myo51 (SPBC2D10.14c)


Gene Standard Namemyo51 Characterisation Statuspublished
Systematic IDSPBC2D10.14c Feature Typeprotein coding
Synonyms Name Description
Productmyosin type V Product Size1471aa, 167.66 kDa
Genomic Location Chromosome II, 2994929-2990178 (4752nt); CDS:2994814-2990305 (4510nt)

Ensembl Gene Location
GO Molecular Function
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005524ATP bindingIEAUniProtKB-KW:KW-0067GO_REF:0000037559
GO:0003779actin bindingIEAUniProtKB-KW:KW-0009GO_REF:000003738
GO:0005516calmodulin bindingIEAUniProtKB-KW:KW-0112GO_REF:000003710
GO:0000146microfilament motor activityISMPFAM:PF00063GO_REF:00000014
GO Biological Process
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0061572actin filament bundle organizationIMPPMID:2305173414
GO:0000915cytokinesis, actomyosin contractile ring assemblyIMPPMID:1111269127
GO:0090338positive regulation of formin-nucleated actin cable assemblyIMPPMID:230517342
GO Cellular Component
Term IDTerm NameEvidenceWith/FromReferenceCount
GO:0005826actomyosin contractile ring28
during mitotic interphaseIDAPMID:11112691
GO:0000935barrier septumIDAPMID:2305173418
GO:0032153cell division siteIDAPMID:23051734292
GO:0005829cytosolIDAPMID:168233722317
GO:0070648formin-nucleated actin cableIDAPMID:230517341
GO:0016459myosin complexIEAUniProtKB-KW:KW-0518GO_REF:00000378
Fission Yeast Phenotype Ontology

Population Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002060viable vegetative cell populationno_namePMID:111126913755
Microscopymyo51ΔNullPMID:20473289
Microscopymyo51ΔNullPECO:0000005, PECO:0000137PMID:23697806

Cell Phenotype

Term IDTerm NameEvidenceAlleleExpressionConditionReferenceCount
FYPO:0002441decreased rate of actin cable retrograde transportMicroscopymyo51ΔNullPMID:230517342
FYPO:0001122elongated vegetative cellnot recorded (overexpression)PMID:11112691624
FYPO:0002487normal actin cable morphologyMicroscopymyo51ΔNullPMID:230517343
FYPO:0001294normal actin cortical patch localizationMicroscopymyo51ΔNullPMID:230517347
FYPO:0001587normal protein localization to cell tipMicroscopymyo51ΔNullPMID:230517347
affecting myo52
affecting for3Microscopymyo51ΔNullPMID:23051734
FYPO:0002443normal rate of actin cable retrograde transportMicroscopymyo51-ΔTail (C-terminal truncation)Not specifiedPMID:230517341
FYPO:0001125normal vegetative cell shapeMicroscopymyo51ΔNullPMID:230517342
FYPO:0002177viable vegetative cell with normal cell morphologyMicroscopymyo51ΔNullPECO:0000005, PECO:0000137PMID:236978063078
penetrance FYPO_EXT:0000001
Transcript
Ensembl transcript structure with UTRs, exons and introns

Exons

Exon Start End
129949292994786
229947302990810
329907702990178

UTRs

Region Start End Reference
five_prime_UTR29949292994815PMID:21511999
three_prime_UTR29903042990178PMID:21511999
Protein Features

