chr4 (SPBC1289.01c)

Gene Standard Namechr4 Characterisation Statuspublished
Systematic IDSPBC1289.01c Feature Typeprotein coding
Synonymscfh3, SPBC1539.11c Name DescriptionChs Four Homologue
Product1,3-beta-glucan synthase regulatory factor Chf3/Chr4 Product Size633aa, 70.02 kDa
Genomic Location Chromosome II, 4383830-4381386 (2445nt); CDS:4383541-4381640 (1902nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0043495protein anchorRCAGO_REF:000000110
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0034613cellular protein localization554
localizes bgs1IMPPMID:19237545
GO:0071470cellular response to osmotic stressIMPPMID:1923754544
GO:1902411mitotic barrier septum assemblyIMPPMID:1544930910
GO:0032951regulation of beta-glucan biosynthetic processIGIbgs1PMID:192375458
GO:0090093regulation of fungal-type cell wall beta-glucan biosynthetic processIDAPMID:192375452
GO:0010962regulation of glucan biosynthetic processIDAPMID:1923754510
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:00001481,3-beta-D-glucan synthase complexIPIbgs1PMID:192375455
GO:0046658anchored component of plasma membraneRCAGO_REF:000000127
GO:0000935barrier septumIDAPMID:1544930916
GO:0032153cell division siteIDAPMID:16823372295
GO:0051286cell tipIDAPMID:15449309188
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000083sensitive to enfumafunginchr4ΔNullPMID:192375451
FYPO:0000270sensitive to osmotic stresschr4ΔNullPMID:1923754587
FYPO:0002060viable vegetative cell populationMicroscopychr4ΔNullPECO:0000005, PECO:0000137PMID:236978063760
not recorded (unrecorded)PMID:15449309

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000043abnormal glucan synthesischr4ΔNullPMID:192375451
FYPO:0002177viable vegetative cell with normal cell morphology3086
penetrance FYPO_EXT:0000001Microscopychr4ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08238 Pfam IPR006597 Sel1-like 438 473 6
PF08238 Pfam IPR006597 Sel1-like 278 314 6
PF08238 Pfam IPR006597 Sel1-like 512 543 6
PF08238 Pfam IPR006597 Sel1-like 479 511 6
PF00515 Pfam IPR001440 Tetratricopeptide TPR1 316 343 14
SM00671 SMART IPR006597 Sel1-like 475 511 7
SM00671 SMART IPR006597 Sel1-like 315 346 7
SM00671 SMART IPR006597 Sel1-like 278 314 7
SM00671 SMART IPR006597 Sel1-like 438 474 7
SM00671 SMART IPR006597 Sel1-like 512 543 7
PS50293 Prosite Profiles IPR013026 Tetratricopeptide repeat-containing domain 315 348 27
PS50293 Prosite Profiles IPR013026 Tetratricopeptide repeat-containing domain 512 545 27
PS50005 Prosite Profiles IPR019734 Tetratricopeptide repeat 315 348 23
PS50005 Prosite Profiles IPR019734 Tetratricopeptide repeat 512 545 23
PTHR11102 HMMPANTHER 1 555 7
PTHR11102:SF60 HMMPANTHER 1 555 1 Gene3D IPR011990 Tetratricopeptide-like helical 422 560 55 Gene3D IPR011990 Tetratricopeptide-like helical 259 367 55
SSF81901 SuperFamily 423 552 9
SSF81901 SuperFamily 220 360 9
Coil ncoils Rabaptin coiled-coil domain 536 557 968

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000212SEL1 repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000212

Protein Properties

Ave. residue weight 110.61 Da
Charge -20.00
Isoelectric point 4.83
Molecular weight 70.02 kDa
Number of residues 633

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
present during mitotic M phaseS3PMID:21712547
present during mitotic M phaseS105PMID:21712547
present during mitotic M phaseS113PMID:21712547
present during mitotic M phaseS112PMID:21712547
present during mitotic M phaseS123PMID:21712547
present during mitotic M phaseS24PMID:21712547
present during mitotic M phaseS110PMID:21712547
present during mitotic M phaseS111PMID:21712547
present during mitotic M phase
present during mitotic M phaseT122PMID:21712547
MOD:00703isoprenylated residueNASPMID:192375458
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
4013.68during GO:0072690PECO:0000014,
experimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3.1during GO:0072690PECO:0000014,
experimental evidencePMID:23101633
0.7during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
experimental evidencePMID:23101633
Species Distribution
conserved in fungi only603
conserved in fungi4569
conserved in eukaryotes4482

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
imp2contractile ring protein Imp2 Synthetic Growth DefectPMID:22905165
cdc15extended Fer/CIP4 (EFC) domain protein Cdc15 Synthetic Growth DefectPMID:22905165
act1actin Act1 Synthetic Growth DefectPMID:22905165
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cdc15extended Fer/CIP4 (EFC) domain protein Cdc15 Affinity Capture-WesternPMID:22905165
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
External References
Database Identifier Description
NBRP SPBC1289.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1289.01c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1289.01c BioGRID Interaction Datasets
Expression Viewer SPBC1289.01c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1289.01c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1289.01c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1289.01c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1289.01c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1289.01c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC1289.01c Cell Cycle Data
GEO SPBC1289.01c GEO profiles
PInt SPBC1289.01c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene25397161,3-beta-glucan synthase regulatory factor Chf3/Chr4
EntrezGene25397161,3-beta-glucan synthase regulatory factor Chf3/Chr4
SPD / RIKEN46/46B04Orfeome Localization Data
UniProtKB/SwissProtO94614Chitin synthase regulatory factor 4
ModBaseO94614Database of comparative protein structure models
STRINGO94614Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_5968251,3-beta-glucan synthase regulatory factor Chf3/Chr4
RefSeq mRNANM_001023845972h- 1,3-beta-glucan synthase regulatory factor Chf3/Chr4 (chr4), mRNA
European Nucleotide ArchiveCAB51343ENA Protein Mapping
European Nucleotide ArchiveCAB51343.1ENA Protein Mapping
UniParcUPI000006B463UniProt Archive

Literature for chr4

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014