csn1 (SPBC215.03c)


Gene Standard Namecsn1 Characterisation Statuspublished
Systematic IDSPBC215.03c Feature Typeprotein coding
Synonyms Name Description
ProductCOP9/signalosome complex subunit Csn1 Product Size422aa, 48.66 kDa
Genomic Location Chromosome II, 4029873-4027314 (2560nt); CDS:4029559-4028117 (1443nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
cellular response to DNA damage stimulus208
Annotation ExtensionEvidenceWith/FromReference
cullin deneddylation6
Annotation ExtensionEvidenceWith/FromReference
protein catabolic process206
Annotation ExtensionEvidenceWith/FromReference
regulation of chromatin silencing at centromere6
Annotation ExtensionEvidenceWith/FromReference
regulation of chromatin silencing at silent mating-type cassette4
Annotation ExtensionEvidenceWith/FromReference
regulation of protein deneddylation1
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
COP9 signalosome8
Annotation ExtensionEvidenceWith/FromReference
cytosol2314
Annotation ExtensionEvidenceWith/FromReference
nucleus2695
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term NameAlleleExpressionCount
decreased mating efficiencycsn1ΔNull252
normal growth on methyl methanesulfonatecsn1ΔNull28
normal growth on sodium butyratecsn1ΔNull55
normal growth on trichostatin Acsn1ΔNull113
resistance to hydrogen peroxidecsn1ΔNull73
sensitive to 4-nitroquinoline N-oxidecsn1ΔNull159
sensitive to 5-fluorouracilcsn1ΔNull271
sensitive to bortezomibcsn1ΔNull256
sensitive to caffeinecsn1ΔNull108
sensitive to camptothecincsn1ΔNull224
sensitive to doxorubicincsn1ΔNull91
sensitive to hydroxyureacsn1ΔNull534
sensitive to tacrolimuscsn1ΔNull80
sensitive to thiabendazolecsn1ΔNull211
sensitive to UV during vegetative growthcsn1ΔNull141
sensitive to valproic acidcsn1ΔNull155
viable vegetative cell populationcsn1ΔNull3795

Cell Phenotype

Term NameAlleleExpressionCount
abnormal microtubule cytoskeleton morphology during mitotic interphasecsn1ΔNull186
abnormal mitotic cell cyclecsn1ΔNull846
abnormal prospore membrane formationcsn1ΔNull25
abolished sporulationcsn1ΔNull55
decreased chromatin silencing at centromere outer repeat regioncsn1ΔNull34
decreased chromatin silencing at silent mating-type cassettecsn1ΔNull19
decreased histone H3-K9 methylation at centromere outer repeatcsn1ΔNull16
decreased histone H3-K9 methylation at mating-type region heterochromatincsn1ΔNull5
decreased protein secretion14
affecting pho1csn1ΔNull
elongated vegetative cellcsn1ΔNull760
increased centromeric outer repeat transcript-derived siRNA levelcsn1ΔNull3
increased protein level during vegetative growth78
affecting cdt2csn1ΔNull
normal protein binding56
affecting ddb1 and cdt2csn1ΔNull
normal protein degradation during vegetative growth10
affecting cdt2csn1ΔNull
normal protein localization to nucleus55
affecting cdt2csn1ΔNull
viable elongated vegetative cellcsn1ΔNull289
viable vegetative cell with abnormal cell shapecsn1ΔNull478
Target Of
OntologyRelationshipGeneProductReference
FYPO affected by mutation in csn2 COP9/signalosome complex subunit Csn2 PMID:16252005
FYPO affected by mutation in ddb1 damaged DNA binding protein Ddb1 PMID:16252005
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons4029873..4029499, 4029439..4029165, 4029090..4028347, 4028305..4027314
mRNA4029873..4027314
5' UTR4029873..4029560PMID:21511999
CDS4029559..4029499, 4029439..4029165, 4029090..4028347, 4028305..4028117
3' UTR4028116..4027314PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF10602 Pfam IPR019585 26S proteasome, regulatory subunit Rpn7 77 245 2
PF01399 Pfam IPR000717 Proteasome component (PCI) domain 262 365 15
SM00088 SMART IPR000717 Proteasome component (PCI) domain 298 387 13
PTHR14145 HMMPANTHER 11 365 2
PTHR14145:SF2 HMMPANTHER 11 365 1
1.10.10.10 Gene3D IPR011991 Winged helix-turn-helix DNA-binding domain 297 371 46
1.25.40.10 Gene3D IPR011990 Tetratricopeptide-like helical domain 117 213 62
SSF48452 SuperFamily 114 213 50
SSF46785 SuperFamily 293 370 49
Coil ncoils Rabaptin coiled-coil domain 89 113 968

View domain organization at Pfam

Protein Properties

Ave. residue weight 115.30 Da
Charge -12.50
Isoelectric point 4.79
Molecular weight 48.66 kDa
Number of residues 422
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS367 1672
Annotation ExtensionEvidenceResidueReference
experimental evidence S367 PMID:24763107
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7686during GO:0000080PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
