sre1 (SPBC19C2.09)

Gene Standard Namesre1 ChromosomeII
Systematic IDSPBC19C2.09 Gene Start1691270
Synonyms Gene End1694691
Productsterol regulatory element binding protein, transcription factor Sre1 Gene Length3422
Feature Typeprotein coding CDS Start1691828
Name Description CDS End1694530
Characterisation Statuspublished CDS Length2703

Ensembl Gene Location
  1. mug124
  2. SPNCRNA.1452
  3. SPNCRNA.1453
  4. fba1
  5. prp38
  6. sre1
  7. SPBC19C2.10
  8. SPNCRNA.1454
  9. mdm34
  10. mrpl51
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0001491viable vegetative cellno_name (unrecorded)unrecordedPMID:15797383
Microscopysre1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIMPPMID:16537923
has_direct_input sterol_regulatory_elementIDAPMID:16537923
has_direct_input sterol_regulatory_elementIDAPMID:22017871
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionICGO:0000978PMID:16537923
has_direct_input hem13IMPPMID:22017871
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
happens_during cellular response to hypoxia, has_regulation_target SPAC3A11.07IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target SPCC4G3.17IMPPMID:16537923
GO:0003677DNA bindingIDAPMID:16537923
GO:0005515protein bindingIPIhrd1PMID:19520858
GO:0046983protein dimerization activityIEAIPR011598GO_REF:0000002
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0010629negative regulation of gene expressionIEPPMID:18276645
GO:0010630regulation of transcription, start site selectionIEPPMID:18276645
GO:0032933SREBP signaling pathwayIMPPMID:15797383
GO:0035961positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoterIMPPMID:15797383
GO:0045944positive regulation of transcription from RNA polymerase II promoter
has_regulation_target hem13IMPPMID:15797383
has_regulation_target erg25IMPPMID:15797383
has_regulation_target erg31IMPPMID:15797383
GO:0061419positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
happens_during cellular response to hypoxia, has_regulation_target hem14IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target erg11IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target SPBC215.11cIMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target hem13IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target css1IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target dap1IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target osm1IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target sur2IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target erg31IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target mmd1IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target sre1IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target erg25IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target scs7IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target hem15IMPPMID:16537923
happens_during cellular response to hypoxia, has_regulation_target SPBC106.12cIMPPMID:16537923
GO:0070455positive regulation of heme biosynthetic processIEPPMID:16537923
GO:0071456cellular response to hypoxiaIMPPMID:22017871
IMPPMID:15797383
GO:0072592oxygen metabolic process
requiredIMPPMID:15797383
GO:1900413positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoterIMPPMID:16537923
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIEASL-0191GO_REF:0000039
GO:0032936SREBP-SCAP complexIDAPMID:15797383
GO:0071458integral to cytosolic side of endoplasmic reticulum membraneTASPMID:16537923
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
116912701694691

References

Region Start End Reference
three_prime_UTR16945311694691PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF09427 IPR019006 Pfam Domain of unknown function DUF2014 517 769 1
PF00010 IPR011598 Pfam Myc-type, basic helix-loop-helix (bHLH) domain 261 333 4
SM00353 IPR011598 SMART Myc-type, basic helix-loop-helix (bHLH) domain 266 338 4
TMhelix TMHMM 511 530 955
TMhelix TMHMM 441 463 955
PS50888 IPR011598 Prosite Profiles Myc-type, basic helix-loop-helix (bHLH) domain 260 332 4
G3DSA:4.10.280.10 IPR011598 Gene3D 261 351 4
SSF47459 IPR011598 SuperFamily 258 350 4
PTHR11630:SF49 hmmpanther 50 189 2
PTHR11630 hmmpanther 50 189 8
Coil ncoils Rabaptin coiled-coil domain 322 350 974

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReference
SO:0001061propeptide_cleavage_sitePMID:15797383
SO:0001812transmembrane_helix

