amo1 (SPBC15D4.10c)

Gene Standard Nameamo1 Characterisation Statuspublished
Systematic IDSPBC15D4.10c Feature Typeprotein coding
Synonyms Name DescriptionAberrent Microtubules when Overexpressed
Productnuclear rim protein Amo1 Product Size475aa, 51.79 kDa
Genomic Location Chromosome II, 3030224-3028685 (1540nt); CDS:3030192-3028705 (1488nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
metal ion binding747
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
cell cycle960
Annotation ExtensionEvidenceWith/FromReference
cytoplasmic microtubule organization12
Annotation ExtensionEvidenceWith/FromReference
establishment of nucleus localization20
Annotation ExtensionEvidenceWith/FromReference
establishment or maintenance of cell polarity regulating cell shape57
Annotation ExtensionEvidenceWith/FromReference
establishment or maintenance of microtubule cytoskeleton polarity3
Annotation ExtensionEvidenceWith/FromReference
negative regulation of microtubule polymerization1
Annotation ExtensionEvidenceWith/FromReference
during mitotic interphase
GO Cellular Component
Term NameCount
nuclear membrane35
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
NOT mitotic spindle pole body
Annotation ExtensionEvidenceWith/FromReference
NOT nuclear pore
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased mating efficiencyamo1ΔNull247
inviable vegetative cell populationnot recorded (wild type)1427
resistance to clotrimazole10
expressivity FYPO_EXT:0000003amo1ΔNull
resistance to cobalt56
expressivity FYPO_EXT:0000002amo1ΔNull
resistance to terbinafine11
expressivity FYPO_EXT:0000003amo1ΔNull
sensitive to amphotericin Bamo1ΔNull69
sensitive to hydroxyurea518
expressivity FYPO_EXT:0000003amo1ΔNull
viable vegetative cell populationamo1ΔNull3781

Cell Phenotype

Term NameAlleleExpressionCount
curved vegetative cellnot recorded (unrecorded)103
viable vegetative cell with normal cell morphology3092
penetrance FYPO_EXT:0000001amo1ΔNull
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PS50103 Prosite Profiles IPR000571 Zinc finger, CCCH-type 1 25 14
PTHR21495:SF39 HMMPANTHER 1 326 1
PTHR21495 HMMPANTHER 1 326 1
Coil ncoils Rabaptin coiled-coil domain 111 132 971

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000137zinc finger proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000137
PBO:0000416zf-CCCH typeTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000416

Protein Properties

Ave. residue weight 109.04 Da
Charge 4.00
Isoelectric point 8.59
Molecular weight 51.79 kDa
Number of residues 475

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1670
present during mitotic M phaseS142
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S142 PMID:21712547
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3434during GO:0000080PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
3597during GO:0000085PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
2190during GO:0072690PECO:0000126,
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.6during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
0.38during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Species Distribution
no apparent S. cerevisiae ortholog597
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3432
conserved in vertebrates3407
conserved in eukaryotes only2503