8321during GO:0000084PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
8458during GO:0000085PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
8281during GO:0000087PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
7451during GO:0072690PECO:0000126,
PECO:0000005
single cellmass spectrometry evidencePMID:24763107
834.11during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.2during GO:0072690PECO:0000005,
PECO:0000014
population wideexperimental evidencePMID:23101633
0.44during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog598
predominantly single copy (one to one)3092
conserved in fungi4604
conserved in eukaryotes4516
conserved in metazoa3430
conserved in vertebrates3405
conserved in eukaryotes only2502
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
affinity capturescdt2WD repeat protein Cdt2 Affinity Capture-WesternPMID:16252005
affinity captured bycdt2WD repeat protein Cdt2 Affinity Capture-MSPMID:16252005
affinity capturescsn2COP9/signalosome complex subunit Csn2 Affinity Capture-WesternPMID:11854407
affinity captured bycsn2COP9/signalosome complex subunit Csn2 Affinity Capture-WesternPMID:11854407
affinity captured bycsn2COP9/signalosome complex subunit Csn2 Affinity Capture-WesternPMID:11337588
affinity captured bycul1cullin 1 Affinity Capture-MSPMID:23535663
affinity captured bycul1cullin 1 Affinity Capture-WesternPMID:12183637
modifiescul3cullin 3 Biochemical ActivityPMID:11504566
affinity capturesddb1damaged DNA binding protein Ddb1 Affinity Capture-WesternPMID:16252005
affinity captured byubp12CSN-associated deubiquitinating enzyme Ubp12 Affinity Capture-WesternPMID:12718879
Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
negative genetic interaction withair1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:18818364
negative genetic interaction withalg9mannosyltransferase complex subunit Alg9 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
negative genetic interaction withamk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
negative genetic interaction withapq12nuclear membrane organization protein Apq12 (predicted) Negative GeneticPMID:22681890
negative genetic interaction witharb1argonaute inhibitor protein 1 Negative GeneticPMID:22681890
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:18818364
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:22681890
negative genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
positive genetic interaction withath1ataxin-2 homolog Positive GeneticPMID:22681890
positive genetic interaction withatp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withatp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withbdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:18818364
negative genetic interaction withbio2biotin synthase Negative GeneticPMID:22681890
negative genetic interaction withbrc1BRCT domain protein Brc1 Negative GeneticPMID:22681890
positive genetic interaction withcaf4CCR4-Not complex subunit Caf4/Mdv1 (predicted) Positive GeneticPMID:18818364
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcds1replication checkpoint kinase Cds1 Negative GeneticPMID:18818364
synthetic growth defect withchk1Chk1 protein kinase Synthetic Growth DefectPMID:18931302
positive genetic interaction withchp1chromodomain protein Chp1 Positive GeneticPMID:22681890
negative genetic interaction withcid12poly(A) polymerase Cid12 Negative GeneticPMID:18818364
positive genetic interaction withcid12poly(A) polymerase Cid12 Positive GeneticPMID:22681890
negative genetic interaction withclr2chromatin silencing protein Clr2 Negative GeneticPMID:22681890
synthetic growth defect withclr3histone deacetylase (class II) Clr3 Synthetic Growth DefectPMID:18931302
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:18818364
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:22681890
positive genetic interaction withcoq5C-methyltransferase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:18818364
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withcph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
synthetic growth defect withctf18RFC-like complex subunit Ctf18 Synthetic Growth DefectPMID:18931302
negative genetic interaction withctf18RFC-like complex subunit Ctf18 Negative GeneticPMID:18818364
negative genetic interaction withctp1CtIP-related endonuclease Negative GeneticPMID:22681890
