ght4 (SPBC1683.08)

Gene Standard Nameght4 Characterisation Statuspublished
Systematic IDSPBC1683.08 Feature Typeprotein coding
Synonyms Name Description
Producthexose transmembrane transporter Ght4 Product Size557aa, 62.13 kDa
Genomic Location Chromosome II, 155751-159570 (3820nt); CDS:157555-159228 (1674nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
NOT D-glucose transmembrane transporter activity
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
hexose transmembrane transport8
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
integral component of plasma membrane52
Annotation ExtensionEvidenceWith/FromReference
plasma membrane250
Annotation ExtensionEvidenceWith/FromReference
plasma membrane of cell tip16
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Single-allele Phenotypes

Population Phenotype

Term NameGenotypesCount
normal cell population growth during glucose starvationght4Δ8
normal growth on gluconate carbon sourceght4Δ1
normal growth on glucose carbon sourceght4Δ225
viable vegetative cell populationght4Δ3815

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyght4Δ3095
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR155751..157554PMID:21511999
3' UTR159229..159570PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00083 Pfam IPR005828 Major facilitator, sugar transporter-like 10 467 16
TMhelix TMHMM 369 391 959
TMhelix TMHMM 332 349 959
TMhelix TMHMM 266 288 959
TMhelix TMHMM 53 74 959
TMhelix TMHMM 416 438 959
TMhelix TMHMM 300 322 959
TMhelix TMHMM 89 111 959
TMhelix TMHMM 10 32 959
TMhelix TMHMM 177 199 959
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 9 456 55
PS00217 Prosite Patterns IPR005829 Sugar transporter, conserved site 119 144 6
PS00216 Prosite Patterns IPR005829 Sugar transporter, conserved site 318 335 15
PTHR24063:SF337 HMMPANTHER 1 496 8
PTHR24063 HMMPANTHER 1 496 11
1.20.1250.20 Gene3D Glycerate/sugar phosphate transporter, conserved site 47 204 72
1.20.1250.20 Gene3D Glycerate/sugar phosphate transporter, conserved site 261 464 72
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 45 214 76
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 249 465 76
SignalP-noTM signalp 1 24 212
PR00171 PRINTS IPR003663 Sugar/inositol transporter 276 286 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 114 133 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 369 390 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 392 404 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 17 27 10
TIGR00879 tigrfam IPR003663 Sugar/inositol transporter 7 463 10

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.54 Da
Charge 8.50
Codon Adpatation Index 0.45
Isoelectric point 8.43
Molecular weight 62.13 kDa
Number of residues 557
Gene Expression

Qualitative Gene Expression

protein levelincreased during GO:0042149Western blot evidencePMID:25411338
RNA levelincreased during GO:0042149quantitative PCRPMID:25411338

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1095during GO:0072690PECO:0000005,
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.83during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
0.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
conserved in fungi4604
conserved in eukaryotes4514

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
negative genetic interaction witheso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
negative genetic interaction withSPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
positive genetic interaction withssp2AMP-activated protein serine/threonine kinase alpha subunit Ssp2 Positive GeneticPMID:22681890
negative genetic interaction withtel2Tel2/Rad-5/Clk-2 family protein Tel2 Negative GeneticPMID:22681890
negative genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC1683.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1683.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1683.08 BioGRID Interaction Datasets
Expression Viewer SPBC1683.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1683.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1683.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1683.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1683.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1683.08 Transcriptome Viewer (Bähler Lab)
GEO SPBC1683.08 GEO profiles
PInt SPBC1683.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1683.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC1683.08 Fission yeast phenotypic data & analysis
Cyclebase SPBC1683.08.1 Cell Cycle Data
SPD / RIKEN35/35A06Orfeome Localization Data
UniProtKB/SwissProtO59932High-affinity hexose transporter ght4
ModBaseO59932Database of comparative protein structure models
STRINGO59932Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595064hexose transporter Ght4
RefSeq mRNANM_001020970972h- hexose transporter Ght4 (ght4), mRNA
European Nucleotide ArchiveAF051140ENA EMBL mapping
European Nucleotide ArchiveCU329671ENA EMBL mapping
European Nucleotide ArchiveAAC63976ENA Protein Mapping
European Nucleotide ArchiveAAC63976.1ENA Protein Mapping
European Nucleotide ArchiveCAB91170ENA Protein Mapping
European Nucleotide ArchiveCAB91170.1ENA Protein Mapping
UniParcUPI000012B421UniProt Archive

Literature for ght4

Search: Europe PMC or PubMed

Release Version: PomBase:28_55 - 09 Sep 2015