psd1 (SPBC16E9.18)


Gene Standard Namepsd1 Characterisation Statuspublished
Systematic IDSPBC16E9.18 Feature Typeprotein coding
SynonymsSPBC1E8.01 Name Description
Productphosphatidylserine decarboxylase Psd1 Product Size437aa, 49.13 kDa
Genomic Location Chromosome II, 1955636-1957371 (1736nt); CDS:1955709-1957022 (1314nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004609phosphatidylserine decarboxylase activityIMPPMID:192869803
IGIpsd2, psd3PMID:19286980
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006656phosphatidylcholine biosynthetic processISSUniProtKB:P39006GO_REF:00000018
GO:0006646phosphatidylethanolamine biosynthetic processIMPPMID:192869808
IGIpsd2, psd3PMID:19286980
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005743mitochondrial inner membraneISSUniProtKB:P39006GO_REF:0000001156
GO:0005739mitochondrionIDAPMID:16823372758
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001164normal growth on glucose carbon sourceCell growth assaypsd1ΔNullPECO:0000102, PECO:0000126, PECO:0000005PMID:19286980165
Cell growth assaypsd1ΔNullPECO:0000103, PECO:0000137, PECO:0000005PMID:19286980
Cell growth assaypsd1ΔNullPECO:0000103, PECO:0000126, PECO:0000005PMID:19286980
Cell growth assaypsd1ΔNullPECO:0000102, PECO:0000137, PECO:0000005PMID:19286980
FYPO:0002060viable vegetative cell populationMicroscopypsd1ΔNullPECO:0000005, PECO:0000137PMID:236978063751
Microscopypsd1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0001315normal vegetative cell morphologyMicroscopypsd1ΔNullPECO:0000137PMID:1928698073
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001Microscopypsd1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
119556361957371
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF02666 Pfam IPR003817 Phosphatidylserine decarboxylase-related 131 430 3
TMhelix TMHMM 30 52 959
PTHR10067 HMMPANTHER IPR005221 Phosphatidylserine decarboxylase 26 432 3
PTHR10067:SF0 HMMPANTHER 26 432 3
TIGR00163 tigrfam IPR005221 Phosphatidylserine decarboxylase 118 430 3

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.42 Da
Charge 22.50
Isoelectric point 9.95
Molecular weight 49.13 kDa
Number of residues 437
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3258during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
3113during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
3112during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
851.73during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.7during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.66during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in bacteria1002
conserved in metazoa3428
conserved in vertebrates3402
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
External References
Database Identifier Description
NBRP SPBC16E9.18 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC16E9.18 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC16E9.18 BioGRID Interaction Datasets
Expression Viewer SPBC16E9.18 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC16E9.18 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC16E9.18 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC16E9.18 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC16E9.18 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC16E9.18 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC16E9.18 Cell Cycle Data
GEO SPBC16E9.18 GEO profiles
PInt SPBC16E9.18 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC16E9.18 Peptides identified in tandem mass spectrometry proteomics experiments
IntEnz4.1.1.65Integrated relational Enzyme database
Rhea4.1.1.65Annotated reactions database
SPD / RIKEN22/22H06Orfeome Localization Data
UniProtKB/SwissProtO14333Phosphatidylserine decarboxylase proenzyme 1, mitochondrial
ModBaseO14333Database of comparative protein structure models
STRINGO14333Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595799phosphatidylserine decarboxylase Psd1
RefSeq mRNANM_001021700972h- phosphatidylserine decarboxylase Psd1 (psd1), mRNA
European Nucleotide ArchiveCAB16910.2ENA Protein Mapping
MetaCycPWY-5669Phosphatidylethanolamine biosynthesis I
UniParcUPI000006C8C3UniProt Archive
UniPathwayUPA00558Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2

Literature for psd1

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014