trt1 (SPBC29A3.14c)

Gene Standard Nametrt1 ChromosomeII
Systematic IDSPBC29A3.14c Gene Start2066165
Synonyms Gene End2062472
Producttelomerase reverse transcriptase 1 protein Trt1 Gene Length3694
Feature Typeprotein coding CDS Start2066110
Name Description CDS End2062472
Characterisation Statuspublished CDS Length3639

Ensembl Gene Location
  1. atp14
  2. SPBC29A3.11c
  3. pdp1
  4. rps902
  5. SPNCRNA.1484
  6. trt1
  7. rsm23
  8. rrs1
  9. SPBTRNAGLY.09
  10. gef3
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000266sensitive to DNA damaging agentscompetitive growth assay evidencetrt1delta (deletion)deletionPMID:20537132
FYPO:0000268sensitive to UVcompetitive growth assay evidencetrt1delta (deletion)deletionPMID:20537132
FYPO:0002060viable vegetative cell populationMicroscopytrt1delta (deletion)deletionPMID:20473289
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0003677DNA bindingIEAUniProtKB:KW-0238GO_REF:0000037
GO:0003721telomeric template RNA reverse transcriptase activityIMPPMID:9774280
GO:0003723RNA bindingIPIter1PMID:18157152
GO:0005515protein bindingIPIest1PMID:12676088
GO:0046872metal ion bindingIEAUniProtKB:KW-0479GO_REF:0000037
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0006278RNA-dependent DNA replicationICGO:0003721GO_REF:0000001
GO:0007004telomere maintenance via telomeraseIMPPMID:9774280
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0000228nuclear chromosomeICGO:0003721GO_REF:0000001
GO:0000333telomerase catalytic core complexIDAPMID:18157152
GO:0000781chromosome, telomeric regionICGO:0003721GO_REF:0000001
GO:0005634nucleusIDAPMID:16823372
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
120661652065853
220657962065716
320656442065526
420654742065212
520651752064783
620647432064673
720646332064364
820643232064207
920641552063986
1020639442063760
1120637132063565
1220635232063310
1320632722063023
1420629832062817
1520627732062677
1620626342062472

References

Region Start End Reference
five_prime_UTR20661652066111PMID:21511999
five_prime_UTR20661652066111PMID:21511999
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF00078 IPR000477 Pfam Reverse transcriptase 544 806 15
PF12009 IPR021891 Pfam Telomerase ribonucleoprotein complex - RNA-binding domain 342 476 1
SM00975 IPR021891 SMART Telomerase ribonucleoprotein complex - RNA-binding domain 341 477 1
PS50878 IPR000477 Prosite Profiles Reverse transcriptase 486 807 15
SSF56672 SuperFamily 540 618 24
SSF56672 SuperFamily 680 779 24
PR01365 IPR003545 PRINTS Telomere reverse transcriptase 698 714 1
PR01365 IPR003545 PRINTS Telomere reverse transcriptase 444 458 1
PR01365 IPR003545 PRINTS Telomere reverse transcriptase 736 748 1
PR01365 IPR003545 PRINTS Telomere reverse transcriptase 582 598 1
PTHR12066:SF0 hmmpanther 1 988 1
PTHR12066 hmmpanther 1 988 1

