csn1 (SPBC215.03c)


Gene Standard Namecsn1 Characterisation Statuspublished
Systematic IDSPBC215.03c Feature Typeprotein coding
Synonyms Name Description
ProductCOP9/signalosome complex subunit Csn1 Product Size422aa, 48.66 kDa
Genomic Location Chromosome II, 4029873-4027314 (2560nt); CDS:4029559-4028117 (1443nt)

Ensembl Gene Location
GO Biological Process
Term NameCount
cellular response to DNA damage stimulus209
Annotation ExtensionEvidenceWith/FromReference
cullin deneddylation6
Annotation ExtensionEvidenceWith/FromReference
protein catabolic process208
Annotation ExtensionEvidenceWith/FromReference
regulation of chromatin silencing at centromere6
Annotation ExtensionEvidenceWith/FromReference
regulation of chromatin silencing at silent mating-type cassette6
Annotation ExtensionEvidenceWith/FromReference
regulation of protein deneddylation1
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
COP9 signalosome8
Annotation ExtensionEvidenceWith/FromReference
cytosol2306
Annotation ExtensionEvidenceWith/FromReference
nucleus2692
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
decreased mating efficiencycsn1Δ272
normal growth on methyl methanesulfonatecsn1Δ36
normal growth on sodium butyratecsn1Δ55
normal growth on trichostatin Acsn1Δ114
resistance to hydrogen peroxidecsn1Δ75
sensitive to 4-nitroquinoline N-oxidecsn1Δ159
sensitive to 5-fluorouracilcsn1Δ273
sensitive to bortezomibcsn1Δ255
sensitive to caffeine during vegetative growthcsn1Δ110
sensitive to camptothecincsn1Δ228
sensitive to doxorubicincsn1Δ95
sensitive to hydroxyureacsn1Δ548
sensitive to tacrolimuscsn1Δ81
sensitive to thiabendazolecsn1Δ264
sensitive to UV during vegetative growthcsn1Δ150
sensitive to valproic acidcsn1Δ155
viable vegetative cell populationcsn1Δ3837

Cell Phenotype

Term NameGenotypesCount
abnormal horsetail nucleus morphologycsn1-E46 (Q9->stop)7
csn1Δ
abnormal microtubule cytoskeleton morphology during mitotic interphasecsn1Δ186
abnormal mitotic cell cyclecsn1Δ858
abnormal premeiotic DNA replicationcsn1Δ24
abnormal prospore membrane formationcsn1Δ30
abolished sporulationcsn1Δ54
decreased chromatin silencing at centromere outer repeatcsn1Δ45
decreased chromatin silencing at silent mating-type cassettecsn1Δ25
decreased histone H3-K9 methylation at centromere outer repeatcsn1Δ21
decreased histone H3-K9 methylation at mating-type region heterochromatincsn1Δ6
decreased protein secretion14
affects localization of pho1csn1Δ
elongated vegetative cellcsn1Δ791
increased centromeric outer repeat transcript-derived siRNA levelcsn1Δ4
increased duration of horsetail movementcsn1-E46 (Q9->stop)4
csn1Δ
increased protein level during vegetative growth102
affecting cdt2csn1Δ
normal protein binding73
affecting ddb1 and cdt2csn1Δ
normal protein degradation during vegetative growth25
affecting cdt2csn1Δ
normal protein localization to nucleus76
affecting cdt2csn1Δ
viable elongated vegetative cellcsn1Δ317
viable vegetative cell with abnormal cell shapecsn1Δ699

FYPO Multi-allele Phenotypes

Population Phenotype

Term NameGenotypes
decreased mating efficiencycds1Δ, csn1Δ
inviable cell populationmik1Δ, wee1-50, csn1Δ
sensitive to doxorubicintop2-191, csn1Δ

