ral2 (SPBC21.05c)

Gene Standard Nameral2 ChromosomeII
Systematic IDSPBC21.05c Gene Start3222399
Synonyms Gene End3219942
ProductRas1-Scd pathway protein Ral2 Gene Length2458
Feature Typeprotein coding CDS Start3222181
Name DescriptionRAs Like CDS End3220346
Characterisation Statuspublished CDS Length1836

Ensembl Gene Location
  1. pmh1
  2. mis17
  3. SPBC21.03c
  4. rtc5
  5. med8
  6. ral2
  7. cdc7
  8. SPNCRNA.1587
  9. ppk24
  10. spn7
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000280sterileCell growth assayral2mutant (unknown)unknownNot specifiedPMID:3071741
FYPO:0000551pseudohyphal growth abolishedral2delta (deletion)deletionPMID:19542312
FYPO:0000584decreased sporulationCell growth assayhomozygous diploid (ral2mutant/ral2mutant)otherNot specifiedPMID:3071741
FYPO:0002060viable vegetative cell populationMicroscopyral2delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0030695GTPase regulator activityNASGO_REF:0000051
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000747conjugation with cellular fusionIMPPMID:8575018
IMPPMID:3071741
GO:0010570regulation of filamentous growthIMPPMID:19542312
GO:0010811positive regulation of cell-substrate adhesionIMPPMID:19542312
GO:0032005signal transduction involved in conjugation with cellular fusionIGIras1PMID:2586528
GO:0032488Cdc42 protein signal transductionNASGO_REF:0000001
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005737cytoplasmISSUniProtKB:P53094GO_REF:0000001
GO:0005783endoplasmic reticulumIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
132223993219942

References

Region Start End Reference
three_prime_UTR32203453219942PMID:21511999
three_prime_UTR32203453219942PMID:21511999
five_prime_UTR32223993222182PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF13415 Pfam 41 89 1
G3DSA:2.120.10.80 IPR015915 Gene3D 26 204 5
G3DSA:2.120.10.80 IPR015915 Gene3D 305 385 5
SSF117281 SuperFamily 24 134 3
SSF117281 SuperFamily 302 382 3
SSF117281 SuperFamily 161 202 3
PTHR23244 hmmpanther 23 380 3
PTHR23244:SF103 hmmpanther 23 380 1

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0001445BTB/POZ domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001445
PBO:0001938kelch repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001938

Protein Properties

Ave. residue weight 114.32 Da
Charge 0.00
Isoelectric point 6.51
Molecular weight 69.85 kDa
Number of residues 611
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencePECO:0000014,
PECO:0000005		population_wide468.59PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.43PMID:23101633
experimental evidencePECO:0000014,
PECO:0000005		population_wide1.2PMID:23101633
Pathway
DescriptionQualifierReference
Ras1-Scd
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi only
conserved in fungi
conserved in eukaryotes
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
scd1RhoGEF Scd1 Phenotypic SuppressionPMID:3071741
ras1GTPase Ras1 Phenotypic SuppressionPMID:2586528
Phenotypic SuppressionPMID:3071741
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
skp1SCF ubiquitin ligase complex subunit Skp1 Two-hybridPMID:17016471
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External References
Database Identifier Description
NBRP SPBC21.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC21.05c Retrieval of eukaryotic orthologs
BioGrid SPBC21.05c BioGRID Interaction Datasets
Bähler Lab SPBC21.05c Cell Cycle Expression Profile
Bähler Lab SPBC21.05c Meiosis/Sporulation Expression Profies
Bähler Lab SPBC21.05c Pheromone response/mating expression profiles
Bähler Lab SPBC21.05c Environmental stress expression profiles
Bähler Lab SPBC21.05c Bähler Lab Transcriptome Viewer
Cyclebase SPBC21.05c Cell Cycle Data
PInt SPBC21.05c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC21.05c Entrez Gene
EntrezGene2540760Ras1-Scd pathway protein Ral2
Uniprot_genenameRAL2
WikiGene2540760Ras1-Scd pathway protein Ral2
UniProtKB/SwissProtP15258Protein ral2
ModBaseP15258Database of comparative protein structure models
Pfam Protein DomainsP15258Pfam Domain Arrangement
RefSeq PeptideNP_596339Ras1-Scd pathway protein Ral2
RefSeq mRNANM_001022260972h- Ras1-Scd pathway protein Ral2 (ral2), mRNA
European Nucleotide ArchiveAAA35331ENA Protein Mapping
European Nucleotide ArchiveCAB36885ENA Protein Mapping
SPD / RIKEN33/33E05Orfeome Localization Data
UniParcUPI00001330F4UniProt Archive

Literature for ral2
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013