psd1 (SPBC16E9.18)


Gene Standard Namepsd1 Characterisation Statuspublished
Systematic IDSPBC16E9.18 Feature Typeprotein coding
SynonymsSPBC1E8.01 Name Description
Productphosphatidylserine decarboxylase Psd1 Product Size437aa, 49.13 kDa
Genomic Location Chromosome II, 1955636-1957371 (1736nt); CDS:1955709-1957022 (1314nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004609phosphatidylserine decarboxylase activityIMPPMID:192869803
IGIpsd2, psd3PMID:19286980
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006656phosphatidylcholine biosynthetic processISSUniProtKB:P39006GO_REF:00000018
GO:0006646phosphatidylethanolamine biosynthetic processIGIpsd2, psd3PMID:192869808
IMPPMID:19286980
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005743mitochondrial inner membraneISSUniProtKB:P39006GO_REF:0000001155
GO:0005739mitochondrionIDAPMID:16823372758
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001164normal growth on glucose carbon sourceCell growth assaypsd1ΔNullPECO:0000102, PECO:0000126, PECO:0000005PMID:19286980145
Cell growth assaypsd1ΔNullPECO:0000103, PECO:0000126, PECO:0000005PMID:19286980
Cell growth assaypsd1ΔNullPECO:0000102, PECO:0000137, PECO:0000005PMID:19286980
Cell growth assaypsd1ΔNullPECO:0000103, PECO:0000137, PECO:0000005PMID:19286980
FYPO:0002060viable vegetative cell populationMicroscopypsd1ΔNullPECO:0000005, PECO:0000137PMID:236978063760
Microscopypsd1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001315normal vegetative cell morphologyMicroscopypsd1ΔNullPECO:0000137PMID:1928698070
FYPO:0002177viable vegetative cell with normal cell morphology3086
penetrance FYPO_EXT:0000001Microscopypsd1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
119556361957371

UTRs

Region Coordinates Reference
mRNA1955636..1957371PMID:19286980
exon1955709..1957022PMID:19286980
mRNA1955636..1957371PMID:21511999
exon1955709..1957022PMID:21511999
five_prime_UTR1955636..1955708PMID:21511999
three_prime_UTR1957023..1957371PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02666 Pfam IPR003817 Phosphatidylserine decarboxylase-related 131 430 3
TMhelix TMHMM 30 52 959
PTHR10067 HMMPANTHER IPR005221 Phosphatidylserine decarboxylase 39 433 3
TIGR00163 tigrfam IPR005221 Phosphatidylserine decarboxylase 118 430 3

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.42 Da
Charge 22.50
Isoelectric point 9.95
Molecular weight 49.13 kDa
Number of residues 437
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
851.73during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
3113during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
3258during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
3112during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2.7during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
0.66during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3393
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
External References
Database Identifier Description
NBRP SPBC16E9.18 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC16E9.18 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC16E9.18 BioGRID Interaction Datasets
Expression Viewer SPBC16E9.18 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC16E9.18 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC16E9.18 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC16E9.18 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC16E9.18 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC16E9.18 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC16E9.18 Cell Cycle Data
GEO SPBC16E9.18 GEO profiles
PInt SPBC16E9.18 Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2539756phosphatidylserine decarboxylase
EntrezGene2539756phosphatidylserine decarboxylase
KEGGMAP00260KEGG Pathway Database
IntEnz4.1.1.65Integrated relational Enzyme database
Rhea4.1.1.65Annotated reactions database
KEGGMAP00561KEGG Pathway Database
PUBMED19286980
SPD / RIKEN22/22H06Orfeome Localization Data
UniProtKB/SwissProtO14333Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
ModBaseO14333Database of comparative protein structure models
STRINGO14333Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595799phosphatidylserine decarboxylase
RefSeq mRNANM_001021700972h- phosphatidylserine decarboxylase (SPBC16E9.18), mRNA
European Nucleotide ArchiveCAB16910ENA Protein Mapping
European Nucleotide ArchiveCAB16910.2ENA Protein Mapping
UniParcUPI000006C8C3UniProt Archive

Literature for psd1

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014