isp4 (SPBC29B5.02c)

Gene Standard Nameisp4 ChromosomeII
Systematic IDSPBC29B5.02c Gene Start1553467
Synonyms Gene End1550293
ProductOPT oligopeptide transporter family Isp4 Gene Length3175
Feature Typeprotein coding CDS Start1552791
Name Description CDS End1550434
Characterisation Statuspublished CDS Length2358

Ensembl Gene Location
  1. fic1
  2. SPNCRNA.1441
  3. atf1
  4. isp4
  5. SPNCRNA.1442
  6. SPNCRNA.1443
  7. SPNCRNA.1444
  8. rpl26
  9. SPBC29B5.04c
Fission Yeast Phenotype Ontology

Ontology Graph

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Term IDTerm NameEvidenceAlleleAllele TypeExpressionConditionReference
FYPO:0001491viable vegetative cellMicroscopyisp4delta (deletion)deletionPMID:20473289
FYPO:0001577abolished cell population growth on tetrapeptide nitrogen sourceCell growth assayisp4delta (deletion)deletionPMID:22226946
GO Molecular Function

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Term IDTerm NameEvidenceWith/FromReference
GO:0035673oligopeptide transmembrane transporter activityNASGO_REF:0000001
GO:1901584tetrapeptide transmembrane transporter activityIMPPMID:22226946
GO Biological Process

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Term IDTerm NameEvidenceWith/FromReference
GO:0000747conjugation with cellular fusionIMPPMID:7954893
GO:0015031protein transportIEAUniProtKB:KW-0653GO_REF:0000037
GO:0031142induction of conjugation upon nitrogen starvationIEPPMID:7954893
GO:1901583tetrapeptide transmembrane transportIMPPMID:22226946
GO Cellular Component

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Term IDTerm NameEvidenceWith/FromReference
GO:0005783endoplasmic reticulumIDAPMID:16823372
GO:0005789endoplasmic reticulum membraneIEASL-0097GO_REF:0000039
GO:0005794Golgi apparatus
happens_during cellular response to nitrogen levelsIDAPMID:22226946
GO:0005886plasma membrane
happens_during cellular response to nitrogen starvationIDAPMID:22226946
GO:0016021integral to membraneIEAUniProtKB:KW-0812GO_REF:0000037
Transcript
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Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
115534671550293

References

Region Start End Reference
five_prime_UTR15534671552792PMID:18488015
Protein Features
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Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID InterPro Database Description Start End All Genes
PF03169 IPR004813 Pfam Oligopeptide transporter, OPT superfamily 89 740 3
TMhelix TMHMM 720 742 955
TMhelix TMHMM 92 114 955
TMhelix TMHMM 264 286 955
TMhelix TMHMM 462 484 955
TMhelix TMHMM 579 596 955
TMhelix TMHMM 491 513 955
TMhelix TMHMM 411 433 955
TMhelix TMHMM 222 244 955
TMhelix TMHMM 643 662 955
TMhelix TMHMM 611 630 955
TMhelix TMHMM 196 218 955
TMhelix TMHMM 685 707 955
TMhelix TMHMM 536 558 955
TMhelix TMHMM 338 360 955
PTHR22601 hmmpanther 25 784 3
TIGR00728 IPR004813 tigrfam Oligopeptide transporter, OPT superfamily 73 743 3
TIGR00727 IPR004648 tigrfam Tetrapeptide transporter, OPT1/isp4 67 748 3

View domain organization at Pfam

Sequence Ontology

Term IDTerm NameReference
SO:0001812transmembrane_helix

Protein Properties

Ave. residue weight 113.62 Da
Charge -3.50
Isoelectric point 5.99
Molecular weight 89.19 kDa
Number of residues 785
Sequence
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Gene Expression
DescriptionEvidenceDuringConditionRangeAverage per CellReference
protein levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide26065.45PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000005,
PECO:0000014		population_widePMID:23101633
RNA levelexperimental evidencecell quiescence following G1 arrest due to nitrogen limitationPECO:0000127,
PECO:0000014,
PECO:0000005		population_wide15PMID:23101633
experimental evidencevegetative growth of a single-celled organismPECO:0000014,
PECO:0000005		population_wide2.9PMID:23101633
expression microarray evidenceincreasedPMID:22840777
Species Distribution
DescriptionQualifierReference
conserved in fungi
conserved in eukaryotes
Manually curated orthologous groups
SpeciesGeneDescription

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Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
SPAC821.05translation initiation factor eIF3h (p40) Negative GeneticPMID:22681890
cdt2WD repeat protein Cdt2 Positive GeneticPMID:22681890
gcn5SAGA complex histone acetyltransferase catalytic subunit Gcn5 Positive GeneticPMID:22681890
mug81ATP-dependent RNA helicase Slh1 (predicted) Negative GeneticPMID:22681890
ccr4CCR4-Not complex subunit Ccr4 (predicted) Positive GeneticPMID:22681890
ptr2PTR family peptide transporter Ptr2 Synthetic Growth DefectPMID:22226946
sdh4TIM22 inner membrane protein import complex anchor subunit Tim18 Negative GeneticPMID:22681890
kin1microtubule affinity-regulating kinase Kin1 Positive GeneticPMID:22681890
ssp2serine/threonine protein kinase Ssp2 Positive GeneticPMID:22681890
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External References
Database Identifier Description
NBRP SPBC29B5.02c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC29B5.02c Retrieval of eukaryotic orthologs
BioGrid SPBC29B5.02c BioGRID Interaction Datasets
Bähler Lab SPBC29B5.02c Cell Cycle Expression Profile
Bähler Lab SPBC29B5.02c Meiosis/Sporulation Expression Profies
Bähler Lab SPBC29B5.02c Pheromone response/mating expression profiles
Bähler Lab SPBC29B5.02c Environmental stress expression profiles
Bähler Lab SPBC29B5.02c Bähler Lab Transcriptome Viewer
Cyclebase SPBC29B5.02c Cell Cycle Data
PInt SPBC29B5.02c Bähler Lab Protein-Protein Interaction Predictor
Entrez Gene SPBC29B5.02c Entrez Gene
WikiGene2540364OPT oligopeptide transporter family
Uniprot_genenameISP4
EntrezGene2540364OPT oligopeptide transporter family
SPD / RIKEN33/33G09Orfeome Localization Data
UniProtKB/SwissProtP40900Sexual differentiation process protein isp4
ModBaseP40900Database of comparative protein structure models
Pfam Protein DomainsP40900Pfam Domain Arrangement
RefSeq PeptideNP_595653OPT oligopeptide transporter family
RefSeq mRNANM_001021547972h- OPT oligopeptide transporter family (isp4), mRNA
European Nucleotide ArchiveBAA03147ENA Protein Mapping
European Nucleotide ArchiveBAA12193ENA Protein Mapping
European Nucleotide ArchiveBAA87199ENA Protein Mapping
European Nucleotide ArchiveCAC05511ENA Protein Mapping
SPD / RIKEN33/33G09Orfeome Localization Data

Literature for isp4
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Search: UK PMC or PubMed

Release Version: PomBase:18.34 - 04 Apr 2013