dnt1 (SPBC25D12.02c)

Gene Standard Namednt1 ChromosomeII
Systematic IDSPBC25D12.02c Gene Start3717257
Synonyms Gene End3714945
Productnucleolar protein Dnt1 Gene Length2313
Feature Typeprotein coding CDS Start3717051
Name Description CDS End3715200
Characterisation Statuspublished CDS Length1852

Ensembl Gene Location
  1. SPBC19F5.03
  2. SPBC19F5.04
  3. ppp1
  4. dnt1
  5. mcm7
  6. suc22
  7. trm1
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002060viable vegetative cell populationMicroscopydnt1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0005515protein bindingIPIclp1PMID:17538026
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000183chromatin silencing at rDNAIMPPMID:17538026
GO:0031030negative regulation of septation initiation signaling cascade
different_pathwayIGIclp1PMID:17538026
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005730nucleolus
constitutiveIDAPMID:17538026
GO:0005737cytoplasmIDAPMID:16823372
GO:0005819spindle
exists_during mitotic cell cycleIDAPMID:17538026
exists_during mitotic anaphase BIDAPMID:17538026
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
137172573716909
237168563714945

References

Region Start End Reference
three_prime_UTR37151993714945PMID:21511999
three_prime_UTR37151993714945PMID:21511999
five_prime_UTR37172573717052PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF10407 IPR018844 Pfam Nucleolar protein Dnt1-like, N-terminal 15 83 1

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residuePMID:19547744

Protein Properties

Ave. residue weight 110.15 Da
Charge -26.00
Isoelectric point 4.65
Molecular weight 65.98 kDa
Number of residues 599
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide3844.61PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide2696.74PMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide1.9PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.55PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi only
conserved in fungi
conserved in eukaryotes
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
clp1Cdc14-related protein phosphatase Clp1/Flp1 Synthetic RescuePMID:17538026
dma1mitotic spindle checkpoint protein Dma1 Synthetic RescuePMID:22809626
Phenotypic Suppression
Phenotypic Enhancement
cdc14SIN component Cdc14 Synthetic RescuePMID:17538026
sid1PAK-related GC kinase Sid1 Synthetic RescuePMID:17538026
sid2NDR kinase Sid2 Synthetic RescuePMID:17538026
rrn5RNA polymerase I upstream activation factor complex subunit Rrn5 Synthetic Growth DefectPMID:17538026
myo2myosin II heavy chain Synthetic RescuePMID:17538026
nuc1DNA-directed RNA polymerase I complex large subunit Nuc1 Synthetic LethalityPMID:17538026
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
clp1Cdc14-related protein phosphatase Clp1/Flp1 Two-hybridPMID:17538026
dma1mitotic spindle checkpoint protein Dma1 Affinity Capture-MSPMID:22809626
Reconstituted Complex
Two-hybrid
Affinity Capture-Western
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External References
Database Identifier Description
NBRP SPBC25D12.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC25D12.02c Retrieval of eukaryotic orthologs
BioGrid SPBC25D12.02c BioGRID Interaction Datasets
Bähler Lab SPBC25D12.02c Cell Cycle Expression Profile
Bähler Lab SPBC25D12.02c Meiosis/Sporulation Expression Profies
Bähler Lab SPBC25D12.02c Pheromone response/mating expression profiles
Bähler Lab SPBC25D12.02c Environmental stress expression profiles
Bähler Lab SPBC25D12.02c Bähler Lab Transcriptome Viewer
Cyclebase SPBC25D12.02c Cell Cycle Data
PInt SPBC25D12.02c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC25D12.02c Entrez Gene
EntrezGene2540499nucleolar protein Dnt1
Uniprot_genenameDNT1
WikiGene2540499nucleolar protein Dnt1
SPD / RIKEN46/46A05Orfeome Localization Data
UniProtKB/SwissProtO74354Nucleolar protein dnt1
ModBaseO74354Database of comparative protein structure models
Pfam Protein DomainsO74354Pfam Domain Arrangement
RefSeq PeptideNP_596544nucleolar protein Dnt1
RefSeq mRNANM_001022465972h- nucleolar protein Dnt1 (dnt1), mRNA
European Nucleotide ArchiveCAA20098ENA Protein Mapping
UniParcUPI0000069C20UniProt Archive

Literature for dnt1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013