eso1 (SPBC16A3.11)


Gene Standard Nameeso1 Characterisation Statuspublished
Systematic IDSPBC16A3.11 Feature Typeprotein coding
Synonyms Name Description
Productsister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Product Size872aa, 98.91 kDa
Genomic Location Chromosome II, 4279656-4276864 (2793nt); CDS:4279591-4276973 (2619nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
acetyltransferase activity37
Annotation ExtensionEvidenceWith/FromReference
damaged DNA binding18
Annotation ExtensionEvidenceWith/FromReference
DNA-directed DNA polymerase activity29
Annotation ExtensionEvidenceWith/FromReference
metal ion binding751
Annotation ExtensionEvidenceWith/FromReference
peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor1
Annotation ExtensionEvidenceWith/FromReference
protein binding868
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
error-free translesion synthesis6
Annotation ExtensionEvidenceWith/FromReference
error-prone translesion synthesis6
Annotation ExtensionEvidenceWith/FromReference
establishment of mitotic sister chromatid cohesion3
Annotation ExtensionEvidenceWith/FromReference
peptidyl-lysine N6-acetylation1
Annotation ExtensionEvidenceWith/FromReference
positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric2
Annotation ExtensionEvidenceWith/FromReference
protein acetylation59
Annotation ExtensionEvidenceWith/FromReference
regulation of maintenance of mitotic sister chromatid cohesion5
Annotation ExtensionEvidenceWith/FromReference
translesion synthesis7
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
nuclear chromatin359
Annotation ExtensionEvidenceWith/FromReference
nuclear replication fork61
Annotation ExtensionEvidenceWith/FromReference
nucleus2692
Annotation ExtensionEvidenceWith/FromReference
site of double-strand break49
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
abolished cell population growth at high temperatureG799D (G799D)34
decreased cell population growth at high temperatureW804G (W804G)172
inviable vegetative cell populationeso1-H171451
eso1Δ
normal cell population growth at low temperatureG799D (G799D)29
W804G (W804G)
normal growth on glucose carbon sourceW804G (W804G)282
normal vegetative cell population growtheso1-H17839
normal vegetative cell population growth ratecatalytic site mutant (D147N)79
sensitive to ionizing radiation during vegetative growthG799D (G799D)72
sensitive to thiabendazoleG799D (G799D)326
sensitive to UV during vegetative growthcatalytic site mutant (D147N)151

Cell Phenotype

Term NameGenotypesCount
abnormal mitotic cell cycleeso1Δ877
abolished protein acetylation3
affecting psm3eso1-H17
decreased error-free translesion synthesis of cyclobutane pyrimidine dimerseso1Δ6
decreased error-free translesion synthesis of pyrimidine-pyrimidone 6-4 photoproductseso1Δ8
decreased error-prone translesion synthesis of pyrimidine-pyrimidone 6-4 photoproductseso1Δ8
decreased maintenance of protein localization to heterochromatin at centromere outer repeat2
affects localization of rad21eso1-H17
elongated vegetative cell793
increased duration of mitotic DNA damage checkpoint during cellular response to UVcatalytic site mutant (D147N)3
inviable elongated vegetative celleso1Δ417
inviable vegetative cell, abnormal cell shape, normal cell sizeeso1Δ199
lagging mitotic chromosomesG799D (G799D)37
mutatoreso1Δ14
normal chromatin silencing at centromereW804G (W804G)12
G799D (G799D)
normal chromatin silencing at silent mating-type cassetteW804G (W804G)22
normal protein localization to heterochromatin at centromere outer repeat4
affecting rad21eso1-H17

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
decreased cell population growth at high temperatureG799D (G799D), not3Δ
W804G (W804G), rdp1Δ
spt2Δ, G799D (G799D)
G799D (G799D), rox3Δ
W804G (W804G), raf2Δ
swi6Δ, W804G (W804G)
decreased cell population growth at low temperatureW804G (W804G), rdp1Δ
decreased cell population growth on glucose carbon sourcerdp1Δ, W804G (W804G)
decreased vegetative cell population growthhsk1-89 (L337P, E403K, L416P), eso1-H17
inviable vegetative cell populationeso1-H17, orc5-H37 (L266P, P375L)
normal cell population growth at high temperatureG799D (G799D), pds5Δ
normal growth on methyl methanesulfonatekpa1Δ, rev3Δ, eso1Δ
kpa1Δ, brc1+, rev3Δ, eso1Δ
sensitive to methyl methanesulfonatesmc6-74 (A151T), eso1Δ, rev3Δ, kpa1Δ
smc6-74 (A151T), eso1Δ, brc1+, rev3Δ, kpa1Δ

Cell Phenotype

Term NameGenotypes
abolished error-free translesion synthesis of cyclobutane pyrimidine dimerskpa1Δ, rev1Δ, rev3Δ, eso1Δ
rad8Δ, eso1Δ
rhp18Δ, eso1Δ
abolished error-prone translesion synthesis of pyrimidine-pyrimidone 6-4 photoproductsrhp18Δ, eso1Δ