Cell Phenotype

Term NameGenotypes
abolished meiosiscsn1Δ, mei4+
decreased duration of horsetail movementcsn1Δ, mei4+
Target Of
OntologyRelationshipGeneProduct
FYPO affected by mutation in csn2 COP9/signalosome complex subunit Csn2
FYPO affected by mutation in ddb1 damaged DNA binding protein Ddb1
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons4029873..4029499, 4029439..4029165, 4029090..4028347, 4028305..4027314
Intron4029498..4029440, 4029164..4029091, 4028346..4028306
5' UTR4029873..4029560PMID:21511999
3' UTR4028116..4027314PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF10602 Pfam IPR019585 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 77 246 2
PF01399 Pfam IPR000717 Proteasome component (PCI) domain 263 365 14
SM00088 SMART IPR000717 Proteasome component (PCI) domain 298 387 13
PTHR14145:SF2 HMMPANTHER IPR033008 COP9 signalosome complex subunit 1 8 422 1
PTHR14145 HMMPANTHER 8 422 2
1.25.40.10 Gene3D IPR011990 Tetratricopeptide-like helical domain 117 213 62
1.10.10.10 Gene3D IPR011991 Winged helix-turn-helix DNA-binding domain 297 371 46
SSF46785 SuperFamily IPR011991 Winged helix-turn-helix DNA-binding domain 293 370 49
SSF48452 SuperFamily IPR011990 Tetratricopeptide-like helical domain 114 213 50
Coil ncoils Predicted coiled-coil protein (DUF2205) 89 112 1057

View domain organization at Pfam

Protein Properties

Ave. residue weight 115.30 Da
Charge -12.50
Codon Adaptation Index 0.41
Isoelectric point 4.79
Molecular weight 48.66 kDa
Number of residues 422
Modifications

Protein Modifications

Term NameResidueCount
O-phospho-L-serineS367 1676
Annotation ExtensionEvidenceResidueReference
experimental evidence S367 PMID:24763107
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for csn1 (SPBC215.03c)

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
7686during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
8321during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
8458during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
8281during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
834.11during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
7451during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.2during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
0.44during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
no apparent S. cerevisiae ortholog601
predominantly single copy (one to one)3092
conserved in fungi4605
conserved in eukaryotes4515
conserved in metazoa3424
conserved in vertebrates3399
conserved in eukaryotes only2505
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Physical Interactions

Source: BioGRID

Load genes that interact physically with SPBC215.03c into the Query Builder
View all interactions in esyN
View the HCPIN interactions in esyN

