278
ReactomeREACT_188629
ReactomeREACT_199398
ReactomeREACT_205526
ReactomeREACT_215140
ReactomeREACT_219807
ReactomeREACT_219991
ReactomeREACT_221258
ReactomeREACT_222028
ReactomeREACT_222044
UniParcUPI00001273F9UniProt Archive

Literature for cdc2

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014