decreased error-free translesion synthesis of cyclobutane pyrimidine dimerskpa1Δ, eso1Δ
eso1Δ, kpa1Δ, rev1Δ
kpa1Δ, rev3Δ, eso1Δ
decreased error-free translesion synthesis of pyrimidine-pyrimidone 6-4 photoproductsrhp18Δ, eso1Δ
kpa1Δ, rev3Δ, eso1Δ
decreased error-prone translesion synthesis of pyrimidine-pyrimidone 6-4 photoproductskpa1Δ, rev3Δ, eso1Δ
rad8Δ, eso1Δ
lagging mitotic chromosomesG799D (G799D), pds5Δ
spt2Δ, G799D (G799D)
mutatorswi7-H4, rad30Δ (partial deletion, removing DNA polymerase eta domain)
rad30Δ (partial deletion, removing DNA polymerase eta domain), rev3Δ, swi7-H4
kpa1Δ, rad30Δ (partial deletion, removing DNA polymerase eta domain), swi7-H4
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons4279656..4276864
mRNA4279656..4276864
5' UTR4279656..4279592AB039861
CDS4279591..4276973
3' UTR4276972..4276864AB039861
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF13878 Pfam IPR028005 N-acetyltransferase ESCO, zinc-finger 643 678 1
PF00817 Pfam IPR001126 UmuC domain 32 253 3
PF13880 Pfam IPR028009 N-acetyltransferase ESCO, acetyl-transferase domain 797 856 1
PS50173 Prosite Profiles IPR001126 UmuC domain 29 285 3
PTHR11076:SF11 HMMPANTHER 119 161 1
PTHR11076:SF11 HMMPANTHER 573 866 1
PTHR11076 HMMPANTHER 22 96 3
PTHR11076 HMMPANTHER 573 866 3
PTHR11076 HMMPANTHER 119 161 3
PTHR11076:SF11 HMMPANTHER 208 507 1
PTHR11076:SF11 HMMPANTHER 22 96 1
PTHR11076 HMMPANTHER 208 507 3
3.30.70.270 Gene3D Helicase/polymerase/peptidase polyprotein, Calicivirus-type 110 171 16
3.30.70.270 Gene3D Helicase/polymerase/peptidase polyprotein, Calicivirus-type 208 264 16
3.30.1490.100 Gene3D IPR017961 DNA polymerase, Y-family, little finger domain 343 453 3
1.10.150.20 Gene3D UvrABC system, subunit C 266 338 15
SSF56672 SuperFamily 6 319 24
SSF100879 SuperFamily IPR017961 DNA polymerase, Y-family, little finger domain 341 449 3

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0000137zinc finger proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000137
PBO:0000153zf-C2H2 typeTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000153

Protein Properties

Ave. residue weight 113.43 Da
Charge 10.00
Codon Adaptation Index 0.38
Isoelectric point 7.79
Molecular weight 98.91 kDa
Number of residues 872
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1676
present during mitotic M phaseS505
Annotation ExtensionEvidenceResidueReference
present during mitotic M phase experimental evidence S505 PMID:21712547
mannosylated residue 89
Annotation ExtensionEvidenceResidueReference
mass spectrometry evidence PMID:26644575
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for eso1 (SPBC16A3.11)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
801during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
518during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
479during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.5during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.39during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
metabolic disorders143
DNA repair-deficiency disorders10
xeroderma pigementosum8
Roberts syndrome1
Genome Organisation
DescriptionQualifierReferenceCount
tandem fusion protein14
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4606
conserved in eukaryotes4516
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2506
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC16A3.11 into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds DNA-binding domain construct withatg11autophagy protein Atg11 Two-hybridPMID:26771498
binds DNA-binding domain construct withpds5mitotic and meiotic cohesin-associated protein Pds5 Two-hybridPMID:11598020
binds activation domain construct withpds5mitotic and meiotic cohesin-associated protein Pds5 Two-hybridPMID:11598020
binds activation domain construct withnup120nucleoporin Nup120 Two-hybridPMID:26771498
binds activation domain construct witheso1sister chromatid cohesion protein/DNA polymerase eta Eso1 fusion protein Two-hybridPMID:26771498
binds activation domain construct withpcn1PCNA Two-hybridPMID:22308326
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC16A3.11 into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
rescuesrad9checkpoint clamp complex protein Rad9 Phenotypic SuppressionPMID:17515930
rescuesbrc1BRCT domain protein Brc1 Phenotypic SuppressionPMID:15972456
negative genetic interaction withSPBPB10D8.06ctransmembrane transporter (predicted) Negative GeneticPMID:23050226
negative genetic interaction withare1acyl-coA-sterol acyltransferase Are1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPAC20H4.06cRNA-binding protein, involved in splicing (predicted) Negative GeneticPMID:23050226