Gene Product Evidence Reference
modifiescul3cullin 3 Biochemical ActivityPMID:11504566
affinity capturescdt2WD repeat protein Cdt2 Affinity Capture-WesternPMID:16252005
affinity capturesddb1damaged DNA binding protein Ddb1 Affinity Capture-WesternPMID:16252005
affinity capturescsn2COP9/signalosome complex subunit Csn2 Affinity Capture-WesternPMID:11854407
affinity captured bycdt2WD repeat protein Cdt2 Affinity Capture-MSPMID:16252005
affinity captured bycul1cullin 1 Affinity Capture-WesternPMID:12183637
affinity captured bycsn2COP9/signalosome complex subunit Csn2 Affinity Capture-WesternPMID:11337588
affinity captured byubp12CSN-associated deubiquitinating enzyme Ubp12 Affinity Capture-WesternPMID:12718879
Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC215.03c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withSPCC285.10cSPRY domain protein Positive GeneticPMID:22681890
positive genetic interaction withSPCC16C4.106-phosphogluconolactonase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withstp1protein tyrosine phosphatase Stp1 Positive GeneticPMID:18818364
positive genetic interaction withsrb10cyclin-dependent protein Srb mediator subunit kinase Srb10 Positive GeneticPMID:22681890
positive genetic interaction withppr2mitochondrial PPR repeat protein Ppr2 Positive GeneticPMID:22681890
positive genetic interaction withspd1ribonucleotide reductase (RNR) inhibitor Positive GeneticPMID:22681890
positive genetic interaction withjmj2histone demethylase Jmj2 Positive GeneticPMID:18818364
positive genetic interaction withath1ataxin-2 homolog Positive GeneticPMID:22681890
positive genetic interaction withsck2serine/threonine protein kinase Sck2 Positive GeneticPMID:24463365
positive genetic interaction withcaf4CCR4-Not complex subunit Caf4/Mdv1 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withatp11mitochondrial F1-ATPase chaperone Atp11 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withpab2poly(A) binding protein Pab2 Positive GeneticPMID:22681890
positive genetic interaction withswr1SNF2 family ATP-dependent DNA helicase Swr1 Positive GeneticPMID:18818364
positive genetic interaction withsaf5splicing factor Saf5 Positive GeneticPMID:22681890
positive genetic interaction withtom70mitochondrial TOM complex subunit Tom70 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withcid12poly(A) polymerase Cid12 Positive GeneticPMID:22681890
positive genetic interaction withmrpl39mitochondrial ribosomal protein subunit L39 (predicted) Positive GeneticPMID:22681890
positive genetic interaction withfsc1fasciclin domain protein Fsc1 Positive GeneticPMID:22681890
positive genetic interaction withhmt2sulfide-quinone oxidoreductase Positive GeneticPMID:22681890
positive genetic interaction withSPAP8A3.07cphospho-2-dehydro-3-deoxyheptonate aldolase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withSPBC839.03cneddylation protein Dcn1 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withcoq5C-methyltransferase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withpho24-nitrophenylphosphatase Positive GeneticPMID:18818364
positive genetic interaction withsce3translation initiation factor (predicted) Positive GeneticPMID:22681890
positive genetic interaction withpht1histone H2A variant H2A.Z, Pht1 Positive GeneticPMID:22681890
positive genetic interaction withiwr1RNA polymerase II nuclear import protein Iwr1 (predicted) Positive GeneticPMID:18818364
positive genetic interaction withrrf1mitochondrial translation termination factor Rrf1 Positive GeneticPMID:22681890
positive genetic interaction withtal1transaldolase (predicted) Positive GeneticPMID:22681890
positive genetic interaction withath2Ath1 complex protein Ath2 nuclease, XP-G family (predicted) Positive GeneticPMID:22681890
positive genetic interaction withsum2translation initiation inhibitor (predicted) Positive GeneticPMID:18818364
positive genetic interaction withSPAC688.12cSchizosaccharomyces specific protein Positive GeneticPMID:22681890
positive genetic interaction withchp1chromodomain protein Chp1 Positive GeneticPMID:22681890
positive genetic interaction withpzh1serine/threonine protein phosphatase Pzh1 Positive GeneticPMID:22681890
positive genetic interaction withddb1damaged DNA binding protein Ddb1 Positive GeneticPMID:25274039
