cdc2 (SPBC11B10.09)


Gene Standard Namecdc2 Characterisation Statuspublished
Systematic IDSPBC11B10.09 Feature Typeprotein coding
Synonymscdk1, pi002, SPACTOKYO_453.34, swo2, tws1, wee2 Name DescriptionTWo Spored,
Cell Division Cycle
Productcyclin-dependent protein kinase Cdk1/Cdc2 Product Size297aa, 34.36 kDa
Genomic Location Chromosome II, 1500197-1502095 (1899nt); CDS:1500340-1501528 (1189nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
ATP binding557
Annotation ExtensionEvidenceWith/FromReference
cyclin-dependent protein kinase activity6
Annotation ExtensionEvidenceWith/FromReference
cyclin-dependent protein serine/threonine kinase activity5
protein binding887
Annotation ExtensionEvidenceWith/FromReference
protein kinase activity116
Annotation ExtensionEvidenceWith/FromReference
protein serine/threonine kinase activity106
GO Biological Process
Term NameCount
negative regulation of conjugation with cellular fusion25
Annotation ExtensionEvidenceWith/FromReference
negative regulation of double-strand break repair via nonhomologous end joining1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of exit from mitosis1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of G0 to G1 transition23
Annotation ExtensionEvidenceWith/FromReference
negative regulation of mitotic attachment of spindle microtubules to kinetochore1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of mitotic spindle elongation1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of mitotic telomere tethering at nuclear periphery1
Annotation ExtensionEvidenceWith/FromReference
negative regulation of protein dephosphorylation4
Annotation ExtensionEvidenceWith/FromReference
negative regulation of ubiquitin protein ligase activity4
Annotation ExtensionEvidenceWith/FromReference
positive regulation of attachment of mitotic spindle microtubules to kinetochore3
Annotation ExtensionEvidenceWith/FromReference
positive regulation of double-strand break repair via homologous recombination2
Annotation ExtensionEvidenceWith/FromReference
positive regulation of G1/S transition of mitotic cell cycle4
Annotation ExtensionEvidenceWith/FromReference
positive regulation of G2/M transition of mitotic cell cycle19
Annotation ExtensionEvidenceWith/FromReference
positive regulation of mitotic cell cycle DNA replication3
Annotation ExtensionEvidenceWith/FromReference
positive regulation of protein localization to nucleus7
Annotation ExtensionEvidenceWith/FromReference
positive regulation of septation initiation signaling7
Annotation ExtensionEvidenceWith/FromReference
positive regulation of signal transduction involved in mitotic G2 DNA damage checkpoint1
Annotation ExtensionEvidenceWith/FromReference
regulation of cell size14
Annotation ExtensionEvidenceWith/FromReference
regulation of meiotic cell cycle49
Annotation ExtensionEvidenceWith/FromReference
response to intra-S DNA damage checkpoint signaling4
Annotation ExtensionEvidenceWith/FromReference
response to mitotic DNA integrity checkpoint signaling1
Annotation ExtensionEvidenceWith/FromReference
traversing start control point of mitotic cell cycle4
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cyclin-dependent protein kinase holoenzyme complex11
Annotation ExtensionEvidenceWith/FromReference
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
mitotic spindle midzone24
Annotation ExtensionEvidenceWith/FromReference
nuclear chromatin365
Annotation ExtensionEvidenceWith/FromReference
nucleus2700
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
decreased cell population growth at low temperaturecdc2-r4 (D90N)95
decreased septation indexcdc2-33 (A177T)21
increased frequency of apoptosiscdc2-Y15F (Y15F)11
increased number of cells with 1C DNA contentcdc2-3w (C67Y)66
inviable vegetative cell populationcdc2-3w (C67Y)1455
cdc2-4w (G200T)
cdc2Δ
loss of viability upon nitrogen starvationcdc2-974 (I35N)53
normal growth during cellular response to UVcdc2-1w (G146D)79
normal growth on arsenatecdc2-3w (C67Y)4
normal growth on hydroxyureacdc2-1w (G146D)75
normal septation indexcdc2-3w (C67Y)11
normal sporulation frequencytws1-N22 (E42K)14
normal vegetative cell population growthcdc2-1w (G146D)813
normal vegetative cell population growth ratetws1-N22 (E42K)80
sensitive to caffeine during vegetative growthcdc2-33 (A177T)110
sensitive to camptothecincdc2-1w (G146D)257
sensitive to ethanolcdc2-M26 (P137S)5
cdc2-M56 (P137S)
sensitive to hydroxyureacdc2-3w (C67Y)594
sensitive to methyl methanesulfonatecdc2-Y15F (Y15F)331
sensitive to plumbagincdc2+/cdc2- (heterozygous diploid)12
viable vegetative cell populationcdc2-1w (G146D)3850

Cell Phenotype

Term NameGenotypesCount
abnormal meiosiscdc2-N22 (E42K)134
abnormal mitotic cell cyclecdc2Δ894
abnormal mitotic cell cycle arrest with replicated DNAcdc2-33 (A177T)45
cdc2-L7 (P208S)
abnormal mitotic cell cycle regulation during cellular response to hydroxyureacdc2-3w (C67Y)15
abnormal protein phosphorylation during vegetative growth173
affecting cdc2cdc2-1w (G146D)
abnormal sporulation resulting in formation of two-spore ascustws1-N22 (E42K)13
cdc2-N22 (E42K)
cdc2-59 (P248L, C67Y)
cdc2-33 (A177T)
abnormally arrested mitotic cell cycle progressionAla167 (T167A)165
cdc2-33 (A177T)
Val167 (T167V)
Val177 (A177V)
cdc2Δ
Arg33 (K33R)
abolished meiosiscdc2-M26 (P137S)20
abolished meiosis Icdc2-M26 (P137S)3
abolished meiosis IIcdc2-33 (A177T)5
cdc2-7
abolished premeiotic DNA replicationY15F (Y15F)15
cdc2-33 (A177T)
cdc2-M26 (P137S)
cdc2-M63 (G227C)
abolished protein binding147
