cut3 (SPBC146.03c)

Gene Standard Namecut3 ChromosomeII
Systematic IDSPBC146.03c Gene Start1006688
Synonymssmc4 Gene End1002263
Productcondensin complex subunit Cut3 Gene Length4426
Feature Typeprotein coding CDS Start1006463
Name Description CDS End1002489
Characterisation Statuspublished CDS Length3975

Ensembl Gene Location
  1. med15
  2. SPBC146.02
  3. SPNCRNA.1403
  4. cut3
  5. SPBC146.04
  6. cwf25
  7. SPNCRNA.1404
  8. fan1
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000229cutno_name (unrecorded)unrecordedPMID:7957061
FYPO:0002061inviable vegetative cell populationMicroscopycut3delta (deletion)deletionPMID:20473289
no_name (unrecorded)unrecordedPMID:7957061
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPIcti1PMID:15148393
GO:0005524ATP bindingIEAUniProtKB:KW-0067GO_REF:0000037
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000070mitotic sister chromatid segregation
requiredIMPPMID:7957061
GO:0006281DNA repairIEAIPR024704GO_REF:0000002
GO:0006310DNA recombinationIEAIPR024704GO_REF:0000002
GO:0007062sister chromatid cohesionIEAIPR024704GO_REF:0000002
GO:0007076mitotic chromosome condensationIMPPMID:7957061
GO:0034613cellular protein localization
same_pathwayIMPPMID:18362178
has_input cut14
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0000796condensin complexIDAPMID:10485849
GO:0000939condensed chromosome inner kinetochore
exists_during mitotic metaphaseIGIcut14PMID:18362178
exists_during mitotic prophaseIGIcut14PMID:18362178
GO:0005634nucleusIDAPMID:16823372
exists_during mitotic cell cycleIDAPMID:10485849
GO:0005737cytoplasm
exists_during interphase of mitotic cell cycleIDAPMID:10485849
GO:0005829cytosolIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
110066881002263

References

Region Start End Reference
five_prime_UTR10066881006464PMID:21511999
five_prime_UTR10066881006464PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF02463 IPR003395 Pfam RecF/RecN/SMC 126 1312 6
PF06470 IPR010935 Pfam SMCs flexible hinge 651 764 4
SM00968 IPR010935 SMART SMCs flexible hinge 651 764 4
G3DSA:3.40.50.300 Gene3D 1185 1322 279
G3DSA:3.40.50.300 Gene3D 128 294 279
G3DSA:3.40.50.300 Gene3D 1040 1041 279
SSF75553 IPR010935 SuperFamily 616 798 4
SSF52540 SuperFamily 127 290 294
SSF52540 SuperFamily 426 457 294
SSF52540 SuperFamily 1205 1309 294
Coil ncoils Rabaptin coiled-coil domain 976 1018 974
Coil ncoils Rabaptin coiled-coil domain 379 421 974
Coil ncoils Rabaptin coiled-coil domain 477 505 974
Coil ncoils Rabaptin coiled-coil domain 428 449 974
Coil ncoils Rabaptin coiled-coil domain 825 853 974
Coil ncoils Rabaptin coiled-coil domain 530 551 974
Coil ncoils Rabaptin coiled-coil domain 586 607 974
Coil ncoils Rabaptin coiled-coil domain 867 926 974
Coil ncoils Rabaptin coiled-coil domain 1032 1067 974
PIRSF005719 IPR024704 PIRSF Structural maintenance of chromosomes protein 123 1323 3
PTHR18937 hmmpanther 110 1324 5
PTHR18937:SF13 hmmpanther 110 1324 1

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:10485849
PMID:19547744

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000849SMC familyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000849

