ght4 (SPBC1683.08)


Gene Standard Nameght4 Characterisation Statuspublished
Systematic IDSPBC1683.08 Feature Typeprotein coding
Synonyms Name Description
Producthexose transmembrane transporter Ght4 Product Size557aa, 62.13 kDa
Genomic Location Chromosome II, 155751-159570 (3820nt); CDS:157555-159228 (1674nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
NOT D-glucose transmembrane transporter activity
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
hexose transmembrane transport8
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
integral component of plasma membrane49
Annotation ExtensionEvidenceWith/FromReference
plasma membrane255
Annotation ExtensionEvidenceWith/FromReference
plasma membrane of cell tip18
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
normal cell population growth during glucose starvationght4Δ8
normal growth on gluconate carbon sourceght4Δ1
normal growth on glucose carbon sourceght4Δ273
viable vegetative cell populationght4Δ3837

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyght4Δ3100
Target Of
OntologyRelationshipGeneProduct
GO substrate of sst2 human AMSH/STAMBP protein homolog, ubiquitin specific-protease
GO substrate of ubp15 ubiquitin C-terminal hydrolase Ubp15
GO substrate of ubp4 ubiquitin C-terminal hydrolase Ubp4
GO substrate of ubp5 ubiquitin C-terminal hydrolase Ubp5
GO substrate of ubp9 ubiquitin C-terminal hydrolase Ubp9
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons155751..159570
5' UTR155751..157554PMID:21511999
3' UTR159229..159570PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00083 Pfam IPR005828 Major facilitator, sugar transporter-like 10 467 16
TMhelix TMHMM 10 32 953
TMhelix TMHMM 416 438 953
TMhelix TMHMM 332 349 953
TMhelix TMHMM 177 199 953
TMhelix TMHMM 300 322 953
TMhelix TMHMM 53 74 953
TMhelix TMHMM 266 288 953
TMhelix TMHMM 89 111 953
TMhelix TMHMM 369 391 953
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 9 456 55
PS00217 Prosite Patterns IPR005829 Sugar transporter, conserved site 119 144 6
PS00216 Prosite Patterns IPR005829 Sugar transporter, conserved site 318 335 15
PTHR23500:SF131 HMMPANTHER 5 522 8
PTHR23500 HMMPANTHER 5 522 10
1.20.1250.20 Gene3D Major facilitator superfamily domain 261 464 72
1.20.1250.20 Gene3D Major facilitator superfamily domain 47 204 72
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 249 465 76
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 45 214 76
SignalP-noTM signalp 1 24 207
PR00171 PRINTS IPR003663 Sugar/inositol transporter 114 133 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 392 404 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 276 286 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 369 390 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 17 27 10
TIGR00879 TIGRFAM IPR003663 Sugar/inositol transporter 7 463 10

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.54 Da
Charge 8.50
Codon Adaptation Index 0.45
Isoelectric point 8.43
Molecular weight 62.13 kDa
Number of residues 557
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
protein levelincreased during GO:0042149Western blot evidencePMID:25411338
RNA levelincreased during GO:0042149quantitative PCRPMID:25411338

Quantitative Gene Expression

View graphical display of gene expression data for ght4 (SPBC1683.08)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1095during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.83during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4605
conserved in eukaryotes4515
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC1683.08 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
negative genetic interaction withtel2Tel2/Rad-5/Clk-2 family protein Tel2 Negative GeneticPMID:22681890
negative genetic interaction withSPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
negative genetic interaction witheso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
negative genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
positive genetic interaction withssp2AMP-activated protein serine/threonine kinase alpha subunit Ssp2 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC1683.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1683.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1683.08 BioGRID Interaction Datasets
Expression Viewer SPBC1683.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1683.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1683.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1683.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1683.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1683.08 Transcriptome Viewer (Bähler Lab)
GEO SPBC1683.08 GEO profiles
PInt SPBC1683.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1683.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC1683.08 Fission yeast phenotypic data & analysis
Cyclebase SPBC1683.08.1 Cell Cycle Data
SPD / RIKEN35/35A06Orfeome Localization Data
UniProtKB/SwissProtO59932High-affinity hexose transporter ght4
ModBaseO59932Database of comparative protein structure models
STRINGO59932Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595064hexose transporter Ght4
RefSeq mRNANM_001020970972h- hexose transporter Ght4 (ght4), mRNA

Literature for ght4

Search: Europe PMC or PubMed

Release Version: PomBase:30_58 - 11 Mar 2016