ctr6 (SPBC23G7.16)

Gene Standard Namectr6 Characterisation Statuspublished
Systematic IDSPBC23G7.16 Feature Typeprotein coding
Synonyms Name Description
Productvacuolar copper transmembrane transporter Ctr6 Product Size148aa, 16.75 kDa
Genomic Location Chromosome II, 2100018-2101253 (1236nt); CDS:2100273-2101061 (789nt)

Ensembl Gene Location
GO Molecular Function
Term NameCount
copper ion transmembrane transporter activity5
Annotation ExtensionEvidenceWith/FromReference
protein binding866
Annotation ExtensionEvidenceWith/FromReference
GO Biological Process
Term NameCount
copper ion transmembrane transport6
Annotation ExtensionEvidenceWith/FromReference
GO Cellular Component
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Single-allele Phenotypes

Population Phenotype

Term NameGenotypesCount
sensitive to copperctr6+10
sensitive to silverctr6+1
viable vegetative cell populationctr6Δ3815

Cell Phenotype

Term NameGenotypesCount
decreased copper importctr6+3
decreased RNA level during cellular response to copper ion starvation2
affecting ctr4ctr6+
decreased superoxide dismutase activityctr6Δ4
viable vegetative cell with normal cell morphologyctr6Δ3095
Target Of
FYPO affected by mutation in cuf1 nutritional copper sensing transcription factor Cuf1
GO regulated by cuf1 nutritional copper sensing transcription factor Cuf1
Ensembl transcript structure with UTRs, exons and introns

Transcript Structure

Region Coordinates Reference
Exons2100018..2100317, 2100387..2100412, 2100520..2100780, 2100875..2100896, 2100969..2101253
Intron2100318..2100386, 2100413..2100519, 2100781..2100874, 2100897..2100968
5' UTR2100018..2100272PMID:21511999
CDS2100273..2100317, 2100387..2100412, 2100520..2100780, 2100875..2100896, 2100969..2101061
3' UTR2101062..2101253PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF04145 Pfam IPR007274 Ctr copper transporter 14 133 3
TMhelix TMHMM 32 54 959
TMhelix TMHMM 105 127 959
PTHR12483 HMMPANTHER IPR007274 Ctr copper transporter 1 133 3

View domain organization at Pfam

Protein Properties

Ave. residue weight 113.16 Da
Charge 9.50
Codon Adpatation Index 0.45
Isoelectric point 9.21
Molecular weight 16.75 kDa
Number of residues 148
Gene Expression

Qualitative Gene Expression

protein levelincreased during GO:0035874Western blot evidencePMID:12244050
decreased during GO:0071280Western blot evidencePMID:12244050
RNA leveldecreased during GO:0071280Northern assay evidencePMID:12244050
increased during GO:0035874Northern assay evidencePMID:12244050
present during GO:0072690Northern assay evidencePMID:12244050

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
6649during GO:0000080PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
6274during GO:0000085PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
7097during GO:0072690PECO:0000005,
single cellmass spectrometry evidencePMID:24763107
34196.19during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
21424.79during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
3.1during GO:0072690PECO:0000014,
population wideexperimental evidencePMID:23101633
1.7during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
population wideexperimental evidencePMID:23101633
promoter contains CuSE3
Taxonomic Conservation
predominantly single copy (one to one)3090
conserved in fungi4604
conserved in eukaryotes4514
conserved in metazoa3421
conserved in vertebrates3396
conserved in eukaryotes only2503

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

View these interactions in esyN

Gene Product Evidence Reference
phenotype enhanced byctr4copper transporter complex subunit Ctr4 Phenotypic EnhancementPMID:12244050
External References
Database Identifier Description
NBRP SPBC23G7.16 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC23G7.16 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC23G7.16 BioGRID Interaction Datasets
Expression Viewer SPBC23G7.16 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC23G7.16 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC23G7.16 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC23G7.16 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC23G7.16 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC23G7.16 Transcriptome Viewer (Bähler Lab)
GEO SPBC23G7.16 GEO profiles
PInt SPBC23G7.16 Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC23G7.16 Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC23G7.16 Fission yeast phenotypic data & analysis
Cyclebase SPBC23G7.16.1 Cell Cycle Data
SPD / RIKEN09/09H10Orfeome Localization Data
UniProtKB/SwissProtQ9USV7Copper transport protein ctr6
ModBaseQ9USV7Database of comparative protein structure models
STRINGQ9USV7Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_595861vacuolar copper transporter Ctr6
RefSeq mRNANM_001021766972h- vacuolar copper transporter Ctr6 (ctr6), mRNA
European Nucleotide ArchiveCU329671ENA EMBL mapping
European Nucleotide ArchiveCAB58134ENA Protein Mapping
European Nucleotide ArchiveCAB58134.1ENA Protein Mapping
UniParcUPI0000128661UniProt Archive

Literature for ctr6

Search: Europe PMC or PubMed

Release Version: PomBase:28_55 - 09 Sep 2015