msp1 (SPBC1718.06)


Gene Standard Namemsp1 Characterisation Statuspublished
Systematic IDSPBC1718.06 Feature Typeprotein coding
Synonymsmgm1 Name Description
Productmitochondrial dynamin family GTPase Msp1 Product Size903aa, 101.90 kDa
Genomic Location Chromosome II, 3479675-3482664 (2990nt); CDS:3479898-3482609 (2712nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005525GTP bindingIEAUniProtKB-KW:KW-0342GO_REF:0000037113
GO:0003924GTPase activityIEAIPR001401GO_REF:000000261
GO:0005515protein bindingIPIcdr1PMID:9928955861
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0008053mitochondrial fusionIGIdnm1PMID:105473743
IMPPMID:9928955
GO:0000002mitochondrial genome maintenance35
requiredIMPPMID:9928955
requiredIGIdnm1PMID:10547374
GO:0007005mitochondrion organizationIMPPMID:9928955282
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000329fungal-type vacuole membraneIDAPMID:1682337291
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371017
GO:0005758mitochondrial intermembrane spaceIDAPMID:1054737429
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopymsp1ΔNullPMID:204732891315
FYPO:0002060viable vegetative cell populationMicroscopymsp1ΔNullPECO:0000005, PECO:0000137PMID:236978063760

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3086
penetrance FYPO_EXT:0000001Microscopymsp1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
134796753482664

UTRs

Region Coordinates Reference
five_prime_UTR3479675..3479897PMID:21511999
three_prime_UTR3482610..3482664PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01031 Pfam IPR000375 Dynamin central domain 448 549 3
PF00350 Pfam IPR001401 Dynamin, GTPase domain 266 440 4
SM00053 SMART IPR001401 Dynamin, GTPase domain 244 475 3
PS00410 Prosite Patterns IPR019762 Dynamin, GTPase region, conserved site 289 298 3
PS51388 Prosite Profiles IPR020850 GTPase effector domain, GED 805 898 3
PTHR11566:SF12 HMMPANTHER 221 825 1
PTHR11566 HMMPANTHER IPR022812 Dynamin superfamily 221 825 3
3.40.50.300 Gene3D IPR027417 P-loop containing nucleoside triphosphate hydrolase 242 540 279
SSF52540 SuperFamily IPR027417 P-loop containing nucleoside triphosphate hydrolase 238 539 294
PR00195 PRINTS IPR022812 Dynamin superfamily 428 444 3
PR00195 PRINTS IPR022812 Dynamin superfamily 409 427 3
PR00195 PRINTS IPR022812 Dynamin superfamily 288 305 3
PR00195 PRINTS IPR022812 Dynamin superfamily 263 281 3
PR00195 PRINTS IPR022812 Dynamin superfamily 450 469 3
PR00195 PRINTS IPR022812 Dynamin superfamily 360 377 3

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.85 Da
Charge 10.00
Isoelectric point 7.75
Molecular weight 101.90 kDa
Number of residues 903
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
2787during GO:0000080PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
2575during GO:0000084PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
2237during GO:0072690PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
843.63during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
1444.16during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
2310during GO:0000085PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107
2694during GO:0000087PECO:0000005,
PECO:0000126
mass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
2.5during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
Disease Association
DescriptionQualifierReferenceCount
neurological disorders38
optic atrophy2
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
cdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Affinity Capture-WesternPMID:9928955
Two-hybrid
Reconstituted Complex
External References
Database Identifier Description
NBRP SPBC1718.06 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1718.06 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1718.06 BioGRID Interaction Datasets
Expression Viewer SPBC1718.06 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1718.06 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1718.06 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1718.06 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1718.06 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1718.06 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC1718.06 Cell Cycle Data
GEO SPBC1718.06 GEO profiles
PInt SPBC1718.06 Protein-Protein Interaction Predictor (Bähler Lab)
EntrezGene2539844mitochondrial GTPase Msp1
WikiGene2539844mitochondrial GTPase Msp1
SPD / RIKEN33/33H10Orfeome Localization Data
UniProtKB/SwissProtP87320Protein msp1, mitochondrial
ModBaseP87320Database of comparative protein structure models
STRINGP87320Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596452mitochondrial GTPase Msp1
RefSeq mRNANM_001022371972h- mitochondrial GTPase Msp1 (msp1), mRNA
European Nucleotide ArchiveCAA69196ENA Protein Mapping
European Nucleotide ArchiveCAA69196.1ENA Protein Mapping
European Nucleotide ArchiveCAB75996ENA Protein Mapping
European Nucleotide ArchiveCAB75996.1ENA Protein Mapping
UniParcUPI000012F637UniProt Archive

Literature for msp1

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014