negative genetic interaction withdad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
negative genetic interaction withdad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
negative genetic interaction withdbl8tRNA-splicing endonuclease positive effector Dbl8 Negative GeneticPMID:18818364
negative genetic interaction withdcc1Ctf18 RFC-like complex subunit Dcc1 Negative GeneticPMID:22681890
positive genetic interaction withddb1damaged DNA binding protein Ddb1 Positive GeneticPMID:25274039
negative genetic interaction withdni2tetraspan protein Dni2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withdsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:22681890
negative genetic interaction withebs1EST1 family nonsense-mediated mRNA decay (NMD) pathway protein Ebs1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withebs1EST1 family nonsense-mediated mRNA decay (NMD) pathway protein Ebs1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction witheif21translation initiation factor eIF2A (predicted) Negative GeneticPMID:18818364
negative genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
rescued byepe1Jmjc domain chromatin associated protein Epe1 Phenotypic SuppressionPMID:25274039
negative genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:22681890
negative genetic interaction witherd1Erd1 homolog (predicted) Negative GeneticPMID:22681890
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:22681890
negative genetic interaction withfml1ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1 Negative GeneticPMID:18818364
positive genetic interaction withfsc1fasciclin domain protein Fsc1 Positive GeneticPMID:22681890
negative genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
negative genetic interaction withgmh5alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withhap2HMG box protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withhat1histone acetyltransferase Hat1 Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:18818364
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
negative genetic interaction withhmo1HMG box protein Hmo1 Negative GeneticPMID:18818364
positive genetic interaction withhmt2sulfide-quinone oxidoreductase Positive GeneticPMID:22681890
negative genetic interaction withhob3BAR adaptor protein Hob3 Negative GeneticPMID:22681890
negative genetic interaction withhrp1ATP-dependent DNA helicase Hrp1 Negative GeneticPMID:18818364
negative genetic interaction withhrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withhta1histone H2A alpha Negative GeneticPMID:22681890
synthetic growth defect withhus1checkpoint clamp complex protein Hus1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withhus1checkpoint clamp complex protein Hus1 Negative GeneticPMID:18818364
negative genetic interaction withidp1isocitrate dehydrogenase Idp1 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withiwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withjmj2histone demethylase Jmj2 Positive GeneticPMID:18818364
negative genetic interaction withklp6kinesin-like protein Klp6 Negative GeneticPMID:18818364
negative genetic interaction withklp6kinesin-like protein Klp6 Negative GeneticPMID:22681890
negative genetic interaction withlaf1clr6 L associated factor 1 Laf1 Negative GeneticPMID:18818364
negative genetic interaction withlsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:18818364
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:18818364
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
negative genetic interaction withmex67mRNA export receptor, Tap, nucleoporin Mex67 Negative GeneticPMID:22681890
negative genetic interaction withmid1medial ring protein Mid1 Negative GeneticPMID:22681890
negative genetic interaction withmik1mitotic inhibitor kinase Mik1 Negative GeneticPMID:22681890
negative genetic interaction withmms1E3 ubiquitin ligase complex subunit Mms1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:22681890
negative genetic interaction withmoc3transcription factor Moc3 Negative GeneticPMID:22681890
synthetic growth defect withmph1dual specificity protein kinase Mph1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:18818364
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
synthetic growth defect withmrc1mediator of replication checkpoint 1 Synthetic Growth DefectPMID:18931302
negative genetic interaction withmre11Mre11 nuclease Negative GeneticPMID:18818364
