ppk21 (SPBC1778.10c)

Gene Standard Nameppk21 ChromosomeII
Systematic IDSPBC1778.10c Gene Start3116630
SynonymsSPBC4C3.11 Gene End3114231
Productserine/threonine protein kinase Ppk21 Gene Length2400
Feature Typeprotein coding CDS Start3116386
Name Description CDS End3114461
Characterisation Statuspublished CDS Length1926

Ensembl Gene Location
  1. fim1
  2. SPBC1778.07
  3. arc3
  4. SPBC1778.09
  5. ppk21
  6. pre3
  7. SPBC4C3.09
  8. SPNCRNA.1580
  9. mug136
  10. prl23
  11. SPBC4C3.07
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationppk21delta (deletion)deletionPMID:15821139
Microscopyppk21delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0004674protein serine/threonine kinase activityISMPFAM:PF00069GO_REF:0000001
GO:0005524ATP bindingISMPFAM:PF00069GO_REF:0000001
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000910cytokinesisTASPMID:15821139
GO:0006468protein phosphorylationISMPFAM:PF00069GO_REF:0000001
GO:0007165signal transductionNASGO_REF:0000051
GO:0033554cellular response to stressIEPPMID:12529438
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005829cytosolIDAPMID:16823372
GO:0032153cell division siteIDAPMID:16823372
GO:0044732mitotic spindle pole bodyIDAPMID:16823372
GO:0051286cell tipIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
131166303116183
231160793115843
331157883115679
431156153115445
531153943114231

References

Region Start End Reference
three_prime_UTR31144603114231PMID:21511999
five_prime_UTR31166303116387PMID:21511999
three_prime_UTR31144603114231PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00069 IPR000719 Pfam Protein kinase, catalytic domain 56 315 109
SM00220 IPR002290 SMART Serine/threonine- / dual specificity protein kinase, catalytic domain 55 315 74
PS50011 IPR000719 Prosite Profiles Protein kinase, catalytic domain 55 315 110
PS00108 IPR008271 Prosite Patterns Serine/threonine-protein kinase, active site 175 187 97
PS00107 IPR017441 Prosite Patterns Protein kinase, ATP binding site 61 93 73
G3DSA:3.30.200.20 Gene3D 15 164 108
G3DSA:2.30.29.30 IPR011993 Gene3D 446 539 35
G3DSA:2.30.29.30 IPR011993 Gene3D 390 391 35
G3DSA:2.30.29.30 IPR011993 Gene3D 315 329 35
G3DSA:1.10.510.10 Gene3D 165 314 111
SSF56112 IPR011009 SuperFamily 54 399 127
PTHR24352 hmmpanther 50 551 3
PTHR24352:SF0 hmmpanther 50 551 1

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:19547744

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0004366PKC subfamilyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0004366

