tts1 (SPBC1539.04)

Gene Standard Nametts1 Characterisation Statuspublished
Systematic IDSPBC1539.04 Feature Typeprotein coding
Synonyms Name DescriptionTeTra Spanning protein
Producttetra spanning protein 1, Tts1 Product Size279aa, 31.57 kDa
Genomic Location Chromosome II, 4368286-4369816 (1531nt); CDS:4368389-4369414 (1026nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005515protein bindingIPISPBC651.13cPMID:20434336887
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0034613cellular protein localization556
localizes rtn1IMPPMID:20434336
GO:0007105cytokinesis, site selectionIMPPMID:204343366
GO:0071786endoplasmic reticulum tubular network organization3
in cell cortexIMPPMID:20434336
GO:0071790establishment of spindle pole body localization to nuclear envelopeIGIcut11PMID:204343362
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005794Golgi apparatusIDAPMID:16823372355
GO:0032153cell division site292
during mitotic cell cycleIDAPMID:8873452
GO:0032541cortical endoplasmic reticulumIDAPMID:204343365
GO:0005783endoplasmic reticulumIDAPMID:16823372594
GO:0016021integral component of membraneISSTMHMMGO_REF:00000241016
GO:0005635nuclear envelopeIDAPMID:20434336136
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopytts1ΔNullPMID:204732893755
Microscopytts1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000032abnormal cytokinesisno_namePMID:2043433679
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopytts1ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Target Of
localized by rtn1 reticulon-like protein Rtn1 PMID:20434336
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Start End Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF03661 Pfam IPR005344 Uncharacterised protein family UPF0121 25 256 1
TMhelix TMHMM 57 79 959
TMhelix TMHMM 170 192 959
TMhelix TMHMM 100 122 959
TMhelix TMHMM 25 47 959
PTHR12703 HMMPANTHER 2 279 1
PTHR12703:SF0 HMMPANTHER 2 279 1
Low complexity (SEG) seg 181 193
Low complexity (SEG) seg 262 279

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount

Protein Properties

Ave. residue weight 113.15 Da
Charge 25.00
Isoelectric point 11.09
Molecular weight 31.57 kDa
Number of residues 279
Gene Expression

Qualitative Gene Expression

RNA levelincreased,
in presence of methyl methanesulfonate
expression microarray evidencePMID:12529438
increasedexpression microarray evidencePMID:12529438
during GO:0071470
increasedexpression microarray evidencePMID:12529438
during GO:0034605
in presence of cadmium sulfate
expression microarray evidencePMID:12529438
increasedexpression microarray evidencePMID:12529438
during GO:0034599

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
6577.81during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
7921.96during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
9.3during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
yop1ER membrane protein DP1/Yop1 Phenotypic EnhancementPMID:20434336
scs2VAP family protein Scs2 Phenotypic SuppressionPMID:23041194
rtn1reticulon-like protein Rtn1 Phenotypic EnhancementPMID:20434336
scs22VAP family protein Scs22 Phenotypic SuppressionPMID:23041194
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
rtn1reticulon-like protein Rtn1 Co-purificationPMID:20434336
External References
Database Identifier Description
NBRP SPBC1539.04 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1539.04 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1539.04 BioGRID Interaction Datasets
Expression Viewer SPBC1539.04 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1539.04 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1539.04 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1539.04 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1539.04 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1539.04 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC1539.04 Cell Cycle Data
GEO SPBC1539.04 GEO profiles
PInt SPBC1539.04 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2539923conserved eukaryotic protein
EntrezGene2539923conserved eukaryotic protein
SPD / RIKEN15/15D12Orfeome Localization Data
UniProtKB/SwissProtQ9Y7Z5Tetra-spanning protein 1
ModBaseQ9Y7Z5Database of comparative protein structure models
StringQ9Y7Z5Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596818conserved eukaryotic protein
RefSeq mRNANM_001023838972h- conserved eukaryotic protein (SPBC1539.04), mRNA
European Nucleotide ArchiveCAB51336ENA Protein Mapping
UniParcUPI000006AA70UniProt Archive

Literature for tts1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014