Graphical View

Ensembl protein image with mapped locations of structural domains

Protein Families and Domains

Feature ID Database InterPro Description Start End Count
PF00063 Pfam IPR001609 Myosin head, motor domain 69 737 5
PF01843 Pfam IPR018444 Dil domain 1298 1399 3
PF00612 Pfam IPR000048 IQ motif, EF-hand binding site 777 795 3
PF00612 Pfam IPR000048 IQ motif, EF-hand binding site 850 869 3
PF00612 Pfam IPR000048 IQ motif, EF-hand binding site 754 773 3
PF00612 Pfam IPR000048 IQ motif, EF-hand binding site 801 820 3
SM00242 SMART IPR001609 Myosin head, motor domain 59 750 5
SM00015 SMART IPR000048 IQ motif, EF-hand binding site 847 869 5
SM00015 SMART IPR000048 IQ motif, EF-hand binding site 799 821 5
SM00015 SMART IPR000048 IQ motif, EF-hand binding site 751 773 5
SM00015 SMART IPR000048 IQ motif, EF-hand binding site 870 892 5
SM00015 SMART IPR000048 IQ motif, EF-hand binding site 774 796 5
PS50096 Prosite Profiles IPR000048 IQ motif, EF-hand binding site 800 825 5
PS50096 Prosite Profiles IPR000048 IQ motif, EF-hand binding site 753 781 5
PS50096 Prosite Profiles IPR000048 IQ motif, EF-hand binding site 777 804 5
PS50096 Prosite Profiles IPR000048 IQ motif, EF-hand binding site 848 877 5
PS51126 Prosite Profiles IPR002710 Dilute 1171 1417 3
PTHR13140 HMMPANTHER 10 1025 8
PTHR13140:SF191 HMMPANTHER 10 1025 2
G3DSA:1.20.5.190 Gene3D 777 818 2
SSF52540 SuperFamily IPR027417 40 800 294
SSF52540 SuperFamily IPR027417 797 844 294
Coil ncoils Rabaptin coiled-coil domain 967 988 975
Low complexity (SEG) seg 932 945
PR00193 PRINTS IPR001609 Myosin head, motor domain 152 177 5
PR00193 PRINTS IPR001609 Myosin head, motor domain 201 228 5
PR00193 PRINTS IPR001609 Myosin head, motor domain 95 114 5
PR00193 PRINTS IPR001609 Myosin head, motor domain 487 515 5
PR00193 PRINTS IPR001609 Myosin head, motor domain 434 462 5

View domain organization at Pfam

Manually Curated Family or Sub-families

Term IDTerm NameReferenceCount
PBO:0001026IQ domainTemporary processing gif - replaced by AJAX with count of genes annotated with the term PBO:0001026

Protein Properties

Ave. residue weight 113.98 Da
Charge 53.00
Isoelectric point 9.29
Molecular weight 167.66 kDa
Number of residues 1471
Sequence
Gene Expression

Quantitative Gene Expression

Protein Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
987.38during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
1223.96during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633

RNA Level

Molecules/Cell (average)DuringConditionScaleEvidenceReference
0.39during cell quiescence following G1 arrest due to nitrogen limitationPECO:0000005,
PECO:0000014,
PECO:0000127
population_wideexperimental evidencePMID:23101633
1.1during GO:0072690PECO:0000005,
PECO:0000014
population_wideexperimental evidencePMID:23101633
Species Distribution
DescriptionQualifierReferenceCount
conserved in fungi4564
conserved in eukaryotes4482
conserved in metazoa3419
conserved in vertebrates3394
conserved in eukaryotes only2485
Orthologs