negative genetic interaction withgst1glutathione S-transferase Gst1 Negative GeneticPMID:23050226
negative genetic interaction withSPAC869.09conserved fungal protein Negative GeneticPMID:23050226
negative genetic interaction withcti6histone deacetylase complex subunit Cti6 Negative GeneticPMID:23050226
negative genetic interaction withSPAC4H3.04cUPF0103 family Negative GeneticPMID:23050226
negative genetic interaction withraf2Rik1-associated factor Raf2 Negative GeneticPMID:23050226
negative genetic interaction withSPAC4H3.03cglucan 1,4-alpha-glucosidase (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPAC3C7.13cglucose-6-phosphate 1-dehydrogenase (predicted) Negative GeneticPMID:23050226
negative genetic interaction withspn6meiotic (sorulation) septin Spn6 Negative GeneticPMID:23050226
negative genetic interaction withcps1vacuolar carboxypeptidase (predicted) Negative GeneticPMID:23050226
negative genetic interaction withdef1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withcyt1cytochrome c1 Cyt1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withclr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:23050226
negative genetic interaction withSPAC1039.02phosphoprotein phosphatase (predicted) Negative GeneticPMID:23050226
negative genetic interaction withnts1Clr6 histone deacetylase complex subunit Nts1 Negative GeneticPMID:23050226
negative genetic interaction withSPBC651.04Schizosaccharomyces specific protein Negative GeneticPMID:23050226
negative genetic interaction withpam17TIM23 translocase complex-associated motor subunit Pam17 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withctr4copper transporter complex subunit Ctr4 Negative GeneticPMID:23050226
negative genetic interaction withSPAC17A2.11Schizosaccharomyces pombe specific protein Negative GeneticPMID:23050226
negative genetic interaction withSPAC1071.09cDNAJ domain protein, DNAJC9 family (predicted) Negative GeneticPMID:23050226
negative genetic interaction withomh3alpha-1,2-mannosyltransferase Omh3 (predicted) Negative GeneticPMID:23050226
negative genetic interaction witherg28Erg28 protein (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPBC1683.06curidine ribohydrolase (predicted) Negative GeneticPMID:23050226
negative genetic interaction withmhf1kinetochore protein, CENP-S ortholog, FANCM-MHF complex subunit Mhf1 Negative GeneticPMID:23050226
negative genetic interaction withSPCC1450.03ribonucleoprotein (RNP) complex (predicted) Negative GeneticPMID:23050226
negative genetic interaction withclr1SHREC complex subunit Clr1 Negative GeneticPMID:23050226
negative genetic interaction withtps2trehalose-phosphate synthase Tps2 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withcwf16splicing factor Cwf16 Negative GeneticPMID:23050226
negative genetic interaction withSPAC17H9.08mitochondrial coenzyme A transmembrane transporter (predicted) Negative GeneticPMID:23050226
negative genetic interaction withynd1nucleoside diphosphatase Ynd1 Negative GeneticPMID:23050226
negative genetic interaction withmbf1transcriptional coactivator, multiprotein bridging factor Mbf1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withalr1alanine racemase Alr1 Negative GeneticPMID:23050226
negative genetic interaction withght4hexose transmembrane transporter Ght4 Negative GeneticPMID:23050226
negative genetic interaction withlsb5cortical component Lsb5 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withswi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:23050226
negative genetic interaction withSPAC630.06cconserved fungal protein Negative GeneticPMID:23050226
negative genetic interaction withssb3DNA replication factor A subunit Ssb3 Negative GeneticPMID:23050226
negative genetic interaction withstc1LIM-like protein linking chromatin modification to RNAi, Stc1 Negative GeneticPMID:23050226
negative genetic interaction withpub2HECT-type ubiquitin-protein ligase E3 Pub2 Negative GeneticPMID:23050226
negative genetic interaction withSPCC18.02transmembrane transporter (predicted) Negative GeneticPMID:23050226
negative genetic interaction withrik1silencing protein Rik1 Negative GeneticPMID:23050226
negative genetic interaction withSPAC23D3.12inorganic phosphate transmembrane transporter (predicted) Negative GeneticPMID:23050226
negative genetic interaction withtfb6holo TFIIH complex subunit Tfb6 Negative GeneticPMID:23050226
negative genetic interaction withSPBC13E7.03cRNA hairpin binding protein (predicted) Negative GeneticPMID:23050226