View domain organization at Pfam

Protein Properties

Ave. residue weight 117.74 Da
Charge 72.00
Isoelectric point 10.29
Molecular weight 116.33 kDa
Number of residues 988
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
deletion mutant expression profiling PMID:15642092
alternative splicing
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127		population_widePMID:23101633
experimental evidencePECO:0000005,
PECO:0000014		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide0.28PMID:23101633
experimental evidencePECO:0000014,
PECO:0000005		population_wide0.66PMID:23101633
Species Distribution
DescriptionQualifierReference
predominantly single copy (one to one)
conserved in fungi
conserved in eukaryotes
conserved in metazoa
conserved in vertebrates
conserved in eukaryotes only
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPAC24C9.12cglycine hydroxymethyltransferase (predicted) Negative GeneticPMID:22681890
tea2kinesin-like protein Tea2 Negative GeneticPMID:22681890
cip1RNA-binding protein Cip1 Negative GeneticPMID:22681890
SPBC839.02arrestin Aly1 related, implicated in endocytosis Negative GeneticPMID:22681890
rps120140S ribosomal protein S12 (predicted) Negative GeneticPMID:22681890
nup60nucleoporin Nup60 Negative GeneticPMID:22681890
mug51variant protein kinase 19 family protein Positive GeneticPMID:22681890
rok1ATP-dependent RNA helicase Rok1 (predicted) Negative GeneticPMID:22681890
rpl160160S ribosomal protein L13/L16 (predicted) Negative GeneticPMID:22681890
itr1myo-inositol transporter Itr1 Positive GeneticPMID:22681890
zip1transcription factor Zip1 Negative GeneticPMID:22681890
SPBC1271.14glutamate N-acetyltransferase (predicted) Negative GeneticPMID:22681890
mto1MT organizer Mto1 Negative GeneticPMID:22681890
mcl1DNA polymerase alpha accessory factor Mcl1 Negative GeneticPMID:22681890
SPAC1610.02cmitochondrial ribosomal protein subunit L1 (predicted) Negative GeneticPMID:22681890
SPAPB1E7.04cchitinase (predicted) Negative GeneticPMID:22681890
SPAC17H9.13cglutamate 5-kinase (predicted) Negative GeneticPMID:22681890
ctp1CtIP-related endonuclease Phenotypic SuppressionPMID:23335786
rad50DNA repair protein Rad50 Phenotypic SuppressionPMID:23335786
SPBC13E7.03cRNA hairpin binding protein (predicted) Negative GeneticPMID:22681890
erd1Erd1 homolog (predicted) Negative GeneticPMID:22681890
nup61nucleoporin Nup61 Negative GeneticPMID:22681890
arg6acetylglutamate synthase Arg6 (predicted) Negative GeneticPMID:22681890
ccq1telomere maintenance protein Ccq1 Phenotypic EnhancementPMID:20040595
Negative GeneticPMID:22681890
mgr2mitochondrial membrane protein Mgr2 (predicted) Negative GeneticPMID:22681890
rps00140S ribosomal protein S0A (p40) Negative GeneticPMID:22681890
SPAC9G1.05actin cortical patch component Aip1 (predicted) Negative GeneticPMID:22681890
nse6Smc5-6 complex non-SMC subunit Nse6 Negative GeneticPMID:22681890
raf1Rik1-associated factor Raf1 Negative GeneticPMID:22681890
reb1RNA polymerase I transcription termination factor Reb1 Negative GeneticPMID:22681890
mre11Mre11 nuclease Phenotypic SuppressionPMID:23335786
mfm2M-factor precursor Mfm2 Negative GeneticPMID:22681890
def1RNAPII degradation factor Def1 (predicted) Negative GeneticPMID:22681890
pvg2galactose residue biosynthesis protein Pvg2 Negative GeneticPMID:22681890
SPAC13G6.13sequence orphan Negative GeneticPMID:22681890
meu10GPI anchored cell surface protein involved in ascospore wall assembly Meu10 Negative GeneticPMID:22681890
tel1ATM checkpoint kinase Phenotypic EnhancementPMID:20505337
ckb2CK2 family regulatory subunit (predicted) Negative GeneticPMID:22681890
rad16DNA repair endonuclease XPF Phenotypic SuppressionPMID:23335786
