ptr2 (SPBC13A2.04c)

Gene Standard Nameptr2 Characterisation Statuspublished
Systematic IDSPBC13A2.04c Feature Typeprotein coding
Synonyms Name Description
ProductPTR family peptide transporter Ptr2 Product Size618aa, 68.50 kDa
Genomic Location Chromosome II, 3408492-3405575 (2918nt); CDS:3407692-3405836 (1857nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
dipeptide transmembrane transporter activity3
Annotation ExtensionEvidenceWith/FromReference
dipeptide transporter activity3
Annotation ExtensionEvidenceWith/FromReference
tripeptide transporter activity3
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
dipeptide transmembrane transport4
Annotation ExtensionEvidenceWith/FromReference
tripeptide transmembrane transport5
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cell division site301
Annotation ExtensionEvidenceWith/FromReference
fungal-type vacuole133
Annotation ExtensionEvidenceWith/FromReference
integral component of plasma membrane50
Annotation ExtensionEvidenceWith/FromReference
plasma membrane of cell tip12
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001576abolished cell population growth on dipeptide nitrogen sourceCell growth assayptr2ΔNullPMID:222269462
FYPO:0002060viable vegetative cell populationMicroscopyptr2ΔNullPMID:204732893759
Microscopyptr2ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopyptr2ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
FYPO affected by mutation in ubr11 UBR ubiquitin-protein ligase E3 Ubr11 PMID:22226946
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00854 Pfam IPR000109 Proton-dependent oligopeptide transporter family 158 519 1
TMhelix TMHMM 479 501 959
TMhelix TMHMM 398 420 959
TMhelix TMHMM 248 267 959
TMhelix TMHMM 363 385 959
TMhelix TMHMM 433 455 959
TMhelix TMHMM 539 561 959
TMhelix TMHMM 162 184 959
TMhelix TMHMM 189 211 959
TMhelix TMHMM 513 535 959
TMhelix TMHMM 272 294 959
PS01023 Prosite Patterns IPR018456 PTR2 family proton/oligopeptide symporter, conserved site 247 259 1
PS01022 Prosite Patterns IPR018456 PTR2 family proton/oligopeptide symporter, conserved site 147 171 1
PTHR11654:SF7 HMMPANTHER 5 616 1
PTHR11654 HMMPANTHER IPR000109 Proton-dependent oligopeptide transporter family 5 616 1
1.20.1250.20 Gene3D 402 571 72
SSF103473 SuperFamily IPR016196 Major facilitator superfamily domain, general substrate transporter 343 564 76
SSF103473 SuperFamily IPR016196 Major facilitator superfamily domain, general substrate transporter 82 305 76

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 110.84 Da
Charge -5.00
Isoelectric point 5.22
Molecular weight 68.50 kDa
Number of residues 618

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
present during cellular response to thiabendazole
present during mitotic M phaseexperimental evidenceS596PMID:21712547
present during mitotic M phaseexperimental evidenceS601PMID:21712547
present during mitotic M phaseexperimental evidenceS22PMID:21712547
present during mitotic M phaseexperimental evidenceS43PMID:21712547
present during mitotic M phaseexperimental evidenceS44PMID:21712547
present during mitotic M phaseexperimental evidenceS25PMID:21712547
experimental evidenceS601PMID:24763107
MOD:00047O-phospho-L-threonineexperimental evidenceT38PMID:21712547692
present during mitotic M phase
present during mitotic M phaseexperimental evidenceT45PMID:21712547
MOD:00048O4'-phospho-L-tyrosineexperimental evidenceY603PMID:2171254785
present during mitotic M phase
MOD:00696phosphorylated residueNASPMID:182575171922
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
920.94during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
1563.88during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
2.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
conserved in fungi4600
conserved in eukaryotes4514
conserved in bacteria1000
conserved in metazoa3425
conserved in vertebrates3400