negative genetic interaction withrad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Negative GeneticPMID:23050226
negative genetic interaction withspt2non-specific DNA binding protein Spt2 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPAC11G7.01serine-rich Schizosaccharomyces specific protein Negative GeneticPMID:23050226
negative genetic interaction withleo1RNA polymerase II associated Paf1 complex (predicted) Negative GeneticPMID:23050226
negative genetic interaction withecm313-methyl-2-oxobutanoatehydroxymethyltransferase Ecm31 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withrad8ubiquitin-protein ligase E3 Rad8 Negative GeneticPMID:23050226
negative genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:23050226
negative genetic interaction withvps3CORVET complex subunit, GTPase regulator Vps3 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withspf31DNAJ protein Spf31 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withsil1nucleotide exchange factor for the ER lumenal Hsp70 chaperone, Sil1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withtea4tip elongation aberrant protein Tea4 Negative GeneticPMID:23050226
negative genetic interaction withSPAC806.04cprotein-glutamate O-methyltransferase (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPBC1271.05czf-AN1 type zinc finger protein Negative GeneticPMID:23050226
negative genetic interaction withcwf11complexed with Cdc5 protein Cwf11 Negative GeneticPMID:23050226
negative genetic interaction witharg3ornithine carbamoyltransferase Arg3 Negative GeneticPMID:23050226
negative genetic interaction withstt41-phosphatidylinositol 4-kinase Stt4 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPAC1F12.04cconserved fungal protein Negative GeneticPMID:23050226
negative genetic interaction withrpl380160S ribosomal protein L38 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withapl5AP-3 adaptor complex subunit Apl5 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withpsk1serine/threonine protein kinase Psk1 Negative GeneticPMID:23050226
negative genetic interaction withmeu10GPI anchored cell surface protein involved in ascospore wall assembly Meu10 Negative GeneticPMID:23050226
negative genetic interaction withrpn1019S proteasome regulatory subunit Rpn10 Negative GeneticPMID:23050226
negative genetic interaction withSPCC584.16cSchizosaccharomyces specific protein Negative GeneticPMID:23050226
negative genetic interaction withirc3ATP helicase Irc3 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withmit1SHREC complex ATP-dependent DNA helicase subunit Mit1 Negative GeneticPMID:23050226
negative genetic interaction withvsl1vacuolar SNARE Vsl1/Vam7 Negative GeneticPMID:23050226
negative genetic interaction withash2Ash2-trithorax family protein Negative GeneticPMID:23050226
negative genetic interaction withbud23rRNA (guanine) methyltransferase Bud23 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withcbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Negative GeneticPMID:23050226
negative genetic interaction withfub1PI31 proteasome inhibitor Fub1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withsfp47Ubp4 interactor Sfp47 Negative GeneticPMID:23050226
negative genetic interaction withSPAC22H10.02conserved fungal protein Negative GeneticPMID:23050226
negative genetic interaction withddb1damaged DNA binding protein Ddb1 Negative GeneticPMID:23050226
negative genetic interaction witharg12argininosuccinate synthase Arg12 Negative GeneticPMID:23050226
negative genetic interaction withlaf1Clr6 L associated factor 1 Laf1 Negative GeneticPMID:23050226
negative genetic interaction withatp14F1-ATPase subunit H (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPBC17D1.05Schizosaccharomyces specific protein Negative GeneticPMID:23050226
negative genetic interaction withpho24-nitrophenylphosphatase Negative GeneticPMID:23050226
negative genetic interaction withtif213translation initiation factor eIF2 gamma subunit Negative GeneticPMID:23050226
negative genetic interaction withegd2nascent polypeptide-associated complex alpha subunit Egd2 Negative GeneticPMID:23050226
negative genetic interaction withefc25Ras1 guanyl-nucleotide exchange factor Efc25 Negative GeneticPMID:23050226
negative genetic interaction withppa3protein phosphatase type 2A Ppa1 Negative GeneticPMID:23050226
negative genetic interaction withSPBC1105.01rRNA processing protein Rrp12-like (predicted) Negative GeneticPMID:23050226
negative genetic interaction withclr2chromatin silencing protein Clr2 Negative GeneticPMID:23050226
negative genetic interaction withmsh6MutS protein homolog Negative GeneticPMID:23050226
