SPBC21C3.09c


Gene Standard NameUnassigned Characterisation Statusbiological role inferred
Systematic IDSPBC21C3.09c Feature Typeprotein coding
Synonyms Name Description
Productfumarylacetoacetate hydrolase family protein (predicted) Product Size221aa, 24.17 kDa
Genomic Location Chromosome II, 3812481-3810897 (1585nt); CDS:3812188-3811374 (815nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
hydrolase activity837
Annotation ExtensionEvidenceWith/FromReference
metal ion binding750
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
tyrosine catabolic process1
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Term NameCount
mitochondrion752
Annotation ExtensionEvidenceWith/FromReference
FYPO Single-Allele Phenotypes
Gene Deletion Viability: Viable

Population Phenotype

Term NameGenotypesCount
viable vegetative cell populationSPBC21C3.09cΔ3837

Cell Phenotype

Term NameGenotypesCount
viable vegetative cell with normal cell morphologySPBC21C3.09cΔ3100
Transcript
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons3812481..3812142, 3811992..3810897
Intron3812141..3811993
5' UTR3812481..3812189PMID:21511999
3' UTR3811373..3810897PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF01557 Pfam IPR011234 Fumarylacetoacetase, C-terminal-related 7 200 1
PTHR11820 HMMPANTHER 7 219 1
PTHR11820:SF7 HMMPANTHER 7 219 1
3.90.850.10 Gene3D IPR011234 Fumarylacetoacetase, C-terminal-related 2 200 1
SSF56529 SuperFamily IPR011234 Fumarylacetoacetase, C-terminal-related 4 200 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 109.38 Da
Charge 6.50
Codon Adaptation Index 0.42
Isoelectric point 9.41
Molecular weight 24.17 kDa
Number of residues 221
Sequence
Gene Expression

Quantitative Gene Expression

View graphical display of gene expression data for SPBC21C3.09c

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
208709during GO:0000080PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
201351during GO:0000084PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
212717during GO:0000085PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
223346during GO:0000087PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
15326.76during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
201858during GO:0072690PECO:0000005,
PECO:0000126
single cellmass spectrometry evidencePMID:24763107
7990.87during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
5.6during GO:0072690PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
1.1during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005
population wideexperimental evidencePMID:23101633
Taxonomic Conservation
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4605
conserved in eukaryotes4515
conserved in bacteria1001
conserved in metazoa3424
conserved in vertebrates3399
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Load genes that interact genetically with SPBC21C3.09c into the Query Builder
View these interactions in esyN

Gene Product Evidence Reference
positive genetic interaction withvps35retromer complex subunit Vps35 Positive GeneticPMID:22681890
positive genetic interaction withprw1Clr6 histone deacetylase complex subunit Prw1 Positive GeneticPMID:22681890
positive genetic interaction withres1MBF transcription factor complex subunit Res1 Positive GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC21C3.09c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC21C3.09c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC21C3.09c BioGRID Interaction Datasets
Expression Viewer SPBC21C3.09c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC21C3.09c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC21C3.09c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC21C3.09c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC21C3.09c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC21C3.09c Transcriptome Viewer (Bähler Lab)
GEO SPBC21C3.09c GEO profiles
PInt SPBC21C3.09c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC21C3.09c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC21C3.09c Fission yeast phenotypic data & analysis
Cyclebase SPBC21C3.09c.1 Cell Cycle Data
SPD / RIKEN10/10E01Orfeome Localization Data
UniProtKB/SwissProtQ9P7L4Uncharacterized hydrolase C21C3.09c
ModBaseQ9P7L4Database of comparative protein structure models
STRINGQ9P7L4Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596589fumarylacetoacetate hydrolase family protein (predicted)
RefSeq mRNANM_001022509972h- fumarylacetoacetate hydrolase family protein (predicted) (SPBC21C3.09c), mRNA

Literature for SPBC21C3.09c

Search: Europe PMC or PubMed

Release Version: PomBase:30_58 - 11 Mar 2016