sec11 (SPBC1685.03)


Gene Standard Namesec11 Characterisation Statusbiological role inferred
Systematic IDSPBC1685.03 Feature Typeprotein coding
Synonymsppp69 Name Description
Productsignal peptidase subunit Sec11 (predicted) Product Size189aa, 21.40 kDa
Genomic Location Chromosome II, 499181-500762 (1582nt); CDS:499374-500161 (788nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
peptidase activity132
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
protein targeting to ER22
Annotation ExtensionEvidenceWith/FromReference
signal peptide processing6
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum596
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane962
Annotation ExtensionEvidenceWith/FromReference
signal peptidase complex4
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationsec11Δ1452

Cell Phenotype

Term NameGenotypesCount
inviable sporesec11Δ476
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons499181..499397, 499556..499869, 499930..500762
Intron499398..499555, 499870..499929
mRNA499181..500762
5' UTR499181..499373PMID:21511999
CDS499374..499397, 499556..499869, 499930..500161
3' UTR500162..500762PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00717 Pfam IPR019759 Peptidase S24/S26A/S26B 43 127 3
TMhelix TMHMM 162 184 953
PTHR10806 HMMPANTHER IPR001733 Peptidase S26B 2 65 1
PTHR10806 HMMPANTHER IPR001733 Peptidase S26B 83 187 1
2.10.109.10 Gene3D IPR028360 Peptidase S24/S26, beta-ribbon domain 41 128 3
SSF51306 SuperFamily IPR015927 Peptidase S24/S26A/S26B/S26C 40 157 3
PR00728 PRINTS IPR001733 Peptidase S26B 43 58 1
PR00728 PRINTS IPR001733 Peptidase S26B 118 129 1
TIGR02228 TIGRFAM IPR001733 Peptidase S26B 21 161 1
SignalP-noTM signalp 1 25 207

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.24 Da
Charge -2.50
Codon Adaptation Index 0.39
Isoelectric point 5.25
Molecular weight 21.40 kDa
Number of residues 189
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for sec11 (SPBC1685.03)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7106during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
8623during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
8369during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
1635.99during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
3475.72during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.62during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4606
conserved in eukaryotes4516
conserved in bacteria1002
conserved in metazoa3424
conserved in vertebrates3399
conserved in archaea238
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC1685.03 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds activation domain construct withsec11signal peptidase subunit Sec11 (predicted) Two-hybridPMID:26771498
External References
Database Identifier Description
NBRP SPBC1685.03 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1685.03 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1685.03 BioGRID Interaction Datasets
Expression Viewer SPBC1685.03 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1685.03 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1685.03 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1685.03 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1685.03 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1685.03 Transcriptome Viewer (Bähler Lab)
GEO SPBC1685.03 GEO profiles
PInt SPBC1685.03 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1685.03 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC1685.03 Fission yeast phenotypic data & analysis
Cyclebase SPBC1685.03.1 Cell Cycle Data
SPD / RIKEN09/09H03Orfeome Localization Data
UniProtKB/SwissProtO74323Signal peptidase complex catalytic subunit sec11
ModBaseO74323Database of comparative protein structure models
STRINGO74323Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595207signal peptidase subunit Sec11 (predicted)
RefSeq mRNANM_001021113972h- signal peptidase subunit Sec11 (predicted) (sec11), mRNA
European Nucleotide ArchiveCAA20051.1ENA Protein Mapping
UniParcUPI000006AC6AUniProt Archive

Literature for sec11

Search: Europe PMC or PubMed

Release Version: PomBase:30_60 - 12 May 2016