msp1 (SPBC1718.06)


Gene Standard Namemsp1 Characterisation Statuspublished
Systematic IDSPBC1718.06 Feature Typeprotein coding
Synonymsmgm1 Name Description
Productmitochondrial dynamin family GTPase Msp1 Product Size903aa, 101.90 kDa
Genomic Location Chromosome II, 3479675-3482664 (2990nt); CDS:3479898-3482609 (2712nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
GTP binding113
Annotation ExtensionEvidenceWith/FromReference
GTPase activity62
Annotation ExtensionEvidenceWith/FromReference
protein binding854
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
mitochondrial fusion3
Annotation ExtensionEvidenceWith/FromReference
mitochondrial genome maintenance28
Annotation ExtensionEvidenceWith/FromReference
mitochondrion organization292
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
extrinsic component of mitochondrial inner membrane10
Annotation ExtensionEvidenceWith/FromReference
fungal-type vacuole membrane91
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viability depends on conditions

Population Phenotype

Term NameAlleleExpressionCount
inviable vegetative cell populationmsp1ΔNull1428
loss of viability in stationary phasemsp1ΔNull46
viable vegetative cell populationmsp1ΔNull3792

Cell Phenotype

Term NameAlleleExpressionCount
decreased cellular respirationmsp1ΔNull7
inviable after spore germination, multiple cell divisionsmsp1ΔNull220
mitochondria present in decreased numbers during vegetative growthmsp1ΔNull1
mitochondrial aggregationmsp1+ (wild type)Overexpression4
mtDNA absent from cellmsp1ΔNull1
viable vegetative cell with normal cell morphologymsp1ΔNull3092
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in yta12 mitochondrial m-AAA protease Yta12 (predicted) PMID:20621843
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3479675..3482664
mRNA3479675..3482664
5' UTR3479675..3479897PMID:21511999
CDS3479898..3482609
3' UTR3482610..3482664PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00350 Pfam Dynamin, GTPase domain 266 440 4
PF01031 Pfam IPR000375 Dynamin central domain 448 549 3
SM00053 SMART IPR001401 Dynamin, GTPase domain 244 475 3
PS51718 Prosite Profiles IPR030381 Dynamin-type guanine nucleotide-binding (G) domain 260 531 4
PS51388 Prosite Profiles IPR020850 GTPase effector domain, GED 805 898 3
PS00410 Prosite Patterns IPR019762 Dynamin, GTPase region, conserved site 289 298 3
PTHR11566 HMMPANTHER IPR022812 Dynamin superfamily 221 825 3
PTHR11566:SF12 HMMPANTHER 221 825 1
3.40.50.300 Gene3D IPR027417 P-loop containing nucleoside triphosphate hydrolase 242 540 288
SSF52540 SuperFamily IPR027417 P-loop containing nucleoside triphosphate hydrolase 238 539 294
PR00195 PRINTS IPR022812 Dynamin superfamily 428 444 3
PR00195 PRINTS IPR022812 Dynamin superfamily 360 377 3
PR00195 PRINTS IPR022812 Dynamin superfamily 263 281 3
PR00195 PRINTS IPR022812 Dynamin superfamily 288 305 3
PR00195 PRINTS IPR022812 Dynamin superfamily 450 469 3
PR00195 PRINTS IPR022812 Dynamin superfamily 409 427 3

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReferenceCount
SO:0000418signal_peptide279

Protein Properties

Ave. residue weight 112.85 Da
Charge 10.00
Isoelectric point 7.75
Molecular weight 101.90 kDa
Number of residues 903
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2787during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2575during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2310during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
2694during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
843.63during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
2237during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
1444.16during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2.5during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
1.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
neurological disorders99
optic atrophy2
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity capturescdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Affinity Capture-WesternPMID:9928955
forms complex withcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Reconstituted ComplexPMID:9928955
binds DNA-binding domain construct withcdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Two-hybridPMID:9928955
External References
Database Identifier Description
NBRP SPBC1718.06 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1718.06 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1718.06 BioGRID Interaction Datasets
Expression Viewer SPBC1718.06 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1718.06 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1718.06 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1718.06 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1718.06 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1718.06 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC1718.06 Cell Cycle Data
GEO SPBC1718.06 GEO profiles
PInt SPBC1718.06 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1718.06 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC1718.06 Fission yeast phenotypic data & analysis
SPD / RIKEN33/33H10Orfeome Localization Data
UniProtKB/SwissProtP87320Protein msp1, mitochondrial
ModBaseP87320Database of comparative protein structure models
STRINGP87320Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596452mitochondrial dynamin family GTPase Msp1
RefSeq mRNANM_001022371972h- mitochondrial dynamin family GTPase Msp1 (msp1), mRNA
European Nucleotide ArchiveCAA69196.1ENA Protein Mapping
European Nucleotide ArchiveCAB75996.1ENA Protein Mapping
UniParcUPI000012F637UniProt Archive

Literature for msp1

Search: Europe PMC or PubMed

Release Version: PomBase:25_50 - 10 Mar 2015