positive genetic interaction withmrpl39mitochondrial ribosomal protein subunit L39 (predicted) Positive GeneticPMID:22681890
negative genetic interaction withmso1endocytic docking protein Mso1 Negative GeneticPMID:22681890
negative genetic interaction withmug154conserved fungal protein Negative GeneticPMID:18818364
negative genetic interaction withmug80cyclin Clg1 (predicted) Negative GeneticPMID:22681890
synthetic growth defect withmus7DNA repair protein Mus7/Mms22 Synthetic Growth DefectPMID:18931302
negative genetic interaction withngg1SAGA complex subunit Ngg1 Negative GeneticPMID:18818364
negative genetic interaction withngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
negative genetic interaction withnot2CCR4-Not complex subunit Not2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withnot3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withnot3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:22681890
synthetic growth defect withnse5Smc5-6 complex non-SMC subunit Nse5 Synthetic Growth DefectPMID:18931302
synthetic growth defect withnse6Smc5-6 complex non-SMC subunit Nse6 Synthetic Growth DefectPMID:18931302
negative genetic interaction withnse6Smc5-6 complex non-SMC subunit Nse6 Negative GeneticPMID:22681890
negative genetic interaction withnup132nucleoporin Nup132 Negative GeneticPMID:22681890
negative genetic interaction withnup60nucleoporin Nup60 Negative GeneticPMID:18818364
negative genetic interaction withomt24-alpha-hydroxytetrahydrobiopterin dehydratase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withpab2poly(A) binding protein Pab2 Negative GeneticPMID:18818364
positive genetic interaction withpab2poly(A) binding protein Pab2 Positive GeneticPMID:22681890
negative genetic interaction withpac2cAMP-independent regulatory protein Pac2 Negative GeneticPMID:22681890
negative genetic interaction withpdp1PWWP domain protein Pdp1 Negative GeneticPMID:18818364
negative genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
positive genetic interaction withpho24-nitrophenylphosphatase Positive GeneticPMID:18818364
positive genetic interaction withpht1histone H2A variant H2A.Z, Pht1 Positive GeneticPMID:22681890
negative genetic interaction withpmc1mediator complex subunit Pmc1 Negative GeneticPMID:18818364
negative genetic interaction withpmt3SUMO Negative GeneticPMID:22681890
negative genetic interaction withpob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
negative genetic interaction withpof2F-box protein Pof2 Negative GeneticPMID:22681890
synthetic growth defect withpof3F-box protein Pof3 Synthetic Growth DefectPMID:18931302
negative genetic interaction withpof9F-box protein Pof9 Negative GeneticPMID:22681890
negative genetic interaction withpop2F-box/WD repeat protein Pop2 Negative GeneticPMID:22681890
positive genetic interaction withppr2mitochondrial PPR repeat protein Ppr2 Positive GeneticPMID:22681890
negative genetic interaction withprw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
negative genetic interaction withprz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
positive genetic interaction withpzh1serine/threonine protein phosphatase Pzh1 Positive GeneticPMID:22681890
negative genetic interaction withrad1checkpoint clamp complex protein Rad1 Negative GeneticPMID:22681890
synthetic growth defect withrad17RFC related checkpoint protein Rad17 Synthetic Growth DefectPMID:18931302
negative genetic interaction withrad17RFC related checkpoint protein Rad17 Negative GeneticPMID:18818364
negative genetic interaction withrad17RFC related checkpoint protein Rad17 Negative GeneticPMID:22681890
synthetic growth defect withrad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Synthetic Growth DefectPMID:18931302
negative genetic interaction withrad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Negative GeneticPMID:18818364
synthetic growth defect withrad3ATR checkpoint kinase Rad3 Synthetic Growth DefectPMID:18931302
negative genetic interaction withrad3ATR checkpoint kinase Rad3 Negative GeneticPMID:22681890
synthetic growth defect withrad9checkpoint clamp complex protein Rad9 Synthetic Growth DefectPMID:18931302
negative genetic interaction withrad9checkpoint clamp complex protein Rad9 Negative GeneticPMID:18818364
negative genetic interaction withrad9checkpoint clamp complex protein Rad9 Negative GeneticPMID:22681890
negative genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:22681890
negative genetic interaction withrap1telomere binding protein Rap1 Negative GeneticPMID:22681890