affecting cdc2 and suc1cdc2-56 (G183E)
abolished protein kinase activity27
affecting cdc2cdc2-56 (G183E)
abolished protein localization to kinetochore during vegetative growth22
affects localization of nsk1cdc2-as (F84G)
abolished protein phosphorylation during vegetative growth55
affecting srw1cdc2-33 (A177T)
affecting mde4cdc2-as (F84G)
abolished re-entry into mitotic cell cycle after pheromone arrestcdc2-M26 (P137S)1
cut during cellular response to hydroxyureacdc2-4w (G200T)44
cdc2-3w (C67Y)
decreased arsenate reductase activitycdc2-3w (C67Y)2
decreased protein binding99
affecting cdc2 and suc1cdc2-56 (G183E)
affecting cdc2 and suc1cdc2-L7 (P208S)
affecting cdc2 and suc1cdc2-33 (A177T)
affecting cdc2 and cdc13cdc2-L7 (P208S)
decreased protein kinase activitycdc2-L7 (P208S)56
cdc2-M35 (G43E)
cdc2-A21 (D90N)
affecting cdc2cdc2-33 (A177T)
affecting cdc2cdc2-M55
affecting cdc2cdc2-56 (G183E)
affecting cdc2cdc2-M35 (G43E)
affecting cdc2cdc2-L7 (P208S)
decreased protein localization to chromatin at replication origin10
affects localization of cdc13cdc2-33 (A177T)
decreased protein phosphorylation during mitotic G2 phase3
affecting srw1cdc2-M26 (P137S)
decreased protein phosphorylation during vegetative growthcdc2-as (F84G)104
cdc2-33 (A177T)
affecting pol1cdc2-33 (A177T)
affecting cdc13cdc2-33 (A177T)
affecting cdc13cdc2-L7 (P208S)
affecting cdc13cdc2-56 (G183E)
affecting orc2cdc2-L7 (P208S)
affecting orc2cdc2-33 (A177T)
decreased protein serine phosphorylation during vegetative growth19
affecting fkh2cdc2-ts
affecting rap1cdc2-33 (A177T)
decreased protein threonine phosphorylation9
affecting fkh2cdc2-ts
affecting rap1cdc2-33 (A177T)
decreased response to S-phase DNA damage checkpoint signalingcdc2-Y15F (Y15F)2
delayed onset of premeiotic DNA replicationY15F (Y15F)3
delayed onset of protein localization to nucleoplasm during cellular response to hydrogen peroxidecdc2-as (F84G)4
elongated cell during nitrogen starvationcdc2-974 (I35N)23
fragmented DNA during nitrogen starvationcdc2-974 (I35N)13
increased cellular reactive oxygen species level during vegetative growthcdc2-Y15F (Y15F)28
increased mRNA splicing, via spliceosome1
affecting cdc2cdc2-I2mut (TTGACG287ACACAT)
increased RNA splicing at cryptic splice sites4
affecting cdc2cdc2-I2mut (TTGACG287ACACAT)
inviable after spore germination with elongated germ tubecdc2Δ164
inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cellscdc2-59 (P248L, C67Y)88
inviable after spore germination, without cell division, with elongated germ tubecdc2Δ66
inviable elongated mononucleate aseptate cellcdc2-E9 (D242N)44
cdc2-17 (G212S)
cdc2-
cdc2-M63 (G227C)
cdc2-33 (A177T)
cdc2-E8 (D213N)
inviable elongated mononucleate aseptate vegetative cell with cell cycle arrest in mitotic G2 phasecdc2-A21 (D90N)7
inviable elongated vegetative cellcdc2-17 (G212S)420
cdc2-M26 (P137S)
cdc2-48 (Y292H)
cdc2-M63 (G227C)
cdc2-56 (G183E)
cdc2-L7 (P208S)
cdc2Δ
cdc2-33 (A177T)
cdc2-18 (L269S)
cdc2-45 (F210L)
cdc2-M35 (G43E)
inviable vegetative cellL248 (P248L)1358
mitotic G1/S transition delaycdc2-L7 (P208S)13
cdc2-33 (A177T)
normal cell cycle regulation during cellular response to hydroxyureacdc2-1w (G146D)20
normal cell cycle regulation during cellular response to ionizing radiationcdc2-3w (C67Y)17
normal interphase cytoplasmic microtubulescdc2-3w (C67Y)8
normal mitotic cell cycleArg34 (K34R)129
normal mitotic spindlecdc2-3w (C67Y)18
normal premeiotic DNA replicationcdc2-33 (A177T)25
normal protein binding91
affecting cdc2 and suc1cdc2-M56 (P137S)
affecting cdc2 and suc1cdc2-M55
normal protein kinase activity23
affecting cdc2cdc2-56 (G183E)
normal protein localization to chromatin at replication origin6
affecting mrc1cdc2-33 (A177T)
normal protein localization to nucleus during vegetative growth83
affecting cdc13cdc2Δ
normal protein phosphorylation during nitrogen starvation10
affecting ssp2cdc2-1w (G146D)
normal protein phosphorylation during vegetative growth96
affecting srw1cdc2-33 (A177T)
affecting pol1cdc2-33 (A177T)
normal regulation of mitotic cell cyclecdc2-59 (P248L, C67Y)64
normal sporulationcdc2-3w (C67Y)53
normal telomere lengthcdc2-3w (C67Y)35
normal vegetative cell lengthcdc2-33 (A177T)10
premature protein localization to mitotic spindle2
affects localization of mde4cdc2-as (F84G)
protein mislocalized to nucleus during meiosis I1
affects localization of rna1tws1-N22 (E42K)
septation following abnormal chromosome segregation, with binucleate and anucleate compartment formation during cellular response to hydroxyureacdc2-4w (G200T)4
cdc2-3w (C67Y)
swollen sporetws1-N22 (E42K)5
viable elongated vegetative cell, elongated upon mitotic entrycdc2-33 (A177T)12
viable small vegetative cellcdc2-Y15F (Y15F)54
cdc2-3w (C67Y)
cdc2-4w (G200T)
cdc2-3w (C67Y)
cdc2-1w (G146D)
cdc2-56 (G183E)
viable vegetative cellCdc2-F15 (T15F)3659

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
abnormal mitotic cell cycle arrest with unreplicated DNAcdc2-Y15F (Y15F), cdc10-V50 (H362Y)
abolished cell population growth at high temperaturewee1-50, cdc2-3w (C67Y)
decreased cell population growth on glucose carbon sourcemcs6-13 (L238R), cdc2-3w (C67Y)
decreased conjugation frequencysrw1::ura4, cdc2-M35 (G43E)
decreased vegetative cell population growthcdc2-1w (G146D), slx8-29
wee1-50, cdc2-4w (G200T)
cdc2-3w (C67Y), skb1Δ, cdc25Δ
increased septation indexcdc2-M63 (G227C), nmt::T167E (T167E)
inviable vegetative cell populationcdc2-3w (C67Y), cdc17-K42 (E298K)
cdc2-3w (C67Y), cdc20-M10
cdc25-22 (C532Y), cdc2-3w (C67Y), mcs2-75
