SPBC146.04


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPBC146.04 Feature Typeprotein coding
Synonyms Name Description
Productsulfhydryl oxidase (predicted) Product Size192aa, 22.39 kDa
Genomic Location Chromosome II, 1007901-1008710 (810nt); CDS:1008018-1008596 (579nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
flavin-linked sulfhydryl oxidase activity2
Annotation ExtensionEvidenceWith/FromReference
protein disulfide isomerase activity10
Annotation ExtensionEvidenceWith/FromReference
thiol oxidase activity3
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process

GO Slim Terms

protein folding


Term NameCount
protein folding104
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4208
Annotation ExtensionEvidenceWith/FromReference
cytosol2315
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum membrane205
Annotation ExtensionEvidenceWith/FromReference
ER to Golgi transport vesicle25
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
nucleus2696
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
viable vegetative cell populationSPBC146.04ΔNull3792

Cell Phenotype

Term NameAlleleExpressionCount
viable vegetative cell with normal cell morphologySPBC146.04ΔNull3092
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1007901..1008710
mRNA1007901..1008710
5' UTR1007901..1008017PMID:21511999
CDS1008018..1008596
3' UTR1008597..1008710AU008890
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04777 Pfam IPR017905 ERV/ALR sulfhydryl oxidase domain 72 162 2
TMhelix TMHMM 7 29 959
PS51324 Prosite Profiles IPR017905 ERV/ALR sulfhydryl oxidase domain 61 162 2
PTHR12645 HMMPANTHER 5 192 2
PTHR12645:SF1 HMMPANTHER 5 192 1
1.20.120.310 Gene3D IPR017905 ERV/ALR sulfhydryl oxidase domain 30 167 2
SSF69000 SuperFamily IPR017905 ERV/ALR sulfhydryl oxidase domain 71 166 2

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 116.61 Da
Charge 2.50
Isoelectric point 7.20
Molecular weight 22.39 kDa
Number of residues 192
Sequence
Gene Expression

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.1during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.29during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds DNA-binding domain construct withman1LEM domain protein Man1, Sad1 interacting factor Two-hybridPMID:23695164
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withdsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:22681890
positive genetic interaction withhrp3ATP-dependent DNA helicase Hrp3 Positive GeneticPMID:22681890
positive genetic interaction withhrq1RecQ type DNA helicase Hrq1 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withsdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:22681890
negative genetic interaction withste20Rictor homolog, Ste20 Negative GeneticPMID:22681890
negative genetic interaction withtor1phosphatidylinositol kinase Tor1 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC146.04 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC146.04 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC146.04 BioGRID Interaction Datasets
Expression Viewer SPBC146.04 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC146.04 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC146.04 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC146.04 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC146.04 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC146.04 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC146.04 Cell Cycle Data
GEO SPBC146.04 GEO profiles
PInt SPBC146.04 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC146.04 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC146.04 Fission yeast phenotypic data & analysis
SPD / RIKEN06/06C05Orfeome Localization Data
UniProtKB/SwissProtQ9Y806FAD-linked sulfhydryl oxidase erv2
ModBaseQ9Y806Database of comparative protein structure models
STRINGQ9Y806Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595393sulfhydryl oxidase (predicted)
RefSeq mRNANM_001021300972h- sulfhydryl oxidase (predicted) (SPBC146.04), mRNA
European Nucleotide ArchiveCAB46757.1ENA Protein Mapping
UniParcUPI000006B1B2UniProt Archive

Literature for SPBC146.04

Search: Europe PMC or PubMed

Release Version: PomBase:25_50 - 10 Mar 2015