zfs1 (SPBC1718.07c)

Gene Standard Namezfs1 ChromosomeII
Systematic IDSPBC1718.07c Gene Start3487862
Synonymsmoc4 Gene End3482848
ProductCCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Gene Length5015
Feature Typeprotein coding CDS Start3484668
Name DescriptionMulticopy suppressor of Overexpressed Cyr1 CDS End3483454
Characterisation Statuspublished CDS Length1215

Ensembl Gene Location
  1. SPBC1718.04
  2. trs31
  3. SPNCRNA.1603
  4. msp1
  5. zfs1
  6. SPNCRNA.1604
  7. SPNCRNA.1605
  8. SPNCRNA.1606
  9. SPBPB7E8.01
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000648small viable vegetative cellMicroscopyzfs1delta (deletion)deletionPECO:0000137PMID:22624651
FYPO:0002060viable vegetative cell populationno_name (unrecorded)unrecordedPMID:10462526
Microscopyzfs1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPImoc3PMID:16273369
GO:0008270zinc ion bindingIEAIPR000571GO_REF:0000002
GO:0035925mRNA 3'-UTR AU-rich region binding
has_direct_input SPAC1556.03-1IDAPMID:18042546
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000750pheromone-dependent signal transduction involved in conjugation with cellular fusionIMPPMID:8534915
GO:0006402mRNA catabolic processIMPPMID:18042546
GO:0007093mitotic cell cycle checkpointIMPPMID:10462526
GO:0007094mitotic spindle assembly checkpointIGImad2PMID:12186944
GO:0010972negative regulation of G2/M transition of mitotic cell cycleIMPPMID:22624651
GO:0031030negative regulation of septation initiation signaling cascadeIGIcdc16PMID:10462526
GO:0031137regulation of conjugation with cellular fusionIGIcyr1PMID:16273369
GO:0045839negative regulation of mitosisIMPPMID:10462526
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleus
exists_during cellular response to nitrogen starvationIDAPMID:8534915
GO:0005829cytosolIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
134878623482848

References

Region Start End Reference
three_prime_UTR34834533482848PMID:21511999
three_prime_UTR34834533482848PMID:21511999
five_prime_UTR34878623484669PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00642 IPR000571 Pfam Zinc finger, CCCH-type 327 352 6
PF00642 IPR000571 Pfam Zinc finger, CCCH-type 365 390 6
SM00356 IPR000571 SMART Zinc finger, CCCH-type 326 353 8
SM00356 IPR000571 SMART Zinc finger, CCCH-type 364 391 8
PS50103 IPR000571 Prosite Profiles Zinc finger, CCCH-type 364 392 14
PS50103 IPR000571 Prosite Profiles Zinc finger, CCCH-type 326 354 14
G3DSA:4.10.1000.10 Gene3D 360 392 5
G3DSA:4.10.1000.10 Gene3D 325 359 5
SSF90229 SuperFamily 326 357 7
SSF90229 SuperFamily 361 392 7
PTHR12547 hmmpanther 326 392 1

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:18257517
PMID:19547744

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000137zinc finger proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000137
PBO:0000416zf-CCCH typeTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000416

