chr4 (SPBC1289.01c)


Gene Standard Namechr4 Characterisation Statuspublished
Systematic IDSPBC1289.01c Feature Typeprotein coding
Synonymscfh3, SPBC1539.11c Name DescriptionChs Four Homologue
Product1,3-beta-glucan synthase regulatory factor Chf3/Chr4 Product Size633aa, 70.02 kDa
Genomic Location Chromosome II, 4383830-4381386 (2445nt); CDS:4383541-4381640 (1902nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
barrier septum assembly44
Annotation ExtensionEvidenceWith/FromReference
cellular protein localization551
Annotation ExtensionEvidenceWith/FromReference
cellular response to osmotic stress32
Annotation ExtensionEvidenceWith/FromReference
regulation of beta-glucan biosynthetic process8
Annotation ExtensionEvidenceWith/FromReference
regulation of fungal-type cell wall beta-glucan biosynthetic process2
Annotation ExtensionEvidenceWith/FromReference
regulation of glucan biosynthetic process9
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
1,3-beta-D-glucan synthase complex5
Annotation ExtensionEvidenceWith/FromReference
anchored component of plasma membrane26
Annotation ExtensionEvidenceWith/FromReference
barrier septum13
Annotation ExtensionEvidenceWith/FromReference
cell division site305
Annotation ExtensionEvidenceWith/FromReference
cell tip194
Annotation ExtensionEvidenceWith/FromReference
cytosol2314
Annotation ExtensionEvidenceWith/FromReference
nucleus2695
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
sensitive to enfumafunginchr4ΔNull1
sensitive to osmotic stresschr4ΔNull99
viable vegetative cell populationchr4ΔNull3795
unnamed (unrecorded)

Cell Phenotype

Term NameAlleleExpressionCount
abnormal glucan synthesischr4ΔNull1
viable vegetative cell with normal cell morphologychr4ΔNull3093
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons4383830..4381386
mRNA4383830..4381386
5' UTR4383830..4383542PMID:21511999
CDS4383541..4381640
3' UTR4381639..4381386PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08238 Pfam IPR006597 Sel1-like 278 314 6
PF08238 Pfam IPR006597 Sel1-like 438 473 6
PF00515 Pfam IPR001440 Tetratricopeptide TPR1 316 343 13
PF08238 Pfam IPR006597 Sel1-like 512 543 6
PF08238 Pfam IPR006597 Sel1-like 479 511 6
SM00028 SMART IPR019734 Tetratricopeptide repeat 315 348 26
SM00028 SMART IPR019734 Tetratricopeptide repeat 512 545 26
SM00671 SMART IPR006597 Sel1-like 512 543 7
SM00671 SMART IPR006597 Sel1-like 278 314 7
SM00671 SMART IPR006597 Sel1-like 438 474 7
SM00671 SMART IPR006597 Sel1-like 475 511 7
SM00671 SMART IPR006597 Sel1-like 315 346 7
PS50293 Prosite Profiles IPR013026 Tetratricopeptide repeat-containing domain 315 348 27
PS50005 Prosite Profiles IPR019734 Tetratricopeptide repeat 315 348 23
PS50005 Prosite Profiles IPR019734 Tetratricopeptide repeat 512 545 23
PS50293 Prosite Profiles IPR013026 Tetratricopeptide repeat-containing domain 512 545 27
PTHR11102:SF60 HMMPANTHER 1 555 1
PTHR11102 HMMPANTHER 1 555 7
1.25.40.10 Gene3D IPR011990 Tetratricopeptide-like helical domain 422 560 62
1.25.40.10 Gene3D IPR011990 Tetratricopeptide-like helical domain 259 367 62
SSF81901 SuperFamily 423 552 9
SSF81901 SuperFamily 220 360 9
Coil ncoils Rabaptin coiled-coil domain 536 557 968

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000212SEL1 repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000212

Protein Properties

Ave. residue weight 110.61 Da
Charge -20.00
Isoelectric point 4.83
Molecular weight 70.02 kDa
Number of residues 633
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
present during mitotic M phaseS110
present during mitotic M phaseS3
present during mitotic M phaseS113
present during mitotic M phaseS105
present during mitotic M phaseS112
present during mitotic M phaseS123
S113
present during mitotic M phaseS24
present during mitotic M phaseS111
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S3 PMID:21712547
present during mitotic M phase experimental evidence S24 PMID:21712547
present during mitotic M phase experimental evidence S105 PMID:21712547
present during mitotic M phase experimental evidence S110 PMID:21712547
present during mitotic M phase experimental evidence S111 PMID:21712547
present during mitotic M phase experimental evidence S112 PMID:21712547
experimental evidence S113 PMID:24763107
present during mitotic M phase experimental evidence S113 PMID:21712547
present during mitotic M phase experimental evidence S123 PMID:21712547
O-phospho-L-threonine 698
present during mitotic M phaseT117
present during mitotic M phaseT122
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence T117 PMID:21712547
present during mitotic M phase experimental evidence T122 PMID:21712547
isoprenylated residue 17
Annotation ExtensionEvidenceResidueReference
NAS PMID:19237545
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4013.68during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.1during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.7during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi only620
conserved in fungi4604
conserved in eukaryotes4516
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bycdc15extended Fer/CIP4 (EFC) domain protein Cdc15 Affinity Capture-WesternPMID:22905165
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
synthetic growth defect withact1actin Act1 Synthetic Growth DefectPMID:22905165
synthetic growth defect withcdc15extended Fer/CIP4 (EFC) domain protein Cdc15 Synthetic Growth DefectPMID:22905165
synthetic growth defect withimp2contractile ring protein Imp2 Synthetic Growth DefectPMID:22905165
External References
Database Identifier Description
NBRP SPBC1289.01c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1289.01c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1289.01c BioGRID Interaction Datasets
Expression Viewer SPBC1289.01c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1289.01c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1289.01c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1289.01c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1289.01c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1289.01c Transcriptome Viewer (Bähler Lab)
GEO SPBC1289.01c GEO profiles
PInt SPBC1289.01c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1289.01c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC1289.01c Fission yeast phenotypic data & analysis
Cyclebase SPBC1289.01c.1 Cell Cycle Data
SPD / RIKEN46/46B04Orfeome Localization Data
UniProtKB/SwissProtO94614Chitin synthase regulatory factor 4
ModBaseO94614Database of comparative protein structure models
STRINGO94614Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_5968251,3-beta-glucan synthase regulatory factor Chf3/Chr4
RefSeq mRNANM_001023845972h- 1,3-beta-glucan synthase regulatory factor Chf3/Chr4 (chr4), mRNA
European Nucleotide ArchiveCAB51343.1ENA Protein Mapping
UniParcUPI000006B463UniProt Archive

Literature for chr4

Search: Europe PMC or PubMed

Release Version: PomBase:26_51 - 07 Apr 2015