ppp1 (SPBC19F5.05c)


Gene Standard Nameppp1 Characterisation Statusbiological_role_inferred
Systematic IDSPBC19F5.05c Feature Typeprotein coding
SynonymsSPBC25D12.01c Name Description
Productpescadillo-family BRCT domain protein Ppp1 (predicted) Product Size607aa, 69.19 kDa
Genomic Location Chromosome II, 3713713-3711419 (2295nt); CDS:3713619-3711604 (2016nt)

Ensembl Gene Location
GO Biological Process

GO Slim Terms

ribosome biogenesis


GO Cellular Component
Term NameCount
nucleolus363
Annotation ExtensionEvidenceWith/FromReference
nucleus2696
Annotation ExtensionEvidenceWith/FromReference
PeBoW complex3
Annotation ExtensionEvidenceWith/FromReference
preribosome, large subunit precursor15
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term NameAlleleExpressionCount
inviable vegetative cell populationppp1ΔNull1438

Cell Phenotype

Term NameAlleleExpressionCount
inviable after spore germination with normal, unseptated germ tube morphologyppp1ΔNull237
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3713713..3713598, 3713559..3713392, 3713237..3711419
mRNA3713713..3711419
5' UTR3713713..3713620PMID:21511999
CDS3713619..3713598, 3713559..3713392, 3713237..3711604
3' UTR3711603..3711419PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF06732 Pfam IPR010613 Pescadillo 5 285 1
PF00533 Pfam IPR001357 BRCT domain 349 428 8
SM00292 SMART IPR001357 BRCT domain 350 431 10
PS50172 Prosite Profiles IPR001357 BRCT domain 348 441 13
PTHR12221 HMMPANTHER 1 604 1
3.40.50.10190 Gene3D IPR001357 BRCT domain 347 431 13
SSF52113 SuperFamily IPR001357 BRCT domain 351 442 12
Coil ncoils Rabaptin coiled-coil domain 573 597 968
Coil ncoils Rabaptin coiled-coil domain 279 300 968
Coil ncoils Rabaptin coiled-coil domain 540 561 968
MF_03028 hamap IPR010613 Pescadillo 2 602 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000443BRCT domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000443

Protein Properties

Ave. residue weight 113.99 Da
Charge 4.00
Isoelectric point 7.15
Molecular weight 69.19 kDa
Number of residues 607
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serine 1672
present during cellular response to thiabendazoleS467
Annotation ExtensionEvidenceResidueReference
present during cellular response to thiabendazole IDA S467 PMID:18257517
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA leveldecreased during GO:0071470expression microarray evidencePMID:12529438
decreased in presence of methyl methanesulfonate expression microarray evidencePMID:12529438
decreased during GO:0034599expression microarray evidencePMID:12529438
decreased in presence of cadmium sulfate expression microarray evidencePMID:12529438
decreased during GO:0034605expression microarray evidencePMID:12529438

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
27650during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
28346during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
27548during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
28186during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
12849.07during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
29362during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
4054.75during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7.7during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4603
conserved in eukaryotes4514
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2501
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity captured bymlo3RNA binding protein Mlo3 Affinity Capture-MSPMID:21436456
affinity captured byred5human ZC3H3 homolog Affinity Capture-MSPMID:24713849
External References
Database Identifier Description
NBRP SPBC19F5.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC19F5.05c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC19F5.05c BioGRID Interaction Datasets
Expression Viewer SPBC19F5.05c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC19F5.05c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC19F5.05c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC19F5.05c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC19F5.05c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC19F5.05c Transcriptome Viewer (Bähler Lab)
GEO SPBC19F5.05c GEO profiles
PInt SPBC19F5.05c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC19F5.05c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC19F5.05c Fission yeast phenotypic data & analysis
Cyclebase SPBC19F5.05c.1 Cell Cycle Data
SPD / RIKEN27/27E05Orfeome Localization Data
UniProtKB/SwissProtO60164Pescadillo homolog
ModBaseO60164Database of comparative protein structure models
STRINGO60164Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596543pescadillo-family BRCT domain protein (predicted)
RefSeq mRNANM_001022464972h- pescadillo-family BRCT domain protein (predicted) (ppp1), mRNA
European Nucleotide ArchiveBAA87283.1ENA Protein Mapping
European Nucleotide ArchiveCAA18653.1ENA Protein Mapping
UniParcUPI000013166EUniProt Archive

Literature for ppp1

Search: Europe PMC or PubMed

Release Version: PomBase:26_53 - 27 May 2015