SPBC12C2.11


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPBC12C2.11 Feature Typeprotein coding
SynonymsSPBC21D10.02 Name Description
Productglutamine-fructose-6-phosphate transaminase (predicted) Product Size696aa, 77.32 kDa
Genomic Location Chromosome II, 2450963-2448092 (2872nt); CDS:2450854-2448491 (2364nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030246carbohydrate bindingIEAIPR001347GO_REF:000000215
GO:0004360glutamine-fructose-6-phosphate transaminase (isomerizing) activityISOSGD:S000001587GO_REF:00000241
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006048UDP-N-acetylglucosamine biosynthetic processIEA UniPathway:UPA00113GO_REF:00000415
GO:0016051carbohydrate biosynthetic processIEAIPR005855GO_REF:000000246
GO:0006031chitin biosynthetic processISOSGD:S000001587GO_REF:00000243
GO:0045229external encapsulating structure organizationISOSGD:S000001587GO_REF:000002429
GO:0006541glutamine metabolic processIEAUniProtKB-KW:KW-0315GO_REF:000003719
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722316
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopySPBC12C2.11ΔNullPECO:0000005, PECO:0000137PMID:236978061315
MicroscopySPBC12C2.11ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000311inviable after spore germination with normal, unseptated germ tube morphology237
penetrance FYPO_EXT:0000001MicroscopySPBC12C2.11ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
124509632450850
224507812450711
324505052448092

UTRs

Region Coordinates Reference
five_prime_UTR2450963..2450855PMID:21511999
three_prime_UTR2448490..2448092PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00310 Pfam IPR000583 Class II glutamine amidotransferase domain 74 204 3
PF00310 Pfam IPR000583 Class II glutamine amidotransferase domain 2 47 3
PF01380 Pfam IPR001347 Sugar isomerase (SIS) 379 505 1
PF01380 Pfam IPR001347 Sugar isomerase (SIS) 551 677 1
PS51278 Prosite Profiles IPR017932 Glutamine amidotransferase type 2 domain 2 303 5
PS51464 Prosite Profiles IPR001347 Sugar isomerase (SIS) 375 514 1
PS51464 Prosite Profiles IPR001347 Sugar isomerase (SIS) 547 686 1
PTHR10937 HMMPANTHER 2 696 1
PTHR10937:SF0 HMMPANTHER IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising 2 696 1
3.60.20.10 Gene3D IPR029055 Nucleophile aminohydrolases, N-terminal 2 204 19
3.60.20.10 Gene3D IPR029055 Nucleophile aminohydrolases, N-terminal 272 312 19
3.40.50.10490 Gene3D 331 531 5
3.40.50.10490 Gene3D 532 696 5
SSF56235 SuperFamily IPR029055 Nucleophile aminohydrolases, N-terminal 265 309 22
SSF56235 SuperFamily IPR029055 Nucleophile aminohydrolases, N-terminal 2 202 22
SSF53697 SuperFamily 334 696 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.09 Da
Charge 1.50
Isoelectric point 6.63
Molecular weight 77.32 kDa
Number of residues 696
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
40670during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
39348during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
40026during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
11365.78during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
3434.99during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
41435during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
40464during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
6.6during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
2.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3393
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPBC12C2.11 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC12C2.11 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC12C2.11 BioGRID Interaction Datasets
Expression Viewer SPBC12C2.11 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC12C2.11 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC12C2.11 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC12C2.11 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC12C2.11 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC12C2.11 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC12C2.11 Cell Cycle Data
GEO SPBC12C2.11 GEO profiles
PInt SPBC12C2.11 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2539622glutamine-fructose-6-phosphate transaminase (predicted)
EntrezGene2539622glutamine-fructose-6-phosphate transaminase (predicted)
IntEnz2.6.1.16Integrated relational Enzyme database
Rhea2.6.1.16Annotated reactions database
SPD / RIKEN38/38C11Orfeome Localization Data
UniProtKB/SwissProtQ09740Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]
ModBaseQ09740Database of comparative protein structure models
STRINGQ09740Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596011glutamine-fructose-6-phosphate transaminase (predicted)
RefSeq mRNANM_001021919972h- glutamine-fructose-6-phosphate transaminase (predicted) (SPBC12C2.11), mRNA
MEROPSC44.971
European Nucleotide ArchiveCAA20758ENA Protein Mapping
European Nucleotide ArchiveCAA20758.1ENA Protein Mapping
UniParcUPI00001620E5UniProt Archive

Literature for SPBC12C2.11

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014