erv2 (SPBC146.04)

Gene Standard Nameerv2 Characterisation Statusbiological role inferred
Systematic IDSPBC146.04 Feature Typeprotein coding
Synonyms Name Description
Productsulfhydryl oxidase Erv2 (predicted) Product Size192aa, 22.39 kDa
Genomic Location Chromosome II, 1007901-1008710 (810nt); CDS:1008018-1008596 (579nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
flavin-linked sulfhydryl oxidase activity2
Annotation ExtensionEvidenceWith/FromReference
protein disulfide isomerase activity10
Annotation ExtensionEvidenceWith/FromReference
thiol oxidase activity4
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum membrane203
Annotation ExtensionEvidenceWith/FromReference
ER to Golgi transport vesicle25
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane969
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationerv2Δ3862

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyerv2Δ3103
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR1007901..1008017PMID:21511999
3' UTR1008597..1008710AU008890
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04777 Pfam IPR017905 ERV/ALR sulfhydryl oxidase domain 72 162 2
TMhelix TMHMM 7 29 950
PS51324 Prosite Profiles IPR017905 ERV/ALR sulfhydryl oxidase domain 61 162 2
PTHR12645 HMMPANTHER 1 192 2
PTHR12645:SF1 HMMPANTHER 1 192 1 Gene3D IPR017905 ERV/ALR sulfhydryl oxidase domain 30 167 2
SSF69000 SuperFamily IPR017905 ERV/ALR sulfhydryl oxidase domain 71 166 2

View domain organization at Pfam

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 116.61 Da
Charge 2.50
Codon Adaptation Index 0.35
Isoelectric point 7.20
Molecular weight 22.39 kDa
Number of residues 192
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for erv2 (SPBC146.04)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.1during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.29during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC146.04 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds DNA-binding domain construct withman1LEM domain protein Man1, Sad1 interacting factor Two-hybridPMID:23695164
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC146.04 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withtim18TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:22681890
positive genetic interaction withhrq1RecQ type DNA helicase Hrq1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withhrp3ATP-dependent DNA helicase Hrp3 Positive GeneticPMID:22681890
negative genetic interaction withtor1serine/threonine protein kinase Tor1 Negative GeneticPMID:22681890
negative genetic interaction withste20Rictor homolog, Ste20 Negative GeneticPMID:22681890
negative genetic interaction withdsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC146.04 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC146.04 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC146.04 BioGRID Interaction Datasets
Expression Viewer SPBC146.04 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC146.04 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC146.04 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC146.04 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC146.04 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC146.04 Transcriptome Viewer (Bähler Lab)
GEO SPBC146.04 GEO profiles
PInt SPBC146.04 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC146.04 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC146.04 Fission yeast phenotypic data & analysis
Cyclebase SPBC146.04.1 Cell Cycle Data
SPD / RIKEN06/06C05Orfeome Localization Data
UniProtKB/SwissProtQ9Y806FAD-linked sulfhydryl oxidase erv2
ModBaseQ9Y806Database of comparative protein structure models
STRINGQ9Y806Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595393sulfhydryl oxidase (predicted)
RefSeq mRNANM_001021300972h- sulfhydryl oxidase (predicted) (SPBC146.04), mRNA
European Nucleotide ArchiveCAB46757.1ENA Protein Mapping
UniParcUPI000006B1B2UniProt Archive

Literature for erv2

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017