meu17 (SPBC14C8.05c)

Gene Standard Namemeu17 Characterisation Statuspublished
Systematic IDSPBC14C8.05c Feature Typeprotein coding
Synonyms Name DescriptionMeiotic Expression Upregulated
Productglucan-alpha-1,4-glucosidase Product Size450aa, 51.16 kDa
Genomic Location Chromosome II, 2213495-2211798 (1698nt); CDS:2213372-2212020 (1353nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
glucan 1,4-alpha-glucosidase activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
glycogen catabolic process1
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cell surface89
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum602
Annotation ExtensionEvidenceWith/FromReference
Golgi apparatus358
Annotation ExtensionEvidenceWith/FromReference
prospore membrane33
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
sensitive to bortezomibmeu17Δ255
viable vegetative cell populationmeu17Δ3862

Cell Phenotype

Term NameGenotypesCount
abnormal microtubule cytoskeleton organization during vegetative growthmeu17+ (wild type)298
decreased pre-mRNA level5
affecting pwi1meu17Δ
elongated telomeresmeu17Δ176
viable vegetative cell with normal cell morphologymeu17Δ3103
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR2213495..2213373PMID:21511999
3' UTR2212019..2211798PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00723 Pfam IPR011613 Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family 41 440 2
PTHR31616 HMMPANTHER 1 447 2
PTHR31616:SF0 HMMPANTHER 1 447 2 Gene3D IPR012341 Six-hairpin glycosidase 25 446 7
SSF48208 SuperFamily IPR008928 Six-hairpin glycosidase-like 24 446 9
PR00736 PRINTS IPR000165 Glucoamylase 428 443 1
PR00736 PRINTS IPR000165 Glucoamylase 131 148 1
PR00736 PRINTS IPR000165 Glucoamylase 149 168 1
PR00736 PRINTS IPR000165 Glucoamylase 197 215 1
PR00736 PRINTS IPR000165 Glucoamylase 395 416 1
PR00736 PRINTS IPR000165 Glucoamylase 59 76 1
PR00736 PRINTS IPR000165 Glucoamylase 308 327 1
SignalP-noTM signalp 1 16 207

View domain organization at Pfam

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 113.70 Da
Charge -11.00
Codon Adaptation Index 0.49
Isoelectric point 4.94
Molecular weight 51.16 kDa
Number of residues 450
Gene Expression

Qualitative Gene Expression

RNA levelincreased during GO:0051321experimental evidencePMID:11376151
increased during GO:0034293experimental evidencePMID:PMPB:0

Quantitative Gene Expression

View graphical display of gene expression data for meu17 (SPBC14C8.05c)

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.049during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.022during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in bacteria1005

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC14C8.05c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withsre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
External References
Database Identifier Description
NBRP SPBC14C8.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC14C8.05c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC14C8.05c BioGRID Interaction Datasets
Expression Viewer SPBC14C8.05c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC14C8.05c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC14C8.05c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC14C8.05c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC14C8.05c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC14C8.05c Transcriptome Viewer (Bähler Lab)
GEO SPBC14C8.05c GEO profiles
PInt SPBC14C8.05c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC14C8.05c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC14C8.05c Fission yeast phenotypic data & analysis
Cyclebase SPBC14C8.05c.1 Cell Cycle Data
SPD / RIKEN21/21A04Orfeome Localization Data
IntEnz3.2.1.3Integrated relational Enzyme database
Rhea3.2.1.3Annotated reactions database
UniProtKB/SwissProtO60087Probable glucoamylase
ModBaseO60087Database of comparative protein structure models
STRINGO60087Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595908glucan-alpha-1,4-glucosidase
RefSeq mRNANM_001021816972h- glucan-alpha-1,4-glucosidase (meu17), mRNA
European Nucleotide ArchiveAB054301ENA EMBL mapping
European Nucleotide ArchiveCAA18423.1ENA Protein Mapping
MetaCycPWY-5941Glycogen degradation II
KEGG00500+ and sucrose metabolism
UniParcUPI0000125A82UniProt Archive

Literature for meu17

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017