Gene Standard NameUnassigned Characterisation Statusbiological_role_inferred
Systematic IDSPBC21C3.09c Feature Typeprotein coding
Synonyms Name Description
Productfumarylacetoacetate hydrolase family protein (predicted) Product Size221aa, 24.17 kDa
Genomic Location Chromosome II, 3812481-3810897 (1585nt); CDS:3812188-3811374 (815nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0016787hydrolase activityIEAUniProtKB-KW:KW-0378GO_REF:0000037842
GO:0046872metal ion bindingIEAUniProtKB-KW:KW-0479GO_REF:0000037747
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006572tyrosine catabolic processISMPFAM:PF01557GO_REF:00000011
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopySPBC21C3.09cΔNullPECO:0000005, PECO:0000137PMID:236978063755

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopySPBC21C3.09cΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Start End Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01557 Pfam IPR002529 Fumarylacetoacetase, C-terminal 7 200 1
PTHR11820:SF7 HMMPANTHER 2 208 1
PTHR11820 HMMPANTHER 2 208 1
G3DSA:3.90.850.10 Gene3D IPR011234 2 200 1
SSF56529 SuperFamily IPR011234 4 200 1
Low complexity (SEG) seg 22 37
Low complexity (SEG) seg 184 193

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.38 Da
Charge 6.50
Isoelectric point 9.41
Molecular weight 24.17 kDa
Number of residues 221
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
15326.76during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
7990.87during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
5.6during GO:0072690PECO:0000005,
population_wideexperimental evidencePMID:23101633
1.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
population_wideexperimental evidencePMID:23101633
Species Distribution
predominantly single copy (one to one)3080
conserved in fungi4564
conserved in eukaryotes4482
conserved in bacteria1001
conserved in metazoa3419
conserved in vertebrates3394

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
vps35retromer complex subunit Vps35 Positive GeneticPMID:22681890
res1MBF transcription factor complex subunit Res1 Positive GeneticPMID:22681890
prw1Clr6 histone deacetylase complex subunit Prw1 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC21C3.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC21C3.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC21C3.09c BioGRID Interaction Datasets
Expression Viewer SPBC21C3.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC21C3.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC21C3.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC21C3.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC21C3.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC21C3.09c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC21C3.09c Cell Cycle Data
GEO SPBC21C3.09c GEO profiles
PInt SPBC21C3.09c Protein-Protein Interaction Predictor (Bähler Lab)
WikiGene2540605fumarylacetoacetate (FAA) hydrolase
EntrezGene2540605fumarylacetoacetate (FAA) hydrolase
SPD / RIKEN10/10E01Orfeome Localization Data
UniProtKB/SwissProtQ9P7L4Uncharacterized hydrolase C21C3.09c
ModBaseQ9P7L4Database of comparative protein structure models
StringQ9P7L4Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596589fumarylacetoacetate (FAA) hydrolase
RefSeq mRNANM_001022509972h- fumarylacetoacetate (FAA) hydrolase (SPBC21C3.09c), mRNA
European Nucleotide ArchiveBAA87171ENA Protein Mapping
European Nucleotide ArchiveCAB76045ENA Protein Mapping
UniParcUPI000006A6FEUniProt Archive

Literature for SPBC21C3.09c

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014