SPBC18E5.02c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPBC18E5.02c Feature Typeprotein coding
SynonymsSPBC29A3.20c Name Description
Productserine palmitoyltransferase complex subunit (predicted) Product Size509aa, 57.47 kDa
Genomic Location Chromosome II, 2079050-2076986 (2065nt); CDS:2078859-2077163 (1697nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004758serine C-palmitoyltransferase activity2
contributes_toISOSGD:S000004911GO_REF:0000024
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0030148sphingolipid biosynthetic processISOSGD:S000004911GO_REF:000002420
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005783endoplasmic reticulumIDAPMID:16823372594
GO:0016021integral component of membraneIEAUniProtKB-KW:KW-0812GO_REF:00000371018
GO:0017059serine C-palmitoyltransferase complexISOSGD:S000004911GO_REF:00000243
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopySPBC18E5.02cΔNullPECO:0000005, PECO:0000137PMID:236978061337
MicroscopySPBC18E5.02cΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000311inviable after spore germination with normal, unseptated germ tube morphologyMicroscopySPBC18E5.02cΔNullPECO:0000005, PECO:0000137PMID:23697806237
FYPO:0002151inviable spore462
penetrance FYPO_EXT:0000001MicroscopySPBC18E5.02cΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
120790502078614
220785552078455
320783982077408
420773542076986
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00155 Pfam IPR004839 Aminotransferase, class I/classII 128 489 11
PTHR13693:SF2 HMMPANTHER 1 504 1
PTHR13693 HMMPANTHER 1 504 3
3.40.640.10 Gene3D IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 146 383 31
SSF53383 SuperFamily IPR015424 Pyridoxal phosphate-dependent transferase 87 494 31

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.91 Da
Charge 0.50
Isoelectric point 6.58
Molecular weight 57.47 kDa
Number of residues 509
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
27174during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
27021during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
27111during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
25206during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
27606during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
16262.98during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
7132.53during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.5during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.96during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in metazoa3428
conserved in vertebrates3402
conserved in eukaryotes only2498
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
paa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22119525
External References
Database Identifier Description
NBRP SPBC18E5.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC18E5.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC18E5.02c BioGRID Interaction Datasets
Expression Viewer SPBC18E5.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC18E5.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC18E5.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC18E5.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC18E5.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC18E5.02c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC18E5.02c Cell Cycle Data
GEO SPBC18E5.02c GEO profiles
PInt SPBC18E5.02c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC18E5.02c Peptides identified in tandem mass spectrometry proteomics experiments
IntEnz2.3.1.50Integrated relational Enzyme database
Rhea2.3.1.50Annotated reactions database
SPD / RIKEN35/35D03Orfeome Localization Data
UniProtKB/SwissProtO59682Serine palmitoyltransferase 1
ModBaseO59682Database of comparative protein structure models
STRINGO59682Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595848serine palmitoyltransferase complex subunit (predicted)
RefSeq mRNANM_001021752972h- serine palmitoyltransferase complex subunit (predicted) (SPBC18E5.02c), mRNA
European Nucleotide ArchiveCAA18397.1ENA Protein Mapping
UniParcUPI000006C847UniProt Archive

Literature for SPBC18E5.02c

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014