sen34 (SPBC19C7.07c)

Gene Standard Namesen34 Characterisation Statusbiological role inferred
Systematic IDSPBC19C7.07c Feature Typeprotein coding
Synonyms Name Description
ProducttRNA-splicing endonuclease catalytic subunit Sen34 (predicted) Product Size284aa, 32.81 kDa
Genomic Location Chromosome II, 2835231-2833988 (1244nt); CDS:2835032-2834178 (855nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
tRNA-intron endonuclease activity4
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
tRNA-type intron splice site recognition and cleavage4
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
mitochondrial outer membrane47
Annotation ExtensionEvidenceWith/FromReference
tRNA-intron endonuclease complex4
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Inviable

Population Phenotype

Term NameGenotypesCount
inviable vegetative cell populationsen34Δ1468

Cell Phenotype

Term NameGenotypesCount
inviable small vegetative cellsen34Δ28
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
5' UTR2835231..2835033PMID:21511999
3' UTR2834177..2833988PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01974 Pfam IPR006677 tRNA intron endonuclease, catalytic domain-like 179 255 2
PTHR13070 HMMPANTHER 1 284 1
3.40.1350.10 Gene3D IPR011856 tRNA endonuclease-like domain 174 283 3
SSF53032 SuperFamily IPR006677 tRNA intron endonuclease, catalytic domain-like 179 255 3
PIRSF017250 PIRSF IPR016690 tRNA-splicing endonuclease, SEN34 subunit 1 284 1
TIGR00324 TIGRFAM IPR006676 tRNA-splicing endonuclease 173 255 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 115.52 Da
Charge -1.00
Codon Adaptation Index 0.40
Isoelectric point 6.32
Molecular weight 32.81 kDa
Number of residues 284
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for sen34 (SPBC19C7.07c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1589.63during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.6during GO:0072690PECO:0000126,
population wideexperimental evidencePMID:23101633
0.42during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
predominantly single copy (one to one)3087
conserved in fungi4608
conserved in eukaryotes4516
conserved in metazoa3498
conserved in vertebrates3473
conserved in archaea243

Manually curated orthologous groups


Orthologs in Compara

Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC19C7.07c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
binds DNA-binding domain construct withsen15tRNA-splicing endonuclease subunit Sen15 (predicted) Two-hybridPMID:26771498
External References
Database Identifier Description
NBRP SPBC19C7.07c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC19C7.07c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC19C7.07c BioGRID Interaction Datasets
Expression Viewer SPBC19C7.07c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC19C7.07c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC19C7.07c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC19C7.07c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC19C7.07c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC19C7.07c Transcriptome Viewer (Bähler Lab)
GEO SPBC19C7.07c GEO profiles
PInt SPBC19C7.07c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC19C7.07c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC19C7.07c Fission yeast phenotypic data & analysis
Cyclebase SPBC19C7.07c.1 Cell Cycle Data
SPD / RIKEN11/11C07Orfeome Localization Data
IntEnz3.1.27.9Integrated relational Enzyme database
Rhea3.1.27.9Annotated reactions database
UniProtKB/SwissProtO60156Probable tRNA-splicing endonuclease subunit sen34
ModBaseO60156Database of comparative protein structure models
STRINGO60156Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596163tRNA-splicing endonuclease catalytic subunit Sen34 (predicted)
RefSeq mRNANM_001022083972h- tRNA-splicing endonuclease catalytic subunit Sen34 (predicted) (sen34), mRNA
European Nucleotide ArchiveCAA19575.1ENA Protein Mapping
MetaCycPWY-6689Trna splicing
UniParcUPI000006961EUniProt Archive

Literature for sen34

Search: Europe PMC or PubMed

Release Version: PomBase:30_62 - 30 Jan 2017