slm9 (SPBC15D4.03)


Gene Standard Nameslm9 Characterisation Statuspublished
Systematic IDSPBC15D4.03 Feature Typeprotein coding
Synonyms Name Description
Producthira protein Slm9 Product Size807aa, 90.43 kDa
Genomic Location Chromosome II, 3015406-3018155 (2750nt); CDS:3015538-3017961 (2424nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
protein binding863
Annotation ExtensionEvidenceWith/FromReference
transcription corepressor activity5
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cellular protein localization508
Annotation ExtensionEvidenceWith/FromReference
cellular response to nitrogen starvation24
Annotation ExtensionEvidenceWith/FromReference
chromatin modification218
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at centromere59
Annotation ExtensionEvidenceWith/FromReference
chromatin silencing at silent mating-type cassette36
Annotation ExtensionEvidenceWith/FromReference
DNA replication-independent nucleosome assembly10
Annotation ExtensionEvidenceWith/FromReference
mitotic sister chromatid segregation184
Annotation ExtensionEvidenceWith/FromReference
negative regulation of transcription from RNA polymerase II promoter63
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytosol2306
Annotation ExtensionEvidenceWith/FromReference
HIR complex4
Annotation ExtensionEvidenceWith/FromReference
nuclear chromatin358
Annotation ExtensionEvidenceWith/FromReference
nucleus2692
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationslm9Δ3837

Cell Phenotype

Term NameGenotypesCount
abnormal mitotic cell cycleslm9Δ858
abnormal positive regulation of transcription11
affecting hhf1slm9Δ
affecting hht1slm9Δ
affecting hta2slm9Δ
affecting hht3slm9Δ
affecting hhf3slm9Δ
affecting hhf2slm9Δ
affecting hht2slm9Δ
affecting hta1slm9Δ
elongated vegetative cellslm9Δ791
viable elongated vegetative cellslm9Δ317
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3015406..3018155
5' UTR3015406..3015537PMID:21511999
3' UTR3017962..3018155PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF07569 Pfam IPR011494 TUP1-like enhancer of split 528 743 2
PF00400 Pfam IPR001680 WD40 repeat 175 212 82
SM00320 SMART IPR001680 WD40 repeat 319 356 112
SM00320 SMART IPR001680 WD40 repeat 267 313 112
SM00320 SMART IPR001680 WD40 repeat 46 92 112
SM00320 SMART IPR001680 WD40 repeat 173 212 112
PS00678 Prosite Patterns IPR019775 WD40 repeat, conserved site 300 314 65
PS50082 Prosite Profiles IPR001680 WD40 repeat 180 215 100
PS50294 Prosite Profiles IPR017986 WD40-repeat-containing domain 180 221 104
PTHR13831 HMMPANTHER IPR031120 WD repeat HIR1 172 801 2
PTHR13831:SF0 HMMPANTHER 172 801 2
2.130.10.10 Gene3D IPR015943 WD40/YVTN repeat-like-containing domain 20 130 145
2.130.10.10 Gene3D IPR015943 WD40/YVTN repeat-like-containing domain 164 376 145
2.130.10.10 Gene3D IPR015943 WD40/YVTN repeat-like-containing domain 473 581 145
SSF50978 SuperFamily IPR017986 WD40-repeat-containing domain 174 357 135
SSF50978 SuperFamily IPR017986 WD40-repeat-containing domain 16 134 135

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0000190WD repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000190