negative genetic interaction withrcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Negative GeneticPMID:18818364
negative genetic interaction withrhp14XP-A family homolog Rhp14 Negative GeneticPMID:18818364
negative genetic interaction withrnh201ribonuclease H2 complex subunit Rnh201 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withrnh201ribonuclease H2 complex subunit Rnh201 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
negative genetic interaction withrpl210260S ribosomal protein L21 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrpl230160S ribosomal protein L23 Negative GeneticPMID:22681890
negative genetic interaction withrpl380160S ribosomal protein L38 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrps110240S ribosomal protein S11 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrps2340S ribosomal protein S23 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrpt419S proteasome regulatory subunit Rpt4 (predicted) Negative GeneticPMID:22681890
positive genetic interaction withrrf1mitochondrial translation termination factor Rrf1 Positive GeneticPMID:22681890
negative genetic interaction withrrg9mitochondrial genome maintenance protein Rrg9 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrtn1reticulon-like protein Rtn1 Negative GeneticPMID:22681890
negative genetic interaction withrxt2histone deacetylase complex subunit Rxt2 Negative GeneticPMID:22681890
synthetic growth defect withryh1GTPase Ryh1 Synthetic Growth DefectPMID:18931302
positive genetic interaction withsaf5splicing factor Saf5 Positive GeneticPMID:22681890
positive genetic interaction withsce3translation initiation factor (predicted) Positive GeneticPMID:22681890
positive genetic interaction withsck2serine/threonine protein kinase Sck2 Positive GeneticPMID:24463365
negative genetic interaction withscs7sphingosine hydroxylase Scs7 Negative GeneticPMID:18818364
negative genetic interaction withscs7sphingosine hydroxylase Scs7 Negative GeneticPMID:22681890
negative genetic interaction withsen1ATP-dependent 5' to 3' DNA/RNA helicase Sen1 Negative GeneticPMID:22681890
negative genetic interaction withsey1GTP binding protein Sey1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
synthetic growth defect withshk2PAK-related kinase Shk2 Synthetic Growth DefectPMID:18931302
negative genetic interaction withslx9ribosome biogenesis protein Slx9 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withsnt2Lid2 complex subunit Snt2 Negative GeneticPMID:22681890
synthetic growth defect withspa2cell polarity protein Spa2 Synthetic Growth DefectPMID:18931302
positive genetic interaction withSPAC139.01cnuclease, XP-G family (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPAC17H9.04cRNA-binding protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC1805.14Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC29E6.09Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPAC5H10.04NADPH dehydrogenase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPAC688.12cSchizosaccharomyces specific protein Positive GeneticPMID:22681890
negative genetic interaction withSPAC824.09cGTPase activating protein (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPAPB1E7.11cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC11B10.08WW domain containing conserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC13E7.07Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:18818364
negative genetic interaction withSPBC36.10mitochondrial intermembrane space protein; involved in phospholipid metabolism (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC651.04Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPBC725.01aspartate aminotransferase (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPBC839.03cneddylation protein Dcn1 (predicted) Positive GeneticPMID:18818364
negative genetic interaction withspc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
negative genetic interaction withSPCC1235.01Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPCC1259.08conserved fungal protein, DUF2457 family Negative GeneticPMID:22681890
positive genetic interaction withSPCC16C4.106-phosphogluconolactonase (predicted) Positive GeneticPMID:22681890
negative genetic interaction withSPCC18.17cproteasome assembly chaperone (predicted) Negative GeneticPMID:22681890
positive genetic interaction withSPCC285.10cSPRY domain protein Positive GeneticPMID:22681890
