scr1 (SPBC1D7.02c)


Gene Standard Namescr1 Characterisation Statuspublished
Systematic IDSPBC1D7.02c Feature Typeprotein coding
Synonyms Name Description
Producttranscription factor Scr1 Product Size565aa, 59.71 kDa
Genomic Location Chromosome II, 1752100-1755619 (3520nt); CDS:1753589-1755286 (1698nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingNASGO_REF:000005194
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activityNASGO_REF:000000189
GO:0046872metal ion bindingIEAUniProtKB-KW:KW-0479GO_REF:0000037749
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000122negative regulation of transcription from RNA polymerase II promoter77
regulates gld1IMPPMID:20396879
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722316
GO:0005634nucleusISSrsv1GO_REF:00000242740
Fission Yeast Phenotype Ontology

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000796increased glycerol dehydrogenase activityEnzyme assay datascr1-ΔNullPECO:0000126PMID:203968793
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
117521001755619

UTRs

Region Coordinates Reference
five_prime_UTR1752100..1753588PMID:21511999
three_prime_UTR1755287..1755619PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF13465 Pfam 42 67 9
SM00355 SMART IPR015880 Zinc finger, C2H2-like 54 78 29
SM00355 SMART IPR015880 Zinc finger, C2H2-like 26 48 29
PS00028 Prosite Patterns IPR007087 Zinc finger, C2H2 28 48 28
PS00028 Prosite Patterns IPR007087 Zinc finger, C2H2 56 78 28
PS50157 Prosite Profiles IPR007087 Zinc finger, C2H2 54 83 20
PS50157 Prosite Profiles IPR007087 Zinc finger, C2H2 26 53 20
PTHR10042:SF22 HMMPANTHER 5 521 2
PTHR10042 HMMPANTHER 5 521 4
3.30.160.60 Gene3D IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain 24 47 13
3.30.160.60 Gene3D IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain 48 80 13
SSF57667 SuperFamily 24 78 26

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000137zinc finger proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000137
PBO:0000153zf-C2H2 typeTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000153

Protein Properties

Ave. residue weight 105.69 Da
Charge 37.00
Isoelectric point 10.66
Molecular weight 59.71 kDa
Number of residues 565
Modifications

Protein Modifications

Term IDTerm NameEvidenceResidueReferenceCount
MOD:00046O-phospho-L-serineS261PMID:247631071663
S265PMID:24763107
MOD:00696phosphorylated residueNASPMID:195477441915
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
1724.36during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
1960.92during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
4.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
PECO:0000127,
PECO:0000005
experimental evidencePMID:23101633
6.8during GO:0072690PECO:0000014,
PECO:0000005
experimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi only603
conserved in fungi4569
conserved in eukaryotes4482
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
tup11transcriptional corepressor Tup11 Phenotypic EnhancementPMID:11238405
tup12transcriptional corepressor Tup12 Phenotypic EnhancementPMID:11238405
External References
Database Identifier Description
NBRP SPBC1D7.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1D7.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1D7.02c BioGRID Interaction Datasets
Expression Viewer SPBC1D7.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1D7.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1D7.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1D7.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1D7.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1D7.02c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC1D7.02c Cell Cycle Data
GEO SPBC1D7.02c GEO profiles
PInt SPBC1D7.02c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2540768transcription factor Scr1
EntrezGene2540768transcription factor Scr1
SPD / RIKEN39/39E12Orfeome Localization Data
UniProtKB/SwissProtO14335DNA-binding protein scr1
ModBaseO14335Database of comparative protein structure models
STRINGO14335Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595717transcription factor Scr1
RefSeq mRNANM_001021615972h- transcription factor Scr1 (scr1), mRNA
European Nucleotide ArchiveCAB10978ENA Protein Mapping
European Nucleotide ArchiveCAB10978.1ENA Protein Mapping
UniParcUPI000013568FUniProt Archive

Literature for scr1

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014