SPBC16C6.03c

Report an error | Help

Gene Standard NameUnassigned Characterisation Statusbiological role inferred
Systematic IDSPBC16C6.03c Feature Typeprotein coding
Synonyms Name Description
Productribosome assembly protein (predicted) Product Size207aa, 23.47 kDa
Genomic Location Chromosome II, 4333581-4332178 (1404nt); CDS:4333123-4332356 (768nt)

Ensembl Gene Location
  1. vps1302
  2. SPBC16C6.03c
  3. dbl6
  4. tma22
  5. vps10
  6. vps10-antisense-1
GO Biological Process

GO Slim Terms

ribosome biogenesis


Report an error | Help
Term NameCount
ribosomal large subunit assembly16
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Report an error | Help
Term NameCount
nucleolus366
Annotation ExtensionEvidenceWith/FromReference
nucleus2690
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Report an error | Help
Term NameGenotypesCount
resistance to tamoxifenSPBC16C6.03cΔ61
sensitive to 4-nitroquinoline N-oxideSPBC16C6.03cΔ159
sensitive to clotrimazoleSPBC16C6.03cΔ108
sensitive to terbinafineSPBC16C6.03cΔ103
viable vegetative cell populationSPBC16C6.03cΔ3862

Cell Phenotype

Report an error | Help
Term NameGenotypesCount
elongated telomeresSPBC16C6.03cΔ176
viable vegetative cell with normal cell morphologySPBC16C6.03cΔ3103
Transcript
Report an error | Help
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons4333581..4332746, 4332687..4332541, 4332454..4332178
Intron4332745..4332688, 4332540..4332455
mRNA4333581..4332178
5' UTR4333581..4333124PMID:21511999
CDS4333123..4332746, 4332687..4332541, 4332454..4332356
3' UTR4332355..4332178PMID:21511999
Protein Features
Report an error | Help

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF10453 Pfam IPR019496 Nuclear fragile X mental retardation-interacting protein 1, conserved domain 96 130 1
PTHR13309 HMMPANTHER 1 169 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.38 Da
Charge 16.00
Codon Adaptation Index 0.36
Isoelectric point 10.58
Molecular weight 23.47 kDa
Number of residues 207
Sequence
Report an error | Help
Gene Expression
Report an error | Help

Quantitative Gene Expression

View graphical display of gene expression data for SPBC16C6.03c

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2during GO:0072690PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
0.8during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000126,
PECO:0000005		population wideexperimental evidencePMID:23101633
Warning
DescriptionQualifierReferenceCount
gene structure updated PMID:21511999435
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in eukaryotes only2525
Orthologs
Report an error | Help

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC16C6.03c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds DNA-binding domain construct withhit1zf-HIT family C/D snoRNP assembly protein Hit1 (predicted) Two-hybridPMID:26771498
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC16C6.03c into the Query Builder
View these interactions in esyN

Report an error | Help
Gene Product Evidence Reference
negative genetic interaction withSPBC31F10.10czf-MYND type zinc finger protein Negative GeneticPMID:22681890
negative genetic interaction withrec14Ski complex subunit Rec14 Negative GeneticPMID:22681890
negative genetic interaction withsty1MAP kinase Sty1 Negative GeneticPMID:22681890
negative genetic interaction withair1TRAMP complex zinc knuckle subunit Air1 Negative GeneticPMID:22681890
negative genetic interaction withsum2translation initiation inhibitor (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
negative genetic interaction withpob3FACT complex subunit Pob3 Negative GeneticPMID:22681890
negative genetic interaction withmug154conserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC21C3.03ABC1 kinase family protein Negative GeneticPMID:22681890
negative genetic interaction withtma23ribosome biogenesis protein Tma23 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withtop1DNA topoisomerase I Negative GeneticPMID:22681890
negative genetic interaction withrpl2660S ribosomal protein L26 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
negative genetic interaction withprz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
negative genetic interaction withutp16U3 snoRNP-associated protein Utp16 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrei1ribosome biogenesis protein Rei1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
negative genetic interaction withmbx1MADS-box transcription factor Mbx1 Negative GeneticPMID:22681890
negative genetic interaction withpab2poly(A) binding protein Pab2 Negative GeneticPMID:22681890
negative genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
negative genetic interaction withres1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
positive genetic interaction withelp3elongator complex subunit Elp3 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPAC1486.03cRNA-binding splicing factor (predicted) Positive GeneticPMID:22681890
positive genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Positive GeneticPMID:22681890
positive genetic interaction withatg6autophagy associated beclin family protein Atg6 Positive GeneticPMID:22681890
positive genetic interaction withrad51RecA family recombinase Rad51/Rhp51 Positive GeneticPMID:22681890
positive genetic interaction withelp2elongator complex subunit Elp2 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withatp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withcwf19complexed with Cdc5 protein Cwf19 Positive GeneticPMID:22681890
External References
Report an error | Help
Database Identifier Description
NBRP SPBC16C6.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC16C6.03c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC16C6.03c BioGRID Interaction Datasets
Expression Viewer SPBC16C6.03c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC16C6.03c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC16C6.03c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC16C6.03c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC16C6.03c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC16C6.03c Transcriptome Viewer (Bähler Lab)
GEO SPBC16C6.03c GEO profiles
PInt SPBC16C6.03c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC16C6.03c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC16C6.03c Fission yeast phenotypic data & analysis
Cyclebase SPBC16C6.03c.1 Cell Cycle Data
SPD / RIKEN09/09E06Orfeome Localization Data
UniProtKB/SwissProtO42927Uncharacterized protein C16C6.03c
ModBaseO42927Database of comparative protein structure models
STRINGO42927Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596801ribosome assembly protein (predicted)
RefSeq mRNANM_001023822972h- ribosome assembly protein (predicted) (SPBC16C6.03c), mRNA
European Nucleotide ArchiveCAA16911.4ENA Protein Mapping
UniParcUPI000228F3C6UniProt Archive

Literature for SPBC16C6.03c
Report an error | Help

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017