csn1 (SPBC215.03c)

Gene Standard Namecsn1 ChromosomeII
Systematic IDSPBC215.03c Gene Start4029873
Synonyms Gene End4027314
ProductCOP9/signalosome complex subunit Csn1 Gene Length2560
Feature Typeprotein coding CDS Start4029559
Name Description CDS End4028117
Characterisation Statuspublished CDS Length1443

Ensembl Gene Location
  1. isa2
  2. vma7
  3. mge1
  4. SPBC215.01
  5. csn1
  6. bob1
  7. git11
  8. SPBTRNAASN.03
  9. SPNCRNA.435
  10. SPNCRNA.436
  11. SPNCRNA.1657
  12. gpd1
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000091sensitive to thiabendazolecompetitive growth assay evidencecsn1delta (deletion)deletionPMID:20537132
FYPO:0000266sensitive to DNA damaging agentscompetitive growth assay evidencecsn1delta (deletion)deletionPMID:20537132
FYPO:0000268sensitive to UVcompetitive growth assay evidencecsn1delta (deletion)deletionPMID:20537132
FYPO:0000269sensitive to microtubule depolymerizing drugscompetitive growth assay evidencecsn1delta (deletion)deletionPMID:20537132
FYPO:0001122elongated vegetative cellcsn1delta (deletion)deletionPMID:11504566
FYPO:0001491viable vegetative cellMicroscopycsn1delta (deletion)deletionPMID:20473289
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006974response to DNA damage stimulusIMPPMID:11854407
GO:0010388cullin deneddylationNASGO_REF:0000001
GO:0030163protein catabolic processIGIspd1PMID:12695334
GO:0051445regulation of meiotic cell cycleIMPPMID:15805471
GO:0060625regulation of protein deneddylationIMPcul1PMID:11504566
GO:0090329regulation of DNA-dependent DNA replicationIMPPMID:11854407
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
GO:0005829cytosolIDAPMID:16823372
GO:0008180signalosomeIEAUniProtKB:KW-0736GO_REF:0000037
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
140298734029499
240294394029165
340290904028347
440283054027314

References

Region Start End Reference
three_prime_UTR40281164027314PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF10602 IPR019585 Pfam 26S proteasome, regulatory subunit Rpn7 77 245 2
PF01399 IPR000717 Pfam Proteasome component (PCI) domain 262 365 15
SM00088 IPR000717 SMART Proteasome component (PCI) domain 298 387 13
G3DSA:1.10.10.10 IPR011991 Gene3D 297 371 43
SSF48452 SuperFamily 114 213 50
SSF46785 SuperFamily 293 370 49
Coil ncoils Rabaptin coiled-coil domain 89 113 974
PTHR14145 hmmpanther 8 376 2
PTHR14145:SF2 hmmpanther 8 376 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 115.30 Da
Charge -12.50
Isoelectric point 4.79
Molecular weight 48.66 kDa
Number of residues 422
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide834.11PMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.44PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide1.2PMID:23101633
Species Distribution
DescriptionQualifierReference
no apparent S. cerevisiae ortholog
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPAC1610.01conserved eukaryotic protein Positive GeneticPMID:22681890
SPAC688.12csequence orphan Positive GeneticPMID:22681890
SPAC637.06alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:22681890
prz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
rrg9mitochondrial genome maintenance protein Rrg9 (predicted) Negative GeneticPMID:22681890
rtn1reticulon-like protein Rtn1 Negative GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
SPBC11B10.08WW domain containing conserved fungal protein Negative GeneticPMID:22681890
SPAC222.14cGTP binding protein Sey1 (predicted) Negative GeneticPMID:22681890
hmt2sulfide-quinone oxidoreductase Positive GeneticPMID:22681890
rap1telomere binding protein Rap1 Negative GeneticPMID:22681890
mus7DNA repair protein Mus7/Mms22 Synthetic Growth DefectPMID:18931302
mug154conserved fungal protein Negative GeneticPMID:18818364
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
clr3histone deacetylase (class II) Clr3 Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
atp11F1-ATPase chaperone Atp11 (predicted) Positive GeneticPMID:22681890
Positive GeneticPMID:18818364
idp1isocitrate dehydrogenase Idp1 (predicted) Negative GeneticPMID:22681890
rrf1mitochondrial translation termination factor Rrf1 Positive GeneticPMID:22681890
rps2340S ribosomal protein S23 (predicted) Negative GeneticPMID:22681890
hta1histone H2A alpha Negative GeneticPMID:22681890
rpl210260S ribosomal protein L21 (predicted) Negative GeneticPMID:22681890
