scr1 (SPBC1D7.02c)


Gene Standard Namescr1 Characterisation Statuspublished
Systematic IDSPBC1D7.02c Feature Typeprotein coding
Synonyms Name Description
Producttranscription factor Scr1 Product Size565aa, 59.71 kDa
Genomic Location Chromosome II, 1752100-1755619 (3520nt); CDS:1753589-1755286 (1698nt)

Ensembl Gene Location
GO Molecular Function
GO Biological Process
Term NameCount
negative regulation of transcription from RNA polymerase II promoter62
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
cytoplasm4211
Annotation ExtensionEvidenceWith/FromReference
cytosol2302
Annotation ExtensionEvidenceWith/FromReference
nucleus2692
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes

Population Phenotype

Term NameGenotypesCount
decreased cell population growth on glucose carbon sourcescr1+ (wild type)319

Cell Phenotype

Term NameGenotypesCount
increased glycerol dehydrogenase activityscr1-Δ3
increased RNA level during vegetative growth256
affecting ght5scr1Δ
Target Of
OntologyRelationshipGeneProduct
FYPO localization affected by mutation in sds23 PP2A-type phosphatase inhibitor Sds23/Moc1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons1752100..1755619
mRNA1752100..1755619
5' UTR1752100..1753588PMID:21511999
CDS1753589..1755286
3' UTR1755287..1755619PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
SM00355 SMART IPR015880 Zinc finger, C2H2-like 54 78 19
SM00355 SMART IPR015880 Zinc finger, C2H2-like 26 48 19
PS50157 Prosite Profiles IPR007087 Zinc finger, C2H2 26 53 20
PS50157 Prosite Profiles IPR007087 Zinc finger, C2H2 54 83 20
PS00028 Prosite Patterns IPR007087 Zinc finger, C2H2 56 78 28
PS00028 Prosite Patterns IPR007087 Zinc finger, C2H2 28 48 28
PTHR24409 HMMPANTHER 23 79 7
3.30.160.60 Gene3D IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain 48 80 15
3.30.160.60 Gene3D IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain 24 47 15
SSF57667 SuperFamily 24 78 26

View domain organization at Pfam

Term IDTerm NameReferenceCount
PBO:0000137zinc finger proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000137
PBO:0000153zf-C2H2 typeTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000153

Protein Properties

Ave. residue weight 105.69 Da
Charge 37.00
Codon Adaptation Index 0.40
Isoelectric point 10.66
Molecular weight 59.71 kDa
Number of residues 565
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS261, S265 1676
Annotation ExtensionEvidenceResidueReference
experimental evidence S261 PMID:24763107
experimental evidence S265 PMID:24763107
phosphorylated residue 1931
Annotation ExtensionEvidenceResidueReference
IDA PMID:19547744
Sequence
Gene Expression

Qualitative Gene Expression

DescriptionLevelEvidenceReference
RNA levelincreased during GO:0042149quantitative PCRPMID:25411338

Quantitative Gene Expression

View graphical display of gene expression data for scr1 (SPBC1D7.02c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1960.92during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
1724.36during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
6.8during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
4.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
conserved in fungi only618
conserved in fungi4606
conserved in eukaryotes4516
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC1D7.02c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
modified bydsk1SR protein-specific kinase Dsk1 Biochemical ActivityPMID:26167880
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC1D7.02c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
phenotype enhanced bytup11transcriptional corepressor Tup11 Phenotypic EnhancementPMID:11238405
phenotype enhanced bytup12transcriptional corepressor Tup12 Phenotypic EnhancementPMID:11238405
synthetically rescuessds23PP2A-type phosphatase inhibitor Sds23/Moc1 Synthetic RescuePMID:25411338
External References
Database Identifier Description
NBRP SPBC1D7.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC1D7.02c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC1D7.02c BioGRID Interaction Datasets
Expression Viewer SPBC1D7.02c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC1D7.02c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC1D7.02c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC1D7.02c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC1D7.02c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC1D7.02c Transcriptome Viewer (Bähler Lab)
GEO SPBC1D7.02c GEO profiles
PInt SPBC1D7.02c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC1D7.02c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC1D7.02c Fission yeast phenotypic data & analysis
Cyclebase SPBC1D7.02c.1 Cell Cycle Data
SPD / RIKEN39/39E12Orfeome Localization Data
UniProtKB/SwissProtO14335DNA-binding protein scr1
ModBaseO14335Database of comparative protein structure models
STRINGO14335Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595717transcription factor Scr1
RefSeq mRNANM_001021615972h- transcription factor Scr1 (scr1), mRNA

Literature for scr1

Search: Europe PMC or PubMed

Release Version: PomBase:30_59 - 12 Apr 2016