cdc2-3w (C67Y), cdc25-22 (C532Y), mcs2-75
cdc25-22 (C532Y), cdc2-3w (C67Y), dis2+
cdc2-1w (G146D), cdc25::ura4
cdc2-3w (C67Y), wee1-50, sty1Δ
cdc2-3w (C67Y), mcs2-75
cdc2-3w (C67Y), wee1-50, wis1Δ
cdc2-M63 (G227C), nmt::T167E (T167E)
cdc22-M45, cdc2-3w (C67Y)
cdc2-33 (A177T), pop1-364
wee1-50, cdc2-3w (C67Y)
cdc25-22 (C532Y), cdc2-1w (G146D), dis2+
normal vegetative cell population growthskb1Δ, cdc2-3w (C67Y)
sensitive to arsenatecdc2-3w (C67Y), cdc25Δ
sensitive to camptothecincdc2-1w (G146D), wee1Δ
sensitive to hydroxyureacdc2-1w (G146D), wee1Δ
cdc2-1w (G146D), slx8-29
sensitive to UV during vegetative growthcdc2-1w (G146D), wee1Δ
slow vegetative cell population growthE167 (T167E), cdc2-33 (A177T)
viable vegetative cell populationcdc2-3w (C67Y), mcs6::ura4+, mcs2-75
cdc25-22 (C532Y), cdc2-1w (G146D), dis2+
cdc25-22 (C532Y), cdc2-3w (C67Y), dis2+
mcs4-13, cdc2+, wee1-50, cdc25-22 (C532Y)
cdc2-3w (C67Y), csk1+, cdc25-22 (C532Y), mcs2-75
srk1+, cdc2-3w (C67Y)
cdc2-3w (C67Y), wee1+ (wild type)
cdc25::ura4, cdc2-3w (C67Y)
cdc2-3w (C67Y), mcs2-75
wee1-50, mcs4Δ, cdc2-3w (C67Y)
cdc2-3w (C67Y), mcs6+, cdc25-22 (C532Y), mcs2-75

Cell Phenotype

Term NameGenotypes
abnormal mitotic cell cycle arrest with replicated DNAcdc2-L7 (P208S), A167 (T167A)
abnormal mitotic cell cycle regulation during cellular response to hydroxyureacut5-T401, cdc2-1w (G146D)
cdc25Δ, cdc2-3w (C67Y)
cdc2-3w (C67Y), cdc20-M10
cut5-T401, cdc2-3w (C67Y)
cdc2-3w (C67Y), cdc17-K42 (E298K)
cdc22-M45, cdc2-3w (C67Y)
abnormal mitotic sister chromatid segregationE167 (T167E), cdc2::huCDC2 (gene replacement)
abnormal protein phosphorylation during vegetative growth
affecting cdc2cdc2-1w (G146D), cdc13-245 (E255R)
affecting cdc2cdc2-1w (G146D), wee1Δ
affecting cdc2cdc2-1w (G146D), mik1Δ
abnormal sporulation resulting in formation of ascus with more than four sporescdc13Δ, puc1Δ, rem1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cig2Δ, cdc2Δ, cig1Δ
abnormal sporulation resulting in formation of two-spore ascuscdc2-1w (G146D), cdc25-22 (C532Y)
suc1-210, cdc2-M26 (P137S)
cdc13Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc2Δ
cdc2Δ, puc1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc13Δ, cig2Δ, cig1Δ
abnormally arrested mitotic cell cycle progressionpyp3+, cdc2-33 (A177T)
abolished activation of bipolar cell growthorb2-34, cdc2-33 (A177T)
abolished protein kinase activity
affecting cdc2cdc2::huCDC2 (gene replacement), A167 (T167A)
affecting cdc2E167 (T167E), cdc2::huCDC2 (gene replacement)
affecting cdc2 (Y15F, T167E), cdc2::huCDC2 (gene replacement)
affecting cdc2A167,F15 (T167A, Y15F), cdc2::huCDC2 (gene replacement)
affecting cdc2cdc2-M63 (G227C), nmt::T167E (T167E)
abolished protein localization to nucleoplasm during cellular response to hydrogen peroxide
affects localization of clp1pmk1Δ, cdc2-as (F84G), rad3Δ
affects localization of clp1pmk1Δ, cdc2-as (F84G)
affects localization of clp1rad3Δ, cdc2-as (F84G)
abolished protein localization to nucleoplasm during cellular response to hydroxyurea
affects localization of clp1pmk1Δ, cdc2-as (F84G), rad3Δ
abolished protein phosphorylation
affecting cdc2A167,F15 (T167A, Y15F), cdc2::huCDC2 (gene replacement)
abolished protein serine phosphorylation at RxxS site during cellular response to hydrogen peroxide
affecting clp1pmk1Δ, cdc2-as (F84G), rad3Δ
abolished protein serine phosphorylation at RxxS site during cellular response to hydroxyurea
affecting clp1pmk1Δ, cdc2-as (F84G), rad3Δ
abolished protein threonine phosphorylation
affecting cdc2E167 (T167E), cdc2::huCDC2 (gene replacement)
affecting cdc2Y167 (T167Y), cdc2::huCDC2 (gene replacement)
affecting cdc2cdc2::huCDC2 (gene replacement), A167 (T167A)
altered DNA level during vegetative growthwee1-50, cdc2-3w (C67Y)
cutcdc2-3w (C67Y), orp1-4
cdc2-1w (G146D), orp1-4
cut during cellular response to hydroxyureacdc25Δ, cdc2-3w (C67Y)
cdc2-3w (C67Y), wee1+ (wild type)
decreased protein binding
affecting cdc2 and cdc13cdc2::huCDC2 (gene replacement), A167 (T167A)
decreased protein kinase activitywee1-50, cdc2-E8 (D213N)
decreased protein phosphorylation during vegetative growth
affecting cut9cdc2-M63 (G227C), nmt::T167E (T167E)
decreased protein threonine phosphorylation at Thr-Pro site during cellular response to hydrogen peroxide
affecting clp1pmk1Δ, cdc2-as (F84G), rad3Δ
decreased protein threonine phosphorylation at Thr-Pro site during cellular response to hydroxyurea
affecting clp1pmk1Δ, cdc2-as (F84G), rad3Δ
decreased response to S-phase DNA damage checkpoint signalingcdc2-Y15F (Y15F), cdc10-V50 (H362Y)
delayed onset of protein localization to nucleoplasm during cellular response to hydrogen peroxide
affects localization of clp1rad3Δ, cdc2-as (F84G)
delayed onset of protein localization to nucleoplasm during cellular response to hydroxyurea
affects localization of clp1pmk1Δ, cdc2-as (F84G)
DNA content increased during vegetative growthE167 (T167E), cdc2-33 (A177T)
elongated mononucleate vegetative cellcdc2-3w (C67Y), cdc10-129 (T429A)
cut5-T401, cdc2-33 (A177T)
elongated multinucleate multiseptate vegetative cell, single septa between nucleiE167 (T167E), cdc2-33 (A177T)
elongated multiseptate vegetative cellmcs6-13 (L238R), cdc2-3w (C67Y)
elongated vegetative cellmcs6-13 (L238R), wee1-50, cdc2-3w (C67Y)
cdc2-3w (C67Y), wee1-50, mcs2-75
cdc2-3w (C67Y), mcs2-75
increased duration of mitotic M phasecdc21-M68, cdc2-3w (C67Y)
inviable after spore germination, multiple cell divisionsmcs1-77, cdc2-59 (P248L, C67Y)
mcs6-13 (L238R), cdc2-59 (P248L, C67Y)
mcs2-75, cdc2-59 (P248L, C67Y)