ase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
pof3F-box protein Pof3 Synthetic Growth DefectPMID:18931302
erd1Erd1 homolog (predicted) Negative GeneticPMID:22681890
rhp14XP-A family homolog Rhp14 Negative GeneticPMID:18818364
ask1DASH complex subunit Ask1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
dad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
SPAC1F3.03Lgl family protein (predicted) Negative GeneticPMID:22681890
mrc1mediator of replication checkpoint 1 Synthetic Growth DefectPMID:18931302
amk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
ngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
rcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Negative GeneticPMID:18818364
cph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
caf4CCR4-Not complex subunit Caf4/Mdv1 (predicted) Positive GeneticPMID:18818364
pzh1serine/threonine protein phosphatase Pzh1 Positive GeneticPMID:22681890
brc1BRCT domain protein Brc1 Negative GeneticPMID:22681890
SPAC139.01cnuclease, XP-G family (predicted) Positive GeneticPMID:22681890
swd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
nup132nucleoporin Nup132 Negative GeneticPMID:22681890
rad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:18818364
pob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
srb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
SPCC1259.08conserved fungal protein, DUF2457 family Negative GeneticPMID:22681890
arb1argonaute binding protein 1 Negative GeneticPMID:22681890
tlg2SNARE Tlg2 (predicted) Synthetic Growth DefectPMID:18931302
dad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
ctf18RFC-like complex subunit Ctf18 Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:18818364
SPBC651.04sequence orphan Negative GeneticPMID:22681890
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
spo20sec14 cytosolic factor family Sec14 Negative GeneticPMID:22681890
SPBC13E7.07sequence orphan Negative GeneticPMID:22681890
epe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
pho24-nitrophenylphosphatase Positive GeneticPMID:18818364
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
pof2F-box protein Pof2 Negative GeneticPMID:22681890
nup60nucleoporin Nup60 Negative GeneticPMID:18818364
bio2biotin synthase Negative GeneticPMID:22681890
hus1checkpoint clamp complex protein Hus1 Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:18818364
tom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
fml1ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1 Negative GeneticPMID:18818364
ypt4GTPase Ypt4 Negative GeneticPMID:22681890
not2CCR4-Not complex subunit Not2 (predicted) Negative GeneticPMID:18818364
SPAC29E6.09sequence orphan Negative GeneticPMID:22681890
top1DNA topoisomerase I Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:18818364
SPCC736.02sequence orphan Negative GeneticPMID:22681890
SPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:18818364
SPCC70.03cproline dehydrogenase (predicted) Negative GeneticPMID:22681890
nse6Smc5-6 complex non-SMC subunit Nse6 Negative GeneticPMID:22681890
Synthetic Growth DefectPMID:18931302
raf1Rik1-associated factor Raf1 Negative GeneticPMID:22681890
SPBC4B4.04translation initiation factor eIF2A (predicted) Negative GeneticPMID:18818364
SPBC21B10.03cataxin-2 homolog (predicted) Positive GeneticPMID:22681890
SPAC1805.14sequence orphan Negative GeneticPMID:22681890
mug80cyclin Clg1 (predicted) Negative GeneticPMID:22681890
rad9checkpoint clamp complex protein Rad9 Negative GeneticPMID:22681890
Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:18818364
not3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
spc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
alg9mannosyltransferase complex subunit Alg9 (predicted) Negative GeneticPMID:22681890
cds1replication checkpoint kinase Cds1 Negative GeneticPMID:18818364
SPAC5H10.04NADPH dehydrogenase (predicted) Negative GeneticPMID:22681890
pht1histone H2A variant H2A.Z, Pht1 Positive GeneticPMID:22681890
rad3ATR checkpoint kinase Rad3 Negative GeneticPMID:22681890
Synthetic Growth DefectPMID:18931302
upf3up-frameshift suppressor 3 family protein (predicted) Negative GeneticPMID:22681890
SPBC29A10.10ctRNA-splicing endonuclease positive effector (predicted) Negative GeneticPMID:18818364
SPCC16C4.106-phosphogluconolactonase (predicted) Positive GeneticPMID:22681890
