grx4 (SPBC26H8.06)

Gene Standard Namegrx4 ChromosomeII
Systematic IDSPBC26H8.06 Gene Start3957094
Synonyms Gene End3958479
Productglutaredoxin Grx4 Gene Length1386
Feature Typeprotein coding CDS Start3957504
Name Description CDS End3958238
Characterisation Statuspublished CDS Length735

Ensembl Gene Location
  1. SPBC26H8.04c
  2. SPBC26H8.05c
  3. SPNCRNA.431
  4. grx4
  5. snu32
  6. SPBC26H8.13c
  7. SPNCRNA.89
  8. cox17
  9. SPNCRNA.515
  10. SPNCRNA.1651
  11. SPBC26H8.16
  12. nda3
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0002061inviable vegetative cell populationMicroscopygrx4delta (deletion)deletionPMID:20473289
no_name (unrecorded)unrecordedPMID:15796926
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0008794arsenate reductase (glutaredoxin) activityTASPMID:15796926
GO:0009055electron carrier activityIEAIPR002109GO_REF:0000002
GO:0015035protein disulfide oxidoreductase activityIEAIPR002109GO_REF:0000002
GO:0046872metal ion bindingIEAUniProtKB:KW-0479GO_REF:0000037
GO:00515372 iron, 2 sulfur cluster bindingIEAUniProtKB:KW-0001GO_REF:0000037
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0019430removal of superoxide radicalsICGO:0008794GO_REF:0000001
GO:0045454cell redox homeostasisIEAIPR002109, IPR013766GO_REF:0000002
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005634nucleusIDAPMID:16823372
predominantlyIDAPMID:15796926
GO:0005737cytoplasmIDAPMID:15796926
GO:0005829cytosolIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
139570943958479

References

Region Start End Reference
five_prime_UTR39570943957503PMID:21511999
three_prime_UTR39582393958479PMID:21511999
three_prime_UTR39582393958479PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00462 IPR002109 Pfam Glutaredoxin 159 223 5
PF00085 IPR013766 Pfam Thioredoxin domain 6 103 12
PS51354 IPR002109 Prosite Profiles Glutaredoxin 147 244 5
PS51352 IPR012336 Prosite Profiles Thioredoxin-like fold 1 106 12
G3DSA:3.40.30.10 IPR012336 Gene3D 3 105 36
G3DSA:3.40.30.10 IPR012336 Gene3D 150 242 36
SSF52833 IPR012336 SuperFamily 145 243 38
SSF52833 IPR012336 SuperFamily 3 107 38
PTHR10293 IPR004480 hmmpanther Monothiol glutaredoxin-related 3 244 2
PTHR10293:SF19 hmmpanther 3 244 1
TIGR00365 IPR004480 tigrfam Monothiol glutaredoxin-related 148 242 2

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000261thioredoxin familyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000261

Protein Properties

Ave. residue weight 111.06 Da
Charge -8.00
Isoelectric point 4.52
Molecular weight 27.10 kDa
Number of residues 244
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide11776.22PMID:23101633
experimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide18671.77PMID:23101633
RNA levelexperimental evidencesingle-celled organism vegetative growth phasePECO:0000014,
PECO:0000005		population_wide6.7PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide1.1PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
php4CCAAT-binding factor complex subunit Php4 PCAPMID:19502236
Two-hybrid
Two-hybridPMID:22523368
fep1iron-sensing transcription factor Fep1 FRETPMID:21531205
Affinity Capture-Western
Two-hybridPMID:21421748
Affinity Capture-Western
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External References
Database Identifier Description
NBRP SPBC26H8.06 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC26H8.06 Retrieval of eukaryotic orthologs
BioGrid SPBC26H8.06 BioGRID Interaction Datasets
Bähler Lab SPBC26H8.06 Cell Cycle Expression Profile
Bähler Lab SPBC26H8.06 Meiosis/Sporulation Expression Profies
Bähler Lab SPBC26H8.06 Pheromone response/mating expression profiles
Bähler Lab SPBC26H8.06 Environmental stress expression profiles
Bähler Lab SPBC26H8.06 Bähler Lab Transcriptome Viewer
Cyclebase SPBC26H8.06 Cell Cycle Data
PInt SPBC26H8.06 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC26H8.06 Entrez Gene
WikiGene2540578glutaredoxin Grx4
Uniprot_genenameGRX4
EntrezGene2540578glutaredoxin Grx4
SPD / RIKEN08/08H06Orfeome Localization Data
UniProtKB/SwissProtO74790Monothiol glutaredoxin-4
ModBaseO74790Database of comparative protein structure models
Pfam Protein DomainsO74790Pfam Domain Arrangement
RefSeq PeptideNP_596647glutaredoxin Grx4
RefSeq mRNANM_001022569972h- glutaredoxin Grx4 (grx4), mRNA
European Nucleotide ArchiveAAR08197ENA Protein Mapping
European Nucleotide ArchiveCAA21098ENA Protein Mapping
UniParcUPI00000698B2UniProt Archive

Literature for grx4
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013