Manually curated orthologous groups

SpeciesGeneDescriptionLinksCount

Orthologs in Compara


Genetic Interactions

Source: BioGRID

Gene Product Evidence Reference
ams2cell cycle regulated GATA-type transcription factor Ams2 Negative GeneticPMID:22681890
pnk1DNA kinase/phosphatase Pnk1 Negative GeneticPMID:18818364
myo2myosin II heavy chain Phenotypic EnhancementPMID:23185032
ase1antiparallel microtubule cross-linking factor Ase1 Negative GeneticPMID:22681890
lub1WD repeat protein Lub1 Negative GeneticPMID:18818364
cyp4cyclophilin family peptidyl-prolyl cis-trans isomerase Cyp4 (predicted) Negative GeneticPMID:22681890
pyp1tyrosine phosphatase Pyp1 Positive GeneticPMID:22681890
ftp105Ubp5 interacting protein Ftp105 Negative GeneticPMID:18818364
mid1medial ring protein Mid1 Positive GeneticPMID:22681890
myo52myosin type V Phenotypic EnhancementPMID:23051734
mal3EB1 family Mal3 Phenotypic EnhancementPMID:23051734
rad55RecA family ATPase Rad55/Rhp55 Negative GeneticPMID:22681890
elp2elongator complex subunit Elp2 (predicted) Negative GeneticPMID:22681890
hip1hira protein, histone chaperone Hip1 Negative GeneticPMID:22681890
dao1D-amino acid oxidase Positive GeneticPMID:22681890
cyk3cytokinesis protein Cyk3 (predicted) Negative GeneticPMID:22681890
pit1serine/threonine protein kinase, meiotic Pit1 Positive GeneticPMID:22681890
SPBC30B4.06cmitochondrial GIDA family tRNA uridine 5-carboxymethylaminomethyl modification enzyme (predicted) Negative GeneticPMID:22681890
bob1prefoldin subunit 5 (predicted) Negative GeneticPMID:22681890
mrc1mediator of replication checkpoint 1 Negative GeneticPMID:18818364
prw1Clr6 histone deacetylase complex subunit Prw1 Negative GeneticPMID:22681890
ppm1leucine carboxyl methyltransferase Ppm1 (predicted) Negative GeneticPMID:22681890
pom1DYRK family protein kinase Pom1 Negative GeneticPMID:18818364
Negative GeneticPMID:22681890
Physical Interactions

Source: BioGRID

Gene Product Evidence Reference
myo2myosin II heavy chain Affinity Capture-RNAPMID:19805578
rng2IQGAP Affinity Capture-RNAPMID:19805578
myp2myosin II heavy chain Myo3 Affinity Capture-RNAPMID:19805578
myo1myosin type I Affinity Capture-RNAPMID:19805578
hhp2serine/threonine protein kinase Hhp2 Affinity Capture-MSPMID:24055157
myo52myosin type V Affinity Capture-RNAPMID:19805578
External References
Database Identifier Description
NBRP SPBC2D10.14c Fission yeast strain database, National BioResource Project (Japan)
YOGY SPBC2D10.14c Retrieval of eukaryotic orthologs (Bähler Lab)
BioGrid SPBC2D10.14c BioGRID Interaction Datasets
Expression Viewer SPBC2D10.14c Cell Cycle Expression Profile (Bähler Lab)
Expression Viewer SPBC2D10.14c Meiosis/Sporulation Expression Profies (Bähler Lab)
Expression Viewer SPBC2D10.14c Pheromone response/mating expression profiles (Bähler Lab)
Expression Viewer SPBC2D10.14c Environmental stress expression profiles (Bähler Lab)
Pomb(A) SPBC2D10.14c Polyadenylation Viewer (Gullerova lab)
pombeTV SPBC2D10.14c Transcriptome Viewer (Bähler Lab)
Cyclebase SPBC2D10.14c Cell Cycle Data
GEO SPBC2D10.14c GEO profiles
PInt SPBC2D10.14c Protein-Protein Interaction Predictor (Bähler Lab)
EntrezGene2540560myosin type V
WikiGene2540560myosin type V
SPD / RIKEN30/30H10Orfeome Localization Data
UniProtKB/SwissProtO74805Myosin-51
ModBaseO74805Database of comparative protein structure models
StringO74805Network display of known and predicted interactions and functional associations
RefSeq PeptideNP_596233myosin type V
RefSeq mRNANM_001022153972h- myosin type V (myo51), mRNA
European Nucleotide ArchiveCAA21172ENA Protein Mapping
UniParcUPI0000069F9DUniProt Archive

Literature for myo51

Search: Europe PMC or PubMed

Release Version: PomBase:21_41 - 24 Feb 2014