Sequence Ontology

Term IDTerm NameReference
SO:0001531nuclear_export_signalPMID:10485849

Protein Properties

Ave. residue weight 113.79 Da
Charge -1.00
Isoelectric point 6.46
Molecular weight 150.65 kDa
Number of residues 1324
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide437.27PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide1019.97PMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide1.8PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.53PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in bacteria
conserved in metazoa
conserved in vertebrates
conserved in archaea
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPBC15C4.04camino acid permease (predicted) Negative GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:22681890
SPBC1778.05chuman LAMTOR2 ortholog Negative GeneticPMID:22681890
fkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:22681890
SPAC222.14cGTP binding protein Sey1 (predicted) Negative GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
nup124nucleoporin Nup124 Negative GeneticPMID:22681890
sfc3transcription factor TFIIIC complex B box binding subunit Sfc3 Phenotypic EnhancementPMID:19910488
Synthetic RescuePMID:21633354
apq12nuclear membrane organization protein Apq12 (predicted) Negative GeneticPMID:22681890
cut14condensin complex subunit Cut14 Dosage RescuePMID:15507118
ase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
ccq1telomere maintenance protein Ccq1 Negative GeneticPMID:22681890
Phenotypic SuppressionPMID:20709788
snf5SWI/SNF complex subunit Snf5 Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
raf1Rik1-associated factor Raf1 Negative GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:22681890
ulp2SUMO deconjugating cysteine peptidase Ulp2 (predicted) Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:22681890
SPAC222.08cglutamine aminotransferase subunit (predicted) Positive GeneticPMID:22681890
rtt109RTT109 family histone lysine acetyltransferase Positive GeneticPMID:22681890
arp6actin-like protein Arp6 Positive GeneticPMID:22681890
SPBC32H8.01cconserved fungal protein, involved in endocytic trafficking (predicted) Negative GeneticPMID:22681890
SPBC9B6.11cCCR4/nocturin family endoribonuclease (predicted) Negative GeneticPMID:22681890
orc5origin recognition complex subunit Orc5 Dosage RescuePMID:15507118
nic1NiCoT heavy metal ion transporter Nic1 Negative GeneticPMID:22681890
SPCC16C4.106-phosphogluconolactonase (predicted) Negative GeneticPMID:22681890
SPAC1071.03csequence orphan Positive GeneticPMID:22681890
sat1Golgi membrane exchange factor subunit Sat1 (predicted) Negative GeneticPMID:22681890
hrk1haspin related kinase Hrk1 Negative GeneticPMID:22681890
red1RNA elimination defective protein Red1 Negative GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Negative GeneticPMID:22681890
SPAC2F7.17mitochondrial peptide chain release factor (predicted) Positive GeneticPMID:22681890
SPAC1D4.01human C9orf78 ortholog Negative GeneticPMID:22681890
csm1chromosome segregation protein Csm1/Pcs1 Synthetic LethalityPMID:21633354
liz1pantothenate transporter Liz1 Negative GeneticPMID:22681890
cdc18MCM loader Dosage RescuePMID:15507118
raf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
cnd2condensin complex non-SMC subunit Cnd2 Affinity Capture-WesternPMID:21633354
Affinity Capture-MSPMID:10485849
cut14condensin complex subunit Cut14 Affinity Capture-WesternPMID:9285594
Affinity Capture-MSPMID:10485849
rpc25DNA-directed RNA polymerase III complex subunit Rpc25 Affinity Capture-WesternPMID:19910488
pku80Ku domain protein Pku80 Affinity Capture-WesternPMID:23084836
cdc2cyclin-dependent protein kinase Cdk1/Cdc2 Biochemical ActivityPMID:10485849
csm1chromosome segregation protein Csm1/Pcs1 Two-hybridPMID:21633354
ccq1telomere maintenance protein Ccq1 Affinity Capture-MSPMID:20709788
cnd3condensin complex non-SMC subunit Cnd3 Affinity Capture-MSPMID:10485849
cnd1condensin complex non-SMC subunit Cnd1 Affinity Capture-MSPMID:10485849
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External References
Database Identifier Description
NBRP SPBC146.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC146.03c Retrieval of eukaryotic orthologs
BioGrid SPBC146.03c BioGRID Interaction Datasets
Bähler Lab SPBC146.03c Cell Cycle Expression Profile
Bähler Lab SPBC146.03c Meiosis/Sporulation Expression Profies
Bähler Lab SPBC146.03c Pheromone response/mating expression profiles
Bähler Lab SPBC146.03c Environmental stress expression profiles
Bähler Lab SPBC146.03c Bähler Lab Transcriptome Viewer
Cyclebase SPBC146.03c Cell Cycle Data
PInt SPBC146.03c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC146.03c Entrez Gene
WikiGene2539817condensin subunit Cut3
Uniprot_genenameCUT3
EntrezGene2539817condensin subunit Cut3
SPD / RIKEN34/34A12Orfeome Localization Data
UniProtKB/SwissProtP41004Structural maintenance of chromosomes protein 4
ModBaseP41004Database of comparative protein structure models
Pfam Protein DomainsP41004Pfam Domain Arrangement
RefSeq PeptideNP_595392condensin subunit Cut3
RefSeq mRNANM_001021299972h- condensin subunit Cut3 (cut3), mRNA
European Nucleotide ArchiveBAA06454ENA Protein Mapping
European Nucleotide ArchiveBAA87263ENA Protein Mapping
European Nucleotide ArchiveCAB46756ENA Protein Mapping
UniParcUPI000012870DUniProt Archive

Literature for cut3
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013