atf1 (SPBC29B5.01)

Gene Standard Nameatf1 ChromosomeII
Systematic IDSPBC29B5.01 Gene Start1546194
Synonymsgad7, mts1, SPNCRNA.353, SPNG1409, sss1 Gene End1549862
Producttranscription factor, Atf-CREB family Atf1 Gene Length3669
Feature Typeprotein coding CDS Start1547661
Name Description CDS End1549361
Characterisation Statuspublished CDS Length1701

Ensembl Gene Location
  1. SPBC83.16c
  2. SPBC83.19c
  3. SPNCRNA.352
  4. SPBC83.17
  5. fic1
  6. SPNCRNA.1441
  7. atf1
  8. isp4
  9. SPNCRNA.1442
  10. SPNCRNA.1443
Fission Yeast Phenotype Ontology

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0000235abnormal regulation of translation in response to osmotic stressatf1delta (deletion)deletionPMID:18065650
FYPO:0000825increased RNA level during vegetative growthNorthern assay evidenceatf1-delta (deletion)deletionPECO:0000078PMID:9585505
assayed_using bfr1
FYPO:0000988normal cellular response to arsenicCell growth assayatf1delta (deletion)deletionPECO:0000137PMID:9585505
FYPO:0001096normal RNA level during nitrogen starvationNorthern assay evidenceatf1delta (deletion)deletionPECO:0000126, PECO:0000103PMID:9710608
assayed_using fnx1
FYPO:0002060viable vegetative cell populationMicroscopyatf1delta (deletion)deletionPMID:20473289
GO Molecular Function

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceWith/FromReference
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAPMID:15448137
IDAPMID:8557039
has_direct_input m26_siteIDAPMID:15448137
has_direct_input iron_repressed_GATA_elementIDAPMID:9135083
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
has_regulation_target ecm33IDAPMID:20032302
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
has_regulation_target gpx1IMPPMID:10455235
has_regulation_target ish1IMPPMID:11751918
has_regulation_target ecm33IMPPMID:20032302
happens_during cellular response to cadmium ion, has_regulation_target ntp1IMPPMID:15164362
has_regulation_target sro1IMPPMID:18410345
happens_during cellular response to heat, has_regulation_target ntp1IMPPMID:15164362
happens_during regulation of transcription from RNA polymerase II promoter in response to oxidative stress, has_regulation_target hsr1IMPPMID:18003976
has_regulation_target gsa1IMPPMID:12787490
GO:0003723RNA bindingIDAPMID:7518718
GO:0005515protein bindingIPIsty1GO_REF:0000001
GO:0010844recombination hotspot bindingIDAPMID:7958849
GO:0042803protein homodimerization activityIPIatf1PMID:7958849
GO:0043565sequence-specific DNA bindingIDAPMID:7958849
GO:0046982protein heterodimerization activityIPIpcr1PMID:7958849
GO Biological Process

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceWith/FromReference
GO:0006995cellular response to nitrogen starvationIMPPMID:15448137
GO:0009267cellular response to starvation
requiredIMPPMID:9135083
requiredIMPPMID:8557039
GO:0010520regulation of reciprocal meiotic recombinationIMPPMID:9391101
GO:0010846activation of reciprocal meiotic recombinationIMPPMID:9391101
GO:0010847regulation of chromatin assemblyIMPPMID:15448137
GO:0010848regulation of chromatin disassemblyIMPPMID:15448137
GO:0031990mRNA export from nucleus in response to heat stressIMPPMID:15840944
NOT GO:0034599cellular response to oxidative stressIMPPMID:9585505
GO:0036129negative regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide
has_regulation_target bfr1IMPPMID:9585505
GO:0043949regulation of cAMP-mediated signalingIMPPMID:15448137
GO:0045128negative regulation of reciprocal meiotic recombinationIMPPMID:18375981
NOT GO:0046685response to arsenic-containing substanceIGIpap1PMID:16087744
GO:0051039positive regulation of transcription during meiosisIDAPMID:8557039
GO:0070301cellular response to hydrogen peroxideIGIpap1PMID:16087744
NOT GO:0071243cellular response to arsenic-containing substanceIMPPMID:9585505
NOT GO:0071276cellular response to cadmium ionIMPPMID:9585505
GO:1900411regulation of histone acetylation by regulation of transcription from RNA polymerase II promoterIMPPMID:15218150
GO:1900412regulation of histone methylation by regulation of transcription from RNA polymerase II promoterIMPPMID:15218150
GO Cellular Component