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:18818364
pph3serine/threonine protein phosphatase, PP4 complex subunit Pph3 (predicted) Negative GeneticPMID:18818364
klp6kinesin-like protein Klp6 Positive GeneticPMID:18818364
elp5elongator complex subunit Elp5 (predicted) Negative GeneticPMID:18818364
kap114karyopherin Kap14 Positive GeneticPMID:18818364
hht2histone H3 h3.2 Negative GeneticPMID:18818364
swd1Set1C complex subunit Swd1 Positive GeneticPMID:18818364
elp3elongator complex subunit Elp3 (predicted) Negative GeneticPMID:18818364
rem1meiosis-specific cyclin Rem1 Negative GeneticPMID:18818364
pmk1MAP kinase Pmk1 Positive GeneticPMID:18818364
bag101BAG family molecular chaperone regulator Bag101 (predicted) Negative GeneticPMID:18818364
ers1RNA-silencing factor Ers1 Positive GeneticPMID:18818364
syj2inositol-polyphosphate 5-phosphatase, synaptojanin homolog 2 (predicted) Negative GeneticPMID:18818364
rad57RecA family ATPase Rad57/Rhp57 Negative GeneticPMID:18818364
rhp7Rad7 homolog Rhp7 Negative GeneticPMID:18818364
swc5Swr1 complex subunit Swc5 Positive GeneticPMID:18818364
SPAC3A11.03methyltransferase (predicted) Negative GeneticPMID:18818364
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:18818364
obr1ubiquitinated histone-like protein Uhp1 Positive GeneticPMID:18818364
utp16U3 snoRNP-associated protein Utp16 (predicted) Negative GeneticPMID:18818364
hip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
ebs1EST1 family nonsense-mediated mRNA decay (NMD) pathway protein Ebs1 (predicted) Negative GeneticPMID:18818364
fkbp39FKBP-type peptidyl-prolyl cis-trans isomerase (predicted) Negative GeneticPMID:18818364
eaf1RNA polymerase II transcription elongation factor SpEAF Positive GeneticPMID:18818364
nap1nucleosome assembly protein Nap1 Positive GeneticPMID:18818364
rhp26SNF2 family ATP-dependent DNA helicase Rhp26 Negative GeneticPMID:18818364
fft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:18818364
lub1WD repeat protein Lub1 Negative GeneticPMID:18818364
nup131nucleoporin Nup131 Negative GeneticPMID:18818364
utp4U3 snoRNP protein Utp4 (predicted) Negative GeneticPMID:18818364
mal3EB1 family Mal3 Negative GeneticPMID:18818364
mre11Mre11 nuclease Negative GeneticPMID:18818364
rsv2transcription factor Rsv2 Negative GeneticPMID:18818364
SPBC16C6.05mitochondrial translation initiation factor (predicted) Negative GeneticPMID:18818364
rad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Negative GeneticPMID:18818364
tma20RNA-binding protein Tma20 (predicted) Negative GeneticPMID:18818364
cdk11serine/threonine protein kinase cdk11 Negative GeneticPMID:18818364
gcn20AAA family ATPase Gcn20 (predicted) Negative GeneticPMID:18818364
ies2Ino80 complex subunit Ies2 Positive GeneticPMID:18818364
SPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:18818364
sgf29SAGA complex subunit Sgf29 Positive GeneticPMID:18818364
kap113karyopherin Kap113 Positive GeneticPMID:18818364
but1neddylation pathway protein But1 Positive GeneticPMID:18818364
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:18818364
hrp3ATP-dependent DNA helicase Hrp3 Positive GeneticPMID:18818364
yfh7uridine kinase Yfh7 (predicted) Negative GeneticPMID:18818364
srb11cyclin CycC, Srb mediator subunit Srb11 Negative GeneticPMID:18818364
rev7DNA polymerase zeta Rev7 (predicted) Negative GeneticPMID:18818364
hrp1ATP-dependent DNA helicase Hrp1 Negative GeneticPMID:18818364
SPCC645.13transcription elongation regulator (predicted) Negative GeneticPMID:18818364
bcp1thioredoxin peroxidase Bcp1 Positive GeneticPMID:18818364
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:18818364
hta1histone H2A alpha Positive GeneticPMID:18818364
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
SPBC16G5.03ubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:18818364
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
png2ING family homolog Png2 Negative GeneticPMID:18818364
cho1phosphatidyl-N-methylethanolamine N-methyltransferase (predicted) Negative GeneticPMID:18818364
SPBC839.03cneddylation protein Dcn1 (predicted) Negative GeneticPMID:18818364
trm13tRNA 2'-O-methyltransferase Trm13 (predicted) Positive GeneticPMID:18818364
nup60nucleoporin Nup60 Negative GeneticPMID:18818364
rox3mediator complex subunit Med19/Rox3 Negative GeneticPMID:18818364
epe1Jmjc domain chromatin associated protein Epe1 Positive GeneticPMID:18818364
