ght4 (SPBC1683.08)


Gene Standard Nameght4 Characterisation Statuspublished
Systematic IDSPBC1683.08 Feature Typeprotein coding
Synonyms Name Description
Producthexose transmembrane transporter Ght4 Product Size557aa, 62.13 kDa
Genomic Location Chromosome II, 155751-159570 (3820nt); CDS:157555-159228 (1674nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
NOT D-glucose transmembrane transporter activity
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
hexose transmembrane transport8
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
integral component of plasma membrane49
Annotation ExtensionEvidenceWith/FromReference
plasma membrane253
Annotation ExtensionEvidenceWith/FromReference
plasma membrane of cell tip18
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
normal cell population growth during glucose starvationght4Δ8
normal growth on gluconate carbon sourceght4Δ1
normal growth on glucose carbon sourceght4Δ294
viable vegetative cell populationght4Δ3850

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologyght4Δ3102
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons155751..159570
mRNA155751..159570
5' UTR155751..157554PMID:21511999
CDS157555..159228
3' UTR159229..159570PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00083 Pfam IPR005828 Major facilitator, sugar transporter-like 10 467 15
TMhelix TMHMM 10 32 950
TMhelix TMHMM 177 199 950
TMhelix TMHMM 416 438 950
TMhelix TMHMM 332 349 950
TMhelix TMHMM 300 322 950
TMhelix TMHMM 53 74 950
TMhelix TMHMM 266 288 950
TMhelix TMHMM 89 111 950
TMhelix TMHMM 369 391 950
PS00216 Prosite Patterns IPR005829 Sugar transporter, conserved site 318 335 15
PS00217 Prosite Patterns IPR005829 Sugar transporter, conserved site 119 144 6
PS50850 Prosite Profiles IPR020846 Major facilitator superfamily domain 9 456 55
PTHR23500 HMMPANTHER 5 522 10
PTHR23500:SF131 HMMPANTHER 5 522 8
1.20.1250.20 Gene3D Major facilitator superfamily domain 261 464 72
1.20.1250.20 Gene3D Major facilitator superfamily domain 47 204 72
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 45 214 76
SSF103473 SuperFamily IPR020846 Major facilitator superfamily domain 249 465 76
SignalP-noTM signalp 1 24 207
PR00171 PRINTS IPR003663 Sugar/inositol transporter 276 286 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 369 390 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 114 133 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 17 27 10
PR00171 PRINTS IPR003663 Sugar/inositol transporter 392 404 10
TIGR00879 TIGRFAM IPR003663 Sugar/inositol transporter 7 463 10

View domain organization at Pfam

Protein Properties

Ave. residue weight 111.54 Da
Charge 8.50
Codon Adaptation Index 0.45
Isoelectric point 8.43
Molecular weight 62.13 kDa
Number of residues 557
Modifications

Protein Modifications

Term NameResidueCount
O-phosphorylated residueS546,S549 2457
Annotation ExtensionEvidenceResidueReference
IDA S546,S549 PMID:25720772
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
protein levelincreased during GO:0042149Western blot evidencePMID:25411338
RNA levelincreased during GO:0042149quantitative PCRPMID:25411338

Quantitative Gene Expression

View graphical display of gene expression data for ght4 (SPBC1683.08)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1095during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
0.83during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.2during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi4607
conserved in eukaryotes4517
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC1683.08 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Negative GeneticPMID:22681890
negative genetic interaction witheso1mitotic cohesin N-acetyltransferase/DNA polymerase eta Eso1 fusion protein Negative GeneticPMID:23050226
negative genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
negative genetic interaction withtel2Tel2/Rad-5/Clk-2 family protein Tel2 Negative GeneticPMID:22681890
negative genetic interaction withSPAC19B12.11czinc finger protein, human ZNF593 ortholog Negative GeneticPMID:22681890
positive genetic interaction withssp2AMP-activated protein serine/threonine kinase alpha subunit Ssp2 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC1683.08 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1683.08 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1683.08 BioGRID Interaction Datasets
Expression Viewer SPBC1683.08 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1683.08 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1683.08 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1683.08 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1683.08 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1683.08 Transcriptome Viewer (Bähler Lab)
GEO SPBC1683.08 GEO profiles
PInt SPBC1683.08 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1683.08 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC1683.08 Fission yeast phenotypic data & analysis
Cyclebase SPBC1683.08.1 Cell Cycle Data
SPD / RIKEN35/35A06Orfeome Localization Data
UniProtKB/SwissProtO59932High-affinity hexose transporter ght4
ModBaseO59932Database of comparative protein structure models
STRINGO59932Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595064hexose transporter Ght4
RefSeq mRNANM_001020970972h- hexose transporter Ght4 (ght4), mRNA
European Nucleotide ArchiveAAC63976.1ENA Protein Mapping
European Nucleotide ArchiveCAB91170.1ENA Protein Mapping
UniParcUPI000012B421UniProt Archive

Literature for ght4

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016