Protein Properties

Ave. residue weight 107.51 Da
Charge 22.00
Isoelectric point 9.84
Molecular weight 43.44 kDa
Number of residues 404
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
expressed in response to nitrogen starvation PMID:8534915
protein levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000005,
PECO:0000014		population_widePMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide3.2PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide8PMID:23101633
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
clp1Cdc14-related protein phosphatase Clp1/Flp1 Phenotypic EnhancementPMID:22624651
byr1MAP kinase kinase Byr1 Phenotypic SuppressionPMID:8534915
tsc2tuberin Negative GeneticPMID:22681890
Dosage RescuePMID:16624901
atg1autophagy and CVT pathway serine/threonine protein kinase Atg1 Positive GeneticPMID:22681890
sid1PAK-related GC kinase Sid1 Synthetic RescuePMID:10462526
spg1GTPase Spg1 Synthetic RescuePMID:10462526
clr4histone H3 lysine methyltransferase Clr4 Positive GeneticPMID:22681890
sol1SWI/SNF complex subunit Sol1 Phenotypic EnhancementPMID:22624651
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
mid1medial ring protein Mid1 Negative GeneticPMID:22681890
pli1SUMO E3 ligase Pli1 Positive GeneticPMID:22681890
sid2NDR kinase Sid2 Synthetic RescuePMID:10462526
sre2membrane-tethered transcription factor (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
puf3RNA-binding protein Puf3 (predicted) Positive GeneticPMID:22681890
ypa2protein phosphatase type 2A regulator, PTPA family Ypa2 Negative GeneticPMID:22681890
set1histone lysine methyltransferase Set1 Positive GeneticPMID:22681890
sty1MAP kinase Sty1 Phenotypic EnhancementPMID:22624651
swd1Set1C complex subunit Swd1 Positive GeneticPMID:22681890
mob1Sid2-Mob1 kinase complex regulatory subunit Mob1 Phenotypic SuppressionPMID:10769201
fhl1forkhead transcription factor Fhl1 Negative GeneticPMID:22681890
set9histone lysine methyltransferase Set9 Negative GeneticPMID:22681890
tsc1hamartin Negative GeneticPMID:22681890
ndk1nucleoside diphosphate kinase Ndk1 Positive GeneticPMID:22681890
wee1M phase inhibitor protein kinase Wee1 Phenotypic EnhancementPMID:10462526
SPCC18B5.05cphosphomethylpyrimidine kinase (predicted) Positive GeneticPMID:22681890
snf5SWI/SNF complex subunit Snf5 Phenotypic EnhancementPMID:22624651
pac10prefoldin subunit 3 Pac10 (predicted) Positive GeneticPMID:22681890
tol13'(2'),5'-bisphosphate nucleotidase/inositol-1,4- bisphosphate 1-phosphatase Negative GeneticPMID:22681890
cbf12CBF1/Su(H)/LAG-1 family transcription factor Cbf12 Phenotypic SuppressionPMID:22907753
cdc11SIN component scaffold protein, centriolin ortholog Cdc11 Synthetic RescuePMID:10462526
ppk15serine/threonine protein kinase Ppk15 (predicted) Positive GeneticPMID:22681890
dsc2Golgi Dsc E3 ligase complex subunit Dsc2 Negative GeneticPMID:21504829
ppk16serine/threonine protein kinase Ppk16 (predicted) Positive GeneticPMID:22681890
cdc7serine/threonine protein kinase Cdc7 Synthetic RescuePMID:10462526
ras1GTPase Ras1 Phenotypic SuppressionPMID:8534915
php3CCAAT-binding factor complex subunit Php3 Negative GeneticPMID:22681890
ace2transcription factor Ace2 Negative GeneticPMID:22681890
sid4SIN component scaffold protein Sid4 Synthetic RescuePMID:10462526
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Positive GeneticPMID:22681890
ers1RNA-silencing factor Ers1 Negative GeneticPMID:22681890
ppa2serine/threonine protein phosphatase Ppa2 Phenotypic EnhancementPMID:22624651
Negative GeneticPMID:22681890
SPBC19G7.04HMG box protein Negative GeneticPMID:22681890
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:22681890
cdr1NIM1 family serine/threonine protein kinase Cdr1/Nim1 Phenotypic EnhancementPMID:22624651
png2ING family homolog Png2 Negative GeneticPMID:22681890
mra1rRNA (pseudouridine) methyltransferase Mra1 Phenotypic SuppressionPMID:9133664
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
rxt2histone deacetylase complex subunit Rxt2 Negative GeneticPMID:22681890
SPAC227.14uridine kinase (predicted) Positive GeneticPMID:22681890
