SPBC21C3.09c


Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPBC21C3.09c Feature Typeprotein coding
Synonyms Name Description
Productfumarylacetoacetate hydrolase family protein (predicted) Product Size221aa, 24.17 kDa
Genomic Location Chromosome II, 3812481-3810897 (1585nt); CDS:3812188-3811374 (815nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
hydrolase activity842
Annotation ExtensionEvidenceWith/FromReference
metal ion binding747
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
tyrosine catabolic process1
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
mitochondrion758
Annotation ExtensionEvidenceWith/FromReference
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopySPBC21C3.09cΔNullPECO:0000005, PECO:0000137PMID:236978063759
MicroscopySPBC21C3.09cΔNullPMID:20473289

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001MicroscopySPBC21C3.09cΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
138124813812142
238119923810897

UTRs

Region Coordinates Reference
five_prime_UTR3812481..3812189PMID:21511999
three_prime_UTR3811373..3810897PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01557 Pfam IPR002529 Fumarylacetoacetase, C-terminal 7 200 1
PTHR11820:SF7 HMMPANTHER 2 208 1
PTHR11820 HMMPANTHER 2 208 1
3.90.850.10 Gene3D IPR011234 Fumarylacetoacetase, C-terminal-related 2 200 1
SSF56529 SuperFamily IPR011234 Fumarylacetoacetase, C-terminal-related 4 200 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.38 Da
Charge 6.50
Isoelectric point 9.41
Molecular weight 24.17 kDa
Number of residues 221
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
208709during GO:0000080PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
201351during GO:0000084PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
212717during GO:0000085PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
223346during GO:0000087PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
15326.76during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
201858during GO:0072690PECO:0000126,
PECO:0000005
single_cellmass spectrometry evidencePMID:24763107
7990.87during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5.6during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
1.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in bacteria1000
conserved in metazoa3425
conserved in vertebrates3400
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
vps35retromer complex subunit Vps35 Positive GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Positive GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC21C3.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC21C3.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC21C3.09c BioGRID Interaction Datasets
Expression Viewer SPBC21C3.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC21C3.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC21C3.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC21C3.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC21C3.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC21C3.09c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC21C3.09c Cell Cycle Data
GEO SPBC21C3.09c GEO profiles
PInt SPBC21C3.09c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC21C3.09c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC21C3.09c Fission yeast phenotypic data & analysis
SPD / RIKEN10/10E01Orfeome Localization Data
UniProtKB/SwissProtQ9P7L4Uncharacterized hydrolase C21C3.09c
ModBaseQ9P7L4Database of comparative protein structure models
STRINGQ9P7L4Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596589fumarylacetoacetate hydrolase family protein (predicted)
RefSeq mRNANM_001022509972h- fumarylacetoacetate hydrolase family protein (predicted) (SPBC21C3.09c), mRNA
European Nucleotide ArchiveBAA87171.1ENA Protein Mapping
European Nucleotide ArchiveCAB76045.1ENA Protein Mapping
UniParcUPI000006A6FEUniProt Archive

Literature for SPBC21C3.09c

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014