scr1 (SPBC1D7.02c)


Gene Standard Namescr1 Characterisation Statuspublished
Systematic IDSPBC1D7.02c Feature Typeprotein coding
SynonymsSPBC1D7.02 Name Description
Producttranscription factor Scr1 Product Size565aa, 59.71 kDa
Genomic Location Chromosome II, 1752100-1755619 (3520nt); CDS:1753589-1755286 (1698nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
Term NameCount
negative regulation of transcription from RNA polymerase II promoter61
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4213
Annotation ExtensionEvidenceWith/FromReference
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
nucleus2700
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes

Population Phenotype

Term NameGenotypesCount
decreased cell population growth on glucose carbon sourcescr1+ (wild type)380

Cell Phenotype

Term NameGenotypesCount
increased glycerol dehydrogenase activityscr1Δ3
increased RNA level during vegetative growth342
affecting ght5scr1Δ
Target Of
OntologyRelationshipGeneProduct
FYPO localization affected by mutation in sds23 PP2A-type phosphatase inhibitor Sds23/Moc1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1752100..1755619
mRNA1752100..1755619
5' UTR1752100..1753588PMID:21511999
CDS1753589..1755286
3' UTR1755287..1755619PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
SM00355 SMART IPR015880 Zinc finger, C2H2-like 26 48 19
SM00355 SMART IPR015880 Zinc finger, C2H2-like 54 78 19
PS50157 Prosite Profiles IPR007087 Zinc finger, C2H2 26 53 20
PS50157 Prosite Profiles IPR007087 Zinc finger, C2H2 54 83 20
PS00028 Prosite Patterns IPR007087 Zinc finger, C2H2 28 48 28
PS00028 Prosite Patterns IPR007087 Zinc finger, C2H2 56 78 28
PTHR24409 HMMPANTHER 23 79 7
3.30.160.60 Gene3D IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain 24 47 15
3.30.160.60 Gene3D IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain 48 80 15
SSF57667 SuperFamily 24 78 26

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0000137zinc finger proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000137
PBO:0000153zf-C2H2 typeTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000153