Ontology Graph

Contact Curators
Term IDTerm NameEvidenceWith/FromReference
GO:0000790nuclear chromatinNASGO_REF:0000001
GO:0005634nucleusIDAPMID:16823372
Transcript
Contact Curators
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
115461941546464
215473201549862

References

Region Start End Reference
three_prime_UTR15493621549862PMID:21511999
five_prime_UTR15461941546464PMID:21511999
three_prime_UTR15493621549862PMID:21511999
five_prime_UTR15473201547660PMID:21511999
Protein Features
Contact Curators

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF11785 IPR020956 Pfam Transcription factor Aft1, osmotic stress domain 57 100 1
PF11787 IPR021756 Pfam Transcription factor Aft1, HRR domain 238 317 1
PF00170 IPR004827 Pfam Basic-leucine zipper domain 474 530 5
PF11786 IPR021755 Pfam Transcription factor Aft1, HRA domain 148 234 1
SM00338 IPR004827 SMART Basic-leucine zipper domain 470 534 5
PS50217 IPR004827 Prosite Profiles Basic-leucine zipper domain 472 535 6
G3DSA:1.20.5.170 Gene3D 474 535 7
SSF57959 SuperFamily 474 534 6
Coil ncoils Rabaptin coiled-coil domain 497 532 974
PTHR19304 hmmpanther 81 544 4
PTHR19304:SF5 hmmpanther 81 544 1

View domain organization at Pfam

Protein Modifications (PSI-MOD)

Term IDTerm NameEvidenceResidueReference
MOD:00696phosphorylated residue

Manually Curated Family or Sub-families

Term IDTerm NameReferenceAll Genes
PBO:0000545bZIP (basic leucine zipper) transcription factor familyPMID:8824587Temporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0000545
PBO:0002433Atf-CREB subfamilyTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0002433