mcs4-13, cdc2-59 (P248L, C67Y)
inviable after spore germination, without cell division, elongated cellcdc2-1w (G146D), cdc25::ura4
inviable curved elongated vegetative celltea1-3, cdc2-33 (A177T)
inviable elongated aseptate cellatf1+, cdc2-33 (A177T)
inviable elongated mononucleate aseptate cellcdc2-33 (A177T), orb3-167
cdc2-33 (A177T), orb5-19
A167,F15 (T167A, Y15F), cdc2-33 (A177T)
cdc2-33 (A177T), A167 (T167A)
cut1-, cdc2-
Y167 (T167Y), cdc2-33 (A177T)
cdc2-33 (A177T), D167 (T167D)
wee1-50, cdc2-E8 (D213N)
inviable elongated multiseptate vegetative cellmcs6-13 (L238R), mcs4-13, cdc2-3w (C67Y)
inviable elongated vegetative cellcdc2-3w (C67Y), mcs2-75
inviable septated mononucleate vegetative cellwee1-50, cdc2-3w (C67Y)
inviable small vegetative cellcdc2-3w (C67Y), cdc17-K42 (E298K)
cdc2-3w (C67Y), cdc20-M10
cdc22-M45, cdc2-3w (C67Y)
inviable sporecdc2Δ, puc1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc13Δ, cig2Δ, cig1Δ
cdc13Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc2Δ
cdc13Δ, puc1Δ, rem1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cig2Δ, cdc2Δ, cig1Δ
inviable vegetative cellcdc2-M63 (G227C), nmt::T167E (T167E)
large and small daughter nucleiwee1-50, cdc2-3w (C67Y)
lemon-shaped cellcdc2-33 (A177T), orb6-25
mitosis with unreplicated DNAcdc25Δ, cdc2-3w (C67Y)
mitotic catastrophepyp3+, cdc2-3w (C67Y)
mitotic catastrophe with cut, small cellwee1-50, cdc2-3w (C67Y)
mitotic G1/S transition delaycdc2-L7 (P208S), A167 (T167A)
mitotic G2/M transition delaycdc2-3w (C67Y), pcn1+
multiple mitotic spindlesE167 (T167E), cdc2-33 (A177T)
normal actin cortical patch localizationcdc2-33 (A177T), orb5-19
normal actin cytoskeleton morphology during vegetative growthcdc2-33 (A177T), orb3-167
normal cell cycle regulation during cellular response to hydroxyureacdc10-129 (T429A), cdc2-3w (C67Y)
cut5-T401, cdc2-33 (A177T)
cdc2-3w (C67Y), wee1+ (wild type)
normal meiosiscdc13Δ, puc1Δ, rem1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), crs1Δ, cig2Δ, cdc2Δ, cig1Δ
puc1Δ, rem1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cig2Δ, cig1Δ
cdc2Δ, puc1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc13Δ, cig2Δ, cig1Δ
normal meiosis Icdc2Δ, puc1Δ, cdc2-cdc13 fusion (Prcdc13 cdc13-cdc2 -cdc13 terminator), cdc13Δ, cig2Δ, cig1Δ
normal microtubule cytoskeleton morphology during vegetative growthcdc2-33 (A177T), orb3-167
normal protein binding
affecting cdc2 and suc1E167 (T167E), cdc2::huCDC2 (gene replacement)
affecting cdc2 and cdc13E167 (T167E), cdc2::huCDC2 (gene replacement)
normal protein level during mitotic metaphase
affecting cdc13cdc2-M63 (G227C), nmt::T167E (T167E)
normal protein localization to chromatin at replication origin
affecting mcm4cdc2-33 (A177T), cdc13+
normal protein tyrosine phosphorylation during vegetative growth
affecting cdc2cdc2::huCDC2 (gene replacement), A167 (T167A)
affecting cdc2E167 (T167E), cdc2::huCDC2 (gene replacement)
affecting cdc2Y167 (T167Y), cdc2::huCDC2 (gene replacement)
normal vegetative cell growthcdc2-M55, suc1-210
suc1-449, cdc2-M26 (P137S)
suc1-449, cdc2-33 (A177T)
suc1-210, cdc2-M26 (P137S)
suc1-449, cdc2-M55
cdc2-L7 (P208S), suc1-210
suc1-210, cdc2-56 (G183E)
cdc2-33 (A177T), suc1-210
cdc2-L7 (P208S), suc1-449
suc1-449, cdc2-56 (G183E)
normal vegetative cell sizecdc2-3w (C67Y), mcs6::ura4+, mcs2-75
septation following abnormal chromosome segregation, with binucleate and anucleate compartment formation during cellular response to hydroxyureacdc2-3w (C67Y), cdc20-M10
cdc22-M45, cdc2-3w (C67Y)
cdc2-3w (C67Y), cdc17-K42 (E298K)
small vegetative cellcdc2-1w (G146D), mcs2-75
sterilesrw1::ura4, cdc2-M35 (G43E)
viable cell at high temperaturecdc25+ (wild type), wee1-50, cdc2-A21 (D90N)
cdc2-E8 (D213N), wee1-50, cdc25+ (wild type)
cdc2-E9 (D242N), wee1-50, cdc25+ (wild type)
viable elongated vegetative cellcdc2-3w (C67Y), win1-1, cdc25-22 (C532Y)
cdr1-76, cdc2-33 (A177T)
cdc2-3w (C67Y), tor1Δ, cdc25Δ
cdr2-97, cdc2-33 (A177T)
shk1+, cdc2-3w (C67Y), cdc25Δ
cdc25-22 (C532Y), cdc2-3w (C67Y)
cdc25::ura4, cdc2-3w (C67Y)
cdc2-3w (C67Y), skb1Δ, cdc25Δ
cdc2-3w (C67Y), wee1+ (wild type)
viable small vegetative cellmcs1-77, wee1-50, cdc2-3w (C67Y)
mcs4-13, wee1-50, cdc2-3w (C67Y)
cdc2-Y15F (Y15F), tor1Δ
cdc2-3w (C67Y), win1-1
cdc2-1w (G146D), dnt1Δ
viable vegetative cellE167 (T167E), cdc2-33 (A177T)
viable vegetative cell with normal cell sizewin1-1, cdc2-3w (C67Y)
cdc2-3w (C67Y), cdc25-22 (C532Y)
cdc2-M63 (G227C), nmt::T167E (T167E)
cdc2-33 (A177T), cdc2+
S167 (T167S), cdc2-33 (A177T)
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1500197..1500243, 1500286..1500376, 1500445..1500613, 1500686..1500986, 1501088..1501393, 1501448..1502095
Intron1500244..1500285, 1500377..1500444, 1500614..1500685, 1500987..1501087, 1501394..1501447
mRNA1500197..1502095
5' UTR1500197..1500243, 1500286..1500339PMID:21511999
CDS1500340..1500376, 1500445..1500613, 1500686..1500986, 1501088..1501393, 1501448..1501528
3' UTR1501529..1502095PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00069 Pfam IPR000719 Protein kinase domain 4 293 108
SM00220 SMART IPR000719 Protein kinase domain 4 293 107
PS50011 Prosite Profiles IPR000719 Protein kinase domain 4 293 110
PS00107 Prosite Patterns IPR017441 Protein kinase, ATP binding site 10 33 73
PS00108 Prosite Patterns IPR008271 Serine/threonine-protein kinase, active site 130 142 97
PTHR24056 HMMPANTHER 1 295 9
PTHR24056:SF11 HMMPANTHER 1 295 1
1.10.510.10 Gene3D Aminoglycoside phosphotransferase 88 294 112
3.30.200.20 Gene3D Tyrosine-protein kinase, receptor class V, conserved site 2 87 111
