ppp1 (SPBC19F5.05c)


Gene Standard Nameppp1 Characterisation Statusbiological_role_inferred
Systematic IDSPBC19F5.05c Feature Typeprotein coding
SynonymsSPBC25D12.01c Name Description
Productpescadillo-family BRCT domain protein Ppp1 (predicted) Product Size607aa, 69.19 kDa
Genomic Location Chromosome II, 3713713-3711419 (2295nt); CDS:3713619-3711604 (2016nt)

Ensembl Gene Location
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000466maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)IEAHAMAP:MF_03028GO_REF:000002023
GO:0000463maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)IEAHAMAP:MF_03028GO_REF:00000207
GO:0042254ribosome biogenesisISOSGD:S000003335GO_REF:0000024337
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005730nucleolusIDAPMID:16823372343
ISOSGD:S000003335GO_REF:0000024
GO:0005634nucleusIDAPMID:168233722740
GO:0030687preribosome, large subunit precursorIEAHAMAP:MF_03028GO_REF:000002015
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Inviable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyppp1ΔNullPMID:204732891338
Microscopyppp1ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000311inviable after spore germination with normal, unseptated germ tube morphology237
penetrance FYPO_EXT:0000001Microscopyppp1ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
137137133713598
237135593713392
337132373711419

UTRs

Region Coordinates Reference
five_prime_UTR3713713..3713620PMID:21511999
three_prime_UTR3711603..3711419PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00533 Pfam IPR001357 BRCT domain 349 428 8
PF06732 Pfam IPR010613 Pescadillo 5 285 1
SM00292 SMART IPR001357 BRCT domain 350 431 10
PS50172 Prosite Profiles IPR001357 BRCT domain 348 441 13
PTHR12221 HMMPANTHER 1 607 1
3.40.50.10190 Gene3D IPR001357 BRCT domain 347 431 13
SSF52113 SuperFamily IPR001357 BRCT domain 351 442 12
Coil ncoils Rabaptin coiled-coil domain 573 597 968
Coil ncoils Rabaptin coiled-coil domain 279 300 968
Coil ncoils Rabaptin coiled-coil domain 540 561 968

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000443BRCT domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000443

Protein Properties

Ave. residue weight 113.99 Da
Charge 4.00
Isoelectric point 7.15
Molecular weight 69.19 kDa
Number of residues 607
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineIDAS467PMID:182575171670
present during cellular response to thiabendazole
MOD:00696phosphorylated residueNASPMID:182575171922
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA leveldecreased during GO:0034599expression microarray evidencePMID:12529438
decreased in presence of methyl methanesulfonate expression microarray evidencePMID:12529438
decreased during GO:0071470expression microarray evidencePMID:12529438
decreased during GO:0034605expression microarray evidencePMID:12529438
decreased in presence of cadmium sulfate expression microarray evidencePMID:12529438

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
27650during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
28346during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
27548during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
28186during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
29362during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
12849.07during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
4054.75during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7.7during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
red5human ZC3H3 homolog Affinity Capture-MSPMID:24713849
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
mlo3RNA binding protein Mlo3 Affinity Capture-MSPMID:21436456
External References
Database Identifier Description
NBRP SPBC19F5.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC19F5.05c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC19F5.05c BioGRID Interaction Datasets
Expression Viewer SPBC19F5.05c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC19F5.05c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC19F5.05c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC19F5.05c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC19F5.05c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC19F5.05c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC19F5.05c Cell Cycle Data
GEO SPBC19F5.05c GEO profiles
PInt SPBC19F5.05c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC19F5.05c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC19F5.05c Fission yeast phenotypic data & analysis
SPD / RIKEN27/27E05Orfeome Localization Data
UniProtKB/SwissProtO60164Pescadillo homolog
ModBaseO60164Database of comparative protein structure models
STRINGO60164Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596543pescadillo-family BRCT domain protein (predicted)
RefSeq mRNANM_001022464972h- pescadillo-family BRCT domain protein (predicted) (ppp1), mRNA
European Nucleotide ArchiveBAA87283.1ENA Protein Mapping
European Nucleotide ArchiveCAA18653.1ENA Protein Mapping
UniParcUPI000013166EUniProt Archive

Literature for ppp1

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014