sec11 (SPBC1685.03)


Gene Standard Namesec11 Characterisation Statusbiological_role_inferred
Systematic IDSPBC1685.03 Feature Typeprotein coding
Synonyms Name Description
Productsignal peptidase subunit Sec11 (predicted) Product Size189aa, 21.40 kDa
Genomic Location Chromosome II, 499181-500762 (1582nt); CDS:499374-500161 (788nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0008233peptidase activityISOSGD:S000001461GO_REF:0000024139
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0045047protein targeting to ERISOSGD:S000001461GO_REF:000002423
GO:0006508proteolysisISOSGD:S000001461GO_REF:0000024272
GO:0006465signal peptide processingISOSGD:S000001461GO_REF:00000247
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005783endoplasmic reticulumIDAPMID:16823372594
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371017
GO:0005787signal peptidase complexISOSGD:S000001461GO_REF:00000244
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopysec11ΔNullPECO:0000005, PECO:0000137PMID:236978061315
sec11ΔNullPMID:12618370
Microscopysec11ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002151inviable spore457
penetrance FYPO_EXT:0000001Microscopysec11ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
1499181499397
2499556499869
3499930500762

UTRs

Region Coordinates Reference
five_prime_UTR499181..499373PMID:21511999
three_prime_UTR500162..500762PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00717 Pfam IPR019759 Peptidase S24/S26A/S26B 43 116 3
TMhelix TMHMM 162 184 959
PTHR10806 HMMPANTHER IPR001733 Peptidase S26B, eukaryotic signal peptidase 1 189 1
2.10.109.10 Gene3D IPR028360 Peptidase S24/S26, beta-ribbon domain 41 128 3
SSF51306 SuperFamily IPR015927 Peptidase S24/S26A/S26B/S26C 40 157 3
PR00728 PRINTS IPR001733 Peptidase S26B, eukaryotic signal peptidase 43 58 1
PR00728 PRINTS IPR001733 Peptidase S26B, eukaryotic signal peptidase 118 129 1
TIGR02228 tigrfam IPR001733 Peptidase S26B, eukaryotic signal peptidase 21 161 1
SignalP-noTM signalp 1 25 212

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.24 Da
Charge -2.50
Isoelectric point 5.25
Molecular weight 21.40 kDa
Number of residues 189
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3475.72during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
1635.99during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
8369during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
8623during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
7106during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.62during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
3during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3393
conserved in archaea237
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPBC1685.03 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1685.03 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1685.03 BioGRID Interaction Datasets
Expression Viewer SPBC1685.03 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1685.03 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1685.03 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1685.03 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1685.03 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1685.03 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC1685.03 Cell Cycle Data
GEO SPBC1685.03 GEO profiles
PInt SPBC1685.03 Protein-Protein Interaction Predictor (Bähler Lab)
SPD / RIKEN09/09H03Orfeome Localization Data
EntrezGene2539654signal peptidase subunit Sec11 (predicted)
WikiGene2539654signal peptidase subunit Sec11 (predicted)
UniProtKB/SwissProtO74323Signal peptidase complex catalytic subunit sec11
ModBaseO74323Database of comparative protein structure models
STRINGO74323Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595207signal peptidase subunit Sec11 (predicted)
RefSeq mRNANM_001021113972h- signal peptidase subunit Sec11 (predicted) (sec11), mRNA
MEROPSS26.010
European Nucleotide ArchiveCAA20051ENA Protein Mapping
European Nucleotide ArchiveCAA20051.1ENA Protein Mapping
UniParcUPI000006AC6AUniProt Archive

Literature for sec11

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014