pmt3SUMO Negative GeneticPMID:22681890
pof9F-box protein Pof9 Negative GeneticPMID:22681890
omt24-alpha-hydroxytetrahydrobiopterin dehydratase (predicted) Negative GeneticPMID:22681890
SPCC285.10cSPRY domain protein Positive GeneticPMID:22681890
dsc4Golgi Dsc E3 ligase complex subunit Dsc3 Negative GeneticPMID:22681890
laf1clr6 L associated factor 1 Laf1 Negative GeneticPMID:18818364
swi6HP1 family chromodomain protein Swi6 Synthetic Growth DefectPMID:18931302
ssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:18818364
SPBC28F2.11HMG box protein Negative GeneticPMID:18818364
SPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Positive GeneticPMID:22681890
sce3translation initiation factor (predicted) Positive GeneticPMID:22681890
ssb3DNA replication factor A subunit Ssb3 Negative GeneticPMID:22681890
rad17RFC related checkpoint protein Rad17 Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
iwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:18818364
mid1medial ring protein Mid1 Negative GeneticPMID:22681890
spd1ribonucleotide reductase (RNR) inhibitor Phenotypic SuppressionPMID:15805471
Positive GeneticPMID:22681890
hob3BAR adaptor protein Hob3 Negative GeneticPMID:22681890
dcc1Ctf18 RFC-like complex subunit Dcc1 Negative GeneticPMID:22681890
mph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
Synthetic Growth DefectPMID:18931302
Negative GeneticPMID:18818364
tal1transaldolase (predicted) Positive GeneticPMID:22681890
apq12nuclear membrane organization protein Apq12 (predicted) Negative GeneticPMID:22681890
ctp1CtIP-related endonuclease Negative GeneticPMID:22681890
SPCC16C4.20cHMG box protein (predicted) Negative GeneticPMID:22681890
dad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
mrpl39mitochondrial ribosomal protein subunit L39 (predicted) Positive GeneticPMID:22681890
SPAC3G9.05GTPase activating protein (predicted) Synthetic Growth DefectPMID:18931302
moc3transcription factor Moc3 Negative GeneticPMID:22681890
rpl380160S ribosomal protein L38 (predicted) Negative GeneticPMID:22681890
rpl230160S ribosomal protein L23 Negative GeneticPMID:22681890
swr1SNF2 family helicase Swr1 Positive GeneticPMID:18818364
pop2F-box/WD repeat protein Pop2 Negative GeneticPMID:22681890
bdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:18818364
coq5C-methyltransferase (predicted) Positive GeneticPMID:22681890
pmc1mediator complex subunit Pmc1 Negative GeneticPMID:18818364
SPCC1235.01sequence orphan Negative GeneticPMID:22681890
slx9ribosome biogenesis protein Slx9 (predicted) Negative GeneticPMID:18818364
chp1chromodomain protein Chp1 Positive GeneticPMID:22681890
dni2tetraspan protein Dni2 (predicted) Negative GeneticPMID:22681890
ppr2mitochondrial PPR repeat protein Ppr2 Positive GeneticPMID:22681890
rps110240S ribosomal protein S11 (predicted) Negative GeneticPMID:22681890
hat1histone acetyltransferase Hat1 Negative GeneticPMID:22681890
sen1ATP-dependent 5' to 3' DNA/RNA helicase Sen1 Negative GeneticPMID:22681890
rxt2histone deacetylase complex subunit Rxt2 Negative GeneticPMID:22681890
clr2chromatin silencing protein Clr2 Negative GeneticPMID:22681890
SPBC839.03cneddylation protein Dcn1 (predicted) Positive GeneticPMID:18818364
pef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
hrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:22681890
mik1mitotic inhibitor kinase Mik1 Negative GeneticPMID:22681890
vht1vitamin H transporter Vth1 Negative GeneticPMID:22681890
swi3replication fork protection complex subunit Swi3 Synthetic Growth DefectPMID:18931302
air1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:18818364
alp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
tsc2tuberin Negative GeneticPMID:22681890
trm112protein and tRNA methyltransferase regulatory subunit Trm112 (predicted) Negative GeneticPMID:22681890
mex67mRNA export receptor, Tap, nucleoporin Mex67 Negative GeneticPMID:22681890
SPAC824.09cGTPase activating protein (predicted) Negative GeneticPMID:22681890
pdp1PWWP domain protein Pdp1 Negative GeneticPMID:18818364
fft3fun thirty related protein Fft3 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
cph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPAC1F5.05cconserved eukaryotic protein Negative GeneticPMID:22681890
SPAC22H12.05cfasciclin domain protein Positive GeneticPMID:22681890