Protein Properties

Ave. residue weight 105.50 Da
Charge -2.50
Isoelectric point 5.75
Molecular weight 59.71 kDa
Number of residues 566
Sequence
Contact Curators
Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
deletion mutant expression profiling PMID:12529438 PMID:18003976
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide6987.67PMID:23101633
experimental evidencePECO:0000014,
PECO:0000005		population_wide3577.25PMID:23101633
RNA levelexperimental evidencePECO:0000014,
PECO:0000005		population_wide5PMID:23101633
experimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide3PMID:23101633
Subunit Composition
DescriptionQualifierReference
homodimeric PMID:7958849
heterodimeric PMID:7958849
Pathway
DescriptionQualifierReference
links stress-activated MAPK (Sty1) pathway to cAMP-dependent protein kinase (Pka1) pathway PMID:15448137
Species Distribution
DescriptionQualifierReference
orthologs cannot be distinguished
conserved in fungi
conserved in eukaryotes
conserved in eukaryotes only
Contact Curators
Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
rpn1019S proteasome regulatory subunit Rpn10 Synthetic LethalityPMID:10809753
cip1RNA-binding protein Cip1 Synthetic RescuePMID:16407405
pap1transcription factor Pap1/Caf3 Phenotypic EnhancementPMID:11907263
Synthetic LethalityPMID:15247218
Synthetic RescuePMID:16087744
Phenotypic EnhancementPMID:10749922
Negative GeneticPMID:9585505
zip1transcription factor Zip1 Dosage RescuePMID:10102365
ran1serine/threonine protein kinase Ran1 Synthetic RescuePMID:8824587
sck2serine/threonine protein kinase Sck2 Synthetic LethalityPMID:20453258
ubp6ubiquitin C-terminal hydrolase Ubp6 Synthetic LethalityPMID:15533439
sty1MAP kinase Sty1 Synthetic Growth DefectPMID:20061379
Dosage Rescue
Phenotypic Enhancement
Dosage RescuePMID:8824587
Phenotypic SuppressionPMID:9154834
tup11transcriptional corepressor Tup11 Phenotypic SuppressionPMID:11238405
dcr1dicer Phenotypic EnhancementPMID:15218150
ago1argonaute Phenotypic EnhancementPMID:15218150
wis1MAP kinase kinase Wis1 Phenotypic SuppressionPMID:15870269
Synthetic RescuePMID:8824587
prr1transcription factor Prr1 Synthetic Growth DefectPMID:11179424
deb1transcription factor Deb1/Rdp1 Phenotypic EnhancementPMID:15218150
uch2ubiquitin C-terminal hydrolase Uch2 Synthetic Growth DefectPMID:15533439
cip2RNA-binding protein Cip2 Synthetic RescuePMID:16407405
tup12transcriptional corepressor Tup12 Phenotypic SuppressionPMID:11238405
pcr1transcription factor Pcr1 Dosage RescuePMID:10102365
Phenotypic EnhancementPMID:18375616
atf31transcription factor Atf31 Dosage RescuePMID:10102365
atf21transcription factor, Atf-CREB family Atf21 Dosage RescuePMID:10102365
int6eIF3e subunit Int6 Dosage RescuePMID:20875427
cut1separase/separin Synthetic LethalityPMID:16861909
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
pmk1MAP kinase Pmk1 Biochemical ActivityPMID:17881729
rpn1019S proteasome regulatory subunit Rpn10 Affinity Capture-WesternPMID:11584278
swi6HP1 family chromodomain protein Swi6 Affinity Capture-WesternPMID:15292231
clr6histone deacetylase (class I) Clr6 Affinity Capture-WesternPMID:15292231
clr3histone deacetylase (class II) Clr3 Affinity Capture-WesternPMID:15292231
dph1UBA domain protein Dph1 Affinity Capture-WesternPMID:11584278
cbf11CBF1/Su(H)/LAG-1 family transcription factor Cbf11 Affinity Capture-MSPMID:22540037
rhp23Rad23 homolog Rhp23 Affinity Capture-WesternPMID:11584278
fbh1DNA helicase I Affinity Capture-WesternPMID:19836238
sty1MAP kinase Sty1 Biochemical ActivityPMID:8824588
Biochemical ActivityPMID:12383265
Biochemical ActivityPMID:8824587
Affinity Capture-Western
Biochemical ActivityPMID:18272791
pcr1transcription factor Pcr1 Affinity Capture-RNAPMID:22144913
Affinity Capture-WesternPMID:9135083
Affinity Capture-WesternPMID:18375616
Contact Curators
External References
Database Identifier Description
NBRP SPBC29B5.01 Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC29B5.01 Retrieval of eukaryotic orthologs
BioGrid SPBC29B5.01 BioGRID Interaction Datasets
Bähler Lab SPBC29B5.01 Cell Cycle Expression Profile
Bähler Lab SPBC29B5.01 Meiosis/Sporulation Expression Profies
Bähler Lab SPBC29B5.01 Pheromone response/mating expression profiles
Bähler Lab SPBC29B5.01 Environmental stress expression profiles
Bähler Lab SPBC29B5.01 Bähler Lab Transcriptome Viewer
Cyclebase SPBC29B5.01 Cell Cycle Data
PInt SPBC29B5.01 Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC29B5.01 Entrez Gene
WikiGene2540329transcription factor Atf1
Uniprot_genenameATF1
EntrezGene2540329transcription factor Atf1
UniProtKB/SwissProtP52890Transcription factor atf1
ModBaseP52890Database of comparative protein structure models
Pfam Protein DomainsP52890Pfam Domain Arrangement
RefSeq PeptideNP_595652transcription factor Atf1
RefSeq mRNANM_001021546972h- transcription factor Atf1 (atf1), mRNA
European Nucleotide ArchiveAAA93260ENA Protein Mapping
European Nucleotide ArchiveAAB46990ENA Protein Mapping
European Nucleotide ArchiveBAA09817ENA Protein Mapping
European Nucleotide ArchiveBAA09841ENA Protein Mapping
European Nucleotide ArchiveBAA12194ENA Protein Mapping
European Nucleotide ArchiveCAC05510ENA Protein Mapping
SPD / RIKEN33/33C12Orfeome Localization Data
UniParcUPI0000126228UniProt Archive

Literature for atf1
Contact Curators

Search: UK PMC or PubMed

Release Version: PomBase:18_35 - 11 May 2013