negative genetic interaction withSPAC29A4.02ctranslation elongation factor EF-1 gamma subunit Negative GeneticPMID:23050226
negative genetic interaction withrpl270260S ribosomal protein L27 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withlsb1Wiskott-Aldrich syndrome homolog binding protein Lsb1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPAC30.02celongator complex associated protein Kti2 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withbtf3nascent polypeptide-associated complex beta subunit Negative GeneticPMID:23050226
negative genetic interaction withcue2SMR domain protein, possibly involved in DNA repair and neddylation Negative GeneticPMID:23050226
negative genetic interaction withmbx2MADS-box transcription factor Pvg4 Negative GeneticPMID:23050226
negative genetic interaction withchp1chromodomain protein Chp1 Negative GeneticPMID:23050226
negative genetic interaction withSPBC16E9.15heat shock factor binding protein (predicted) Negative GeneticPMID:23050226
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:23050226
negative genetic interaction withsks2heat shock protein, ribosome associated molecular chaperone Sks2 Negative GeneticPMID:23050226
negative genetic interaction withmto2MT organizer Mto2 Negative GeneticPMID:23050226
negative genetic interaction withght1hexose transmembrane transporter Ght1 Negative GeneticPMID:23050226
negative genetic interaction withmug166Schizosaccharomyces specific protein Mug166 Negative GeneticPMID:23050226
negative genetic interaction withSPBC1271.03cNLI interacting factor family phosphatase (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPBC428.10Schizosaccharomyces pombe specific protein Negative GeneticPMID:23050226
negative genetic interaction withspa2cell polarity protein Spa2 Negative GeneticPMID:23050226
negative genetic interaction withect1ethanolamine-phosphate cytidylyltransferase (predicted) Negative GeneticPMID:23050226
negative genetic interaction withmas5DNAJ domain protein Mas5 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPBC3B8.05diphthamide biosynthesis protein Dph1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withgdh2NAD-dependent glutamate dehydrogenase Gdh2 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withmmp2mitochondrial inner membrane peptidase complex catalytic subunit 2 (predicted) Negative GeneticPMID:23050226
negative genetic interaction witherv41COPII-coated vesicle component Erv41 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withatp12mitochondrial F1-ATPase chaperone Atp12 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPCC1183.02glutathione S-transferase, translational elongation factor eEF1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withest1telomerase regulator Est1 Negative GeneticPMID:23050226
negative genetic interaction withSPBC19G7.04HMG box protein Negative GeneticPMID:23050226
negative genetic interaction withapm3AP-3 adaptor complex subunit Apm3 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withset13ribosome L32 lysine methyltransferase Set13 Negative GeneticPMID:23050226
negative genetic interaction withmst2histone acetyltransferase Mst2 Negative GeneticPMID:23050226
negative genetic interaction withmrs2magnesium ion transmembrane transporter Mrs2 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withvps8WD repeat protein Vps8 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPAC212.04cS. pombe specific DUF999 family protein 1 Negative GeneticPMID:23050226
negative genetic interaction withvps901guanyl-nucleotide exchange factor Vps901 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withglt1glutamate synthase Glt1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withmyh1adenine DNA glycosylase Myh1 Negative GeneticPMID:23050226
negative genetic interaction withnxt1mRNA export receptor Nxt1 Negative GeneticPMID:23050226
negative genetic interaction withSPCC70.10Schizosaccharomyces specific protein Negative GeneticPMID:23050226
negative genetic interaction withgid5GID complex armadillo repeat subunit Gid5 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withutp16U3 snoRNP-associated protein Utp16 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:23050226
negative genetic interaction withyip3Rab GTPase binding involved in ER to Golgi vesicle transport Yip3 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPAC11D3.02cELLA family acetyltransferase (predicted) Negative GeneticPMID:23050226
negative genetic interaction withare2acyl-coA-sterol acyltransferase Are2 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withppb1calcium-dependent serine/threonine protein phosphatase calcineurin A, catalytic subunit Ppb1 Negative GeneticPMID:23050226
