chs2 (SPBC1709.01)

Gene Standard Namechs2 ChromosomeII
Systematic IDSPBC1709.01 Gene Start1095163
SynonymsSPBC1734.17 Gene End1098228
Productchitin synthase homolog Chs2 Gene Length3066
Feature Typeprotein coding CDS Start1095358
Name Description CDS End1098185
Characterisation Statuspublished CDS Length2828

Ensembl Gene Location
  1. rsc4
  2. pst3
  3. SPNCRNA.1410
  4. chs2
  5. vrs1
  6. SPBC1709.03
  7. cyp3
  8. SPNCRNA.1411
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopychs2delta (deletion)deletionPMID:20473289
no_name (unrecorded)unrecordedPMID:15277753
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
NOT GO:0004100chitin synthase activityIDAPMID:12914947
GO:0005515protein bindingIPImyp2PMID:16772338
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000915cytokinesis, actomyosin contractile ring assemblyIGIcdc4PMID:16772338
IGIcdc15PMID:16772338
GO:0006031chitin biosynthetic processIEAIPR004834GO_REF:0000002
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0000935barrier septumIDAPMID:12914947
GO:0005887integral to plasma membraneTASPMID:16772338
GO:0032153cell division siteIDAPMID:16823372
GO:0070938contractile ring
localization_dependent_on exocytosisIDAPMID:16772338
localization_dependent_on contractile ringIDAPMID:16772338
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
110951631097357
210974051098228

References

Region Start End Reference
three_prime_UTR10981861098228PMID:21511999
five_prime_UTR10951631095357PMID:21511999
three_prime_UTR10981861098228PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF08407 IPR013616 Pfam Chitin synthase N-terminal 176 252 2
PF01644 IPR004834 Pfam Chitin synthase 255 416 2
TMhelix TMHMM 852 874 955
TMhelix TMHMM 670 692 955
TMhelix TMHMM 884 906 955
TMhelix TMHMM 712 734 955
TMhelix TMHMM 606 628 955
TMhelix TMHMM 641 663 955
TMhelix TMHMM 564 582 955
PD002998 IPR004834 blastprodom Chitin synthase 255 348 2
PTHR22914 hmmpanther 206 899 2

View domain organization at Pfam

Protein Properties

Ave. residue weight 114.02 Da
Charge -3.50
Isoelectric point 6.26
Molecular weight 105.58 kDa
Number of residues 926
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
expression cell cycle regulated PMID:15277753
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000005,
PECO:0000014		population_widePMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000201,
PECO:0000005		single_cell2100PMID:16224022
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.13PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide0.95PMID:23101633
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
dsc2Golgi Dsc E3 ligase complex subunit Dsc2 Positive GeneticPMID:21504829
ste20Rictor homolog, Ste20 Negative GeneticPMID:22681890
chs1chitin synthase I Synthetic RescuePMID:15277753
cdc4myosin II light chain Synthetic LethalityPMID:16772338
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
cdc15extended Fer/CIP4 (EFC) domain protein Cdc15 Synthetic LethalityPMID:16772338
imp2contractile ring protein Imp2 Synthetic RescuePMID:16772338
myp2myosin II heavy chain Myo3 Synthetic LethalityPMID:16772338
cyk3cytokinesis protein Cyk3 (predicted) Phenotypic SuppressionPMID:22573890
myo2myosin II heavy chain Synthetic LethalityPMID:16772338
slx4structure-specific endonuclease subunit Slx4 Positive GeneticPMID:22681890
dad1DASH complex subunit Dad1 Positive GeneticPMID:22681890
atg6beclin family protein, involved in autophagy Negative GeneticPMID:22681890
tor1phosphatidylinositol kinase Tor1 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cdc4myosin II light chain Co-localizationPMID:16772338
exo70exocyst complex subunit Exo70 (predicted) Co-localizationPMID:16772338
cdc14SIN component Cdc14 Co-localizationPMID:16772338
cdc25M phase inducer phosphatase Cdc25 Co-localizationPMID:16772338
cdc16two-component GAP Cdc16 Co-localizationPMID:16772338
myp2myosin II heavy chain Myo3 Affinity Capture-WesternPMID:16772338
Co-localization
rlc1myosin II regulatory light chain Rlc1 Co-localizationPMID:16772338
myo52myosin type V Co-localizationPMID:16772338
cdc11SIN component scaffold protein, centriolin ortholog Cdc11 Co-localizationPMID:16772338
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External References
Database Identifier Description
NBRP SPBC1709.01 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1709.01 Retrieval of eukaryotic orthologs
BioGrid SPBC1709.01 BioGRID Interaction Datasets
Bähler Lab SPBC1709.01 Cell Cycle Expression Profile
Bähler Lab SPBC1709.01 Meiosis/Sporulation Expression Profies
Bähler Lab SPBC1709.01 Pheromone response/mating expression profiles
Bähler Lab SPBC1709.01 Environmental stress expression profiles
Bähler Lab SPBC1709.01 Bähler Lab Transcriptome Viewer
Cyclebase SPBC1709.01 Cell Cycle Data
PInt SPBC1709.01 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC1709.01 Entrez Gene
EntrezGene2540176chitin synthase-like protein 2
Uniprot_genenameCHS2
WikiGene2540176chitin synthase-like protein 2
SPD / RIKEN47/47C07Orfeome Localization Data
UniProtKB/SwissProtO74756Chitin synthase-like protein 2
ModBaseO74756Database of comparative protein structure models
Pfam Protein DomainsO74756Pfam Domain Arrangement
RefSeq PeptideNP_595434chitin synthase-like protein 2
RefSeq mRNANM_001021342972h- chitin synthase-like protein 2 (chs2), mRNA
European Nucleotide ArchiveBAA87271ENA Protein Mapping
European Nucleotide ArchiveCAA21311ENA Protein Mapping
UniParcUPI00001278FFUniProt Archive

Literature for chs2
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013