SSF56112 SuperFamily IPR011009 Protein kinase-like domain 1 296 127

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0003657CDK family kinaseTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0003657

Protein Properties

Ave. residue weight 115.69 Da
Charge 4.50
Codon Adaptation Index 0.43
Isoelectric point 7.68
Molecular weight 34.36 kDa
Number of residues 297
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 2289
Annotation ExtensionEvidenceResidueReference
IDA PMID:3058333
O-phospho-L-threonine 1085
present during mitotic S phase, cellular response to thiabendazoleT167
T14, T167
Annotation ExtensionEvidenceResidueReference
present during mitotic S phase IDA T167 PMID:1655416
present during cellular response to thiabendazole IDA T167 PMID:18257517
IDA PMID:1756737
IDA T167 PMID:25720772
IDA T167 PMID:26131711
IDA PMID:3058333
IDA T14 PMID:25720772
IDA T14 PMID:26131711
O4'-phospho-L-tyrosine 281
added by mik1, wee1Y15
added during mitotic G2 phase, premeiotic DNA replication
present during cellular response to hydroxyurea, cellular response to nitrosative stress, cellular response to thiabendazole, mitotic M phase, mitotic S phaseY15
present during meiosis I
removed by cdc25
removed during cellular response to caffeineY15
removed during meiosis II
absent during mitotic M phase
Y15
Annotation ExtensionEvidenceResidueReference
added by mik1 IDA Y15 PMID:7982971
added by wee1 IDA Y15 PMID:1372994
added during premeiotic DNA replication IDA PMID:10888871
added during mitotic G2 phase IDA PMID:1464318
present during cellular response to nitrosative stress IDA Y15 PMID:22561704
present during mitotic M phase experimental evidence Y15 PMID:21712547
present during cellular response to hydroxyurea IDA Y15 PMID:10036242
present during cellular response to thiabendazole IDA Y15 PMID:18257517
present during mitotic S phase IDA Y15 PMID:1655416
present during meiosis I IDA PMID:10888871
removed by cdc25 IDA PMID:1756737
removed during cellular response to caffeine IDA Y15 PMID:10036242
removed during meiosis II IDA PMID:10888871
absent during mitotic M phase IDA PMID:1464318
IDA Y15 PMID:25720772
IDA Y15 PMID:26131711
phosphorylated residue 2511
added during G0 to G1 transition, cellular response to UV
removed during cellular response to nitrogen starvation
Annotation ExtensionEvidenceResidueReference
added during G0 to G1 transition IDA PMID:3516412
added during cellular response to UV IDA PMID:12960401
removed during cellular response to nitrogen starvation IDA PMID:3516412
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
protein levelconstant during GO:0000278Western blot evidencePMID:3516412
constant during GO:0000278Western blot evidencePMID:2569363
present during GO:0051321Western blot evidencePMID:10888871
unchanged during GO:0072734Western blot evidencePMID:1899230
increased during GO:0006279Western blot evidencePMID:10888871
present during GO:0072690Western blot evidencePMID:2569363

Quantitative Gene Expression

View graphical display of gene expression data for cdc2 (SPBC11B10.09)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5406.86during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
14449during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
2704.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.8during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.52during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Complementation
DescriptionQualifierReference
functionally complemented by H. sapiens CDK1full PMID:3553962 PMID:1944283
full
does not functionally complement S. cerevisiae CDC28 PMID:3796591
functionally complemented by G. gallus cdc2full PMID:1500441
functionally complements S. cerevisiae CDC28 when introns removedfull PMID:3796591
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3093
conserved in fungi4607
conserved in eukaryotes4517
conserved in metazoa3427
conserved in vertebrates3402
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC11B10.09 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
forms complex withdrc1replication preinitiation complex assembly protein Reconstituted ComplexPMID:11937031
forms complex withrum1CDK inhibitor Rum1 Reconstituted ComplexPMID:9303310
forms complex withsuc1cyclin-dependent protein kinase regulatory subunit Suc1 Reconstituted ComplexPMID:2569363
affinity captured bybgs11,3-beta-glucan synthase catalytic subunit Bgs1 Affinity Capture-WesternPMID:11937031
affinity captured bycdc11SIN component scaffold protein, centriolin ortholog Cdc11 Affinity Capture-WesternPMID:15062098
affinity captured byskb1type II protein arginine N-methyltransferase Skb1 Affinity Capture-WesternPMID:9843966
affinity captured bymtl1TRAMP/MTREC complex subunit, ATP-dependent RNA helicase (predicted) Affinity Capture-MSPMID:24713849
affinity captured bypch1P-TEFB associated cyclin, cyclin T Pch1 Affinity Capture-WesternPMID:9115279
affinity captured bypas1cyclin Pas1 Affinity Capture-WesternPMID:10982385
affinity captured bycig2G1/S-specific B-type cyclin Cig2 Affinity Capture-WesternPMID:11163211
affinity captured bysuc1cyclin-dependent protein kinase regulatory subunit Suc1 Affinity Capture-WesternPMID:3322810
affinity captured bycdc13G2/M B-type cyclin Cdc13 Affinity Capture-WesternPMID:9632761
affinity captured byred1RNA elimination defective protein Red1 Affinity Capture-MSPMID:24713849
affinity captured bynsk1Clp1-interacting, microtubule plus-end binding Nsk1 Affinity Capture-WesternPMID:22065639