negative genetic interaction withhap2HMG box protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withpef1Pho85/PhoA-like cyclin-dependent kinase Pef1 Negative GeneticPMID:22681890
negative genetic interaction withsen1ATP-dependent 5' to 3' DNA/RNA helicase Sen1 Negative GeneticPMID:22681890
negative genetic interaction withase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
negative genetic interaction witharp8actin-like protein, Ino80 complex subunit Arp8 Negative GeneticPMID:22681890
negative genetic interaction withrad17RFC related checkpoint protein Rad17 Negative GeneticPMID:18818364
negative genetic interaction withhus1checkpoint clamp complex protein Hus1 Negative GeneticPMID:18818364
negative genetic interaction witharb1argonaute inhibitor protein 1 Negative GeneticPMID:22681890
negative genetic interaction withidp1isocitrate dehydrogenase Idp1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withvph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsnt2Lid2 complex subunit Snt2 Negative GeneticPMID:22681890
negative genetic interaction withamk2AMP-activated protein kinase beta subunit Amk2 Negative GeneticPMID:18818364
negative genetic interaction withmre11Mre11 nuclease Negative GeneticPMID:18818364
negative genetic interaction withebs1EST1 family nonsense-mediated mRNA decay (NMD) pathway protein Ebs1 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withmug154conserved fungal protein Negative GeneticPMID:18818364
negative genetic interaction withscs7sphingosine hydroxylase Scs7 Negative GeneticPMID:22681890
negative genetic interaction withmph1dual specificity protein kinase Mph1 Negative GeneticPMID:22681890
negative genetic interaction withxap5xap-5-like protein Negative GeneticPMID:24957674
negative genetic interaction withswd2Set1C complex subunit Swd2.1 Negative GeneticPMID:18818364
negative genetic interaction withdad3DASH complex subunit Dad3 Negative GeneticPMID:22681890
negative genetic interaction withomt24-alpha-hydroxytetrahydrobiopterin dehydratase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withnrp1RNA-binding protein Negative GeneticPMID:22681890
negative genetic interaction withdad2DASH complex subunit Dad2 Negative GeneticPMID:18818364
negative genetic interaction withepe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
negative genetic interaction withclr3histone deacetylase (class II) Clr3 Negative GeneticPMID:22681890
negative genetic interaction withrad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Negative GeneticPMID:18818364
negative genetic interaction withnup60nucleoporin Nup60 Negative GeneticPMID:18818364
negative genetic interaction withsro7Lgl family protein Sro7 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
negative genetic interaction withpab2poly(A) binding protein Pab2 Negative GeneticPMID:18818364
negative genetic interaction withupf3up-frameshift suppressor 3 family protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPBC13E7.07Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withclr2chromatin silencing protein Clr2 Negative GeneticPMID:22681890
negative genetic interaction withalg9mannosyltransferase complex subunit Alg9 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcph2Clr6 histone deacetylase associated PHD protein-2 Cph2 Negative GeneticPMID:22681890
negative genetic interaction withraf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:22681890
negative genetic interaction withnse6Smc5-6 complex non-SMC subunit Nse6 Negative GeneticPMID:22681890
negative genetic interaction withcid12poly(A) polymerase Cid12 Negative GeneticPMID:18818364
negative genetic interaction withair1zinc knuckle TRAMP complex subunit Air1 Negative GeneticPMID:18818364
negative genetic interaction withSPAC824.09cGTPase activating protein (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAPB1E7.11cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withyaf9YEATS family histone acetyltransferase subunit Yaf9 Negative GeneticPMID:18818364
negative genetic interaction withhat1histone acetyltransferase Hat1 Negative GeneticPMID:22681890
negative genetic interaction withhob3BAR adaptor protein Hob3 Negative GeneticPMID:22681890
negative genetic interaction withSPAC29E6.09Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withhip4histone promoter control protein Hip4 Negative GeneticPMID:22681890
negative genetic interaction withrpl230160S ribosomal protein L23 Negative GeneticPMID:22681890
