SPBC146.04


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPBC146.04 Feature Typeprotein coding
Synonyms Name Description
Productsulfhydryl oxidase (predicted) Product Size192aa, 22.39 kDa
Genomic Location Chromosome II, 1007901-1008710 (810nt); CDS:1008018-1008596 (579nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016971flavin-linked sulfhydryl oxidase activityISSUniProtKB:P12284GO_REF:00000012
GO:0003756protein disulfide isomerase activityISOSGD:S000006241GO_REF:000002412
GO:0016972thiol oxidase activityISOSGD:S000006241GO_REF:00000243
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006457protein foldingISOSGD:S000006241GO_REF:0000024112
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030134ER to Golgi transport vesicleISOSGD:S000346142GO_REF:000002425
GO:0005737cytoplasmIDAPMID:168233724198
GO:0005829cytosolIDAPMID:168233722317
GO:0005789endoplasmic reticulum membraneISSUniProtKB:P38312GO_REF:0000001207
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371016
GO:0005634nucleusIDAPMID:168233722730
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopySPBC146.04ΔNullPECO:0000005, PECO:0000137PMID:236978063755
MicroscopySPBC146.04ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopySPBC146.04ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
110079011008710

UTRs

Region Start End Reference
five_prime_UTR10079011008017PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04777 Pfam IPR017905 ERV/ALR sulfhydryl oxidase domain 72 162 2
TMhelix TMHMM 7 29 959
PS51324 Prosite Profiles IPR017905 ERV/ALR sulfhydryl oxidase domain 61 162 2
PTHR12645 HMMPANTHER 1 190 2
PTHR12645:SF0 HMMPANTHER 1 190 2
G3DSA:1.20.120.310 Gene3D IPR017905 30 167 2
SSF69000 SuperFamily IPR017905 71 166 2

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0001812transmembrane_helix465

Protein Properties

Ave. residue weight 116.61 Da
Charge 2.50
Isoelectric point 7.20
Molecular weight 22.39 kDa
Number of residues 192
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
NDduring GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.29during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
1.1during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ste20Rictor homolog, Ste20 Negative GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:22681890
hrq1RecQ type DNA helicase Hrq1 (predicted) Positive GeneticPMID:22681890
hrp3ATP-dependent DNA helicase Hrp3 Positive GeneticPMID:22681890
tor1phosphatidylinositol kinase Tor1 Negative GeneticPMID:22681890
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Positive GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
man1LEM domain protein Man1, Sad1 interacting factor (predicted) Two-hybridPMID:23695164
External References
Database Identifier Description
NBRP SPBC146.04 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC146.04 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC146.04 BioGRID Interaction Datasets
Expression Viewer SPBC146.04 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC146.04 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC146.04 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC146.04 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC146.04 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC146.04 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC146.04 Cell Cycle Data
GEO SPBC146.04 GEO profiles
PInt SPBC146.04 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2539721sulfhydryl oxidase (predicted)
EntrezGene2539721sulfhydryl oxidase (predicted)
SPD / RIKEN06/06C05Orfeome Localization Data
UniProtKB/SwissProtQ9Y806FAD-linked sulfhydryl oxidase erv2
ModBaseQ9Y806Database of comparative protein structure models
StringQ9Y806Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595393sulfhydryl oxidase (predicted)
RefSeq mRNANM_001021300972h- sulfhydryl oxidase (predicted) (SPBC146.04), mRNA
European Nucleotide ArchiveCAB46757ENA Protein Mapping
UniParcUPI000006B1B2UniProt Archive

Literature for SPBC146.04

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014