tim21 (SPBC1289.09)

Gene Standard Nametim21 ChromosomeII
Systematic IDSPBC1289.09 Gene Start4399249
Synonyms Gene End4400401
ProductTIM23 translocase complex subunit Tim21 (predicted) Gene Length1153
Feature Typeprotein coding CDS Start4399320
Name DescriptionTranslocase of the Inner Membrane CDS End4399991
Characterisation Statusbiological_role_inferred CDS Length672

Ensembl Gene Location
  1. vma10
  2. SPNCRNA.443
  3. ppr8
  4. rpc40
  5. uap1
  6. tim21
  7. adn2
  8. spf38
  9. usp109
  10. SPBC1289.13c
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopytim21delta (deletion)deletionPMID:20473289
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0030150protein import into mitochondrial matrixISOSGD:S000003265GO_REF:0000024
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005739mitochondrionIDAPMID:16823372
GO:0005744mitochondrial inner membrane presequence translocase complexISOSGD:S000003265GO_REF:0000024
GO:0016021integral to membraneIEAUniProtKB:KW-0812GO_REF:0000037
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
143992494400401

References

Region Start End Reference
three_prime_UTR43999924400401PMID:21511999
five_prime_UTR43992494399319PMID:21511999
three_prime_UTR43999924400401PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF08294 IPR013261 Pfam Mitochondrial import inner membrane translocase subunit Tim21 62 199 1
TMhelix TMHMM 70 92 955
PTHR13032:SF1 hmmpanther 1 206 1
PTHR13032 hmmpanther Mitochondrial import inner membrane translocase subunit Tim21 1 206 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.66 Da
Charge 15.50
Isoelectric point 10.27
Molecular weight 25.57 kDa
Number of residues 223
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide2656.07PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide4263.44PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide1.2PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide6.1PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPBC1604.16cRNA-binding protein, G-patch type (predicted) Negative GeneticPMID:22681890
whi5cell cycle transcriptional repressor Whi5 (predicted) Negative GeneticPMID:22681890
msa1RNA-binding protein Msa1 Negative GeneticPMID:22681890
prp1U4/U6 x U5 tri-snRNP complex subunit Prp1 Positive GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Positive GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:22681890
hus1checkpoint clamp complex protein Hus1 Positive GeneticPMID:22681890
SPBC1773.02cthioredoxin peroxidase (predicted) Negative GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Positive GeneticPMID:22681890
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External References
Database Identifier Description
NBRP SPBC1289.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1289.09 Retrieval of eukaryotic orthologs
BioGrid SPBC1289.09 BioGRID Interaction Datasets
Bähler Lab SPBC1289.09 Cell Cycle Expression Profile
Bähler Lab SPBC1289.09 Meiosis/Sporulation Expression Profies
Bähler Lab SPBC1289.09 Pheromone response/mating expression profiles
Bähler Lab SPBC1289.09 Environmental stress expression profiles
Bähler Lab SPBC1289.09 Bähler Lab Transcriptome Viewer
Cyclebase SPBC1289.09 Cell Cycle Data
PInt SPBC1289.09 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC1289.09 Entrez Gene
SPD / RIKEN07/07G04Orfeome Localization Data
EntrezGene2539981TIM23 translocase complex subunit Tim21 (predicted)
Uniprot_genenameTIM21
WikiGene2539981TIM23 translocase complex subunit Tim21 (predicted)
UniProtKB/SwissProtO94618Mitochondrial import inner membrane translocase subunit tim21
ModBaseO94618Database of comparative protein structure models
Pfam Protein DomainsO94618Pfam Domain Arrangement
RefSeq PeptideNP_596833TIM23 translocase complex subunit Tim21 (predicted)
RefSeq mRNANM_001023854972h- TIM23 translocase complex subunit Tim21 (predicted) (tim21), mRNA
European Nucleotide ArchiveCAB38689ENA Protein Mapping
UniParcUPI000006ABAAUniProt Archive

Literature for tim21
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013