negative genetic interaction withdni2tetraspan protein implicated in mating Dni2 (predicted) Negative GeneticPMID:22681890
negative genetic interaction witharp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
negative genetic interaction withprz1calcineurin responsive transcription factor Prz1 Negative GeneticPMID:22681890
negative genetic interaction withalp13MRG family Clr6 histone deacetylase complex subunit Alp13 Negative GeneticPMID:22681890
negative genetic interaction withask1DASH complex subunit Ask1 Negative GeneticPMID:18818364
negative genetic interaction withtop1DNA topoisomerase I Negative GeneticPMID:18818364
negative genetic interaction withhrq1RecQ type DNA helicase Hrq1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withnot3CCR4-Not complex subunit Not3/5 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPBC16H5.13WD repeat protein, human WDR7 ortholog Negative GeneticPMID:18818364
negative genetic interaction withprw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
negative genetic interaction withhmo1HMG box protein Hmo1 Negative GeneticPMID:18818364
negative genetic interaction withpob3FACT complex subunit Pob3 Negative GeneticPMID:18818364
negative genetic interaction withrpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:22681890
negative genetic interaction withngg1SAGA complex subunit Ngg1 Negative GeneticPMID:22681890
negative genetic interaction withrnh201ribonuclease H2 complex subunit Rnh201 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcph1Clr6 histone deacetylase associated PHD protein-1 Cph1 Negative GeneticPMID:22681890
negative genetic interaction withfml1ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1 Negative GeneticPMID:18818364
negative genetic interaction withhta1histone H2A alpha Negative GeneticPMID:22681890
negative genetic interaction withtrm112protein and tRNA methyltransferase regulatory subunit Trm112 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withpmt3SUMO Negative GeneticPMID:22681890
negative genetic interaction withpdp1PWWP domain protein Pdp1 Negative GeneticPMID:18818364
negative genetic interaction withnot2CCR4-Not complex subunit Not2 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withmid1medial ring protein Mid1 Negative GeneticPMID:22681890
negative genetic interaction withpop2F-box/WD repeat protein Pop2 Negative GeneticPMID:22681890
negative genetic interaction withSPCC1259.08conserved fungal protein, DUF2457 family Negative GeneticPMID:22681890
negative genetic interaction withbrc1BRCT domain protein Brc1 Negative GeneticPMID:22681890
negative genetic interaction withfft3SMARCAD1 family ATP-dependent DNA helicase Fft3 Negative GeneticPMID:18818364
negative genetic interaction withrps110240S ribosomal protein S11 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withspc19DASH complex subunit Spc19 Negative GeneticPMID:22681890
negative genetic interaction withvht1vitamin H transmembrane transporter Vht1 Negative GeneticPMID:22681890
negative genetic interaction withrad1checkpoint clamp complex protein Rad1 Negative GeneticPMID:22681890
negative genetic interaction withrhp14XP-A family homolog Rhp14 Negative GeneticPMID:18818364
negative genetic interaction withmms19Dos2 silencing complex subunit Mms19 Negative GeneticPMID:22681890
negative genetic interaction withrps2340S ribosomal protein S23 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withlaf1Clr6 L associated factor 1 Laf1 Negative GeneticPMID:18818364
negative genetic interaction withgcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Negative GeneticPMID:18818364
negative genetic interaction withSPCC736.02Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withssb3DNA replication factor A subunit Ssb3 Negative GeneticPMID:22681890
negative genetic interaction withhrp1ATP-dependent DNA helicase Hrp1 Negative GeneticPMID:18818364
negative genetic interaction withctp1CtIP-related endonuclease Negative GeneticPMID:22681890
negative genetic interaction withrtn1reticulon-like protein Rtn1 Negative GeneticPMID:22681890
negative genetic interaction withmex67mRNA export receptor, Tap, nucleoporin Mex67 Negative GeneticPMID:22681890
negative genetic interaction withSPAC5H10.04NADPH dehydrogenase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmoc3transcription factor Moc3 Negative GeneticPMID:22681890
