pst3 (SPBC1734.16c)

Gene Standard Namepst3 Characterisation Statuspublished
Systematic IDSPBC1734.16c Feature Typeprotein coding
Synonyms Name Description
ProductSIN3 family co-repressor Pst3 Product Size1154aa, 132.88 kDa
Genomic Location Chromosome II, 1094818-1089163 (5656nt); CDS:1094653-1091098 (3556nt)

Ensembl Gene Location
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006338chromatin remodelingNASGO_REF:0000001157
GO:0006342chromatin silencingISSUniProtKB:P22579GO_REF:000000195
GO:0006303double-strand break repair via nonhomologous end joiningISOSGD:S000005364GO_REF:00000247
GO:0016575histone deacetylationICGO:0000118GO_REF:000000124
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0070210Rpd3L-Expanded complexIDAPMID:1904072015
GO:0032221Rpd3S complexIDAPMID:1904072016
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopypst3ΔNullPMID:204732891331
Microscopypst3ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000059abnormal mitotic cell cycleMicroscopypst3ΔNullPECO:0000005, PECO:0000137PMID:23697806638
FYPO:0002262inviable after spore germination, multiple cell divisions, elongated cell94
penetrance FYPO_EXT:0000001Microscopypst3ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF08295 Pfam IPR013194 Histone deacetylase interacting 497 590 3
PF02671 Pfam IPR003822 Paired amphipathic helix 133 179 3
PF02671 Pfam IPR003822 Paired amphipathic helix 275 320 3
PF02671 Pfam IPR003822 Paired amphipathic helix 428 469 3
SM00761 SMART IPR013194 Histone deacetylase interacting 492 592 3
PS51477 Prosite Profiles IPR003822 Paired amphipathic helix 252 322 3
PS51477 Prosite Profiles IPR003822 Paired amphipathic helix 403 472 3
PS51477 Prosite Profiles IPR003822 Paired amphipathic helix 111 181 3
PTHR12346 HMMPANTHER 100 1140 3
PTHR12346:SF0 HMMPANTHER 100 1140 3
1g1eB00 Gene3D IPR003822 Paired amphipathic helix 249 321 3
1g1eB00 Gene3D IPR003822 Paired amphipathic helix 108 180 3
SSF47762 SuperFamily IPR003822 Paired amphipathic helix 108 180 3
SSF47762 SuperFamily IPR003822 Paired amphipathic helix 250 321 3
Coil ncoils Rabaptin coiled-coil domain 584 605 968

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001382SIN3 family co-repressorTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001382

Protein Properties

Ave. residue weight 115.15 Da
Charge 4.50
Isoelectric point 6.82
Molecular weight 132.88 kDa
Number of residues 1154

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
present during mitotic M phase
present during mitotic M phaseS32PMID:21712547
present during mitotic M phaseS34PMID:21712547
level fluctuates during mitotic cell cycleS325PMID:24763107
present during mitotic M phaseS329PMID:21712547
present during mitotic M phaseS336PMID:21712547
present during mitotic M phaseS36PMID:21712547
level fluctuates during mitotic cell cycle
present during mitotic M phaseT326PMID:21712547
present during mitotic M phaseT42PMID:21712547
present during mitotic M phaseT330PMID:21712547
MOD:00696phosphorylated residueNASPMID:195477441921
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3189during GO:0000080PECO:0000005,
mass spectrometry evidencePMID:24763107
3210during GO:0000084PECO:0000005,
mass spectrometry evidencePMID:24763107
3370during GO:0000085PECO:0000005,
mass spectrometry evidencePMID:24763107
3095during GO:0000087PECO:0000005,
mass spectrometry evidencePMID:24763107
3570during GO:0072690PECO:0000005,
mass spectrometry evidencePMID:24763107
1064.8during GO:0072690PECO:0000014,
experimental evidencePMID:23101633
682.18during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
3during GO:0072690PECO:0000014,
experimental evidencePMID:23101633
0.76during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
experimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3080
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
External References
Database Identifier Description
NBRP SPBC1734.16c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1734.16c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1734.16c BioGRID Interaction Datasets
Expression Viewer SPBC1734.16c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1734.16c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1734.16c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1734.16c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1734.16c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1734.16c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC1734.16c Cell Cycle Data
GEO SPBC1734.16c GEO profiles
PInt SPBC1734.16c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1734.16c Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN30/30E08Orfeome Localization Data
EntrezGene2539793SIN3 family co-repressor Pst3
WikiGene2539793SIN3 family co-repressor Pst3
UniProtKB/SwissProtO74755Paired amphipathic helix protein pst3
ModBaseO74755Database of comparative protein structure models
STRINGO74755Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595433SIN3 family co-repressor Pst3
RefSeq mRNANM_001021341972h- SIN3 family co-repressor Pst3 (pst3), mRNA
European Nucleotide ArchiveCAA21310ENA Protein Mapping
European Nucleotide ArchiveCAA21310.1ENA Protein Mapping
UniParcUPI00000697CDUniProt Archive

Literature for pst3

Search: Europe PMC or PubMed

Release Version: PomBase:22_45 - 08 Aug 2014