affinity captured byhsp90Hsp90 chaperone Affinity Capture-WesternPMID:22543982
affinity captured bycdc37Hsp90 co-chaperone Cdc37 Affinity Capture-WesternPMID:16390871
affinity captured bywos2p23 homolog, predicted co-chaperone Wos2 Affinity Capture-WesternPMID:10581266
affinity captured bycbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
affinity captured byshk1PAK-related kinase Shk1 Affinity Capture-WesternPMID:9843966
affinity captured bycdc18MCM loader Affinity Capture-WesternPMID:9436991
affinity captured bypir2zf-C2H2 type zinc finger protein, implicated in RNAi (predicted) Affinity Capture-MSPMID:24713849
affinity captured bychk1Chk1 protein kinase Affinity Capture-WesternPMID:26131711
affinity captured byorc2origin recognition complex subunit Orc2 Affinity Capture-WesternPMID:8552194
affinity capturesrqh1RecQ type DNA helicase Rqh1 Affinity Capture-WesternPMID:24861625
affinity captureshhp1serine/threonine protein kinase Hhp1 Affinity Capture-WesternPMID:24861625
affinity capturescdc18MCM loader Affinity Capture-RNAPMID:22144913
affinity capturesrad16DNA repair endonuclease XPF Affinity Capture-WesternPMID:24861625
affinity capturescdc13G2/M B-type cyclin Cdc13 Affinity Capture-WesternPMID:11329175
affinity capturesrum1CDK inhibitor Rum1 Affinity Capture-WesternPMID:11329175
affinity capturessrs2ATP-dependent DNA helicase, UvrD subfamily Affinity Capture-WesternPMID:24861625
affinity captureschk1Chk1 protein kinase Affinity Capture-WesternPMID:24861625
affinity capturespku70Ku domain protein Pku70 Affinity Capture-WesternPMID:24861625
affinity capturesgad8AGC family protein kinase Gad8 Affinity Capture-WesternPMID:26912660
affinity capturesspd1ribonucleotide reductase (RNR) inhibitor Affinity Capture-WesternPMID:8887552
affinity capturesmus81Holliday junction resolvase subunit Mus81 Affinity Capture-WesternPMID:24861625
affinity capturespku80Ku domain protein Pku80 Affinity Capture-WesternPMID:24861625
affinity captureswos2p23 homolog, predicted co-chaperone Wos2 Affinity Capture-WesternPMID:10581266
modifiesdis2serine/threonine protein phosphatase PP1, Dis2 Biochemical ActivityPMID:16920624
modifiescdc25M phase inducer tyrosine phosphatase Cdc25 Biochemical ActivityPMID:22665807
modifiescdc13G2/M B-type cyclin Cdc13 Biochemical ActivityPMID:2569363
modifiesbub1mitotic spindle checkpoint kinase Bub1 Biochemical ActivityPMID:12606573
modifiescrb2DNA repair protein Rad9 homolog Crb2 Biochemical ActivityPMID:10488332
modifiescut3condensin complex SMC subunit Smc4 Biochemical ActivityPMID:10485849
modifiesclp1Cdc14-related protein phosphatase Clp1/Flp1 Biochemical ActivityPMID:22918952
modifieshcn1anaphase-promoting complex subunit TPR lobe accessory factor Hcn1/Apc12 Biochemical ActivityPMID:16950791
modifiessds23PP2A-type phosphatase inhibitor Sds23/Moc1 Biochemical ActivityPMID:9242669
modifiescdc18MCM loader Biochemical ActivityPMID:9177184
modifiesbyr4two-component GAP Byr4 Biochemical ActivityPMID:24920823
modifiesmde4microtubule-site clamp monopolin complex subunit Mde4 Biochemical ActivityPMID:19523829
modifiesnsk1Clp1-interacting, microtubule plus-end binding Nsk1 Biochemical ActivityPMID:22065639
modifiesrum1CDK inhibitor Rum1 Biochemical ActivityPMID:10679013
modifiesmbx1MADS-box transcription factor Mbx1 Biochemical ActivityPMID:21098641
modifiesalp7centrosomal transforming acidic coiled-coil (TACC) protein ortholog Alp7 Biochemical ActivityPMID:24790093
modifiesfkh2forkhead transcription factor Fkh2 Biochemical ActivityPMID:18059475
modifiesase1antiparallel microtubule cross-linking factor Ase1 Biochemical ActivityPMID:19686686
modifiescut12spindle pole body protein Cut12 Biochemical ActivityPMID:23333317
modifiesorc2origin recognition complex subunit Orc2 Biochemical ActivityPMID:11486016
binds activation domain construct withpch1P-TEFB associated cyclin, cyclin T Pch1 Two-hybridPMID:9115279
binds activation domain construct withdis2serine/threonine protein phosphatase PP1, Dis2 Two-hybridPMID:26771498
binds activation domain construct withcdc13G2/M B-type cyclin Cdc13 Two-hybridPMID:26771498
binds activation domain construct withsuc1cyclin-dependent protein kinase regulatory subunit Suc1 Two-hybridPMID:26771498
binds activation domain construct withsds23PP2A-type phosphatase inhibitor Sds23/Moc1 Two-hybridPMID:9242669
binds activation domain construct withorc2origin recognition complex subunit Orc2 Two-hybridPMID:8552194
modified bywee1M phase inhibitor protein kinase Wee1 Biochemical ActivityPMID:7982971
modified bymik1mitotic inhibitor kinase Mik1 Biochemical ActivityPMID:7982971
modified bypyp3protein-tyrosine phosphatase Pyp3 Biochemical ActivityPMID:1464318
interacts withsuc1cyclin-dependent protein kinase regulatory subunit Suc1 PCAPMID:26771498
co-purifies withcdc13G2/M B-type cyclin Cdc13 Co-purificationPMID:26131711
co-purifies withchk1Chk1 protein kinase Co-purificationPMID:26131711
co-fractionates withcdc13G2/M B-type cyclin Cdc13 Co-fractionationPMID:2569363
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC11B10.09 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
synthetic growth defect withcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic Growth DefectPMID:3448096
synthetic growth defect withcdr2serine/threonine protein kinase Cdr2 Synthetic Growth DefectPMID:3448096
synthetic growth defect withsrw1substrate-specific mitotic G1 APC coactivator Srw1/Ste9 Synthetic Growth DefectPMID:14985109
synthetic growth defect withelp3elongator complex subunit Elp3 (predicted) Synthetic Growth DefectPMID:22768388