set5histone lysine methyltransferase Set5 (predicted) Negative GeneticPMID:18818364
rpl160160S ribosomal protein L13/L16 (predicted) Positive GeneticPMID:18818364
mod21gamma tubulin complex subunit Mod21 Positive GeneticPMID:18818364
ptc2protein phosphatase 2C Ptc2 Negative GeneticPMID:18818364
chp1chromodomain protein Chp1 Negative GeneticPMID:18818364
ptf1Mst2 histone acetytransferase acytyltransferase complex, predicted phosphoric monoester hydrolase Ptf1 Negative GeneticPMID:18818364
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:18818364
ubp3ubiquitin C-terminal hydrolase Ubp3 Positive GeneticPMID:18818364
rhn1RNA polymerase II transcription termination factor homolog Negative GeneticPMID:18818364
reb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:18818364
pdx1pyruvate dehydrogenase protein x component, Pdx1 (predicted) Negative GeneticPMID:18818364
SPAC1952.06cspliceosomal complex subunit (predicted) Positive GeneticPMID:18818364
ppk8serine/threonine protein kinase Ppk8 (predicted) Negative GeneticPMID:18818364
SPAC323.03cSchizosaccharomyces specific protein Negative GeneticPMID:18818364
ppk16serine/threonine protein kinase Ppk16 (predicted) Negative GeneticPMID:18818364
dad1DASH complex subunit Dad1 Negative GeneticPMID:18818364
pmp1dual-specificity MAP kinase phosphatase Pmp1 Negative GeneticPMID:18818364
rnf10ubiquitin-protein ligase E3 implicated in transcription (predicted) Negative GeneticPMID:18818364
spn1septin Spn1 Negative GeneticPMID:18818364
cid12poly(A) polymerase Cid12 Positive GeneticPMID:18818364
cwf21complexed with Cdc5 protein Cwf21 Positive GeneticPMID:18818364
rcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Negative GeneticPMID:18818364
bub3mitotic spindle checkpoint protein Bub3 Positive GeneticPMID:18818364
set9histone lysine H3-K20 methyltransferase Set9 Negative GeneticPMID:18818364
mms19Dos2 silencing complex subunit Mms19 Positive GeneticPMID:18818364
tea2kinesin-like protein Tea2 Negative GeneticPMID:18818364
klp3kinesin-like protein Klp3 Positive GeneticPMID:18818364
nup40nucleoporin Nup40 Negative GeneticPMID:18818364
dsk1SR protein-specific kinase Dsk1 Positive GeneticPMID:18818364
ppk14serine/threonine protein kinase Ppk14 (predicted) Negative GeneticPMID:18818364
sdc1Dpy-30 domain protein Sdc1 Negative GeneticPMID:18818364
SPAC23A1.07ubiquitin-protein ligase E3 (predicted) Positive GeneticPMID:18818364
SPCC18.10pyridoxine-pyridoxal-pyridoxamine kinase (predicted) Negative GeneticPMID:18818364
ura5orotate phosphoribosyltransferase Ura5 Negative GeneticPMID:18818364
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:18818364
dcr1dicer Positive GeneticPMID:18818364
tfs1transcription elongation factor TFIIS Positive GeneticPMID:18818364
mlo2ubiquitin protein ligase E3 component human N-recognin 7 homolog Mlo2 Positive GeneticPMID:18818364
sir2Sir2 family histone deacetylase Sir2 Negative GeneticPMID:18818364
gnr1heterotrimeric G protein beta subunit Gnr1 Positive GeneticPMID:18818364
ufd2ubiquitin-protein ligase E4 (predicted) Negative GeneticPMID:18818364
External References
Database Identifier Description
NBRP SPBC15D4.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC15D4.10c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC15D4.10c BioGRID Interaction Datasets
Expression Viewer SPBC15D4.10c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC15D4.10c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC15D4.10c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC15D4.10c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC15D4.10c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC15D4.10c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC15D4.10c Cell Cycle Data
GEO SPBC15D4.10c GEO profiles
PInt SPBC15D4.10c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC15D4.10c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC15D4.10c Fission yeast phenotypic data & analysis
SPD / RIKEN24/24A05Orfeome Localization Data
UniProtKB/SwissProtO74315Nucleoporin-like protein amo1
ModBaseO74315Database of comparative protein structure models
STRINGO74315Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596250nuclear rim protein Amo1
RefSeq mRNANM_001022169972h- nuclear rim protein Amo1 (amo1), mRNA
European Nucleotide ArchiveCAA20485.1ENA Protein Mapping
UniParcUPI000006A222UniProt Archive

Literature for amo1

Search: Europe PMC or PubMed

Release Version: PomBase:25_48 - 10 Jan 2015