Protein Properties

Ave. residue weight 109.43 Da
Charge 1.00
Isoelectric point 6.62
Molecular weight 98.49 kDa
Number of residues 900
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
deletion mutant expression profiling PMID:16537923
protein levelexperimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide926.54PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide771.83PMID:23101633
RNA levelexperimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide5.5PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide2.6PMID:23101633
Misc
DescriptionQualifierReference
target of proteasome PMID:19520858 PMID:18418381
autoregulation
stability regulated by oxygen PMID:18418381
target of ERAD pathway PMID:19520858
Miscellaneous Functional Group
DescriptionQualifierReference
membrane-tethered transcription factorInferred from Sequence or Structural Similarity PMID:11790253
Species Distribution
DescriptionQualifierReference
no apparent S. cerevisiae ortholog
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
pvg3galactosylxylosylprotein 3-beta-galactosyltransferase Pvg1 (predicted) Negative GeneticPMID:21504829
SPAC9G1.07sequence orphan Negative GeneticPMID:21504829
est1telomerase regulator Est1 Negative GeneticPMID:21504829
SPBC1271.14glutamate N-acetyltransferase (predicted) Negative GeneticPMID:21504829
dsc5UBX domain containing protein required for Sre1 cleavage Dosage RescuePMID:22086920
lys2homoaconitate hydratase Lys2 Negative GeneticPMID:21504829
atp15F0-ATPase epsilon subunit (predicted) Positive GeneticPMID:21504829
spc2signal peptidase subunit Spc2 (predicted) Positive GeneticPMID:21504829
hri2eIF2 alpha kinase Hri2 Positive GeneticPMID:21504829
SPAC227.17cconserved protein Positive GeneticPMID:21504829
SPAC17H9.13cglutamate 5-kinase (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
cut8tethering factor for nuclear proteasome Cut8 Negative GeneticPMID:21504829
SPAC977.05cconserved fungal family Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
SPBC13E7.03cRNA hairpin binding protein (predicted) Positive GeneticPMID:22681890
arg6acetylglutamate synthase Arg6 (predicted) Negative GeneticPMID:22681890
SPBC365.16conserved protein Negative GeneticPMID:21504829
atg6beclin family protein, involved in autophagy Negative GeneticPMID:21504829
pnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:21504829
def1RNAPII degradation factor Def1 (predicted) Positive GeneticPMID:21504829
ras1GTPase Ras1 Phenotypic SuppressionPMID:9745019
arg11N-acetyl-gamma-glutamyl-phosphate reductase/acetylglutamate kinase Negative GeneticPMID:21504829
aca1L-azetidine-2-carboxylic acid acetyltransferase Aca1 Negative GeneticPMID:21504829
gpd3glyceraldehyde 3-phosphate dehydrogenase Gpd3 Positive GeneticPMID:21504829
lys4homocitrate synthase Negative GeneticPMID:21504829
Negative GeneticPMID:22681890
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Dosage RescuePMID:22086920
cdc48AAA family ATPase Cdc48 Dosage RescuePMID:22086920
zds1zds family protein phosphatase type A regulator Zds1 (predicted) Positive GeneticPMID:21504829
tsf1mitochondrial translation elongation factor EF-Ts Tsf1 Negative GeneticPMID:21504829
SPCC594.01DUF1769 family protein Negative GeneticPMID:21504829
dsc1Golgi Dsc E3 ligase complex subunit Dsc1 Dosage RescuePMID:22086920
arg3ornithine carbamoyltransferase Arg3 Negative GeneticPMID:21504829
ccr1NADPH-cytochrome p450 reductase Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
lys3saccharopine dehydrogenase Lys3 Negative GeneticPMID:22681890
Negative GeneticPMID:21504829
SPBC56F2.08cRNA-binding protein (predicted) Positive GeneticPMID:21504829
scp1Sre1 cleavage activating protein, Scap Scp1 Dosage RescuePMID:22086920
cmk2MAPK-activated protein kinase Cmk2 Positive GeneticPMID:21504829
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
scp1Sre1 cleavage activating protein, Scap Scp1 Affinity Capture-WesternPMID:15797383
ofd12-oxoglutarate and Fe(II) dioxygenase domain containing protein 1 Two-hybridPMID:22017871
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External References
Database Identifier Description
NBRP SPBC19C2.09 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC19C2.09 Retrieval of eukaryotic orthologs
BioGrid SPBC19C2.09 BioGRID Interaction Datasets
Bähler Lab SPBC19C2.09 Cell Cycle Expression Profile
Bähler Lab SPBC19C2.09 Meiosis/Sporulation Expression Profies
Bähler Lab SPBC19C2.09 Pheromone response/mating expression profiles
Bähler Lab SPBC19C2.09 Environmental stress expression profiles
Bähler Lab SPBC19C2.09 Bähler Lab Transcriptome Viewer
Cyclebase SPBC19C2.09 Cell Cycle Data
PInt SPBC19C2.09 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC19C2.09 Entrez Gene
SPD / RIKEN39/39A03Orfeome Localization Data
EntrezGene2540730sterol regulatory element binding protein, transcription factor Sre1
Uniprot_genenameSRE1
WikiGene2540730sterol regulatory element binding protein, transcription factor Sre1
UniProtKB/SwissProtQ9UUD1Sterol regulatory element-binding protein 1 Processed sterol regulatory element-binding protein 1
ModBaseQ9UUD1Database of comparative protein structure models
Pfam Protein DomainsQ9UUD1Pfam Domain Arrangement
RefSeq PeptideNP_595694sterol regulatory element binding protein, transcription factor Sre1
RefSeq mRNANM_001021591972h- sterol regulatory element binding protein, transcription factor Sre1 (sre1), mRNA
European Nucleotide ArchiveCAB52036ENA Protein Mapping
SPD / RIKEN39/39A03Orfeome Localization Data

Literature for sre1
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Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013