synthetic growth defect withwee1M phase inhibitor protein kinase Wee1 Synthetic Growth DefectPMID:11029045
synthetic growth defect withcdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic Growth DefectPMID:20444100
synthetic growth defect withdim1U4/U6 x U5 tri-snRNP complex subunit Dim1 Synthetic Growth DefectPMID:9182666
synthetic growth defect withmcs6TFIIH associated cyclin-dependent protein kinase Mcs6 Synthetic Growth DefectPMID:2474475
synthetic growth defect withslp1substrate-specific mitotic metaphase/anaphase APC coactivator Slp1 Synthetic Growth DefectPMID:9001228
synthetic growth defect withcrb2DNA repair protein Rad9 homolog Crb2 Synthetic Growth DefectPMID:24861625
synthetic growth defect withctu1cytosolic thiouridylase subunit Ctu1 Synthetic Growth DefectPMID:22768388
synthetic growth defect withchk1Chk1 protein kinase Synthetic Growth DefectPMID:24861625
synthetic growth defect withblt1ubiquitin domain-like protein Blt1 Synthetic Growth DefectPMID:24790095
rescuescdc13G2/M B-type cyclin Cdc13 Phenotypic SuppressionPMID:8631306
rescuesmcm4MCM complex subunit Mcm4/Cdc21 Phenotypic SuppressionPMID:8631307
rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:3796591
rescuescdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Phenotypic SuppressionPMID:2004705
rescueswis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:1756736
rescuesspo5meiotic RNA-binding protein 1 Phenotypic SuppressionPMID:24506453
rescuesspo4serine/threonine protein kinase Spo4 Phenotypic SuppressionPMID:23370392
rescuespab1protein phosphatase PP2A regulatory subunit B-55 Pab1 Phenotypic SuppressionPMID:20876564
rescuesbgs11,3-beta-glucan synthase catalytic subunit Bgs1 Phenotypic SuppressionPMID:10704373
rescuespyp1tyrosine phosphatase Pyp1 Phenotypic SuppressionPMID:1448087
rescuessrw1substrate-specific mitotic G1 APC coactivator Srw1/Ste9 Phenotypic SuppressionPMID:14985109
rescuestor1serine/threonine protein kinase Tor1 Phenotypic SuppressionPMID:19546237
rescuesrad4BRCT domain protein Rad4 Phenotypic SuppressionPMID:7957098
rescuescut1separase/separin Phenotypic SuppressionPMID:16453724
rescuesclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic SuppressionPMID:11683392
rescuespyp2tyrosine phosphatase Pyp2 Phenotypic SuppressionPMID:1448087
rescuesfin1serine/threonine protein kinase, NIMA related Fin1 Phenotypic SuppressionPMID:12065422
rescuesslp1substrate-specific mitotic metaphase/anaphase APC coactivator Slp1 Phenotypic SuppressionPMID:9001228
overexpression rescuescdc13G2/M B-type cyclin Cdc13 Dosage RescuePMID:3428262
overexpression rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Dosage RescuePMID:3796591
overexpression rescuescdc37Hsp90 co-chaperone Cdc37 Dosage RescuePMID:16390871
rescued bywee1M phase inhibitor protein kinase Wee1 Phenotypic SuppressionPMID:3032459
rescued bycdc13G2/M B-type cyclin Cdc13 Phenotypic SuppressionPMID:1934126
rescued bywis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:1756736
rescued byclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic SuppressionPMID:15128870
rescued bysuc1cyclin-dependent protein kinase regulatory subunit Suc1 Phenotypic SuppressionPMID:16453733
rescued bycut12spindle pole body protein Cut12 Phenotypic SuppressionPMID:2245912
rescued bycdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:9013342
rescued bymik1mitotic inhibitor kinase Mik1 Phenotypic SuppressionPMID:10637286
rescued bychk1Chk1 protein kinase Phenotypic SuppressionPMID:24861625
rescued bycds1replication checkpoint kinase Cds1 Phenotypic SuppressionPMID:24861625
rescued bySPAC29A4.02ctranslation elongation factor EF-1 gamma subunit Phenotypic SuppressionPMID:14985109
rescued byspd1ribonucleotide reductase (RNR) inhibitor Phenotypic SuppressionPMID:8887552
rescued bycmk2MAPK-activated protein kinase Cmk2 Phenotypic SuppressionPMID:12135745
rescued by overexpression ofsuc1cyclin-dependent protein kinase regulatory subunit Suc1 Dosage RescuePMID:16453733
rescued by overexpression ofwee1M phase inhibitor protein kinase Wee1 Dosage RescuePMID:1427071
rescued by overexpression ofhsp9heat shock protein Hsp9 Dosage RescuePMID:22182414
rescued by overexpression ofcdc13G2/M B-type cyclin Cdc13 Dosage RescuePMID:11711540
rescued by overexpression ofsum1translation initiation factor eIF3i Dosage RescuePMID:9560390
rescued by overexpression ofsum3translation initiation RNA helicase Sum3 Dosage RescuePMID:9832516
rescued by overexpression ofmcs6TFIIH associated cyclin-dependent protein kinase Mcs6 Dosage RescuePMID:8557037
rescued by overexpression ofpyp1tyrosine phosphatase Pyp1 Dosage RescuePMID:9560390
rescued by overexpression ofchk1Chk1 protein kinase Dosage RescuePMID:8497322
rescued by overexpression ofcid13poly(A) polymerase Cid13 Dosage RescuePMID:12062100
synthetically rescuescdc13G2/M B-type cyclin Cdc13 Synthetic RescuePMID:3428262
synthetically rescuessrk1MAPK-activated protein kinase Srk1 Synthetic RescuePMID:15629716
synthetically rescuescdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Synthetic RescuePMID:2245912
synthetically rescuescdr2serine/threonine protein kinase Cdr2 Synthetic RescuePMID:2245912
synthetically rescueswee1M phase inhibitor protein kinase Wee1 Synthetic RescuePMID:24861625
synthetically rescueshhp1serine/threonine protein kinase Hhp1 Synthetic RescuePMID:24861625
synthetically rescuescdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:2245912
synthetically rescuespot1telomere end-binding protein Pot1 Synthetic RescuePMID:26093291