Protein Properties

Ave. residue weight 113.82 Da
Charge 9.50
Isoelectric point 8.38
Molecular weight 62.72 kDa
Number of residues 551
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide3559.93PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide3594PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.64PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide2.1PMID:23101633
Warning
DescriptionQualifierReference
gene structure updated PMID:21511999
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPAC1F12.05endocytosis regulator (predicted) Negative GeneticPMID:22681890
elp3elongator complex, histone acetyltransferase subunit Elp3 (predicted) Positive GeneticPMID:22681890
ies4Ino80 complex subunit Ies4 Negative GeneticPMID:22681890
arf6ADP-ribosylation factor, Arf family Arf6 Negative GeneticPMID:22681890
dao1D-amino acid oxidase (predicted) Negative GeneticPMID:22681890
rok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:22681890
rpp20360S acidic ribosomal protein P2C subunit Negative GeneticPMID:22681890
ppr8mitochondrial PPR repeat protein Ppr8 Negative GeneticPMID:22681890
alf1ATP-dependent microtubule severing protein (predicted) Negative GeneticPMID:22681890
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
mdl1mitochondrial peptide-transporting ATPase Negative GeneticPMID:22681890
atb2tubulin alpha 2 Negative GeneticPMID:22681890
apl6AP-3 adaptor complex subunit Apl6 (predicted) Negative GeneticPMID:22681890
ash2Ash2-trithorax family protein Negative GeneticPMID:22681890
SPAC11G7.01sequence orphan Positive GeneticPMID:22681890
swc2Swr1 complex complex subunit Swc2 Negative GeneticPMID:22681890
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
SPAC1F5.05cconserved eukaryotic protein Negative GeneticPMID:22681890
pun1SUR7 family protein Pun1 (predicted) Negative GeneticPMID:22681890
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
tma20RNA-binding protein Tma20 (predicted) Negative GeneticPMID:22681890
SPAC10F6.04RCC domain protein Ats1 (predicted) Negative GeneticPMID:22681890
SPBC1289.14adducin (predicted) Negative GeneticPMID:22681890
SPAC644.07mitochondrial Rieske ISP assembly ATPase (predicted) Positive GeneticPMID:22681890
SPAC15A10.06CPA1 sodium ion/proton antiporter (predicted) Negative GeneticPMID:22681890
dad2DASH complex subunit Dad2 Negative GeneticPMID:22681890
sum2G2/M transition checkpoint protein Sum2 Negative GeneticPMID:22681890
rpl380160S ribosomal protein L38 (predicted) Negative GeneticPMID:22681890
SPBC1198.01glutathione-dependent formaldehyde dehydrogenase (predicted) Positive GeneticPMID:22681890
cia1histone chaperone Cia1 Synthetic LethalityPMID:22291963
cdb4curved DNA-binding protein Cdb4, peptidase family Negative GeneticPMID:22681890
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
SPAC1805.14sequence orphan Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:22681890
spn1septin Spn1 Negative GeneticPMID:22681890
SPAC24B11.08cCOPII-coated vesicle component Erv46 (predicted) Negative GeneticPMID:22681890
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
SPAC29B12.11chuman WW domain binding protein-2 ortholog Negative GeneticPMID:22681890
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Negative GeneticPMID:21504829
SPBC56F2.03actin-like protein Arp10 (predicted) Negative GeneticPMID:22681890
atl1alkyltransferase-like protein Atl1 Negative GeneticPMID:22681890
set3histone lysine methyltransferase Set3 Negative GeneticPMID:22681890
SPAC186.04cN-terminal of transmembrane channel, truncated Negative GeneticPMID:22681890
slt1sequence orphan Slt1 Negative GeneticPMID:22681890
alg5dolichyl-phosphate beta-glucosyltransferase Alg5 (predicted) Negative GeneticPMID:22681890
SPAC3A11.13prefoldin subunit 6 (predicted) Negative GeneticPMID:22681890
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:21504829
fus1formin Fus1 Positive GeneticPMID:22681890
SPBC1347.09hexaprenyldihydroxybenzoate methyltransferase, Coq3 variant (predicted) Negative GeneticPMID:22681890
mak10NatC N-acetyltransferase complex subunit Mak10 (predicted) Negative GeneticPMID:22681890
SPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Positive GeneticPMID:22681890
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External References
Database Identifier Description
NBRP SPBC1778.10c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1778.10c Retrieval of eukaryotic orthologs
BioGrid SPBC1778.10c BioGRID Interaction Datasets
Bähler Lab SPBC1778.10c Cell Cycle Expression Profile
Bähler Lab SPBC1778.10c Meiosis/Sporulation Expression Profies
Bähler Lab SPBC1778.10c Pheromone response/mating expression profiles
Bähler Lab SPBC1778.10c Environmental stress expression profiles
Bähler Lab SPBC1778.10c Bähler Lab Transcriptome Viewer
Cyclebase SPBC1778.10c Cell Cycle Data
PInt SPBC1778.10c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC1778.10c Entrez Gene
EntrezGene2539807serine/threonine protein kinase Ppk21
Uniprot_genenamePPK21
WikiGene2539807serine/threonine protein kinase Ppk21
SPD / RIKEN26/26G10Orfeome Localization Data
UniProtKB/SwissProtQ9Y7J6Serine/threonine-protein kinase ppk21
ModBaseQ9Y7J6Database of comparative protein structure models
Pfam Protein DomainsQ9Y7J6Pfam Domain Arrangement
RefSeq_mRNA_predictedXM_001713090972h- serine/threonine protein kinase Ppk21 (ppk21), mRNA
RefSeq_peptide_predictedXP_001713142serine/threonine protein kinase Ppk21
European Nucleotide ArchiveCAB39805ENA Protein Mapping
UniParcUPI000228F3ACUniProt Archive

Literature for ppk21
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013