par1protein phosphatase regulatory subunit Par1 Negative GeneticPMID:22681890
rpb7DNA-directed RNA polymerase complex II subunit Rpb7 Negative GeneticPMID:22681890
cdc14SIN component Cdc14 Synthetic RescuePMID:10462526
res1MBF transcription factor complex subunit Res1 Negative GeneticPMID:22681890
cdc16two-component GAP Cdc16 Dosage RescuePMID:10462526
gpa1G-protein alpha subunit Phenotypic SuppressionPMID:8534915
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
rad57RecA family ATPase Rad57/Rhp57 Positive GeneticPMID:22681890
byr2MAP kinase kinase kinase Byr2 Phenotypic SuppressionPMID:8534915
mmb1mitochondria microtubule binder Mmb1 Negative GeneticPMID:22681890
cpp1protein farnesyltransferase beta subunit Cpp1 Dosage RescuePMID:16624901
kin1microtubule affinity-regulating kinase Kin1 Negative GeneticPMID:22681890
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
psu1cell wall protein Psu1, beta-glucosidase (predicted) Two-hybridPMID:19682301
ebp2rRNA processing protein Ebp2 (predicted) Two-hybridPMID:19682301
ef1a-atranslation elongation factor EF-1 alpha Ef1a-a Two-hybridPMID:19682301
arz1armadillo repeat containing, Zfs1 target number 1 Affinity Capture-RNAPMID:22907753
eft202translation elongation factor 2 (EF-2) Eft2,B Two-hybridPMID:19682301
rpl320260S ribosomal protein L32 (predicted) Two-hybridPMID:19682301
pup220S proteasome complex subunit alpha 5, Pup2 (predicted) Two-hybridPMID:19682301
rpl50160S ribosomal protein L5 (predicted) Two-hybridPMID:19682301
tdh1glyceraldehyde-3-phosphate dehydrogenase Tdh1 Two-hybridPMID:19682301
SPCC74.02cmRNA cleavage and polyadenylation specificity factor complex associated protein Two-hybridPMID:19682301
fba1fructose-bisphosphate aldolase Fba1 Two-hybridPMID:19682301
eno101enolase (predicted) Two-hybridPMID:19682301
SPAC589.03csequence orphan Affinity Capture-RNAPMID:22907753
mse1mitochondrial glutamyl-tRNA synthetase Mse1 (predicted) Two-hybridPMID:19682301
mus7DNA repair protein Mus7/Mms22 Affinity Capture-RNAPMID:22907753
ecl3extender of the chronological lifespan protein Ecl3 Affinity Capture-RNAPMID:22907753
crb3WD repeat protein Crb3 Two-hybridPMID:19682301
stg1SM22/transgelin-like actin modulating protein Stg1 Affinity Capture-RNAPMID:22907753
SPBC359.04ccell surface glycoprotein (predicted), DIPSY family Affinity Capture-RNAPMID:22907753
SPAC1F8.07cpyruvate decarboxylase (predicted) Two-hybridPMID:19682301
rpp20260S acidic ribosomal protein P2B subunit Two-hybridPMID:19682301
cbf12CBF1/Su(H)/LAG-1 family transcription factor Cbf12 Affinity Capture-RNAPMID:22907753
rpl120260S ribosomal protein L12.1/L12A Two-hybridPMID:19682301
moc3transcription factor Moc3 Two-hybridPMID:16273369
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External References
Database Identifier Description
NBRP SPBC1718.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1718.07c Retrieval of eukaryotic orthologs
BioGrid SPBC1718.07c BioGRID Interaction Datasets
Bähler Lab SPBC1718.07c Cell Cycle Expression Profile
Bähler Lab SPBC1718.07c Meiosis/Sporulation Expression Profies
Bähler Lab SPBC1718.07c Pheromone response/mating expression profiles
Bähler Lab SPBC1718.07c Environmental stress expression profiles
Bähler Lab SPBC1718.07c Bähler Lab Transcriptome Viewer
Cyclebase SPBC1718.07c Cell Cycle Data
PInt SPBC1718.07c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC1718.07c Entrez Gene
SPD / RIKEN32/32F07Orfeome Localization Data
EntrezGene2539958zinc finger protein
Uniprot_genenameZFS1
WikiGene2539958zinc finger protein
UniProtKB/SwissProtP47979Zinc finger protein zfs1
ModBaseP47979Database of comparative protein structure models
Pfam Protein DomainsP47979Pfam Domain Arrangement
RefSeq PeptideNP_596453zinc finger protein
RefSeq mRNANM_001022372972h- zinc finger protein (zfs1), mRNA
European Nucleotide ArchiveBAA08654ENA Protein Mapping
European Nucleotide ArchiveCAB75997ENA Protein Mapping
UniParcUPI000013C3B9UniProt Archive

Literature for zfs1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013