pzh1serine/threonine protein phosphatase Pzh1 Negative GeneticPMID:22681890
rhp16Rad16 homolog Rhp16 Phenotypic EnhancementPMID:18722173
nbs1Mre11 complex subunit Nbs1 Phenotypic SuppressionPMID:23335786
pdr1ABC transporter Pdr1 Negative GeneticPMID:22681890
lys4homocitrate synthase Negative GeneticPMID:22681890
dcd1deoxycytidylate deaminase (predicted) Negative GeneticPMID:22681890
rad3ATR checkpoint kinase Rad3 Phenotypic EnhancementPMID:20505337
pht1histone H2A variant H2A.Z, Pht1 Negative GeneticPMID:22681890
rps110240S ribosomal protein S11 (predicted) Negative GeneticPMID:22681890
SPAC8C9.12cmitochondrial iron ion transporter (predicted) Negative GeneticPMID:22681890
SPAC8C9.04sequence orphan Negative GeneticPMID:22681890
sat1Golgi membrane exchange factor subunit Sat1 (predicted) Negative GeneticPMID:22681890
mug109Rab GTPase binding protein upregulated in meiosis II (predicted) Negative GeneticPMID:22681890
taz1human TRF ortholog Taz1 Phenotypic SuppressionPMID:20040595
Phenotypic EnhancementPMID:9774280
Synthetic Growth DefectPMID:12676088
SPAC13G6.09SSU-rRNA maturation protein Tsr4 homolog 2 (predicted) Negative GeneticPMID:22681890
pku70Ku domain protein Pku70 Synthetic Growth DefectPMID:11029034
SPAC3A11.13prefoldin subunit 6 (predicted) Negative GeneticPMID:22681890
SPBC336.13cmitochondrial inner membrane peptidase complex catalytic subunit 2 (predicted) Negative GeneticPMID:22681890
rqh1RecQ type DNA helicase Rqh1 Phenotypic EnhancementPMID:22313747
Synthetic Growth Defect
imp1importin alpha Negative GeneticPMID:22681890
spp27RNA polymerase I upstream activation factor complex subunit Spp27 Negative GeneticPMID:22681890
SPBC106.13ubiquitin ligase complex subunit, involved in proteasome-dependent catabolite inactivation of FBPase (predicted) Negative GeneticPMID:22681890
SPAC17H9.08mitochondrial coenzyme A transporter (predicted) Negative GeneticPMID:22681890
raf2Rik1-associated factor Raf2 Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
est1telomerase regulator Est1 Affinity Capture-WesternPMID:12676088
ter1telomerase RNA Affinity Capture-WesternPMID:22446625
Affinity Capture-RNAPMID:22215813
Protein-RNAPMID:22302936
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External References
Database Identifier Description
NBRP SPBC29A3.14c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC29A3.14c Retrieval of eukaryotic orthologs
BioGrid SPBC29A3.14c BioGRID Interaction Datasets
Bähler Lab SPBC29A3.14c Cell Cycle Expression Profile
Bähler Lab SPBC29A3.14c Meiosis/Sporulation Expression Profies
Bähler Lab SPBC29A3.14c Pheromone response/mating expression profiles
Bähler Lab SPBC29A3.14c Environmental stress expression profiles
Bähler Lab SPBC29A3.14c Bähler Lab Transcriptome Viewer
Cyclebase SPBC29A3.14c Cell Cycle Data
PInt SPBC29A3.14c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC29A3.14c Entrez Gene
EntrezGene2540601telomerase reverse transcriptase 1 protein Trt1
Uniprot_genenameTRT1
WikiGene2540601telomerase reverse transcriptase 1 protein Trt1
UniProtKB/SwissProtO13339Telomerase reverse transcriptase
ModBaseO13339Database of comparative protein structure models
Pfam Protein DomainsO13339Pfam Domain Arrangement
RefSeq PeptideNP_595842telomerase reverse transcriptase 1 protein Trt1
RefSeq mRNANM_001021746972h- telomerase reverse transcriptase 1 protein Trt1 (trt1), mRNA
European Nucleotide ArchiveAAC49802ENA Protein Mapping
European Nucleotide ArchiveAAC49803ENA Protein Mapping
European Nucleotide ArchiveCAA18391ENA Protein Mapping
SPD / RIKEN41/41A09Orfeome Localization Data
UniParcUPI0000136BEDUniProt Archive

Literature for trt1
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Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013