negative genetic interaction withSPAC922.04Schizosaccharomyces specific protein Negative GeneticPMID:23050226
negative genetic interaction withrpl360160S ribosomal protein L36 Negative GeneticPMID:23050226
negative genetic interaction withSPCC1259.08conserved fungal protein, DUF2457 family Negative GeneticPMID:23050226
negative genetic interaction withmug51variant protein kinase 19 family protein Negative GeneticPMID:23050226
negative genetic interaction withfap1L-pipecolate oxidase Negative GeneticPMID:23050226
negative genetic interaction withSPCC569.05cspermidine family transmembrane transporter (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPAC23H4.16cSchizosaccharomyces specific protein Negative GeneticPMID:23050226
negative genetic interaction withplp1thioredoxin fold protein Plp1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withalg9mannosyltransferase complex subunit Alg9 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withmfr1fizzy-related protein Mfr1 Negative GeneticPMID:23050226
negative genetic interaction withght7hexose transmembrane transporter Ght7 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withcsi1mitotic chromosome segregation protein Csi1 Negative GeneticPMID:23050226
negative genetic interaction withtma19translationally controlled tumor protein homolog Tma19/Tpt1 Negative GeneticPMID:23050226
negative genetic interaction withSPAC16E8.13ubiquitin-protein ligase E3 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withrec7meiotic recombination protein Rec7 Negative GeneticPMID:23050226
negative genetic interaction withtif452translation initiation factor eIF4E, 4F complex E subunit isoform 2, stress response factor Negative GeneticPMID:23050226
negative genetic interaction withswi3replication fork protection complex subunit Swi3 Negative GeneticPMID:23050226
negative genetic interaction withpmc3mediator complex subunit Med27 Negative GeneticPMID:23050226
negative genetic interaction withggg1glutathione-specific gamma-glutamylcyclotransferase Ggg1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPBC409.19cmetaxin (predicted) Negative GeneticPMID:23050226
negative genetic interaction withlat1dihydrolipoamide S-acetyltransferase E2, Lat1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPBC20F10.02cDUF1741 family protein Negative GeneticPMID:23050226
negative genetic interaction withsyj1inositol-polyphosphate 5-phosphatase (synaptojanin homolog 1) Negative GeneticPMID:23050226
negative genetic interaction withSPACUNK4.09methyltransferase with rhodanese domain (predicted) Negative GeneticPMID:23050226
negative genetic interaction withssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withatg4Atg8 deconjugator Atg4 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withpyp1tyrosine phosphatase Pyp1 Negative GeneticPMID:23050226
negative genetic interaction withmsd1microtubule-anchoring factor Msd1 Negative GeneticPMID:23050226
negative genetic interaction withSPCPB16A4.06cSchizosaccharomyces specific protein Negative GeneticPMID:23050226
negative genetic interaction withSPBC30D10.05csepiapterin reductase (predicted) Negative GeneticPMID:23050226
negative genetic interaction withgpd3glyceraldehyde 3-phosphate dehydrogenase Gpd3 Negative GeneticPMID:23050226
negative genetic interaction withdph1UBA domain protein Dph1 Negative GeneticPMID:23050226
negative genetic interaction withdid2ESCRT III complex subunit Did2 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPAC1039.08serine acetyltransferase (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPCC757.02cepimarase (predicted) Negative GeneticPMID:23050226
negative genetic interaction witherf2palmitoyltransferase Erf2 Negative GeneticPMID:23050226
negative genetic interaction withmlh1MutL family protein Mlh1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withpth2mitochondrial aminoacyl-tRNA hydrolase Pth2 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withgim1prefoldin subunit 6, Gim1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withubr1N-end-recognizing protein, UBR ubiquitin-protein ligase E3 Ubr1 Negative GeneticPMID:23050226
negative genetic interaction withSPAC9E9.05Schizosaccharomyces specific protein Negative GeneticPMID:23050226
negative genetic interaction withmug111major facilitator family transmembrane transporter Mug111 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withgcn1translation elongation regulator Gcn1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPBC19G7.18cSchizosaccharomyces specific protein Negative GeneticPMID:23050226
