Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPBC18E5.02c Feature Typeprotein coding
SynonymsSPBC29A3.20c Name Description
Productserine palmitoyltransferase complex subunit (predicted) Product Size509aa, 57.47 kDa
Genomic Location Chromosome II, 2079050-2076986 (2065nt); CDS:2078859-2077163 (1697nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
serine C-palmitoyltransferase activity2
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
sphingolipid biosynthetic process21
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
endoplasmic reticulum596
Annotation ExtensionEvidenceWith/FromReference
integral component of membrane1018
Annotation ExtensionEvidenceWith/FromReference
serine C-palmitoyltransferase complex4
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term NameAlleleExpressionCount
inviable vegetative cell populationSPBC18E5.02cΔNull1428

Cell Phenotype

Term NameAlleleExpressionCount
inviable after spore germination with normal, unseptated germ tube morphologySPBC18E5.02cΔNull237
inviable sporeSPBC18E5.02cΔNull468
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2079050..2078614, 2078555..2078455, 2078398..2077408, 2077354..2076986
5' UTR2079050..2078860PMID:21511999
CDS2078859..2078614, 2078555..2078455, 2078398..2077408, 2077354..2077163
3' UTR2077162..2076986PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00155 Pfam IPR004839 Aminotransferase, class I/classII 128 489 11
PTHR13693 HMMPANTHER 14 504 3
PTHR13693:SF2 HMMPANTHER 14 504 1
3.40.640.10 Gene3D IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 146 383 31
SSF53383 SuperFamily IPR015424 Pyridoxal phosphate-dependent transferase 87 494 31

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.91 Da
Charge 0.50
Isoelectric point 6.58
Molecular weight 57.47 kDa
Number of residues 509
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
27174during GO:0000080PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
27021during GO:0000084PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
27111during GO:0000085PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
25206during GO:0000087PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
16262.98during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
27606during GO:0072690PECO:0000126,
single cellmass spectrometry evidencePMID:24763107
7132.53during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
4.5during GO:0072690PECO:0000005,
population wideexperimental evidencePMID:23101633
0.96during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured byhhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
affinity captured byhhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
affinity captured bypaa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22119525
External References
Database Identifier Description
NBRP SPBC18E5.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC18E5.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC18E5.02c BioGRID Interaction Datasets
Expression Viewer SPBC18E5.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC18E5.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC18E5.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC18E5.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC18E5.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC18E5.02c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC18E5.02c Cell Cycle Data
GEO SPBC18E5.02c GEO profiles
PInt SPBC18E5.02c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC18E5.02c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC18E5.02c Fission yeast phenotypic data & analysis
IntEnz2.3.1.50Integrated relational Enzyme database
Rhea2.3.1.50Annotated reactions database
SPD / RIKEN35/35D03Orfeome Localization Data
UniProtKB/SwissProtO59682Serine palmitoyltransferase 1
ModBaseO59682Database of comparative protein structure models
STRINGO59682Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595848serine palmitoyltransferase complex subunit (predicted)
RefSeq mRNANM_001021752972h- serine palmitoyltransferase complex subunit (predicted) (SPBC18E5.02c), mRNA
European Nucleotide ArchiveCAA18397.1ENA Protein Mapping
UniParcUPI000006C847UniProt Archive

Literature for SPBC18E5.02c

Search: Europe PMC or PubMed

Release Version: PomBase:25_50 - 10 Mar 2015