negative genetic interaction withSPCC70.03cproline dehydrogenase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC736.02Schizosaccharomyces specific protein Negative GeneticPMID:22681890
rescued byspd1ribonucleotide reductase (RNR) inhibitor Phenotypic SuppressionPMID:24652833
synthetically rescued byspd1ribonucleotide reductase (RNR) inhibitor Synthetic RescuePMID:24652833
rescued byspd1ribonucleotide reductase (RNR) inhibitor Phenotypic SuppressionPMID:15805471
positive genetic interaction withspd1ribonucleotide reductase (RNR) inhibitor Positive GeneticPMID:22681890
negative genetic interaction withspo20sec14 cytosolic factor family Sec14 Negative GeneticPMID:22681890
positive genetic interaction withsrb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
negative genetic interaction withsro7Lgl family protein Sro7 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withssb3DNA replication factor A subunit Ssb3 Negative GeneticPMID:22681890
negative genetic interaction withssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:18818364
positive genetic interaction withstp1protein tyrosine phosphatase Stp1 Positive GeneticPMID:18818364
positive genetic interaction withsum2G2/M transition checkpoint protein Sum2 Positive GeneticPMID:18818364
negative genetic interaction withswd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
synthetic growth defect withswi3replication fork protection complex subunit Swi3 Synthetic Growth DefectPMID:18931302
synthetic growth defect withswi6HP1 family chromodomain protein Swi6 Synthetic Growth DefectPMID:18931302
positive genetic interaction withswr1SNF2 family ATP-dependent DNA helicase Swr1 Positive GeneticPMID:18818364
positive genetic interaction withtal1transaldolase (predicted) Positive GeneticPMID:22681890
synthetic growth defect withtlg2SNARE Tlg2 (predicted) Synthetic Growth DefectPMID:18931302
positive genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
synthetic growth defect withtop1DNA topoisomerase I Synthetic Growth DefectPMID:18931302
negative genetic interaction withtop1DNA topoisomerase I Negative GeneticPMID:18818364
negative genetic interaction withtrm112protein and tRNA methyltransferase regulatory subunit Trm112 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withtsc2tuberin Negative GeneticPMID:22681890
negative genetic interaction withupf3up-frameshift suppressor 3 family protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withvht1vitamin H transmembrane transporter Vht1 Negative GeneticPMID:22681890
negative genetic interaction withvph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:18818364
negative genetic interaction withvph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withxap5xap-5-like protein Negative GeneticPMID:24957674
negative genetic interaction withyaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
negative genetic interaction withypt4GTPase Ypt4 Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC215.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC215.03c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC215.03c BioGRID Interaction Datasets
Expression Viewer SPBC215.03c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC215.03c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC215.03c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC215.03c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC215.03c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC215.03c Transcriptome Viewer (Bähler Lab)
GEO SPBC215.03c GEO profiles
PInt SPBC215.03c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC215.03c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC215.03c Fission yeast phenotypic data & analysis
Cyclebase SPBC215.03c.1 Cell Cycle Data
SPD / RIKEN23/23C05Orfeome Localization Data
UniProtKB/SwissProtO94308COP9 signalosome complex subunit 1
ModBaseO94308Database of comparative protein structure models
STRINGO94308Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596680COP9/signalosome complex subunit Csn1
RefSeq mRNANM_001022603972h- COP9/signalosome complex subunit Csn1 (csn1), mRNA
European Nucleotide ArchiveAAG29548.1ENA Protein Mapping
European Nucleotide ArchiveBAA87087.1ENA Protein Mapping
European Nucleotide ArchiveCAA22117.1ENA Protein Mapping
UniParcUPI000006B11EUniProt Archive

Literature for csn1

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Release Version: PomBase:26_51 - 07 Apr 2015