pst1 (SPBC12C2.10c)


Gene Standard Namepst1 Characterisation Statuspublished
Systematic IDSPBC12C2.10c Feature Typeprotein coding
SynonymsSPBC21D10.01c Name Description
ProductClr6 histone deacetylase complex subunit Pst1 Product Size1522aa, 171.46 kDa
Genomic Location Chromosome II, 2452041-2457119 (5079nt); CDS:2452052-2456757 (4706nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005515protein bindingIPIclr6PMID:12526748861
GO:0003714transcription corepressor activityISOSGD:S000005364PMID:1556532212
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0007049cell cycleIEAUniProtKB-KW:KW-0131GO_REF:0000037631
GO:0006338chromatin remodelingISOSGD:S000005364GO_REF:0000024157
GO:0030702chromatin silencing at centromereIMPPMID:1252674853
GO:0016575histone deacetylationIGIclr6PMID:1252674824
GO:2001141regulation of RNA biosynthetic processISOSGD:S000005364PMID:15565322401
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0033698Rpd3L complexIDAPMID:174501515
GO:0032221Rpd3S complexIDAPMID:1277339216
GO:0031618nuclear centromeric heterochromatinIDAPMID:1252674838
GO:0005634nucleusIDAPMID:100229212740
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopypst1ΔNullPMID:204732891331
Microscopynot recorded (unrecorded)PMID:10022921
Microscopypst1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000059abnormal mitotic cell cycleMicroscopypst1ΔNullPECO:0000005, PECO:0000137PMID:23697806638
FYPO:0000314inviable after spore germination with elongated germ tube163
penetrance FYPO_EXT:0000001Microscopypst1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
124520412452181
224523192457119

UTRs

Region Coordinates Reference
five_prime_UTR2452041..2452051PMID:21511999
three_prime_UTR2456758..2457119PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08295 Pfam IPR013194 Histone deacetylase interacting 592 692 3
PF02671 Pfam IPR003822 Paired amphipathic helix 529 572 3
PF02671 Pfam IPR003822 Paired amphipathic helix 200 246 3
PF02671 Pfam IPR003822 Paired amphipathic helix 367 413 3
SM00761 SMART IPR013194 Histone deacetylase interacting 592 693 3
PS51477 Prosite Profiles IPR003822 Paired amphipathic helix 178 248 3
PS51477 Prosite Profiles IPR003822 Paired amphipathic helix 345 415 3
PS51477 Prosite Profiles IPR003822 Paired amphipathic helix 504 576 3
PTHR12346 HMMPANTHER 1 1328 3
PTHR12346:SF0 HMMPANTHER 1 1328 3
1g1eB00 Gene3D IPR003822 Paired amphipathic helix 514 571 3
1g1eB00 Gene3D IPR003822 Paired amphipathic helix 175 247 3
1g1eB00 Gene3D IPR003822 Paired amphipathic helix 344 414 3
SSF47762 SuperFamily IPR003822 Paired amphipathic helix 342 414 3
SSF47762 SuperFamily IPR003822 Paired amphipathic helix 508 576 3
SSF47762 SuperFamily IPR003822 Paired amphipathic helix 175 247 3
Coil ncoils Rabaptin coiled-coil domain 645 666 968

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001382SIN3 family co-repressorPMID:10022921Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001382

Protein Properties

Ave. residue weight 112.65 Da
Charge -13.00
Isoelectric point 5.98
Molecular weight 171.46 kDa
Number of residues 1522
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineS1434PMID:217125471669
present during mitotic M phase
present during mitotic M phaseS1436PMID:21712547
present during mitotic M phaseS442PMID:21712547
present during mitotic M phaseS1443PMID:21712547
S1443PMID:24763107
present during mitotic M phaseS434PMID:21712547
S1476PMID:24763107
S1474PMID:24763107
S1436PMID:24763107
S1434PMID:24763107
present during mitotic M phaseS902PMID:21712547
present during mitotic M phaseS903PMID:21712547
present during mitotic M phaseS904PMID:21712547
present during mitotic M phaseS330PMID:21712547
present during mitotic M phaseS444PMID:21712547
present during mitotic M phaseS1476PMID:21712547
MOD:00047O-phospho-L-threonineT438PMID:21712547689
present during mitotic M phase
MOD:00696phosphorylated residueNASPMID:195477441921
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3148during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
3052during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
2914during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
3064during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
3371during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
2293.14during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
4970.92during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
4.2during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
1.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
clr6histone deacetylase (class I) Clr6 Affinity Capture-WesternPMID:12526748
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
External References
Database Identifier Description
NBRP SPBC12C2.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC12C2.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC12C2.10c BioGRID Interaction Datasets
Expression Viewer SPBC12C2.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC12C2.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC12C2.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC12C2.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC12C2.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC12C2.10c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC12C2.10c Cell Cycle Data
GEO SPBC12C2.10c GEO profiles
PInt SPBC12C2.10c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC12C2.10c Peptides identified in tandem mass spectrometry proteomics experiments
WikiGene2540018Clr6 histone deacetylase complex subunit Pst1
EntrezGene2540018Clr6 histone deacetylase complex subunit Pst1
SPD / RIKEN48/48G08Orfeome Localization Data
UniProtKB/SwissProtQ09750Paired amphipathic helix protein pst1
ModBaseQ09750Database of comparative protein structure models
STRINGQ09750Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596012Clr6 histone deacetylase complex subunit Pst1
RefSeq mRNANM_001021920972h- Clr6 histone deacetylase complex subunit Pst1 (pst1), mRNA
European Nucleotide ArchiveAAF90180ENA Protein Mapping
European Nucleotide ArchiveAAF90180.1ENA Protein Mapping
European Nucleotide ArchiveCAA20757ENA Protein Mapping
European Nucleotide ArchiveCAA20757.1ENA Protein Mapping
UniParcUPI0000132819UniProt Archive

Literature for pst1

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014