negative genetic interaction withSPBC11B10.08WW domain containing conserved fungal protein Negative GeneticPMID:22681890
negative genetic interaction withpof9F-box protein Pof9 Negative GeneticPMID:22681890
negative genetic interaction withrpl380160S ribosomal protein L38 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withypt4GTPase Ypt4 Negative GeneticPMID:22681890
negative genetic interaction withrpl210260S ribosomal protein L21 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withccr4CCR4-Not complex subunit Ccr4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withrad3ATR checkpoint kinase Rad3 Negative GeneticPMID:22681890
negative genetic interaction withrcd1RNA-binding protein, CCR4-NOT complex subunit Rcd1 Negative GeneticPMID:18818364
negative genetic interaction withklp6kinesin-like protein Klp6 Negative GeneticPMID:22681890
negative genetic interaction withpof2F-box protein Pof2 Negative GeneticPMID:22681890
negative genetic interaction withrrg9mitochondrial genome maintenance protein Rrg9 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withssu72phosphoric ester hydrolase Ssu72 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withSPCC70.03cproline dehydrogenase (predicted) Negative GeneticPMID:22681890
negative genetic interaction withcds1replication checkpoint kinase Cds1 Negative GeneticPMID:18818364
negative genetic interaction withgmh5alpha-1,2-galactosyltransferase (predicted) Negative GeneticPMID:22681890
negative genetic interaction witherd1Erd1 homolog (predicted) Negative GeneticPMID:22681890
negative genetic interaction withclg1cyclin Clg1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withmik1mitotic inhibitor kinase Mik1 Negative GeneticPMID:22681890
negative genetic interaction withslx9ribosome biogenesis protein Slx9 (predicted) Negative GeneticPMID:18818364
negative genetic interaction withdbl8tRNA-splicing endonuclease positive effector Dbl8 Negative GeneticPMID:18818364
negative genetic interaction withrpt419S proteasome regulatory subunit Rpt4 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withbdc1bromodomain containing protein 1, Bdc1 Negative GeneticPMID:18818364
negative genetic interaction withdcc1Ctf18 RFC-like complex subunit Dcc1 Negative GeneticPMID:22681890
negative genetic interaction withtsc2tuberin Negative GeneticPMID:22681890
negative genetic interaction withspo20sec14 cytosolic factor family, glycerophospholipid-transfer protein Spo20/Sec14 Negative GeneticPMID:22681890
negative genetic interaction withapq12nuclear membrane organization protein Apq12 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withdsc4Golgi Dsc E3 ligase complex subunit Dsc4 Negative GeneticPMID:22681890
negative genetic interaction withpac2cAMP-independent regulatory protein Pac2 Negative GeneticPMID:22681890
negative genetic interaction withmed14mediator complex subunit Med14 Negative GeneticPMID:18818364
negative genetic interaction withSPBC36.10mitochondrial intermembrane space protein; involved in phospholipid metabolism (predicted) Negative GeneticPMID:22681890
negative genetic interaction withsgf29SAGA complex subunit Sgf29 Negative GeneticPMID:18818364
negative genetic interaction withdad1DASH complex subunit Dad1 Negative GeneticPMID:22681890
negative genetic interaction withrad9checkpoint clamp complex protein Rad9 Negative GeneticPMID:18818364
negative genetic interaction withnup132nucleoporin Nup132 Negative GeneticPMID:22681890
negative genetic interaction withlsk1P-TEFb-associated cyclin-dependent protein kinase Lsk1 Negative GeneticPMID:18818364
negative genetic interaction withrxt2histone deacetylase complex subunit Rxt2 Negative GeneticPMID:22681890
negative genetic interaction withsey1GTP binding protein Sey1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPAC1805.14Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withSPCC1235.01Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withrap1telomere binding protein Rap1 Negative GeneticPMID:22681890
negative genetic interaction withSPBC651.04Schizosaccharomyces specific protein Negative GeneticPMID:22681890
negative genetic interaction withmms1E3 ubiquitin ligase complex subunit Mms1 (predicted) Negative GeneticPMID:22681890
negative genetic interaction withSPCC18.17cproteasome assembly chaperone (predicted) Negative GeneticPMID:22681890
