pph3 (SPBC26H8.05c)


Gene Standard Namepph3 Characterisation Statusbiological_role_inferred
Systematic IDSPBC26H8.05c Feature Typeprotein coding
Synonyms Name Description
Productserine/threonine protein phosphatase, PP4 complex subunit Pph3 (predicted) Product Size348aa, 39.22 kDa
Genomic Location Chromosome II, 3956123-3954552 (1572nt); CDS:3955929-3954715 (1215nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0046872metal ion bindingIEAUniProtKB-KW:KW-0479GO_REF:0000037747
GO:0004722protein serine/threonine phosphatase activity15
contributes_toISOSGD:S000002482GO_REF:0000024
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0006470protein dephosphorylationISOSGD:S000002482GO_REF:000002435
GO:0007165signal transductionNASGO_REF:0000051394
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005829cytosolIDAPMID:168233722315
GO:0005634nucleusIDAPMID:168233722740
ISOSGD:S000002482GO_REF:0000024
GO:0030289protein phosphatase 4 complexISOSGD:S000002482GO_REF:00000242
Fission Yeast Phenotype Ontology
Gene Deletion Viability: Viable

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationMicroscopypph3ΔNullPMID:204732893759
Microscopypph3ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0000708decreased mating efficiencyhigh throughput nucleotide sequencing assay evidencepph3ΔNullPECO:0000015PMID:23950735240
FYPO:0002177viable vegetative cell with normal cell morphology3089
penetrance FYPO_EXT:0000001Microscopypph3ΔNullPECO:0000005, PECO:0000137PMID:23697806
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
139561233955860
239557443955290
339552363954552

UTRs

Region Coordinates Reference
five_prime_UTR3956123..3955930PMID:21511999
three_prime_UTR3954714..3954552PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00149 Pfam IPR004843 Phosphoesterase domain 47 239 20
SM00156 SMART IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 19 331 10
PS00125 Prosite Patterns IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 110 115 10
PTHR11668 HMMPANTHER 1 348 11
PTHR11668:SF22 HMMPANTHER 1 348 1
3.60.21.10 Gene3D 3 255 23
3.60.21.10 Gene3D 292 341 23
SSF56300 SuperFamily Metallo-dependent phosphatase-like 293 331 22
SSF56300 SuperFamily Metallo-dependent phosphatase-like 3 256 22
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 109 133 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 229 249 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 47 74 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 144 170 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 293 309 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 76 103 10
PR00114 PRINTS IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 173 200 10

View domain organization at Pfam

Protein Properties

Ave. residue weight 112.69 Da
Charge -17.50
Isoelectric point 4.44
Molecular weight 39.22 kDa
Number of residues 348
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
2020.63during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
NDduring cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)ExtensionConditionScaleEvidenceReference
1.8during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
0.72during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
predominantly single copy (one to one)3092
conserved in fungi4600
conserved in eukaryotes4514
conserved in metazoa3425
conserved in vertebrates3400
conserved in eukaryotes only2497
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
pnk1DNA kinase/phosphatase Pnk1 Positive GeneticPMID:18818364
scs7sphingosine hydroxylase Scs7 Negative GeneticPMID:22681890
rik1silencing protein Rik1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
clr4histone H3 lysine methyltransferase Clr4 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
cbs2protein kinase activator (predicted) Negative GeneticPMID:18818364
mga2IPT/TIG ankyrin repeat containing transcription regulator of fatty acid biosynthesis (predicted) Negative GeneticPMID:18818364
ers1RNA-silencing factor Ers1 Negative GeneticPMID:18818364
rpa12DNA-directed RNA polymerase complex I subunit Rpa12 Negative GeneticPMID:18818364
arb1argonaute inhibitor protein 1 Negative GeneticPMID:22681890
cwf21complexed with Cdc5 protein Cwf21 Negative GeneticPMID:18818364
cho1phosphatidyl-N-methylethanolamine N-methyltransferase (predicted) Negative GeneticPMID:18818364
aca1L-azetidine-2-carboxylic acid acetyltransferase Aca1 Positive GeneticPMID:22681890
SPAPB21F2.02Dopey family protein (predicted) Negative GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
apq12nuclear membrane organization protein Apq12 (predicted) Negative GeneticPMID:22681890
fep1iron-sensing transcription factor Fep1 Negative GeneticPMID:22681890
vph2endoplasmic reticulum membrane protein involved in assembly of the V-ATPase (predicted) Negative GeneticPMID:18818364
pds5mitotic cohesin-associated protein Pds5 Negative GeneticPMID:18818364
SPCC4F11.03cSchizosaccharomyces specific protein Negative GeneticPMID:22681890
epe1Jmjc domain chromatin associated protein Epe1 Negative GeneticPMID:18818364
SPBC29A10.16ccytochrome b5 (predicted) Negative GeneticPMID:22681890
dsc3Golgi Dsc E3 ligase complex subunit Dsc3 Positive GeneticPMID:21504829
fin1serine/threonine protein kinase, NIMA related Fin1 Negative GeneticPMID:18818364
msy1MS calcium ion channel protein Msy1 Negative GeneticPMID:22681890
rpl160360S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:18818364
med6mediator complex subunit Med6 Negative GeneticPMID:18818364
amo1nuclear rim protein Amo1 Negative GeneticPMID:18818364
arp42SWI/SNF and RSC complex subunit Arp42 Negative GeneticPMID:18818364
chp1chromodomain protein Chp1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
reb1RNA polymerase I transcription termination factor/ RNA polymerase II transcription factor Reb1 Negative GeneticPMID:18818364
raf1CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1 Negative GeneticPMID:22681890
SPCC1393.08transcription factor, zf-GATA type (predicted) Negative GeneticPMID:22681890
mrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
dcr1dicer Negative GeneticPMID:18818364
alp14TOG ortholog Alp14 Negative GeneticPMID:18818364
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
rdp1RNA-directed RNA polymerase Rdp1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
rsc1RSC complex subunit Rsc1 Negative GeneticPMID:18818364
SPAC10F6.13caspartate aminotransferase (predicted) Positive GeneticPMID:22681890
swi6HP1 family chromodomain protein Swi6 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
External References
Database Identifier Description
NBRP SPBC26H8.05c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC26H8.05c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC26H8.05c BioGRID Interaction Datasets
Expression Viewer SPBC26H8.05c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC26H8.05c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC26H8.05c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC26H8.05c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC26H8.05c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC26H8.05c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC26H8.05c Cell Cycle Data
GEO SPBC26H8.05c GEO profiles
PInt SPBC26H8.05c Protein-Protein Interaction Predictor (Bähler Lab)
PeptideAtlas SPBC26H8.05c Peptides identified in tandem mass spectrometry proteomics experiments
SYSGRO SPBC26H8.05c Fission yeast phenotypic data & analysis
SPD / RIKEN22/22B06Orfeome Localization Data
UniProtKB/SwissProtO74789Putative serine/threonine-protein phosphatase C26H8.05c
ModBaseO74789Database of comparative protein structure models
STRINGO74789Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596646serine/threonine protein phosphatase (predicted)
RefSeq mRNANM_001022568972h- serine/threonine protein phosphatase (predicted) (SPBC26H8.05c), mRNA
European Nucleotide ArchiveCAA21097.1ENA Protein Mapping
UniParcUPI000006BE2AUniProt Archive

Literature for pph3

Search: Europe PMC or PubMed

Release Version: PomBase:23_47 - 27 Oct 2014