SPBC12C2.11


Gene Standard NameUnassigned Characterisation Statusbiological role inferred
Systematic IDSPBC12C2.11 Feature Typeprotein coding
SynonymsSPBC21D10.02 Name Description
Productglutamine-fructose-6-phosphate transaminase (predicted) Product Size696aa, 77.32 kDa
Genomic Location Chromosome II, 2450963-2448092 (2872nt); CDS:2450854-2448491 (2364nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
carbohydrate binding16
Annotation ExtensionEvidenceWith/FromReference
glutamine-fructose-6-phosphate transaminase (isomerizing) activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
chitin biosynthetic process3
Annotation ExtensionEvidenceWith/FromReference
external encapsulating structure organization28
Annotation ExtensionEvidenceWith/FromReference
UDP-N-acetylglucosamine biosynthetic process5
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationSPBC12C2.11Δ1451

Cell Phenotype

Term NameGenotypesCount
inviable after spore germination with normal, unseptated germ tube morphologySPBC12C2.11Δ237
Target Of
OntologyRelationshipGeneProduct
GO substrate of sst2 human AMSH/STAMBP protein homolog, ubiquitin specific-protease
GO substrate of ubp15 ubiquitin C-terminal hydrolase Ubp15
GO substrate of ubp4 ubiquitin C-terminal hydrolase Ubp4
GO substrate of ubp5 ubiquitin C-terminal hydrolase Ubp5
GO substrate of ubp9 ubiquitin C-terminal hydrolase Ubp9
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2450963..2450850, 2450781..2450711, 2450505..2448092
Intron2450849..2450782, 2450710..2450506
mRNA2450963..2448092
5' UTR2450963..2450855PMID:21511999
CDS2450854..2450850, 2450781..2450711, 2450505..2448491
3' UTR2448490..2448092PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01380 Pfam IPR001347 Sugar isomerase (SIS) 551 677 1
PF13522 Pfam 79 202 2
PF01380 Pfam IPR001347 Sugar isomerase (SIS) 379 505 1
PS51464 Prosite Profiles IPR001347 Sugar isomerase (SIS) 375 514 1
PS51464 Prosite Profiles IPR001347 Sugar isomerase (SIS) 547 686 1
PS51278 Prosite Profiles IPR017932 Glutamine amidotransferase type 2 domain 2 303 5
PTHR10937:SF0 HMMPANTHER IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising 1 205 1
PTHR10937 HMMPANTHER 273 696 1
PTHR10937 HMMPANTHER 1 205 1
PTHR10937:SF0 HMMPANTHER IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising 273 696 1
3.60.20.10 Gene3D IPR029055 Nucleophile aminohydrolases, N-terminal 272 312 19
3.60.20.10 Gene3D IPR029055 Nucleophile aminohydrolases, N-terminal 2 204 19
3.40.50.10490 Gene3D Uncharacterised protein family UPF0309 331 531 5
3.40.50.10490 Gene3D Uncharacterised protein family UPF0309 532 696 5
SSF56235 SuperFamily IPR029055 Nucleophile aminohydrolases, N-terminal 2 202 22
SSF53697 SuperFamily 334 696 2
SSF56235 SuperFamily IPR029055 Nucleophile aminohydrolases, N-terminal 265 309 22

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.09 Da
Charge 1.50
Codon Adaptation Index 0.45
Isoelectric point 6.63
Molecular weight 77.32 kDa
Number of residues 696
Modifications

Protein Modifications

Term NameResidueCount
ubiquitinylated lysineK593 512
Annotation ExtensionEvidenceResidueReference
mass spectrometry evidence K593 PMID:26412298
IDA PMID:26412298
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for SPBC12C2.11

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
40464during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
41435during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
39348during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
40026during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
40670during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
11365.78during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
3434.99during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
6.6during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
2.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4606
conserved in eukaryotes4516
conserved in bacteria1001
conserved in metazoa3424
conserved in vertebrates3399
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPBC12C2.11 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC12C2.11 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC12C2.11 BioGRID Interaction Datasets
Expression Viewer SPBC12C2.11 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC12C2.11 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC12C2.11 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC12C2.11 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC12C2.11 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC12C2.11 Transcriptome Viewer (Bähler Lab)
GEO SPBC12C2.11 GEO profiles
PInt SPBC12C2.11 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC12C2.11 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC12C2.11 Fission yeast phenotypic data & analysis
Cyclebase SPBC12C2.11.1 Cell Cycle Data
IntEnz2.6.1.16Integrated relational Enzyme database
Rhea2.6.1.16Annotated reactions database
SPD / RIKEN38/38C11Orfeome Localization Data
UniProtKB/SwissProtQ09740Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]
ModBaseQ09740Database of comparative protein structure models
STRINGQ09740Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596011glutamine-fructose-6-phosphate transaminase (predicted)
RefSeq mRNANM_001021919972h- glutamine-fructose-6-phosphate transaminase (predicted) (SPBC12C2.11), mRNA
MetaCycPWY-6749CMP-legionaminate biosynthesis I
KEGG00250+2.6.1.16Alanine, aspartate and glutamate metabolism
KEGG00520+2.6.1.16Amino sugar and nucleotide sugar metabolism

Literature for SPBC12C2.11

Search: Europe PMC or PubMed

Release Version: PomBase:30_59 - 12 Apr 2016