Protein Properties

Ave. residue weight 112.06 Da
Charge 10.50
Codon Adaptation Index 0.38
Isoelectric point 7.33
Molecular weight 90.43 kDa
Number of residues 807
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1676
present during mitotic M phaseS421
present during mitotic M phaseS425
present during mitotic M phaseS422
present during mitotic M phaseS406
present during mitotic M phaseS398
present during mitotic M phaseS418
S406, S422, S765
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S421 PMID:21712547
present during mitotic M phase experimental evidence S425 PMID:21712547
present during mitotic M phase experimental evidence S422 PMID:21712547
present during mitotic M phase experimental evidence S406 PMID:21712547
present during mitotic M phase experimental evidence S398 PMID:21712547
present during mitotic M phase experimental evidence S418 PMID:21712547
experimental evidence S765 PMID:24763107
experimental evidence S406 PMID:24763107
experimental evidence S422 PMID:24763107
phosphorylated residue 1930
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for slm9 (SPBC15D4.03)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1707during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
103.33during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.1during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Misc
DescriptionQualifierReferenceCount
deletion mutant expression profiling PMID:1962028277
target of proteasomeInferred from Physical Interaction PMID:209761053
target of chaperonin-containing T-complexInferred from Physical Interaction PMID:209761051
Miscellaneous Functional Group
DescriptionQualifierReferenceCount
histone chaperone14
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4605
conserved in eukaryotes4515
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2505
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC15D4.03 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captureship4histone promoter control protein Hip4 Affinity Capture-MSPMID:20976105
affinity capturessir1sulfite reductase Sir1 Affinity Capture-MSPMID:20976105
affinity capturesSPCC1827.06caspartate semialdehyde dehydrogenase (predicted) Affinity Capture-MSPMID:20976105
affinity capturesgpd1glycerol-3-phosphate dehydrogenase Gpd1 Affinity Capture-MSPMID:20976105
affinity capturesatb2tubulin alpha 2 Affinity Capture-MSPMID:20976105
affinity capturescct6chaperonin-containing T-complex zeta subunit Cct6 Affinity Capture-MSPMID:20976105
affinity capturescct8chaperonin-containing T-complex theta subunit Cct8 Affinity Capture-MSPMID:20976105
affinity capturescct4chaperonin-containing T-complex delta subunit Cct4 Affinity Capture-MSPMID:20976105
affinity capturesssa1heat shock protein Ssa1 (predicted) Affinity Capture-MSPMID:20976105
affinity capturesrpt419S proteasome regulatory subunit Rpt4 (predicted) Affinity Capture-MSPMID:20976105
affinity capturesSPBC365.16conserved protein Affinity Capture-MSPMID:20976105
affinity capturestrs1cytoplasmic threonine-tRNA ligase Trs1 (predicted) Affinity Capture-MSPMID:20976105
affinity capturescdc48AAA family ATPase involved in ubiquitin-mediated protein degradation Cdc48 Affinity Capture-MSPMID:20976105
affinity capturesnda3tubulin beta Nda3 Affinity Capture-MSPMID:20976105
affinity captureship1hira protein, histone chaperone Hip1 Affinity Capture-MSPMID:20976105
affinity capturespgk1phosphoglycerate kinase Pgk1 (predicted) Affinity Capture-MSPMID:20976105
affinity capturesrpt319S proteasome regulatory subunit Rpt3 (predicted) Affinity Capture-MSPMID:20976105
affinity capturesvma2V-type ATPase V1 subunit B Affinity Capture-MSPMID:20976105
affinity capturesfba1fructose-bisphosphate aldolase Fba1 Affinity Capture-MSPMID:20976105
affinity capturesslm9hira protein Slm9 Affinity Capture-MSPMID:20976105
affinity capturesrad2414-3-3 protein Rad24 Affinity Capture-MSPMID:20976105
affinity capturescct1chaperonin-containing T-complex alpha subunit Cct1 Affinity Capture-MSPMID:20976105
affinity capturesrpt119S proteasome regulatory subunit Rpt1 (predicted) Affinity Capture-MSPMID:20976105
affinity captureship3HIRA interacting protein Hip3 Affinity Capture-MSPMID:16428807
affinity captureslys4homocitrate synthase Affinity Capture-MSPMID:20976105
affinity capturesrvb1AAA family ATPase Rvb1 Affinity Capture-MSPMID:20976105
affinity capturesdfr1dihydrofolate reductase/ serine hydrolase family fusion protein Dfr1 Affinity Capture-MSPMID:20976105
affinity capturesgus1cytoplasmic glutamate-tRNA ligase gus1 (predicted) Affinity Capture-MSPMID:20976105
affinity capturestef3translation elongation factor eEF3 Affinity Capture-MSPMID:20976105
affinity capturesilv1acetolactate synthase catalytic subunit Affinity Capture-MSPMID:20976105
affinity capturespss1heat shock protein Pss1 Affinity Capture-MSPMID:20976105
affinity capturesanc1mitochondrial adenine nucleotide carrier Anc1 Affinity Capture-MSPMID:20976105
affinity capturesrpt219S proteasome regulatory subunit Rpt2 Affinity Capture-MSPMID:20976105
affinity capturesatp2F1-ATPase beta subunit Atp2 Affinity Capture-MSPMID:20976105
affinity capturesura1carbamoyl-phosphate synthase (glutamine hydrolyzing), aspartate carbamoyltransferase Ura1 Affinity Capture-MSPMID:20976105
affinity capturesrpt519S proteasome regulatory subunit Rpt5 (predicted) Affinity Capture-MSPMID:20976105
affinity captureshsp90Hsp90 chaperone Affinity Capture-MSPMID:20976105
