pst1 (SPBC12C2.10c)


Gene Standard Namepst1 Characterisation Statuspublished
Systematic IDSPBC12C2.10c Feature Typeprotein coding
SynonymsSPBC21D10.01c Name Description
ProductClr6 histone deacetylase complex subunit Pst1 Product Size1522aa, 171.46 kDa
Genomic Location Chromosome II, 2452041-2457119 (5079nt); CDS:2452052-2456757 (4706nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005515protein bindingIPIclr6PMID:12526748887
GO:0003714transcription corepressor activityISOSGD:S000005364PMID:1556532213
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006338chromatin remodelingISOSGD:S000005364GO_REF:0000024156
GO:0030702chromatin silencing at centromereIMPPMID:1252674853
GO:0030261chromosome condensationIMPPMID:1277339218
GO:0016575histone deacetylationIGIclr6PMID:1252674825
GO:2001141regulation of RNA biosynthetic processISOSGD:S000005364PMID:15565322419
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0033698Rpd3L complexIDAPMID:174501515
GO:0032221Rpd3S complexIDAPMID:1277339216
GO:0005721centromeric heterochromatinIDAPMID:1252674833
GO:0005634nucleusIDAPMID:100229212730
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopypst1ΔNullPMID:204732891309
Microscopypst1ΔNullPECO:0000005, PECO:0000137PMID:23697806
no_namePMID:10022921

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000059abnormal mitotic cell cycleMicroscopypst1ΔNullPECO:0000005, PECO:0000137PMID:23697806564
FYPO:0000314inviable after spore germination with elongated germ tubeMicroscopypst1ΔNullPECO:0000005, PECO:0000137PMID:23697806162
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
124520412452181
224523192457119

UTRs

Region Start End Reference
three_prime_UTR24567582457119PMID:21511999
five_prime_UTR24520412452051PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02671 Pfam IPR003822 Paired amphipathic helix 200 246 3
PF02671 Pfam IPR003822 Paired amphipathic helix 367 413 3
PF02671 Pfam IPR003822 Paired amphipathic helix 529 572 3
PF08295 Pfam IPR013194 Histone deacetylase interacting 592 692 3
SM00761 SMART IPR013194 Histone deacetylase interacting 592 693 3
PS51477 Prosite Profiles IPR003822 Paired amphipathic helix 178 248 3
PS51477 Prosite Profiles IPR003822 Paired amphipathic helix 504 576 3
PS51477 Prosite Profiles IPR003822 Paired amphipathic helix 345 415 3
PTHR12346 HMMPANTHER 18 1327 3
G3DSA:1.20.1160.11 Gene3D IPR003822 344 414 3
G3DSA:1.20.1160.11 Gene3D IPR003822 514 571 3
G3DSA:1.20.1160.11 Gene3D IPR003822 175 247 3
SSF47762 SuperFamily IPR003822 342 414 3
SSF47762 SuperFamily IPR003822 508 576 3
SSF47762 SuperFamily IPR003822 175 247 3
Coil ncoils Rabaptin coiled-coil domain 645 666 975
Low complexity (SEG) seg 1465 1477
Low complexity (SEG) seg 1408 1432
Low complexity (SEG) seg 1233 1244
Low complexity (SEG) seg 983 998
Low complexity (SEG) seg 883 897
Low complexity (SEG) seg 951 969
Low complexity (SEG) seg 855 866
Low complexity (SEG) seg 458 469
Low complexity (SEG) seg 442 453
Low complexity (SEG) seg 327 342
Low complexity (SEG) seg 281 295
Low complexity (SEG) seg 160 181
Low complexity (SEG) seg 107 121

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001382SIN3 family co-repressorPMID:10022921Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001382

Protein Properties

Ave. residue weight 112.65 Da
Charge -13.00
Isoelectric point 5.98
Molecular weight 171.46 kDa
Number of residues 1522
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:195477441192
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
4970.92during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
2293.14during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.5during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
4.2during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
clr6histone deacetylase (class I) Clr6 Affinity Capture-WesternPMID:12526748
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
External References
Database Identifier Description
NBRP SPBC12C2.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC12C2.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC12C2.10c BioGRID Interaction Datasets
Expression Viewer SPBC12C2.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC12C2.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC12C2.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC12C2.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC12C2.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC12C2.10c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC12C2.10c Cell Cycle Data
GEO SPBC12C2.10c GEO profiles
PInt SPBC12C2.10c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2540018Clr6 histone deacetylase complex subunit Pst1
EntrezGene2540018Clr6 histone deacetylase complex subunit Pst1
SPD / RIKEN48/48G08Orfeome Localization Data
UniProtKB/SwissProtQ09750Paired amphipathic helix protein pst1
ModBaseQ09750Database of comparative protein structure models
StringQ09750Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596012Clr6 histone deacetylase complex subunit Pst1
RefSeq mRNANM_001021920972h- Clr6 histone deacetylase complex subunit Pst1 (pst1), mRNA
European Nucleotide ArchiveAAF90180ENA Protein Mapping
European Nucleotide ArchiveCAA20757ENA Protein Mapping
UniParcUPI0000132819UniProt Archive

Literature for pst1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014