sen34 (SPBC19C7.07c)


Gene Standard Namesen34 Characterisation Statusbiological_role_inferred
Systematic IDSPBC19C7.07c Feature Typeprotein coding
Synonyms Name Description
ProducttRNA-splicing endonuclease catalytic subunit Sen34 (predicted) Product Size284aa, 32.81 kDa
Genomic Location Chromosome II, 2835231-2833988 (1244nt); CDS:2835032-2834178 (855nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016829lyase activityIEAUniProtKB-KW:KW-0456GO_REF:000003785
GO:0000213tRNA-intron endonuclease activityISOSGD:S000000066GO_REF:00000244
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolyticISOSGD:S000000066GO_REF:000002424
GO:0000379tRNA-type intron splice site recognition and cleavageISOSGD:S000000066GO_REF:00000244
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005741mitochondrial outer membraneISOSGD:S000000066GO_REF:000002443
GO:0000214tRNA-intron endonuclease complexISOSGD:S000000066GO_REF:00000244
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopysen34ΔNullPECO:0000005, PECO:0000137PMID:236978061337
Microscopysen34ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000951inviable small vegetative cell22
penetrance FYPO_EXT:0000001Microscopysen34ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
128352312833988
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01974 Pfam IPR006677 tRNA intron endonuclease, catalytic domain-like 178 251 2
PTHR13070 HMMPANTHER 7 284 1
3.40.1350.10 Gene3D IPR011856 tRNA endonuclease-like domain 174 283 3
SSF53032 SuperFamily IPR006677 tRNA intron endonuclease, catalytic domain-like 179 255 3
PIRSF017250 PIRSF IPR016690 tRNA-splicing endonuclease, SEN34 subunit 1 284 1
TIGR00324 tigrfam IPR006676 tRNA-splicing endonuclease 173 255 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 115.52 Da
Charge -1.00
Isoelectric point 6.32
Molecular weight 32.81 kDa
Number of residues 284
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1589.63during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.6during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.42during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4599
conserved in eukaryotes4514
conserved in metazoa3428
conserved in vertebrates3402
conserved in archaea237
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


External References
Database Identifier Description
NBRP SPBC19C7.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC19C7.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC19C7.07c BioGRID Interaction Datasets
Expression Viewer SPBC19C7.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC19C7.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC19C7.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC19C7.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC19C7.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC19C7.07c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC19C7.07c Cell Cycle Data
GEO SPBC19C7.07c GEO profiles
PInt SPBC19C7.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC19C7.07c Peptides identified in tandem mass spectrometry proteomics experiments
SPD / RIKEN11/11C07Orfeome Localization Data
IntEnz3.1.27.9Integrated relational Enzyme database
Rhea3.1.27.9Annotated reactions database
UniProtKB/SwissProtO60156Probable tRNA-splicing endonuclease subunit sen34
ModBaseO60156Database of comparative protein structure models
STRINGO60156Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596163tRNA-splicing endonuclease catalytic subunit Sen34 (predicted)
RefSeq mRNANM_001022083972h- tRNA-splicing endonuclease catalytic subunit Sen34 (predicted) (sen34), mRNA
European Nucleotide ArchiveCAA19575.1ENA Protein Mapping
UniParcUPI000006961EUniProt Archive

Literature for sen34

Search: Europe PMC or PubMed

Release Version: PomBase:23_46 - 30 Aug 2014