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
far8SIP/FAR complex striatin subunit, Far8/Csc3 Affinity Capture-MSPMID:22119525
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
vps35retromer complex subunit Vps35 Negative GeneticPMID:22681890
cdt2WD repeat protein Cdt2 Negative GeneticPMID:22681890
mph1dual specificity protein kinase Mph1 Positive GeneticPMID:22681890
dad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
set1histone lysine methyltransferase Set1 Positive GeneticPMID:22681890
isp4OPT oligopeptide transporter family Isp4 Synthetic Growth DefectPMID:22226946
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:22681890
ago1argonaute Negative GeneticPMID:22681890
SPBC713.07cvacuolar polyphosphatase (predicted) Positive GeneticPMID:22681890
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
efc25Ras1 guanyl-nucleotide exchange factor Efc25 Negative GeneticPMID:22681890
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:22681890
sty1MAP kinase Sty1 Negative GeneticPMID:22681890
swd1Set1C complex subunit Swd1 Positive GeneticPMID:22681890
mis4adherin, cohesin loading factor Mis4 Negative GeneticPMID:23050226
sre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
SPAC821.05translation initiation factor eIF3h (p40) Positive GeneticPMID:22681890
rcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Negative GeneticPMID:22681890
mcs2TFIIH complex cyclin Mcs2 Negative GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
dsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:21504829
pst2Clr6 histone deacetylase complex subunit Pst2 Negative GeneticPMID:22681890
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
mug80cyclin Clg1 (predicted) Positive GeneticPMID:22681890
sen1ATP-dependent 5' to 3' DNA/RNA helicase Sen1 Negative GeneticPMID:22681890
amk2AMP-activated protein kinase beta subunit Amk2 Positive GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
ubr11UBR ubiquitin-protein ligase E3 Ubr11 Dosage RescuePMID:22226946
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
ptc1protein phosphatase 2C Ptc1 Negative GeneticPMID:22681890
ppk14serine/threonine protein kinase Ppk14 (predicted) Negative GeneticPMID:22681890
erg5C-22 sterol desaturase Erg5 Negative GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Negative GeneticPMID:22681890
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Negative GeneticPMID:22681890
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:22681890
hrr1Helicase Required for RNAi-mediated heterochromatin assembly Hrr1 Negative GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
tsc1hamartin Negative GeneticPMID:22681890
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
SPAC17H9.13cglutamate 5-kinase (predicted) Negative GeneticPMID:22681890
rga3Rho-type GTPase activating protein Rga3 Negative GeneticPMID:22681890
SPBC21C3.03ABC1 kinase family protein Negative GeneticPMID:22681890
SPCC162.11curidine kinase/uracil phosphoribosyltransferase (predicted) Positive GeneticPMID:22681890
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
mkh1MEK kinase (MEKK) Mkh1 Negative GeneticPMID:22681890
gma12alpha-1,2-galactosyltransferase Gma12 Negative GeneticPMID:22681890
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
tsc2tuberin Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC13A2.04c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC13A2.04c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC13A2.04c BioGRID Interaction Datasets
Expression Viewer SPBC13A2.04c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC13A2.04c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC13A2.04c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC13A2.04c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC13A2.04c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC13A2.04c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC13A2.04c Cell Cycle Data
GEO SPBC13A2.04c GEO profiles
PInt SPBC13A2.04c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC13A2.04c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC13A2.04c Fission yeast phenotypic data & analysis
SPD / RIKEN49/49C11Orfeome Localization Data
UniProtKB/SwissProtQ9P380Probable peptide transporter ptr2
ModBaseQ9P380Database of comparative protein structure models
STRINGQ9P380Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596417PTR family peptide transporter (predicted)
RefSeq mRNANM_001022336972h- PTR family peptide transporter (predicted) (SPBC13A2.04c), mRNA
European Nucleotide ArchiveU01171ENA EMBL mapping
European Nucleotide ArchiveBAA87178.1ENA Protein Mapping
European Nucleotide ArchiveCAB99397.1ENA Protein Mapping
UniParcUPI0000069A40UniProt Archive

Literature for ptr2

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014