msp1 (SPBC1718.06)

Gene Standard Namemsp1 Characterisation Statuspublished
Systematic IDSPBC1718.06 Feature Typeprotein coding
Synonymsmgm1 Name Description
Productmitochondrial dynamin family GTPase Msp1 Product Size903aa, 101.90 kDa
Genomic Location Chromosome II, 3479675-3482664 (2990nt); CDS:3479898-3482609 (2712nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005525GTP bindingIEAUniProtKB-KW:KW-0342GO_REF:0000037113
GO:0003924GTPase activityIEAIPR001401GO_REF:000000261
GO:0005515protein bindingIPIcdr1PMID:9928955865
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0008053mitochondrial fusionIMPPMID:99289553
GO:0000002mitochondrial genome maintenance35
GO:0007005mitochondrion organizationIMPPMID:9928955283
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000329fungal-type vacuole membraneIDAPMID:1682337291
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371018
GO:0005758mitochondrial intermembrane spaceIDAPMID:1054737429
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopymsp1ΔNullPMID:204732891337
FYPO:0002060viable vegetative cell populationMicroscopymsp1ΔNullPECO:0000005, PECO:0000137PMID:236978063751

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3088
penetrance FYPO_EXT:0000001Microscopymsp1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
FYPO affected by mutation in yta12 mitochondrial m-AAA protease Yta12 (predicted) PMID:20621843
Ensembl transcript structure with UTRs, exons and introns


Exon Start End
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01031 Pfam IPR000375 Dynamin central domain 448 549 3
PF00350 Pfam IPR001401 Dynamin, GTPase domain 266 440 4
SM00053 SMART IPR001401 Dynamin, GTPase domain 244 475 3
PS51388 Prosite Profiles IPR020850 GTPase effector domain, GED 805 898 3
PS00410 Prosite Patterns IPR019762 Dynamin, GTPase region, conserved site 289 298 3
PTHR11566 HMMPANTHER IPR022812 Dynamin superfamily 219 898 3
PTHR11566:SF11 HMMPANTHER 219 898 1 Gene3D 242 540 288
SSF52540 SuperFamily IPR027417 P-loop containing nucleoside triphosphate hydrolase 238 539 294
PR00195 PRINTS IPR022812 Dynamin superfamily 288 305 3
PR00195 PRINTS IPR022812 Dynamin superfamily 409 427 3
PR00195 PRINTS IPR022812 Dynamin superfamily 428 444 3
PR00195 PRINTS IPR022812 Dynamin superfamily 450 469 3
PR00195 PRINTS IPR022812 Dynamin superfamily 263 281 3
PR00195 PRINTS IPR022812 Dynamin superfamily 360 377 3

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.85 Da
Charge 10.00
Isoelectric point 7.75
Molecular weight 101.90 kDa
Number of residues 903
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2787during GO:0000080PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
2575during GO:0000084PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
2310during GO:0000085PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
2694during GO:0000087PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
843.63during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
2237during GO:0072690PECO:0000126,
single_cellmass spectrometry evidencePMID:24763107
1444.16during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.5during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
1.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Disease Association
neurological disorders39
optic atrophy2
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in metazoa3428
conserved in vertebrates3402
conserved in eukaryotes only2498

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Two-hybridPMID:9928955
Reconstituted Complex
Affinity Capture-Western
External References
Database Identifier Description
NBRP SPBC1718.06 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1718.06 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1718.06 BioGRID Interaction Datasets
Expression Viewer SPBC1718.06 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1718.06 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1718.06 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1718.06 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1718.06 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1718.06 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC1718.06 Cell Cycle Data
GEO SPBC1718.06 GEO profiles
PInt SPBC1718.06 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1718.06 Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN33/33H10Orfeome Localization Data
UniProtKB/SwissProtP87320Protein msp1, mitochondrial
ModBaseP87320Database of comparative protein structure models
STRINGP87320Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596452mitochondrial dynamin family GTPase Msp1
RefSeq mRNANM_001022371972h- mitochondrial dynamin family GTPase Msp1 (msp1), mRNA
European Nucleotide ArchiveCAA69196.1ENA Protein Mapping
European Nucleotide ArchiveCAB75996.1ENA Protein Mapping
UniParcUPI000012F637UniProt Archive

Literature for msp1

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014