meu17 (SPBC14C8.05c)


Gene Standard Namemeu17 Characterisation Statuspublished
Systematic IDSPBC14C8.05c Feature Typeprotein coding
Synonyms Name DescriptionMeiotic Expression Upregulated
Productglucan-alpha-1,4-glucosidase Product Size450aa, 51.16 kDa
Genomic Location Chromosome II, 2213495-2211798 (1698nt); CDS:2213372-2212020 (1353nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
glucan 1,4-alpha-glucosidase activity1
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
ascospore formation76
Annotation ExtensionEvidenceWith/FromReference
glycogen catabolic process1
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cell surface92
Annotation ExtensionEvidenceWith/FromReference
endoplasmic reticulum595
Annotation ExtensionEvidenceWith/FromReference
Golgi apparatus357
Annotation ExtensionEvidenceWith/FromReference
prospore membrane28
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
sensitive to bortezomib256
expressivity FYPO_EXT:0000001meu17ΔNull
viable vegetative cell populationmeu17ΔNull3781

Cell Phenotype

Term NameAlleleExpressionCount
abnormal microtubule cytoskeleton organization during vegetative growthnot recorded (overexpression)59
elongated telomeres160
expressivity FYPO_EXT:0000002meu17ΔNull
viable vegetative cell with normal cell morphology3092
penetrance FYPO_EXT:0000001meu17ΔNull
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
122134952211798

UTRs

Region Coordinates Reference
five_prime_UTR2213495..2213373PMID:21511999
three_prime_UTR2212019..2211798PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00723 Pfam IPR011613 Glycoside hydrolase family 15 41 440 2
1.50.10.10 Gene3D IPR012341 Six-hairpin glycosidase 25 446 7
SSF48208 SuperFamily IPR008928 Six-hairpin glycosidase-like 24 446 9
PR00736 PRINTS IPR000165 Glucoamylase 395 416 1
PR00736 PRINTS IPR000165 Glucoamylase 131 148 1
PR00736 PRINTS IPR000165 Glucoamylase 59 76 1
PR00736 PRINTS IPR000165 Glucoamylase 428 443 1
PR00736 PRINTS IPR000165 Glucoamylase 149 168 1
PR00736 PRINTS IPR000165 Glucoamylase 197 215 1
PR00736 PRINTS IPR000165 Glucoamylase 308 327 1
SignalP-noTM signalp 1 16 212

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0000418signal_peptide279

Protein Properties

Ave. residue weight 113.70 Da
Charge -11.00
Isoelectric point 4.94
Molecular weight 51.16 kDa
Number of residues 450
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0051321experimental evidencePMID:11376151
increased during GO:0034293experimental evidencePMID:PMPB:0

Quantitative Gene Expression

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.049during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.022during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in bacteria1000
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
sre2membrane-tethered transcription factor Sre2 Negative GeneticPMID:21504829
External References
Database Identifier Description
NBRP SPBC14C8.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC14C8.05c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC14C8.05c BioGRID Interaction Datasets
Expression Viewer SPBC14C8.05c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC14C8.05c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC14C8.05c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC14C8.05c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC14C8.05c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC14C8.05c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC14C8.05c Cell Cycle Data
GEO SPBC14C8.05c GEO profiles
PInt SPBC14C8.05c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC14C8.05c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC14C8.05c Fission yeast phenotypic data & analysis
IntEnz3.2.1.3Integrated relational Enzyme database
Rhea3.2.1.3Annotated reactions database
SPD / RIKEN21/21A04Orfeome Localization Data
UniProtKB/SwissProtO60087Probable glucoamylase
ModBaseO60087Database of comparative protein structure models
STRINGO60087Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595908glucan-alpha-1,4-glucosidase
RefSeq mRNANM_001021816972h- glucan-alpha-1,4-glucosidase (meu17), mRNA
European Nucleotide ArchiveAB054301ENA EMBL mapping
European Nucleotide ArchiveCAA18423.1ENA Protein Mapping
MetaCycPWY-5767Glycogen degradation III
KEGG_Enzyme00500+3.2.1.3Starch and sucrose metabolism
UniParcUPI0000125A82UniProt Archive

Literature for meu17

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015