glo1 (SPBC12C2.12c)

Gene Standard Nameglo1 ChromosomeII
Systematic IDSPBC12C2.12c Gene Start2446543
SynonymsSPBC21D10.03c Gene End2447857
Productglyoxalase I Gene Length1315
Feature Typeprotein coding CDS Start2446698
Name Description CDS End2447606
Characterisation Statuspublished CDS Length909

Ensembl Gene Location
  1. ucp3
  2. SPRRNA.40
  3. SPNCRNA.1514
  4. fnx1
  5. glo1
  6. snR33
  7. SPBC12C2.11
  8. SPNCRNA.1515
  9. pst1
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0001491viable vegetative cellMicroscopyglo1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0004462lactoylglutathione lyase activityIDAPMID:15042280
heterologous_systemIGISGD:S000004463PMID:15042280
GO:0008270zinc ion bindingIDAPMID:15042280
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006749glutathione metabolic processIDAPMID:15042280
GO:0019243methylglyoxal catabolic process to D-lactateIMPPMID:15042280
GO:0071470cellular response to osmotic stressTASPMID:15714295
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
ISOSGD:S000004463GO_REF:0000024
GO:0005737cytoplasmISOSGD:S000004463GO_REF:0000024
GO:0005829cytosolIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
124465432447857

References

Region Start End Reference
three_prime_UTR24476072447857PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00903 IPR004360 Pfam Glyoxalase/fosfomycin resistance/dioxygenase domain 11 150 1
PF00903 IPR004360 Pfam Glyoxalase/fosfomycin resistance/dioxygenase domain 167 298 1
PS00935 IPR018146 Prosite Patterns Glyoxalase I, conserved site 93 110 1
PS00935 IPR018146 Prosite Patterns Glyoxalase I, conserved site 241 258 1
PS00934 IPR018146 Prosite Patterns Glyoxalase I, conserved site 14 35 1
PS00934 IPR018146 Prosite Patterns Glyoxalase I, conserved site 169 189 1
G3DSA:3.10.180.10 Gene3D 5 154 2
G3DSA:3.10.180.10 Gene3D 155 301 2
SSF54593 SuperFamily 6 158 2
SSF54593 SuperFamily 164 300 2
PTHR10374 hmmpanther 5 301 1
PTHR10374:SF0 hmmpanther 5 301 1
TIGR00068 IPR004361 tigrfam Glyoxalase I 7 158 1
TIGR00068 IPR004361 tigrfam Glyoxalase I 160 302 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.94 Da
Charge -2.00
Isoelectric point 6.19
Molecular weight 34.41 kDa
Number of residues 302
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide43192.49PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide11869.61PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide3.5PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide8PMID:23101633
Subunit Composition
DescriptionQualifierReference
monomeric PMID:15042280
Catalytic Activity Attributes
DescriptionQualifierReference
k(cat)/ K(m)m 4.3x10(7) M(-1) min(-1) PMID:15042280
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in bacteria
conserved in metazoa
conserved in vertebrates
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
mph1dual specificity protein kinase Mph1 Positive GeneticPMID:22681890
php5CCAAT-binding factor complex subunit Php5 Negative GeneticPMID:22681890
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
vps17retromer complex subunit Vps17 Negative GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
php3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
SPBC1348.10cphospholipase (predicted) Negative GeneticPMID:22681890
cut2securin, sister chromatid separation inhibitor Negative GeneticPMID:22681890
pst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
SPAC1A6.03cphospholipase (predicted) Positive GeneticPMID:22681890
atg6beclin family protein, involved in autophagy Negative GeneticPMID:22681890
dad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
vps35retromer complex subunit Vps35 Negative GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
fft3fun thirty related protein Fft3 Negative GeneticPMID:22681890
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External References
Database Identifier Description
NBRP SPBC12C2.12c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC12C2.12c Retrieval of eukaryotic orthologs
BioGrid SPBC12C2.12c BioGRID Interaction Datasets
Bähler Lab SPBC12C2.12c Cell Cycle Expression Profile
Bähler Lab SPBC12C2.12c Meiosis/Sporulation Expression Profies
Bähler Lab SPBC12C2.12c Pheromone response/mating expression profiles
Bähler Lab SPBC12C2.12c Environmental stress expression profiles
Bähler Lab SPBC12C2.12c Bähler Lab Transcriptome Viewer
Cyclebase SPBC12C2.12c Cell Cycle Data
PInt SPBC12C2.12c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC12C2.12c Entrez Gene
WikiGene2539736glyoxalase I
Uniprot_genenameGLO1
EntrezGene2539736glyoxalase I
IntEnz4.4.1.5
SPD / RIKEN12/12E09Orfeome Localization Data
UniProtKB/SwissProtQ09751Lactoylglutathione lyase
ModBaseQ09751Database of comparative protein structure models
Pfam Protein DomainsQ09751Pfam Domain Arrangement
RefSeq PeptideNP_596010glyoxalase I
RefSeq mRNANM_001021918972h- glyoxalase I (glo1), mRNA
European Nucleotide ArchiveCAA20759ENA Protein Mapping
SPD / RIKEN12/12E09Orfeome Localization Data

Literature for glo1
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Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013