negative genetic interaction withctf18RFC-like complex subunit Ctf18 Negative GeneticPMID:18818364
negative genetic interaction withbio2biotin synthase Negative GeneticPMID:22681890
negative genetic interaction withmso1endocytic docking protein Mso1 Negative GeneticPMID:22681890
negative genetic interaction witheif21translation initiation factor eIF2A (predicted) Negative GeneticPMID:18818364
negative genetic interaction withmaa1mitochondrial aspartate aminotransferase Maa1 (predicted) Negative GeneticPMID:22681890
rescued byepe1Jmjc domain chromatin associated protein Epe1 Phenotypic SuppressionPMID:25274039
rescued byspd1ribonucleotide reductase (RNR) inhibitor Phenotypic SuppressionPMID:15805471
synthetic growth defect withmrc1mediator of replication checkpoint 1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withryh1GTPase Ryh1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withrad17RFC related checkpoint protein Rad17 Synthetic Growth DefectPMID:18931302
synthetic growth defect withclr3histone deacetylase (class II) Clr3 Synthetic Growth DefectPMID:18931302
synthetic growth defect withrad26ATRIP, ATR checkpoint kinase regulatory subunit Rad26 Synthetic Growth DefectPMID:18931302
synthetic growth defect withnse6Smc5-6 complex non-SMC subunit Nse6 Synthetic Growth DefectPMID:18931302
synthetic growth defect withnse5Smc5-6 complex non-SMC subunit Nse5 Synthetic Growth DefectPMID:18931302
synthetic growth defect withmus7DNA repair protein Mus7/Mms22 Synthetic Growth DefectPMID:18931302
synthetic growth defect withpof3F-box protein Pof3 Synthetic Growth DefectPMID:18931302
synthetic growth defect withctf18RFC-like complex subunit Ctf18 Synthetic Growth DefectPMID:18931302
synthetic growth defect withrad3ATR checkpoint kinase Rad3 Synthetic Growth DefectPMID:18931302
synthetic growth defect withrad9checkpoint clamp complex protein Rad9 Synthetic Growth DefectPMID:18931302
synthetic growth defect withmph1dual specificity protein kinase Mph1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withchk1Chk1 protein kinase Synthetic Growth DefectPMID:18931302
synthetic growth defect withspa2cell polarity protein Spa2 Synthetic Growth DefectPMID:18931302
synthetic growth defect withtop1DNA topoisomerase I Synthetic Growth DefectPMID:18931302
synthetic growth defect withswi6HP1 family chromodomain protein Swi6 Synthetic Growth DefectPMID:18931302
synthetic growth defect withtlg2SNARE Tlg2 (predicted) Synthetic Growth DefectPMID:18931302
synthetic growth defect withswi3replication fork protection complex subunit Swi3 Synthetic Growth DefectPMID:18931302
synthetic growth defect withhus1checkpoint clamp complex protein Hus1 Synthetic Growth DefectPMID:18931302
synthetic growth defect withshk2PAK-related kinase Shk2 Synthetic Growth DefectPMID:18931302
synthetic growth defect withtop2DNA topoisomerase II Synthetic Growth DefectPMID:25669599
synthetically rescued byspd1ribonucleotide reductase (RNR) inhibitor Synthetic RescuePMID:24652833
rescued by overexpression ofmei4meiotic forkhead transcription factor Mei4 Dosage RescuePMID:25492408
External References
Database Identifier Description
NBRP SPBC215.03c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC215.03c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC215.03c BioGRID Interaction Datasets
Expression Viewer SPBC215.03c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC215.03c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC215.03c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC215.03c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC215.03c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC215.03c Transcriptome Viewer (Bähler Lab)
GEO SPBC215.03c GEO profiles
PInt SPBC215.03c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC215.03c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC215.03c Fission yeast phenotypic data & analysis
Cyclebase SPBC215.03c.1 Cell Cycle Data
SPD / RIKEN23/23C05Orfeome Localization Data
UniProtKB/SwissProtO94308COP9 signalosome complex subunit 1
ModBaseO94308Database of comparative protein structure models
STRINGO94308Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596680COP9/signalosome complex subunit Csn1
RefSeq mRNANM_001022603972h- COP9/signalosome complex subunit Csn1 (csn1), mRNA

Literature for csn1

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Release Version: PomBase:30_58 - 11 Mar 2016