msp1 (SPBC1718.06)


Gene Standard Namemsp1 Characterisation Statuspublished
Systematic IDSPBC1718.06 Feature Typeprotein coding
Synonymsmgm1 Name Description
Productmitochondrial dynamin family GTPase Msp1 Product Size903aa, 101.90 kDa
Genomic Location Chromosome II, 3479675-3482664 (2990nt); CDS:3479898-3482609 (2712nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
GTP binding113
Annotation ExtensionEvidenceWith/FromReference
GTPase activity61
Annotation ExtensionEvidenceWith/FromReference
protein binding831
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
mitochondrial fusion3
Annotation ExtensionEvidenceWith/FromReference
mitochondrial genome maintenance34
Annotation ExtensionEvidenceWith/FromReference
mitochondrion organization294
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
fungal-type vacuole membrane91
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
mitochondrion758
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viability depends on conditions

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopymsp1ΔNullPMID:204732891338
FYPO:0000245loss of viability in stationary phase41
expressivity FYPO_EXT:0000003Cell growth assaymsp1ΔNullPMID:23521895
FYPO:0002060viable vegetative cell populationMicroscopymsp1ΔNullPECO:0000005, PECO:0000137PMID:236978063759

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000895mitochondrial aggregationMicroscopymsp1+ (wild type)OverexpressionPMID:105473744
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopymsp1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in yta12 mitochondrial m-AAA protease Yta12 (predicted) PMID:20621843
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
134796753482664

UTRs

Region Coordinates Reference
five_prime_UTR3479675..3479897PMID:21511999
three_prime_UTR3482610..3482664PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01031 Pfam IPR000375 Dynamin central domain 448 549 3
PF00350 Pfam IPR001401 Dynamin, GTPase domain 266 440 4
SM00053 SMART IPR001401 Dynamin, GTPase domain 244 475 3
PS51388 Prosite Profiles IPR020850 GTPase effector domain, GED 805 898 3
PS00410 Prosite Patterns IPR019762 Dynamin, GTPase region, conserved site 289 298 3
PTHR11566 HMMPANTHER IPR022812 Dynamin superfamily 219 898 3
PTHR11566:SF11 HMMPANTHER 219 898 1
3.40.50.300 Gene3D 242 540 288
SSF52540 SuperFamily IPR027417 P-loop containing nucleoside triphosphate hydrolase 238 539 294
PR00195 PRINTS IPR022812 Dynamin superfamily 288 305 3
PR00195 PRINTS IPR022812 Dynamin superfamily 409 427 3
PR00195 PRINTS IPR022812 Dynamin superfamily 428 444 3
PR00195 PRINTS IPR022812 Dynamin superfamily 450 469 3
PR00195 PRINTS IPR022812 Dynamin superfamily 263 281 3
PR00195 PRINTS IPR022812 Dynamin superfamily 360 377 3

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0000418signal_peptidePMID:10547374279

Protein Properties

Ave. residue weight 112.85 Da
Charge 10.00
Isoelectric point 7.75
Molecular weight 101.90 kDa
Number of residues 903
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2787during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
2575during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
2310during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
2694during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
2237during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
843.63during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1444.16during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.5during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
neurological disorders98
optic atrophy2
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
cdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Reconstituted ComplexPMID:9928955
Two-hybrid
Affinity Capture-Western
External References
Database Identifier Description
NBRP SPBC1718.06 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1718.06 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1718.06 BioGRID Interaction Datasets
Expression Viewer SPBC1718.06 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1718.06 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1718.06 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1718.06 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1718.06 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1718.06 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC1718.06 Cell Cycle Data
GEO SPBC1718.06 GEO profiles
PInt SPBC1718.06 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1718.06 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC1718.06 Fission yeast phenotypic data & analysis
SPD / RIKEN33/33H10Orfeome Localization Data
UniProtKB/SwissProtP87320Protein msp1, mitochondrial
ModBaseP87320Database of comparative protein structure models
STRINGP87320Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596452mitochondrial dynamin family GTPase Msp1
RefSeq mRNANM_001022371972h- mitochondrial dynamin family GTPase Msp1 (msp1), mRNA
European Nucleotide ArchiveCAA69196.1ENA Protein Mapping
European Nucleotide ArchiveCAB75996.1ENA Protein Mapping
UniParcUPI000012F637UniProt Archive

Literature for msp1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014