affinity capturesmts419S proteasome regulatory subunit Mts4 Affinity Capture-MSPMID:20976105
affinity capturesade1phosphoribosylamine-glycine ligase/phosphoribosylformylglycinamidine cyclo-ligase Affinity Capture-MSPMID:20976105
affinity capturesvrs2mitochondrial valine-tRNA ligase Vrs2/Vas2 Affinity Capture-MSPMID:20976105
affinity capturescts1CTP synthase Cts1 (predicted) Affinity Capture-MSPMID:20976105
affinity captured byhip4histone promoter control protein Hip4 Affinity Capture-WesternPMID:20976105
affinity captured byhip1hira protein, histone chaperone Hip1 Affinity Capture-MSPMID:16428807
affinity captured bycia1histone chaperone Cia1 Affinity Capture-MSPMID:21211723
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC15D4.03 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
synthetic growth defect withctf18RFC-like complex subunit Ctf18 Synthetic Growth DefectPMID:18931302
synthetic growth defect withset1histone lysine methyltransferase Set1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withswi6HP1 family chromodomain protein Swi6 Synthetic Growth DefectPMID:18931302
synthetic growth defect withspa2cell polarity protein Spa2 Synthetic Growth DefectPMID:18931302
synthetic growth defect withmrc1mediator of replication checkpoint 1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withalg6glucosyltransferase Alg6 Synthetic Growth DefectPMID:18931302
synthetic growth defect withmak10NatC N-acetyltransferase complex subunit Mak10 (predicted) Synthetic Growth DefectPMID:18931302
synthetic growth defect withctu1cytosolic thiouridylase subunit Ctu1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withpht1histone H2A variant H2A.Z, Pht1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withres2MBF transcription factor complex subunit Res2 Synthetic Growth DefectPMID:18931302
synthetic growth defect withpof3F-box protein Pof3 Synthetic Growth DefectPMID:18931302
synthetic growth defect withhst2Sirtuin family histone deacetylase Hst2 Synthetic Growth DefectPMID:18931302
synthetic growth defect withrik1silencing protein Rik1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withrud3Golgi matrix protein Rud3 (predicted) Synthetic Growth DefectPMID:18931302
synthetic growth defect withfhl1forkhead transcription factor Fhl1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withpyp2tyrosine phosphatase Pyp2 Synthetic Growth DefectPMID:18931302
synthetic growth defect withpli1SUMO E3 ligase Pli1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withpmt3SUMO Synthetic Growth DefectPMID:18931302
synthetic growth defect withcdc25M phase inducer tyrosine phosphatase Cdc25 Synthetic Growth DefectPMID:9843572
synthetic growth defect withmmd1deoxyhypusine hydroxylase (predicted) Synthetic Growth DefectPMID:18931302
synthetic growth defect withies2Ino80 complex subunit Ies2 Synthetic Growth DefectPMID:18931302
synthetic growth defect withash2Ash2-trithorax family protein Synthetic Growth DefectPMID:18931302
synthetic growth defect withswc2Swr1 complex complex subunit Swc2 Synthetic Growth DefectPMID:18931302
synthetic growth defect withspf1Set1C PHD Finger protein Spf1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withsgf73SAGA complex subunit Sgf73 Synthetic Growth DefectPMID:18931302
synthetic growth defect withcul3cullin 3 Synthetic Growth DefectPMID:18931302
synthetic growth defect withpof9F-box protein Pof9 Synthetic Growth DefectPMID:18931302
synthetic growth defect withhos2histone deacetylase (class I) Hos2 Synthetic Growth DefectPMID:18931302
synthetic growth defect withwee1M phase inhibitor protein kinase Wee1 Synthetic Growth DefectPMID:9843572
rescued bywee1M phase inhibitor protein kinase Wee1 Phenotypic SuppressionPMID:10835386
rescued bycdc25M phase inducer tyrosine phosphatase Cdc25 Phenotypic SuppressionPMID:10835386
rescuesswd1Set1C complex subunit Swd1 Phenotypic SuppressionPMID:19547744
phenotype enhanced bycdr2serine/threonine protein kinase Cdr2 Phenotypic EnhancementPMID:10835386
phenotype enhanced bycdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Phenotypic EnhancementPMID:10835386
External References
Database Identifier Description
NBRP SPBC15D4.03 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC15D4.03 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC15D4.03 BioGRID Interaction Datasets
Expression Viewer SPBC15D4.03 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC15D4.03 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC15D4.03 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC15D4.03 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC15D4.03 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC15D4.03 Transcriptome Viewer (Bähler Lab)
GEO SPBC15D4.03 GEO profiles
PInt SPBC15D4.03 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC15D4.03 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC15D4.03 Fission yeast phenotypic data & analysis
Cyclebase SPBC15D4.03.1 Cell Cycle Data
SPD / RIKEN39/39F12Orfeome Localization Data
UniProtKB/SwissProtO74309Histone transcription regulator slm9
ModBaseO74309Database of comparative protein structure models
STRINGO74309Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596243hira protein Slm9
RefSeq mRNANM_001022162972h- hira protein Slm9 (slm9), mRNA

Literature for slm9

Search: Europe PMC or PubMed

Release Version: PomBase:30_58 - 11 Mar 2016