pac2cAMP-independent regulatory protein Pac2 Negative GeneticPMID:22681890
SPAC17H9.04cRNA-binding protein Negative GeneticPMID:22681890
cid12poly(A) polymerase Cid12 Positive GeneticPMID:22681890
Negative GeneticPMID:18818364
ccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:22681890
chk1Chk1 protein kinase Synthetic Growth DefectPMID:18931302
scs7sphingosine hydroxylase Scs7 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
klp6kinesin-like protein Klp6 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPBC725.01aspartate aminotransferase (predicted) Negative GeneticPMID:22681890
mre11Mre11 nuclease Negative GeneticPMID:18818364
jmj2histone demethylase Jmj2 Positive GeneticPMID:18818364
snt2Lid2 complex subunit Snt2 Negative GeneticPMID:22681890
sum2G2/M transition checkpoint protein Sum2 Positive GeneticPMID:18818364
ebs1EST1 family nonsense-mediated mRNA decay (NMD) pathway protein Ebs1 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
rad1checkpoint clamp complex protein Rad1 Negative GeneticPMID:22681890
sgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
ryh1GTPase Ryh1 Synthetic Growth DefectPMID:18931302
shk2PAK-related kinase Shk2 Synthetic Growth DefectPMID:18931302
mms1E3 ubiquitin ligase complex subunit Mms1 (predicted) Negative GeneticPMID:22681890
mms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:22681890
SPBC36.10mitochondrial intermembrane space protein sorting protein (predicted) Negative GeneticPMID:22681890
SPAPB1E7.11csequence orphan Negative GeneticPMID:22681890
lsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:18818364
rpt419S proteasome regulatory subunit Rpt4 (predicted) Negative GeneticPMID:22681890
stp1protein tyrosine phosphatase Stp1 Positive GeneticPMID:18818364
arp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
SPCC18.17c26S proteasome non-ATPase regulatory subunit (predicted) Negative GeneticPMID:22681890
pab2poly(A) binding protein Pab2 Positive GeneticPMID:22681890
Negative GeneticPMID:18818364
yaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
rnh201ribonuclease H2 complex subunit Rnh201 (predicted) Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
nse5Smc5-6 complex non-SMC subunit Nse5 Synthetic Growth DefectPMID:18931302
hip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
Negative GeneticPMID:18818364
hrp1ATP-dependent DNA helicase Hrp1 Negative GeneticPMID:18818364
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
ddb1damaged DNA binding protein Ddb1 Affinity Capture-WesternPMID:16252005
cdt2WD repeat protein Cdt2 Affinity Capture-WesternPMID:16252005
Affinity Capture-MS
csn2COP9/signalosome complex subunit Csn2 Affinity Capture-WesternPMID:11854407
ubp12CSN-associated deubiquitinating enzyme Ubp12 Affinity Capture-WesternPMID:12718879
cul3cullin 3 Biochemical ActivityPMID:11504566
cul1cullin 1 Affinity Capture-WesternPMID:12183637
Contact Curators
External References
Database Identifier Description
NBRP SPBC215.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC215.03c Retrieval of eukaryotic orthologs
BioGrid SPBC215.03c BioGRID Interaction Datasets
Bähler Lab SPBC215.03c Cell Cycle Expression Profile
Bähler Lab SPBC215.03c Meiosis/Sporulation Expression Profies
Bähler Lab SPBC215.03c Pheromone response/mating expression profiles
Bähler Lab SPBC215.03c Environmental stress expression profiles
Bähler Lab SPBC215.03c Bähler Lab Transcriptome Viewer
Cyclebase SPBC215.03c Cell Cycle Data
PInt SPBC215.03c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC215.03c Entrez Gene
SPD / RIKEN23/23C05Orfeome Localization Data
EntrezGene2540352COP9/signalosome complex subunit Csn1
Uniprot_genenameCSN1
WikiGene2540352COP9/signalosome complex subunit Csn1
UniProtKB/SwissProtO94308COP9 signalosome complex subunit 1
ModBaseO94308Database of comparative protein structure models
Pfam Protein DomainsO94308Pfam Domain Arrangement
RefSeq PeptideNP_596680COP9/signalosome complex subunit Csn1
RefSeq mRNANM_001022603972h- COP9/signalosome complex subunit Csn1 (csn1), mRNA
European Nucleotide ArchiveAAG29548ENA Protein Mapping
European Nucleotide ArchiveBAA87087ENA Protein Mapping
European Nucleotide ArchiveCAA22117ENA Protein Mapping
SPD / RIKEN23/23C05Orfeome Localization Data

Literature for csn1
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Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013