fba1 (SPBC19C2.07)


Gene Standard Namefba1 Characterisation Statuspublished
Systematic IDSPBC19C2.07 Feature Typeprotein coding
Synonyms Name Description
Productfructose-bisphosphate aldolase Fba1 Product Size358aa, 39.57 kDa
Genomic Location Chromosome II, 1688336-1689599 (1264nt); CDS:1688367-1689443 (1077nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0004332fructose-bisphosphate aldolase activityISSUniProtKB:P14540GO_REF:00000011
GO:0008270zinc ion bindingIEAIPR000771GO_REF:0000002248
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006096glycolysisISSUniProtKB:P14540GO_REF:000000117
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005737cytoplasmISSUniProtKB:P14540GO_REF:00000014198
GO:0005829cytosolIDAPMID:168233722317
GO:0005634nucleusIDAPMID:168233722730
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyfba1ΔNullPMID:204732891309
Microscopyfba1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002151inviable sporeMicroscopyfba1ΔNullPECO:0000005, PECO:0000137PMID:23697806447
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
116883361689599
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01116 Pfam IPR000771 Ketose-bisphosphate aldolase, class-II 14 356 1
PS00602 Prosite Patterns IPR000771 Ketose-bisphosphate aldolase, class-II 98 110 1
PS00806 Prosite Patterns IPR000771 Ketose-bisphosphate aldolase, class-II 170 181 1
PTHR30559:SF0 HMMPANTHER 2 358 1
PTHR30559 HMMPANTHER 2 358 1
G3DSA:3.20.20.70 Gene3D IPR013785 10 356 35
SSF51569 SuperFamily 1 357 9
Low complexity (SEG) seg 168 183
Low complexity (SEG) seg 37 54
PIRSF001359 PIRSF IPR000771 Ketose-bisphosphate aldolase, class-II 11 358 1
TIGR00167 tigrfam IPR000771 Ketose-bisphosphate aldolase, class-II 13 357 1
TIGR01520 tigrfam IPR006411 Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype 3 357 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 110.53 Da
Charge -1.50
Isoelectric point 6.32
Molecular weight 39.57 kDa
Number of residues 358
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:195477441192
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelpresentNorthern assay evidencePMID:8286404
during GO:0072690

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1025542.06during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
292133.4during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
66during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
520during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
air1zinc knuckle TRAMP complex subunit Air1 Affinity Capture-MSPMID:20403971
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
sog2leucine-rich repeat protein Lrp1 Affinity Capture-MSPMID:23462181
moc3transcription factor Moc3 Two-hybridPMID:19682301
nak1PAK-related kinase Nak1 Affinity Capture-MSPMID:23462181
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
zfs1CCCH tandem zinc finger protein, human Tristetraprolin homolog Zfs1, involved in mRNA catabolism Two-hybridPMID:19682301
sds23PP2A-type phosphatase inhibitor Sds23/Moc1 Two-hybridPMID:19682301
paa1protein phosphatase regulatory subunit Paa1 Affinity Capture-MSPMID:22403715
Affinity Capture-MSPMID:22119525
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
slm9hira protein Slm9 Affinity Capture-MSPMID:20976105
far8SIP/FAR complex striatin subunit, Far8/Csc3 Affinity Capture-MSPMID:22119525
fic1C2 domain protein Fic1 Affinity Capture-MSPMID:19139265
External References
Database Identifier Description
NBRP SPBC19C2.07 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC19C2.07 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC19C2.07 BioGRID Interaction Datasets
Expression Viewer SPBC19C2.07 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC19C2.07 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC19C2.07 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC19C2.07 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC19C2.07 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC19C2.07 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC19C2.07 Cell Cycle Data
GEO SPBC19C2.07 GEO profiles
PInt SPBC19C2.07 Protein-Protein Interaction Predictor (Bähler Lab)
KEGGMAP00030
IntEnz4.1.2.13Integrated relational Enzyme database
Rhea4.1.2.13Annotated reactions database
KEGGMAP00051
KEGGMAP00010
KEGGMAP00710
WikiGene2540767fructose-bisphosphate aldolase Fba1
EntrezGene2540767fructose-bisphosphate aldolase Fba1
SPD / RIKEN40/40C08Orfeome Localization Data
UniProtKB/SwissProtP36580Fructose-bisphosphate aldolase
ModBaseP36580Database of comparative protein structure models
StringP36580Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595692fructose-bisphosphate aldolase Fba1
RefSeq mRNANM_001021589972h- fructose-bisphosphate aldolase Fba1 (fba1), mRNA
European Nucleotide ArchiveBAA04237ENA Protein Mapping
European Nucleotide ArchiveCAB52034ENA Protein Mapping
UniParcUPI0000125829UniProt Archive

Literature for fba1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014