pof2 (SPBC25B2.11)

Gene Standard Namepof2 Characterisation Statuspublished
Systematic IDSPBC25B2.11 Feature Typeprotein coding
Synonyms Name Description
ProductF-box protein Pof2 Product Size463aa, 52.36 kDa
Genomic Location Chromosome II, 2617862-2619476 (1615nt); CDS:2617862-2619336 (1475nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005515protein bindingIPIskp1PMID:15147268861
GO:0030674protein binding, bridgingISMPFAM:PF00646GO_REF:000000126
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0000151ubiquitin ligase complexISMPFAM:PF00646GO_REF:000000159
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopypof2ΔNullPMID:204732893760
Microscopypof2ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002177viable vegetative cell with normal cell morphology3086
penetrance FYPO_EXT:0000001Microscopypof2ΔNullPECO:0000005, PECO:0000137PMID:23697806
Ensembl transcript structure with UTRs, exons and introns


Exon Start End


Region Coordinates Reference
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF13516 Pfam 328 352 3
PF13516 Pfam 145 164 3
PF13516 Pfam 303 324 3
PF12937 Pfam IPR001810 F-box domain 3 44 4
SM00367 SMART IPR006553 Leucine-rich repeat, cysteine-containing subtype 145 170 1
PS50181 Prosite Profiles IPR001810 F-box domain 1 42 10
PTHR23125 HMMPANTHER 1 416 3
PTHR23125:SF229 HMMPANTHER 1 416 1 Gene3D 250 421 16 Gene3D 2 246 16
SSF52047 SuperFamily 114 371 6
SSF81383 SuperFamily IPR001810 F-box domain 3 91 12

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0000933F-box proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000933
PBO:0001527leucine-rich repeat proteinTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001527

Protein Properties

Ave. residue weight 113.09 Da
Charge 10.50
Isoelectric point 8.09
Molecular weight 52.36 kDa
Number of residues 463
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
experimental evidencePMID:23101633
NDduring GO:0072690PECO:0000014,
experimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.34during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000014,
experimental evidencePMID:23101633
0.74during GO:0072690PECO:0000014,
experimental evidencePMID:23101633
Species Distribution
conserved in fungi4569
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3393
conserved in eukaryotes only2487

Manually curated orthologous groups


Orthologs in Compara

Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
pvg2galactose residue biosynthesis protein Pvg2 Negative GeneticPMID:22681890
set1histone lysine methyltransferase Set1 Negative GeneticPMID:22681890
arv1Arv1-like family protein Arv1 (predicted) Negative GeneticPMID:22681890
ubp3ubiquitin C-terminal hydrolase Ubp3 Phenotypic EnhancementPMID:19547744
zwf2glucose-6-phosphate 1-dehydrogenase Zwf2 (predicted) Negative GeneticPMID:22681890
SPBC25H2.03vacuolar protein involved in phosphoinositide metabolism (predicted) Negative GeneticPMID:22681890
SPBC725.01aspartate aminotransferase (predicted) Negative GeneticPMID:22681890
SPAC56E4.03aromatic aminotransferase (predicted) Negative GeneticPMID:22681890
pam17TIM23 translocase complex-associated motor subunit Pam17 (predicted) Negative GeneticPMID:22681890
dph2diphthamide biosynthesis protein (predicted) Negative GeneticPMID:22681890
pfl4cell surface glycoprotein, adhesion molecule (predicted) Negative GeneticPMID:22681890
nem1Nem1-Spo7 phosphatase complex catalytic subunit Nem1 (predicted) Negative GeneticPMID:22681890
tma20RNA-binding protein Tma20 (predicted) Negative GeneticPMID:22681890
mug178mitochondrial ribosomal protein subunit L51-b (predicted) Positive GeneticPMID:22681890
ppk38Ark1/Prk1 family protein kinase Ppk38 Phenotypic EnhancementPMID:19547744
med13mediator complex subunit Srb9 Positive GeneticPMID:22681890
pex6peroxin-6 (predicted) Negative GeneticPMID:22681890
ppr2mitochondrial PPR repeat protein Ppr2 Positive GeneticPMID:22681890
csn1COP9/signalosome complex subunit Csn1 Negative GeneticPMID:22681890
hop1linear element associated protein Hop1 Negative GeneticPMID:22681890
SPAC23C4.09cDNA-binding TFAR19-related protein (predicted) Negative GeneticPMID:22681890
mac1membrane anchored protein Mac1 Negative GeneticPMID:22681890
SPCC1795.10cSed5 Vesicle Protein Svp26 (predicted) Negative GeneticPMID:22681890
vps25ESCRT II complex subunit Vps25 Negative GeneticPMID:22681890
mug113T5orf172 family protein Negative GeneticPMID:22681890
laf1clr6 L associated factor 1 Laf1 Negative GeneticPMID:22681890
SPAC15A10.06CPA1 sodium ion/proton antiporter (predicted) Negative GeneticPMID:22681890
get4ER membrane insertion protein Get4 (predicted) Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC25B2.11 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC25B2.11 Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC25B2.11 BioGRID Interaction Datasets
Expression Viewer SPBC25B2.11 Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC25B2.11 Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC25B2.11 Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC25B2.11 Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC25B2.11 Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC25B2.11 Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC25B2.11 Cell Cycle Data
GEO SPBC25B2.11 GEO profiles
PInt SPBC25B2.11 Protein-Protein Interaction Predictor (Bähler Lab)
EntrezGene2540355F-box protein Pof2
WikiGene2540355F-box protein Pof2
SPD / RIKEN44/44G08Orfeome Localization Data
UniProtKB/SwissProtO74783SCF E3 ubiquitin ligase complex F-box protein pof2
ModBaseO74783Database of comparative protein structure models
STRINGO74783Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596079F-box protein Pof2
RefSeq mRNANM_001021991972h- F-box protein Pof2 (pof2), mRNA
European Nucleotide ArchiveBAB60689ENA Protein Mapping
European Nucleotide ArchiveBAB60689.1ENA Protein Mapping
European Nucleotide ArchiveCAA21269ENA Protein Mapping
European Nucleotide ArchiveCAA21269.1ENA Protein Mapping
UniParcUPI0000131DBBUniProt Archive

Literature for pof2

Search: Europe PMC or PubMed

Release Version: PomBase:22_44 - 08 Jul 2014