sec11 (SPBC1685.03)

Gene Standard Namesec11 Characterisation Statusbiological_role_inferred
Systematic IDSPBC1685.03 Feature Typeprotein coding
Synonyms Name Description
Productsignal peptidase subunit Sec11 (predicted) Product Size189aa, 21.40 kDa
Genomic Location Chromosome II, 499181-500762 (1582nt); CDS:499374-500161 (788nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
peptidase activity138
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
protein targeting to ER23
Annotation ExtensionEvidenceWith/FromReference
Annotation ExtensionEvidenceWith/FromReference
signal peptide processing7
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum594
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
signal peptidase complex4
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopysec11ΔNullPMID:126183701338
Microscopysec11ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002151inviable spore465
penetrance FYPO_EXT:0000001Microscopysec11ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00717 Pfam IPR019759 Peptidase S24/S26A/S26B 43 116 3
TMhelix TMHMM 162 184 959
PTHR10806 HMMPANTHER IPR001733 Peptidase S26B, eukaryotic signal peptidase 1 189 1 Gene3D IPR028360 Peptidase S24/S26, beta-ribbon domain 41 128 3
SSF51306 SuperFamily IPR015927 Peptidase S24/S26A/S26B/S26C 40 157 3
PR00728 PRINTS IPR001733 Peptidase S26B, eukaryotic signal peptidase 118 129 1
PR00728 PRINTS IPR001733 Peptidase S26B, eukaryotic signal peptidase 43 58 1
TIGR02228 tigrfam IPR001733 Peptidase S26B, eukaryotic signal peptidase 21 161 1
SignalP-noTM signalp 1 25 212

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.24 Da
Charge -2.50
Isoelectric point 5.25
Molecular weight 21.40 kDa
Number of residues 189
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7106during GO:0000080PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
8623during GO:0000085PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
1635.99during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
8369during GO:0072690PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
3475.72during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
0.62during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in bacteria1000
conserved in metazoa3425
conserved in vertebrates3400
conserved in archaea237

Manually curated orthologous groups


Orthologs in Compara

External References
Database Identifier Description
NBRP SPBC1685.03 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1685.03 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1685.03 BioGRID Interaction Datasets
Expression Viewer SPBC1685.03 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1685.03 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1685.03 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1685.03 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1685.03 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1685.03 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC1685.03 Cell Cycle Data
GEO SPBC1685.03 GEO profiles
PInt SPBC1685.03 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1685.03 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC1685.03 Fission yeast phenotypic data & analysis
SPD / RIKEN09/09H03Orfeome Localization Data
UniProtKB/SwissProtO74323Signal peptidase complex catalytic subunit sec11
ModBaseO74323Database of comparative protein structure models
STRINGO74323Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595207signal peptidase subunit Sec11 (predicted)
RefSeq mRNANM_001021113972h- signal peptidase subunit Sec11 (predicted) (sec11), mRNA
European Nucleotide ArchiveCAA20051.1ENA Protein Mapping
UniParcUPI000006AC6AUniProt Archive

Literature for sec11

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014