ppp1 (SPBC19F5.05c)


Gene Standard Nameppp1 Characterisation Statusbiological_role_inferred
Systematic IDSPBC19F5.05c Feature Typeprotein coding
SynonymsSPBC25D12.01c Name Description
Productpescadillo-family BRCT domain protein Ppp1 (predicted) Product Size607aa, 69.19 kDa
Genomic Location Chromosome II, 3713713-3711419 (2295nt); CDS:3713619-3711604 (2016nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0043021ribonucleoprotein complex bindingIEAHAMAP:MF_03028GO_REF:000002017
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000466maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)IEAHAMAP:MF_03028GO_REF:000002022
GO:0000463maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)IEAHAMAP:MF_03028GO_REF:00000206
GO:0042254ribosome biogenesisISOSGD:S000003335GO_REF:0000024327
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005730nucleolusIDAPMID:16823372345
ISOSGD:S000003335GO_REF:0000024
GO:0005634nucleusIDAPMID:168233722730
GO:0030687preribosome, large subunit precursorIEAHAMAP:MF_03028GO_REF:000002014
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002061inviable vegetative cell populationMicroscopyppp1ΔNullPECO:0000005, PECO:0000137PMID:236978061309
Microscopyppp1ΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000311inviable after spore germination with normal, unseptated germ tube morphologyMicroscopyppp1ΔNullPECO:0000005, PECO:0000137PMID:23697806237
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
137137133713598
237135593713392
337132373711419

UTRs

Region Start End Reference
five_prime_UTR37137133713620PMID:21511999
three_prime_UTR37116033711419PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00533 Pfam IPR001357 BRCT domain 349 428 8
PF06732 Pfam IPR010613 Pescadillo 5 285 1
SM00292 SMART IPR001357 BRCT domain 350 431 12
PS50172 Prosite Profiles IPR001357 BRCT domain 348 441 13
PTHR12221 HMMPANTHER 1 607 1
G3DSA:3.40.50.10190 Gene3D IPR001357 347 431 12
SSF52113 SuperFamily IPR001357 351 442 12
Coil ncoils Rabaptin coiled-coil domain 573 597 975
Coil ncoils Rabaptin coiled-coil domain 279 300 975
Coil ncoils Rabaptin coiled-coil domain 540 561 975
Low complexity (SEG) seg 308 326
Low complexity (SEG) seg 346 361
Low complexity (SEG) seg 504 519
Low complexity (SEG) seg 530 544
Low complexity (SEG) seg 549 559
Low complexity (SEG) seg 571 588

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000443BRCT domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000443

Protein Properties

Ave. residue weight 113.99 Da
Charge 4.00
Isoelectric point 7.15
Molecular weight 69.19 kDa
Number of residues 607
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00696phosphorylated residuePMID:182575171192
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA leveldecreasedexpression microarray evidencePMID:12529438
during GO:0034599
decreased,
in presence of cadmium sulfate
expression microarray evidencePMID:12529438
decreased,
in presence of methyl methanesulfonate
expression microarray evidencePMID:12529438
decreasedexpression microarray evidencePMID:12529438
during GO:0071470
decreasedexpression microarray evidencePMID:12529438
during GO:0034605

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
4054.75during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
12849.07during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
7.7during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
epe1Jmjc domain chromatin associated protein Epe1 Affinity Capture-MSPMID:24013502
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
bdf2BET family double bromodomain protein Bdf2 Affinity Capture-MSPMID:24013502
mlo3RNA binding protein Mlo3 Affinity Capture-MSPMID:21436456
hhp1serine/threonine protein kinase Hhp1 Affinity Capture-MSPMID:24055157
External References
Database Identifier Description
NBRP SPBC19F5.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC19F5.05c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC19F5.05c BioGRID Interaction Datasets
Expression Viewer SPBC19F5.05c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC19F5.05c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC19F5.05c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC19F5.05c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC19F5.05c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC19F5.05c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC19F5.05c Cell Cycle Data
GEO SPBC19F5.05c GEO profiles
PInt SPBC19F5.05c Protein-Protein Interaction Predictor (Bähler Lab)
EntrezGene2540659pescadillo-family BRCT domain protein
WikiGene2540659pescadillo-family BRCT domain protein
SPD / RIKEN27/27E05Orfeome Localization Data
UniProtKB/SwissProtO60164Pescadillo homolog
ModBaseO60164Database of comparative protein structure models
StringO60164Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596543pescadillo-family BRCT domain protein
RefSeq mRNANM_001022464972h- pescadillo-family BRCT domain protein (ppp1), mRNA
European Nucleotide ArchiveBAA87283ENA Protein Mapping
European Nucleotide ArchiveCAA18653ENA Protein Mapping
UniParcUPI000013166EUniProt Archive

Literature for ppp1

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014