negative genetic interaction withubp9ubiquitin C-terminal hydrolase Ubp9 Negative GeneticPMID:23050226
negative genetic interaction withwis2cyclophilin family peptidyl-prolyl cis-trans isomerase Wis2 Negative GeneticPMID:23050226
negative genetic interaction withSPAC6G9.15cSchizosaccharomyces specific protein Negative GeneticPMID:23050226
negative genetic interaction withpht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:23050226
negative genetic interaction withufd2ubiquitin-protein ligase E4 Ufd2 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPAC23H3.15cSchizosaccharomyces specific protein Negative GeneticPMID:23050226
negative genetic interaction withchl1ATP-dependent DNA helicase Chl1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withfex1fluoride channel Fex1 Negative GeneticPMID:23050226
negative genetic interaction withlos1karyopherin exportin T Los1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPBC1348.01S. pombe specific DUF999 protein family 5 Negative GeneticPMID:23050226
negative genetic interaction withubc15ubiquitin conjugating enzyme E2 Ubc15 Negative GeneticPMID:23050226
negative genetic interaction withSPBC17G9.12chydrolase (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPBC20F10.03conserved eukaryotic protein Negative GeneticPMID:23050226
negative genetic interaction withSPBC25B2.10Usp (universal stress protein) family protein Negative GeneticPMID:23050226
negative genetic interaction withatg1802WD repeat protein involved in autophagy Atg18b Negative GeneticPMID:23050226
negative genetic interaction withrpl320260S ribosomal protein L32 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withmhf2kinetochore protein, CENP-X ortholog, FANCM-MHF complex subunit Mhf2 Negative GeneticPMID:23050226
negative genetic interaction withrsp1random septum position protein Rsp1 Negative GeneticPMID:23050226
negative genetic interaction withctf8DNA replication factor C complex subunit Ctf8 Negative GeneticPMID:23050226
negative genetic interaction withalp16gamma tubulin complex subunit Alp16 Negative GeneticPMID:23050226
negative genetic interaction withaha1chaperone activator Aha1 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withSPAC12B10.15cribonuclease H2 complex subunit (predicted) Negative GeneticPMID:23050226
negative genetic interaction withppk33serine/threonine protein kinase Ppk33 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withstr1siderophore-iron transmembrane transporter Str1 Negative GeneticPMID:23050226
negative genetic interaction withser3D-3 phosphoglycerate dehydrogenase Ser3 (predicted) Negative GeneticPMID:23050226
negative genetic interaction withbqt2bouquet formation protein Bqt2 Negative GeneticPMID:23050226
negative genetic interaction withzym1metallothionein Zym1 Negative GeneticPMID:23050226
negative genetic interaction withmic19MICOS complex subunit Mic19 Negative GeneticPMID:23050226
negative genetic interaction withSPAP27G11.16Schizosaccharomyces pombe specific protein Negative GeneticPMID:23050226
negative genetic interaction withtip1CLIP170 family protein Tip1 Negative GeneticPMID:23050226
negative genetic interaction withnup60nucleoporin Nup60 Negative GeneticPMID:23050226
negative genetic interaction withsan1sir antagonist, ubiquitin-protein ligase E3 Negative GeneticPMID:23050226
negative genetic interaction withSPAC57A7.09E3 ubiquitin-protein ligase, human RNF family homolog Negative GeneticPMID:23050226
negative genetic interaction withmei2RNA-binding protein involved in meiosis Mei2 Negative GeneticPMID:23050226
negative genetic interaction withcyp4cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp4 (predicted) Negative GeneticPMID:23050226
synthetically rescued bymad2mitotic spindle checkpoint protein Mad2 Synthetic RescuePMID:10779336
synthetically rescued bypcn1PCNA Synthetic RescuePMID:10779336
synthetically rescued bycdc10MBF transcription factor complex subunit Cdc10 Synthetic RescuePMID:10779336
synthetically rescued bywpl1Wings apart-like homolog Wpl1 Synthetic RescuePMID:23050226
synthetically rescued byspt2non-specific DNA binding protein Spt2 (predicted) Synthetic RescuePMID:23050226
synthetically rescued bypsm3mitotic cohesin complex subunit Psm3 Synthetic RescuePMID:21979813
synthetically rescued byrep1MBF transcription factor activator Rep1 Synthetic RescuePMID:10779336
synthetically rescued bynot3CCR4-Not complex subunit Not3/5 (predicted) Synthetic RescuePMID:23050226
synthetically rescued bycdc20DNA polymerase epsilon catalytic subunit Pol2 Synthetic RescuePMID:10779336