synthetically rescuescdc6DNA polymerase delta catalytic subunit Cdc6 Synthetic RescuePMID:9135148
synthetically rescuesrqh1RecQ type DNA helicase Rqh1 Synthetic RescuePMID:26093291
phenotype enhanced byorc2origin recognition complex subunit Orc2 Phenotypic EnhancementPMID:8552194
phenotype enhanced bypmk1MAP kinase Pmk1 Phenotypic EnhancementPMID:22918952
phenotype enhanced bywos2p23 homolog, predicted co-chaperone Wos2 Phenotypic EnhancementPMID:10581266
phenotype enhanced byhsp90Hsp90 chaperone Phenotypic EnhancementPMID:10102358
phenotype enhanced byswr1SNF2 family ATP-dependent DNA helicase Swr1 Phenotypic EnhancementPMID:9571240
phenotype enhanced byhta1histone H2A alpha Phenotypic EnhancementPMID:16314498
phenotype enhanced bycdc10MBF transcription factor complex subunit Cdc10 Phenotypic EnhancementPMID:11513869
phenotype enhanced byhta2histone H2A beta Phenotypic EnhancementPMID:16314498
phenotype enhanced byrum1CDK inhibitor Rum1 Phenotypic EnhancementPMID:7593289
phenotype enhanced bywee1M phase inhibitor protein kinase Wee1 Phenotypic EnhancementPMID:9013342
enhances phenotype ofcig2G1/S-specific B-type cyclin Cig2 Phenotypic EnhancementPMID:8455610
enhances phenotype ofcdc6DNA polymerase delta catalytic subunit Cdc6 Phenotypic EnhancementPMID:9154809
enhances phenotype ofbgs11,3-beta-glucan synthase catalytic subunit Bgs1 Phenotypic EnhancementPMID:10503548
enhances phenotype ofclp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic EnhancementPMID:11683392
enhances phenotype ofrad3ATR checkpoint kinase Rad3 Phenotypic EnhancementPMID:22918952
enhances phenotype ofsep1forkhead transcription factor Sep1 Phenotypic EnhancementPMID:9473044
enhances phenotype ofcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Phenotypic EnhancementPMID:2004705
enhances phenotype ofhsp90Hsp90 chaperone Phenotypic EnhancementPMID:22543982
enhances phenotype ofpmk1MAP kinase Pmk1 Phenotypic EnhancementPMID:22918952
enhances phenotype oforc1origin recognition complex subunit Orc1 Phenotypic EnhancementPMID:12186947
enhances phenotype ofwee1M phase inhibitor protein kinase Wee1 Phenotypic EnhancementPMID:3116001
negative genetic interaction withsnf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
negative genetic interaction withria1GTPase Ria1 (predicted) Negative GeneticPMID:22681890
synthetic lethal withclp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic LethalityPMID:16950131
synthetic lethal withrad54DNA-dependent ATPase Rad54/Rhp54 Synthetic LethalityPMID:8834792
synthetic lethal withres2MBF transcription factor complex subunit Res2 Synthetic LethalityPMID:2474475
synthetic lethal withcdr2serine/threonine protein kinase Cdr2 Synthetic LethalityPMID:9843577
synthetic lethal withwee1M phase inhibitor protein kinase Wee1 Synthetic LethalityPMID:2474475
synthetic lethal withmcs4response regulator Mcs4 Synthetic LethalityPMID:2474475
synthetic lethal withpop1cullin 1 adaptor protein Pop1 Synthetic LethalityPMID:9203581
synthetic lethal withmcs6TFIIH associated cyclin-dependent protein kinase Mcs6 Synthetic LethalityPMID:2474475
synthetic lethal withmcs2TFIIH complex cyclin Mcs2 Synthetic LethalityPMID:2474475
synthetically rescued bymik1mitotic inhibitor kinase Mik1 Synthetic RescuePMID:24861625
synthetically rescued byclp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic RescuePMID:23297348
synthetically rescued bycut12spindle pole body protein Cut12 Synthetic RescuePMID:23333317
synthetically rescued bycdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic RescuePMID:24861625
synthetically rescued bycig2G1/S-specific B-type cyclin Cig2 Synthetic RescuePMID:8455610
synthetically rescued bysty1MAP kinase Sty1 Synthetic RescuePMID:9560390
synthetically rescued byres2MBF transcription factor complex subunit Res2 Synthetic RescuePMID:11029045
overexpression lethal tosrw1substrate-specific mitotic G1 APC coactivator Srw1/Ste9 Dosage LethalityPMID:9398669
inviable in presence of overexpressedpyp3protein-tyrosine phosphatase Pyp3 Dosage LethalityPMID:1464318
External References
Database Identifier Description
NBRP SPBC11B10.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC11B10.09 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC11B10.09 BioGRID Interaction Datasets
Expression Viewer SPBC11B10.09 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC11B10.09 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC11B10.09 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC11B10.09 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC11B10.09 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC11B10.09 Transcriptome Viewer (Bähler Lab)
GEO SPBC11B10.09 GEO profiles
PInt SPBC11B10.09 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC11B10.09 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC11B10.09 Fission yeast phenotypic data & analysis
Cyclebase SPBC11B10.09.1 Cell Cycle Data
SPD / RIKEN50/50D08Orfeome Localization Data
UniProtKB/SwissProtP04551Cyclin-dependent kinase 1
ModBaseP04551Database of comparative protein structure models
STRINGP04551Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595629cyclin-dependent protein kinase Cdk1/Cdc2
RefSeq mRNANM_001021523972h- cyclin-dependent protein kinase Cdk1/Cdc2 (cdc2), mRNA
European Nucleotide ArchiveAAA35293.1ENA Protein Mapping
European Nucleotide ArchiveBAA21379.1ENA Protein Mapping
European Nucleotide ArchiveCAC37513.1ENA Protein Mapping
UniParcUPI00001273F9UniProt Archive

Literature for cdc2

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016