Protein Properties

Ave. residue weight 105.69 Da
Charge 37.00
Codon Adaptation Index 0.40
Isoelectric point 10.66
Molecular weight 59.71 kDa
Number of residues 565
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS261, S265, S299, S300, S303, S410, S445, S449 2289
Annotation ExtensionEvidenceResidueReference
IDA S303 PMID:25720772
IDA S410 PMID:25720772
experimental evidence S265 PMID:24763107
IDA S445 PMID:25720772
IDA S300 PMID:25720772
experimental evidence S261 PMID:24763107
IDA S449 PMID:25720772
IDA S299 PMID:25720772
IDA S265 PMID:25720772
O-phospho-L-threonineT301, T305 1085
Annotation ExtensionEvidenceResidueReference
IDA T305 PMID:25720772
IDA T301 PMID:25720772
phosphorylated residue 2511
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
O-phosphorylated residueS261,S265, S275,S278,S283, S275,S279,S283, S275,S280,T282, S275,S283, S275,T282,S283, S278,S283, S279,S280,S283, S279,T282,S283, S280,S283, S280,T282,S283, S299,S300, S299,T301, S300,S303, S300,T301, S311,S312, S330,S332, S330,S332,S333, S330,S333, S330,S333,T334, S330,S335, S330,S338, S330,T334, S332,S333, S332,S333,S335, S332,S333,T334, S332,S335, S332,T334, S333,T334, S335,Y340, S338,Y340, S389,S393,T406, S393,S396,S401, S393,S401,S405, S408,S410, S408,S410,S424, S408,S410,T420, S408,S424, S410,S424, S410,T416,S424, S410,T420,S424, S443,S449, S445,S449, S479,S482, S479,S482,S485, S518,S532,S535, S518,S535, S520,S532,S535, S521,S532,S535, S532,S535, S532,S537, S532,S538, S532,S539, S537,S538, T301,S303, T334,S335, T412,T416,S424, T412,T420,S424, T477,S479, T477,S482, T477,S482,S485, T477,S491 2457
Annotation ExtensionEvidenceResidueReference
IDA S521,S532,S535 PMID:25720772
IDA T334,S335 PMID:25720772
IDA S279,T282,S283 PMID:25720772
IDA S443,S449 PMID:25720772
IDA S410,S424 PMID:25720772
IDA S532,S535 PMID:25720772
IDA S408,S424 PMID:25720772
IDA S393,S401,S405 PMID:25720772
IDA S332,T334 PMID:25720772
IDA S332,S335 PMID:25720772
IDA S520,S532,S535 PMID:25720772
IDA S335,Y340 PMID:25720772
IDA S332,S333,T334 PMID:25720772
IDA S275,T282,S283 PMID:25720772
IDA S275,S280,T282 PMID:25720772
IDA S537,S538 PMID:25720772
IDA S299,T301 PMID:25720772
IDA S300,T301 PMID:25720772
IDA S332,S333,S335 PMID:25720772
IDA S275,S283 PMID:25720772
IDA T301,S303 PMID:25720772
IDA S300,S303 PMID:25720772
IDA S330,S333 PMID:25720772
IDA S261,S265 PMID:25720772
IDA S311,S312 PMID:25720772
IDA S330,S333,T334 PMID:25720772
IDA T412,T420,S424 PMID:25720772
IDA S280,S283 PMID:25720772
IDA S393,S396,S401 PMID:25720772
IDA S518,S535 PMID:25720772
IDA T477,S491 PMID:25720772
IDA S532,S537 PMID:25720772
IDA T477,S482 PMID:25720772
IDA S410,T420,S424 PMID:25720772
IDA S479,S482 PMID:25720772
IDA S330,S338 PMID:25720772
IDA S275,S278,S283 PMID:25720772
IDA S532,S539 PMID:25720772
IDA S518,S532,S535 PMID:25720772
IDA S278,S283 PMID:25720772
IDA S279,S280,S283 PMID:25720772
IDA S332,S333 PMID:25720772
IDA T477,S479 PMID:25720772
IDA S330,S332 PMID:25720772
IDA S330,S335 PMID:25720772
IDA S330,S332,S333 PMID:25720772
IDA S299,S300 PMID:25720772
IDA S408,S410,S424 PMID:25720772
IDA S408,S410 PMID:25720772
IDA S445,S449 PMID:25720772
IDA S333,T334 PMID:25720772
IDA S408,S410,T420 PMID:25720772
IDA S389,S393,T406 PMID:25720772
IDA T477,S482,S485 PMID:25720772
IDA S479,S482,S485 PMID:25720772
IDA T412,T416,S424 PMID:25720772
IDA S280,T282,S283 PMID:25720772
IDA S410,T416,S424 PMID:25720772
IDA S532,S538 PMID:25720772
IDA S330,T334 PMID:25720772
IDA S275,S279,S283 PMID:25720772
IDA S338,Y340 PMID:25720772
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0042149quantitative PCRPMID:25411338

Quantitative Gene Expression

View graphical display of gene expression data for scr1 (SPBC1D7.02c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1960.92during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
1724.36during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
6.8during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
4.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi only616
conserved in fungi4607
conserved in eukaryotes4517
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC1D7.02c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
modified bydsk1SR protein-specific kinase Dsk1 Biochemical ActivityPMID:26167880
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC1D7.02c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
synthetically rescuessds23PP2A-type phosphatase inhibitor Sds23/Moc1 Synthetic RescuePMID:25411338
phenotype enhanced bytup11transcriptional corepressor Tup11 Phenotypic EnhancementPMID:11238405
phenotype enhanced bytup12transcriptional corepressor Tup12 Phenotypic EnhancementPMID:11238405
External References
Database Identifier Description
NBRP SPBC1D7.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1D7.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1D7.02c BioGRID Interaction Datasets
Expression Viewer SPBC1D7.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1D7.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1D7.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1D7.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1D7.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1D7.02c Transcriptome Viewer (Bähler Lab)
GEO SPBC1D7.02c GEO profiles
PInt SPBC1D7.02c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1D7.02c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC1D7.02c Fission yeast phenotypic data & analysis
Cyclebase SPBC1D7.02c.1 Cell Cycle Data
SPD / RIKEN39/39E12Orfeome Localization Data
UniProtKB/SwissProtO14335DNA-binding protein scr1
ModBaseO14335Database of comparative protein structure models
STRINGO14335Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595717transcription factor Scr1
RefSeq mRNANM_001021615972h- transcription factor Scr1 (scr1), mRNA
European Nucleotide ArchiveCAB10978.1ENA Protein Mapping
UniParcUPI000013568FUniProt Archive

Literature for scr1

Search: Europe PMC or PubMed

Release Version: PomBase:30_61 - 12 Sep 2016