synthetically rescued byrox3mediator complex subunit Med19 Synthetic RescuePMID:23050226
synthetically rescued bypds5mitotic and meiotic cohesin-associated protein Pds5 Synthetic RescuePMID:23050226
synthetically rescued bycig2G1/S-specific B-type cyclin Cig2 Synthetic RescuePMID:10779336
synthetically rescued byres2MBF transcription factor complex subunit Res2 Synthetic RescuePMID:10779336
synthetic growth defect withpsm3mitotic cohesin complex subunit Psm3 Synthetic Growth DefectPMID:21300781
synthetic growth defect withrad16DNA repair endonuclease XPF Synthetic Growth DefectPMID:25293972
synthetic growth defect withhsk1Dbf4(Dfp1)-dependent protein kinase Hsk1 Synthetic Growth DefectPMID:20176980
synthetic growth defect withswi6HP1 family chromodomain protein Swi6 Synthetic Growth DefectPMID:23050226
synthetic growth defect withrdp1RNA-directed RNA polymerase Rdp1 Synthetic Growth DefectPMID:23050226
synthetic growth defect withraf2Rik1-associated factor Raf2 Synthetic Growth DefectPMID:23050226
phenotype enhanced byrev1deoxycytidyl transferase Rev1 (predicted) Phenotypic EnhancementPMID:20453833
phenotype enhanced byrad8ubiquitin-protein ligase E3 Rad8 Phenotypic EnhancementPMID:20453833
phenotype enhanced bykpa1DinB translesion DNA repair polymerase, pol kappa Phenotypic EnhancementPMID:20453833
phenotype enhanced byrev3DNA polymerase zeta catalytic subunit Rev3 (predicted) Phenotypic EnhancementPMID:20453833
phenotype enhanced byrhp18Rad18 homolog ubiquitin protein ligase E3, Rhp18 Phenotypic EnhancementPMID:20453833
synthetic lethal withrad21mitotic cohesin complex, non-SMC subunit Rad21 (kleisin) Synthetic LethalityPMID:10779336
synthetic lethal withmis4adherin, cohesin loading factor Mis4 Synthetic LethalityPMID:10779336
inviable in presence of overexpressedwpl1Wings apart-like homolog Wpl1 Dosage LethalityPMID:21300781
rescued bypsm3mitotic cohesin complex subunit Psm3 Phenotypic SuppressionPMID:21979813
rescued byclr6histone deacetylase (class I) Clr6 Phenotypic SuppressionPMID:21979813
External References
Database Identifier Description
NBRP SPBC16A3.11 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC16A3.11 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC16A3.11 BioGRID Interaction Datasets
Expression Viewer SPBC16A3.11 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC16A3.11 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC16A3.11 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC16A3.11 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC16A3.11 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC16A3.11 Transcriptome Viewer (Bähler Lab)
GEO SPBC16A3.11 GEO profiles
PInt SPBC16A3.11 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC16A3.11 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC16A3.11 Fission yeast phenotypic data & analysis
Cyclebase SPBC16A3.11.1 Cell Cycle Data
SPD / RIKEN38/38F08Orfeome Localization Data
IntEnz2.3.1.-Integrated relational Enzyme database
Rhea2.3.1.-Annotated reactions database
UniProtKB/SwissProtO42917N-acetyltransferase eso1
ModBaseO42917Database of comparative protein structure models
STRINGO42917Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596778sister chromatid cohesion protein/DNA polymerase eta Eso1
RefSeq mRNANM_001023799972h- sister chromatid cohesion protein/DNA polymerase eta Eso1 (eso1), mRNA
KEGG00061+2.3.1.-Fatty acid biosynthesis
KEGG00230+2.7.7.7Purine metabolism
KEGG00240+2.7.7.7Pyrimidine metabolism
KEGG00253+2.3.1.-Tetracycline biosynthesis
KEGG00261+2.3.1.-Monobactam biosynthesis
KEGG00310+2.3.1.-Lysine degradation
KEGG00330+2.3.1.-Arginine and proline metabolism
KEGG00332+2.3.1.-Carbapenem biosynthesis
KEGG00340+2.3.1.-Histidine metabolism
KEGG00350+2.3.1.-Tyrosine metabolism
KEGG00564+2.3.1.-Glycerophospholipid metabolism
KEGG00565+2.3.1.-Ether lipid metabolism
KEGG00604+2.3.1.-Glycosphingolipid biosynthesis - ganglio series
KEGG00623+2.3.1.-Toluene degradation
KEGG00626+2.3.1.-Naphthalene degradation
KEGG00627+2.3.1.-Aminobenzoate degradation
KEGG00642+2.3.1.-Ethylbenzene degradation
KEGG00650+2.3.1.-Butanoate metabolism
KEGG00680+2.3.1.-Methane metabolism
KEGG00903+2.3.1.-Limonene and pinene degradation
KEGG00904+2.3.1.-Diterpenoid biosynthesis
KEGG00906+2.3.1.-Carotenoid biosynthesis
KEGG00940+2.3.1.-Phenylpropanoid biosynthesis
KEGG00942+2.3.1.-Anthocyanin biosynthesis
KEGG00950+2.3.1.-Isoquinoline alkaloid biosynthesis
KEGG00960+2.3.1.-Tropane, piperidine and pyridine alkaloid biosynthesis
KEGG00965+2.3.1.-Betalain biosynthesis

Literature for eso1

Search: Europe PMC or PubMed

Release Version: PomBase:30_59 - 12 Apr 2016